Details for: TAL1

Gene ID: 6886

Symbol: TAL1

Ensembl ID: ENSG00000162367

Description: TAL bHLH transcription factor 1, erythroid differentiation factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 18.6877
    Cell Significance Index: -4.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 11.4506
    Cell Significance Index: -5.8900
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 4.9406
    Cell Significance Index: 2.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.3829
    Cell Significance Index: -1.7100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.2890
    Cell Significance Index: 21.6800
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.8291
    Cell Significance Index: 3.0900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.7606
    Cell Significance Index: 10.9000
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.6334
    Cell Significance Index: 6.5600
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.4786
    Cell Significance Index: 3.4400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.4599
    Cell Significance Index: 3.7500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.3743
    Cell Significance Index: 2.9600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3539
    Cell Significance Index: 5.0900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.2217
    Cell Significance Index: 3.1500
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.1157
    Cell Significance Index: 1.3900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0863
    Cell Significance Index: 0.9800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0707
    Cell Significance Index: 0.8000
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: 0.0553
    Cell Significance Index: 0.6200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0381
    Cell Significance Index: 0.2300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0271
    Cell Significance Index: 0.3800
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.0226
    Cell Significance Index: 0.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -6.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0065
    Cell Significance Index: -4.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0087
    Cell Significance Index: -5.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0090
    Cell Significance Index: -5.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0092
    Cell Significance Index: -7.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0098
    Cell Significance Index: -2.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0179
    Cell Significance Index: -6.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0190
    Cell Significance Index: -8.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0239
    Cell Significance Index: -4.3100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0274
    Cell Significance Index: -1.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0288
    Cell Significance Index: -5.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0311
    Cell Significance Index: -1.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0318
    Cell Significance Index: -6.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0336
    Cell Significance Index: -5.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0371
    Cell Significance Index: -5.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0416
    Cell Significance Index: -5.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0456
    Cell Significance Index: -5.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0466
    Cell Significance Index: -5.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0499
    Cell Significance Index: -6.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0507
    Cell Significance Index: -5.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0521
    Cell Significance Index: -5.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0602
    Cell Significance Index: -1.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0670
    Cell Significance Index: -6.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0710
    Cell Significance Index: -5.6200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0738
    Cell Significance Index: -1.3100
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0778
    Cell Significance Index: -0.7400
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.0779
    Cell Significance Index: -0.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0796
    Cell Significance Index: -5.9400
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.0898
    Cell Significance Index: -0.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0900
    Cell Significance Index: -6.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0924
    Cell Significance Index: -5.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0975
    Cell Significance Index: -5.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1048
    Cell Significance Index: -7.0500
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.1117
    Cell Significance Index: -1.2200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1197
    Cell Significance Index: -0.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1205
    Cell Significance Index: -5.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1312
    Cell Significance Index: -7.3600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1335
    Cell Significance Index: -1.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1388
    Cell Significance Index: -6.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1413
    Cell Significance Index: -3.9500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1422
    Cell Significance Index: -5.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1432
    Cell Significance Index: -7.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1538
    Cell Significance Index: -4.1200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1614
    Cell Significance Index: -3.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1620
    Cell Significance Index: -5.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1630
    Cell Significance Index: -7.2100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1715
    Cell Significance Index: -4.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1782
    Cell Significance Index: -4.5800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1819
    Cell Significance Index: -2.6600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1825
    Cell Significance Index: -4.5500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1861
    Cell Significance Index: -2.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1881
    Cell Significance Index: -5.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1912
    Cell Significance Index: -7.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1951
    Cell Significance Index: -5.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1958
    Cell Significance Index: -6.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2033
    Cell Significance Index: -6.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2039
    Cell Significance Index: -5.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2094
    Cell Significance Index: -5.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2162
    Cell Significance Index: -7.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2182
    Cell Significance Index: -6.9500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2236
    Cell Significance Index: -4.5500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2262
    Cell Significance Index: -2.7800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2328
    Cell Significance Index: -2.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2456
    Cell Significance Index: -7.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2466
    Cell Significance Index: -6.3000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2574
    Cell Significance Index: -4.1300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2578
    Cell Significance Index: -3.5400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2578
    Cell Significance Index: -5.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2603
    Cell Significance Index: -5.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2628
    Cell Significance Index: -5.5000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2638
    Cell Significance Index: -3.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2666
    Cell Significance Index: -7.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2694
    Cell Significance Index: -4.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2696
    Cell Significance Index: -7.0900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2759
    Cell Significance Index: -6.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2765
    Cell Significance Index: -4.7400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2766
    Cell Significance Index: -6.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2831
    Cell Significance Index: -6.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2844
    Cell Significance Index: -5.5500
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.2846
    Cell Significance Index: -0.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** TAL1 is a transcription factor that regulates gene expression by binding to specific DNA sequences, influencing the transcription of target genes. 2. **Erythroid Differentiation:** TAL1 is a key regulator of erythropoiesis, driving the differentiation of proerythroblasts into mature erythrocytes. 3. **Cell Fate Commitment:** TAL1 influences cell fate decisions, promoting the differentiation of certain cell types, such as endothelial cells and intestinal crypt stem cells. 4. **Chromatin Organization:** TAL1 interacts with chromatin-modifying enzymes, regulating chromatin organization and gene expression. 5. **Angiogenesis:** TAL1 has been implicated in angiogenesis, the process of new blood vessel formation, which is essential for tissue development and growth. **Pathways and Functions:** 1. **Erythropoiesis:** TAL1 regulates the expression of genes involved in erythropoiesis, including those involved in hemoglobin synthesis and erythrocyte maturation. 2. **Chromatin Regulation:** TAL1 interacts with chromatin-modifying enzymes, influencing chromatin organization and gene expression. 3. **Cell Fate Commitment:** TAL1 promotes the differentiation of certain cell types, such as endothelial cells and intestinal crypt stem cells. 4. **Angiogenesis:** TAL1 regulates angiogenesis by influencing the expression of genes involved in blood vessel formation. 5. **Transcriptional Regulation:** TAL1 regulates gene expression by binding to specific DNA sequences, influencing the transcription of target genes. **Clinical Significance:** 1. **Hematological Disorders:** Dysregulation of TAL1 has been implicated in various hematological disorders, including anemia and leukemia. 2. **Angiogenesis Disorders:** TAL1 dysregulation has been linked to angiogenesis disorders, such as cancer and cardiovascular disease. 3. **Neurological Disorders:** TAL1 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cancer:** TAL1 has been identified as a potential oncogene in certain types of cancer, including leukemia and lymphoma. In conclusion, TAL1 is a multifunctional transcription factor that plays a critical role in erythropoiesis, cell fate commitment, and chromatin organization. Its dysregulation has been implicated in various clinical disorders, highlighting its importance as a therapeutic target for the treatment of hematological and neurological diseases.

Genular Protein ID: 2758457991

Symbol: TAL1_HUMAN

Name: T-cell acute lymphocytic leukemia protein 1

UniProtKB Accession Codes:

P17542 D3DQ24

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 16 Ensembl 3 EvolutionaryTrace 1 GO 43 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 12 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2247063

Title: The SCL gene is formed from a transcriptionally complex locus.

PubMed ID: 2247063

DOI: 10.1128/mcb.10.12.6426-6435.1990

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 2230650

Title: Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.

PubMed ID: 2230650

DOI: 10.1084/jem.172.5.1403

PubMed ID: 2602361

Title: The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.

PubMed ID: 2602361

DOI: 10.1073/pnas.86.24.10128

PubMed ID: 2303035

Title: The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.

PubMed ID: 2303035

DOI: 10.1002/j.1460-2075.1990.tb08126.x

PubMed ID: 1396592

Title: The SCL gene product: a positive regulator of erythroid differentiation.

PubMed ID: 1396592

DOI: 10.1002/j.1460-2075.1992.tb05500.x

PubMed ID: 8437851

Title: Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues.

PubMed ID: 8437851

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 331
  • Mass: 34271
  • Checksum: 33BBE31589DBB7C7
  • Sequence:
    • MTERPPSEAA RSDPQLEGRD AAEASMAPPH LVLLNGVAKE TSRAAAAEPP VIELGARGGP 
GGGPAGGGGA ARDLKGRDAA TAEARHRVPT TELCRPPGPA PAPAPASVTA ELPGDGRMVQ 
LSPPALAAPA APGRALLYSL SQPLASLGSG FFGEPDAFPM FTTNNRVKRR PSPYEMEITD 
GPHTKVVRRI FTNSRERWRQ QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA 
KLLNDQEEEG TQRAKTGKDP VVGAGGGGGG GGGGAPPDDL LQDVLSPNSS CGSSLDGAAS 
PDSYTEEPAP KHTARSLHPA MLPAADGAGP R

Genular Protein ID: 2527383175

Symbol: Q16509_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q16509

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 1886719

Title: Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene.

PubMed ID: 1886719

Sequence Information:

  • Length: 331
  • Mass: 34285
  • Checksum: 58D0E31589DBB396
  • Sequence:
    • MTERPPSEAA RSDPQLEGRD AAEASMAPPH LVLLNGVAKE TSRAAAAEPP VIELGARGGP 
GGGPAGGGGA ARDLKGRDAA TAEARHRVPT TELCRPPGPA PAPAPASVTA ELPGDGRMVQ 
LSPPALAAPA APGRALLYSL SQPLASLGSG FFGEPDAFPM FTTNNRVKRR PSPYEMEITD 
GPHTKVVRRI FTNSRERWRQ QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA 
KLLNDQEEEG TQRAKTGKDP VVGAGGGGGG GGGGAPPDDL LQDVLSPNSS CGTSLDGAAS 
PDSYTEEPAP KHTARSLHPA MLPAADGAGP R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.