Details for: TARBP1

Gene ID: 6894

Symbol: TARBP1

Ensembl ID: ENSG00000059588

Description: TAR (HIV-1) RNA binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 198.2703
    Cell Significance Index: -30.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 97.4991
    Cell Significance Index: -24.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 70.2148
    Cell Significance Index: -33.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.7035
    Cell Significance Index: -25.8800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.1487
    Cell Significance Index: -25.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.5646
    Cell Significance Index: -31.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.8073
    Cell Significance Index: -31.6300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.4368
    Cell Significance Index: -35.1300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.7454
    Cell Significance Index: -19.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.1347
    Cell Significance Index: -32.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.8432
    Cell Significance Index: 570.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.7132
    Cell Significance Index: 120.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.6722
    Cell Significance Index: 101.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.5100
    Cell Significance Index: 900.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.2488
    Cell Significance Index: 49.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.2403
    Cell Significance Index: 63.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1791
    Cell Significance Index: 432.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.9572
    Cell Significance Index: 131.6000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.5040
    Cell Significance Index: 18.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.4582
    Cell Significance Index: 100.8400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1282
    Cell Significance Index: 780.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0019
    Cell Significance Index: 64.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9217
    Cell Significance Index: 26.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8951
    Cell Significance Index: 50.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8640
    Cell Significance Index: 51.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.8563
    Cell Significance Index: 14.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8405
    Cell Significance Index: 91.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8334
    Cell Significance Index: 23.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8064
    Cell Significance Index: 49.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7684
    Cell Significance Index: 124.9800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.7526
    Cell Significance Index: 9.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7293
    Cell Significance Index: 15.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6267
    Cell Significance Index: 48.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5845
    Cell Significance Index: 527.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4459
    Cell Significance Index: 20.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3303
    Cell Significance Index: 38.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3077
    Cell Significance Index: 55.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2938
    Cell Significance Index: 7.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2638
    Cell Significance Index: 12.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2589
    Cell Significance Index: 6.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2031
    Cell Significance Index: 20.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2023
    Cell Significance Index: 38.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1632
    Cell Significance Index: 89.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1354
    Cell Significance Index: 59.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1085
    Cell Significance Index: 68.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1006
    Cell Significance Index: 189.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0601
    Cell Significance Index: 110.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0593
    Cell Significance Index: 91.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0410
    Cell Significance Index: 1.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0406
    Cell Significance Index: 2.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0404
    Cell Significance Index: 0.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0315
    Cell Significance Index: 42.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0262
    Cell Significance Index: 4.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0221
    Cell Significance Index: 2.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0070
    Cell Significance Index: 0.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0017
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0114
    Cell Significance Index: -7.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0149
    Cell Significance Index: -11.0700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0210
    Cell Significance Index: -0.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0237
    Cell Significance Index: -10.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0259
    Cell Significance Index: -19.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0297
    Cell Significance Index: -0.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0314
    Cell Significance Index: -17.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0328
    Cell Significance Index: -0.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0336
    Cell Significance Index: -4.8900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0341
    Cell Significance Index: -0.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0386
    Cell Significance Index: -29.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0511
    Cell Significance Index: -2.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0911
    Cell Significance Index: -26.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0940
    Cell Significance Index: -19.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0987
    Cell Significance Index: -6.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1040
    Cell Significance Index: -12.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1127
    Cell Significance Index: -3.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1160
    Cell Significance Index: -14.9900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1300
    Cell Significance Index: -2.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1479
    Cell Significance Index: -18.9700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1507
    Cell Significance Index: -3.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1563
    Cell Significance Index: -15.9700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1580
    Cell Significance Index: -1.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1636
    Cell Significance Index: -4.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1652
    Cell Significance Index: -5.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1797
    Cell Significance Index: -4.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1871
    Cell Significance Index: -3.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1967
    Cell Significance Index: -22.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2343
    Cell Significance Index: -14.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2576
    Cell Significance Index: -8.2500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2609
    Cell Significance Index: -3.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2752
    Cell Significance Index: -28.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2835
    Cell Significance Index: -21.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2878
    Cell Significance Index: -6.6500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2960
    Cell Significance Index: -33.7900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3383
    Cell Significance Index: -7.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3529
    Cell Significance Index: -27.9500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3771
    Cell Significance Index: -4.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3873
    Cell Significance Index: -20.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4223
    Cell Significance Index: -25.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4560
    Cell Significance Index: -6.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4758
    Cell Significance Index: -12.2300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.5034
    Cell Significance Index: -4.7900
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.5280
    Cell Significance Index: -4.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA binding protein:** TARBP1 is a RNA binding protein that interacts with various RNA molecules, including HIV-1 RNA, to regulate its translation and stability. 2. **Transcriptional regulation:** TARBP1 is involved in the regulation of transcription by RNA polymerase II, which is essential for the expression of many genes. 3. **Trna methylation:** The protein encoded by TARBP1 possesses trna (guanine) methyltransferase activity, suggesting its involvement in trna methylation. 4. **Cell-specific expression:** TARBP1 is specifically expressed in various cell types, including GABAergic cortical interneurons, A2 amacrine cells, Purkinje cells, and inhibitory interneurons. **Pathways and Functions:** 1. **RNA regulation:** TARBP1 regulates the translation and stability of RNA molecules, including HIV-1 RNA, by interacting with RNA binding proteins and other molecules. 2. **Transcriptional regulation:** TARBP1 is involved in the regulation of transcription by RNA polymerase II, which is essential for the expression of many genes. 3. **Trna methylation:** The protein encoded by TARBP1 possesses trna (guanine) methyltransferase activity, suggesting its involvement in trna methylation. 4. **Gene expression:** TARBP1 is involved in the regulation of gene expression, including the expression of genes involved in neuronal development and function. **Clinical Significance:** 1. **Neurological disorders:** TARBP1 has been implicated in various neurological disorders, including autism spectrum disorder, schizophrenia, and epilepsy, which are characterized by abnormalities in neuronal development and function. 2. **Immune response:** TARBP1 has been shown to play a role in the regulation of the immune response, including the response to viral infections. 3. **Cancer:** TARBP1 has been implicated in the development and progression of certain types of cancer, including leukemia and lymphoma. 4. **Neurodegenerative diseases:** TARBP1 has been shown to be involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In conclusion, TARBP1 is a crucial gene that plays a significant role in RNA regulation, transcriptional regulation, and trna methylation. Its dysregulation has been implicated in various neurological disorders, immune response, cancer, and neurodegenerative diseases. Further research is needed to fully understand the functions of TARBP1 and its role in human disease.

Genular Protein ID: 2368400831

Symbol: TARB1_HUMAN

Name: Probable methyltransferase TARBP1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8846792

Title: The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA.

PubMed ID: 8846792

DOI: 10.1002/j.1460-2075.1995.tb00288.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 7638159

Title: Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat.

PubMed ID: 7638159

DOI: 10.1073/pnas.92.16.7153

PubMed ID: 8626763

Title: Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA.

PubMed ID: 8626763

DOI: 10.1074/jbc.271.8.4201

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 18412263

Title: Crystal structure of the methyltransferase domain of human TARBP1.

PubMed ID: 18412263

DOI: 10.1002/prot.22065

Sequence Information:

  • Length: 1621
  • Mass: 181675
  • Checksum: A8C2BC62B7F1ADA8
  • Sequence:
  • MEWVLAEALL SQSRDPRALL GALCQGEASA ERVETLRFLL QRLEDEEARG SGGAGALPEA 
    AREVAAGYLV PLLRSLRGRP AGGPDPSLQP RHRRRVLRAA GAALRSCVRL AGRPQLAAAL 
    AEEALRDLLA GWRAPGAEAA VEVLAAVGPC LRPREDGPLL ERVAGTAVAL ALGGGGDGDE 
    AGPAEDAAAL VAGRLLPVLV QCGGAALRAV WGGLAAPGAS LGSGRVEEKL LVLSALAEKL 
    LPEPGGDRAR GAREAGPDAR RCWRFWRTVQ AGLGQADALT RKRARYLLQR AVEVSAELGA 
    DCTCGPQEGN GPSLFWWSER KKDELLKFWE NYILIMETLE GNQIHVIKPV LPKLNNLFEY 
    AVSEENGCWL FHPSWHMCIY KRMFESENKI LSKEGVIHFL ELYETKILPF SPEFSEFIIG 
    PLMDALSESS LYSRSPGQPI GSCSPLGLKL QKFLVTYISL LPEEIKSSFL LKFIRKMTSR 
    HWCAVPILFL SKALANVPRH KALGIDGLLA LRDVIHCTMI THQILLRGAA QCYLLQTAMN 
    LLDVEKVSLS DVSTFLMSLR QEESLGRGTS LWTELCDWLR VNESYFKPSP TCSSIGLHKT 
    SLNAYVKSIV QEYVKSSAWE TGENCFMPDW FEAKLVSLMV LLAVDVEGMK TQYSGKQRTE 
    NVLRIFLDPL LDVLMKFSTN AYMPLLKTDR CLQLLLKLLN TCRLKGSSAQ DDEVSTVLQN 
    FFMSTTESIS EFILRRLTMN ELNSVSDLDR CHLYLMVLTE LINLHLKVGW KRGNPIWRVI 
    SLLKNASIQH LQEMDSGQEP TVGSQIQRVV SMAALAMVCE AIDQKPELQL DSLHAGPLES 
    FLSSLQLNQT LQKPHAEEQS SYAHPLECSS VLEESSSSQG WGKIVAQYIH DQWVCLSFLL 
    KKYHTLIPTT GSEILEPFLP AVQMPIRTLQ SALEALTVLS SDQVLPVFHC LKVLVPKLLT 
    SSESLCIESF DMAWKIISSL SNTQLIFWAN LKAFVQFVFD NKVLTIAAKI KGQAYFKIKE 
    IMYKIIEMSA IKTGVFNTLI SYCCQSWIVS ASNVSQGSLS SAKNYSELIL EACIFGTVFR 
    RDQRLVQDVQ TFIENLGHDC AANIVMENTK REDHYVRICA VKFLCLLDGS NMSHKLFIED 
    LAIKLLDKDE LVSKSKKRYY VNSLQHRVKN RVWQTLLVLF PRLDQNFLNG IIDRIFQAGF 
    TNNQASIKYF IEWIIILILH KFPQFLPKFW DCFSYGEENL KTSICTFLAV LSHLDIITQN 
    IPEKKLILKQ ALIVVLQWCF NHNFSVRLYA LVALKKLWTV CKVLSVEEFD ALTPVIESSL 
    HQVESMHGAG NAKKNWQRIQ EHFFFATFHP LKDYCLETIF YILPRLSGLI EDEWITIDKF 
    TRFTDVPLAA GFQWYLSQTQ LSKLKPGDWS QQDIGTNLVE ADNQAEWTDV QKKIIPWNSR 
    VSDLDLELLF QDRAARLGKS ISRLIVVASL IDKPTNLGGL CRTCEVFGAS VLVVGSLQCI 
    SDKQFQHLSV SAEQWLPLVE VKPPQLIDYL QQKKTEGYTI IGVEQTAKSL DLTQYCFPEK 
    SLLLLGNERE GIPANLIQQL DVCVEIPQQG IIRSLNVHVS GALLIWEYTR QQLLSHGDTK 
    P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.