Details for: TCF21

Gene ID: 6943

Symbol: TCF21

Ensembl ID: ENSG00000118526

Description: transcription factor 21

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 25.3324
    Cell Significance Index: -11.9600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 24.8750
    Cell Significance Index: 153.9000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 11.1132
    Cell Significance Index: 65.2900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 7.4809
    Cell Significance Index: 95.8100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.7789
    Cell Significance Index: 46.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.0156
    Cell Significance Index: 100.3800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 2.5325
    Cell Significance Index: 24.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0240
    Cell Significance Index: 43.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.6335
    Cell Significance Index: 52.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6161
    Cell Significance Index: 56.1600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.4697
    Cell Significance Index: 12.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3553
    Cell Significance Index: 61.4300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.2765
    Cell Significance Index: 19.7500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.1933
    Cell Significance Index: 17.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0164
    Cell Significance Index: 193.4300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.8978
    Cell Significance Index: 13.5300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.8584
    Cell Significance Index: 4.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7782
    Cell Significance Index: 76.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5967
    Cell Significance Index: 538.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.5690
    Cell Significance Index: 16.7600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.4262
    Cell Significance Index: 6.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3986
    Cell Significance Index: 64.8300
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.3209
    Cell Significance Index: 1.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3186
    Cell Significance Index: 6.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2884
    Cell Significance Index: 31.3700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1835
    Cell Significance Index: 1.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1413
    Cell Significance Index: 9.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1210
    Cell Significance Index: 2.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1044
    Cell Significance Index: 2.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0486
    Cell Significance Index: 2.9200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.0485
    Cell Significance Index: 0.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0023
    Cell Significance Index: -0.0800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0048
    Cell Significance Index: -0.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0087
    Cell Significance Index: -0.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0166
    Cell Significance Index: -12.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0174
    Cell Significance Index: -0.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0191
    Cell Significance Index: -1.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0195
    Cell Significance Index: -14.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0228
    Cell Significance Index: -14.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0241
    Cell Significance Index: -3.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0254
    Cell Significance Index: -14.3300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0400
    Cell Significance Index: -0.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0532
    Cell Significance Index: -2.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0576
    Cell Significance Index: -10.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0656
    Cell Significance Index: -1.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0664
    Cell Significance Index: -13.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0673
    Cell Significance Index: -13.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0700
    Cell Significance Index: -14.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0836
    Cell Significance Index: -14.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0980
    Cell Significance Index: -12.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1096
    Cell Significance Index: -12.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1282
    Cell Significance Index: -14.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1283
    Cell Significance Index: -9.8500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1367
    Cell Significance Index: -5.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1412
    Cell Significance Index: -3.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1481
    Cell Significance Index: -15.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1768
    Cell Significance Index: -3.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1837
    Cell Significance Index: -13.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1974
    Cell Significance Index: -13.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2167
    Cell Significance Index: -13.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2175
    Cell Significance Index: -5.7200
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.2383
    Cell Significance Index: -2.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2436
    Cell Significance Index: -6.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2545
    Cell Significance Index: -13.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2570
    Cell Significance Index: -14.4200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3119
    Cell Significance Index: -1.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3357
    Cell Significance Index: -3.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3455
    Cell Significance Index: -16.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3539
    Cell Significance Index: -12.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3757
    Cell Significance Index: -13.1600
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.3814
    Cell Significance Index: -3.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4078
    Cell Significance Index: -13.3500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.4155
    Cell Significance Index: -4.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4176
    Cell Significance Index: -11.1500
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.4246
    Cell Significance Index: -6.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4280
    Cell Significance Index: -13.6300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.4303
    Cell Significance Index: -5.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4525
    Cell Significance Index: -12.1300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4543
    Cell Significance Index: -4.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4650
    Cell Significance Index: -13.3300
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.4734
    Cell Significance Index: -6.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4852
    Cell Significance Index: -12.1000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.4903
    Cell Significance Index: -5.0100
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: -0.5091
    Cell Significance Index: -2.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5162
    Cell Significance Index: -14.7300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5205
    Cell Significance Index: -13.0000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.5452
    Cell Significance Index: -6.4800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5464
    Cell Significance Index: -13.9200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5474
    Cell Significance Index: -13.3600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5512
    Cell Significance Index: -13.7500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5575
    Cell Significance Index: -13.3700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5706
    Cell Significance Index: -3.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5726
    Cell Significance Index: -13.2300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5905
    Cell Significance Index: -12.9300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6179
    Cell Significance Index: -13.3500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.6263
    Cell Significance Index: -12.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6290
    Cell Significance Index: -13.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6455
    Cell Significance Index: -12.9600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.6473
    Cell Significance Index: -9.0800
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.6563
    Cell Significance Index: -7.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TCF21 is a member of the BHLH (basic helix-loop-helix) transcription factor family, characterized by its ability to bind to specific DNA sequences and regulate gene expression. It is highly expressed in various tissues, including the lungs, kidneys, and reproductive organs, suggesting its role in tissue development and homeostasis. TCF21 is also known to interact with other transcription factors, such as androgen receptors and nuclear receptors, to modulate gene expression. **Pathways and Functions:** TCF21 is involved in various signaling pathways, including: 1. **Developmental Process:** TCF21 regulates the development of branching structures, such as the ureteric bud and bronchioles, during embryonic development. 2. **Cell Differentiation:** TCF21 promotes the differentiation of epithelial cells, including those in the glomerular capsule and lung alveoli. 3. **Tissue Homeostasis:** TCF21 regulates the expression of genes involved in tissue maintenance, such as those involved in the development of the diaphragm and respiratory system. 4. **Reproductive Structure Development:** TCF21 is involved in the development of reproductive structures, including the testes and ovaries. 5. **Immune Response:** TCF21 has been implicated in the regulation of immune responses, including the differentiation of microglial cells and the regulation of androgen receptor signaling. **Clinical Significance:** Alterations in TCF21 expression have been linked to various diseases, including: 1. **Respiratory Disorders:** TCF21 has been implicated in the development of respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). 2. **Kidney Disease:** TCF21 has been linked to the development of kidney disease, including polycystic kidney disease (PKD) and nephrotic syndrome. 3. **Reproductive Disorders:** TCF21 has been implicated in the development of reproductive disorders, including infertility and reproductive tract abnormalities. 4. **Cancer:** TCF21 has been shown to be involved in the development and progression of various cancers, including lung and breast cancer. In conclusion, TCF21 is a critical transcription factor involved in various developmental processes and tissue homeostasis. Its dysregulation has been linked to various diseases, highlighting the importance of TCF21 in human health and disease. Further research is needed to elucidate the mechanisms by which TCF21 regulates gene expression and to explore its potential as a therapeutic target for various diseases. **Recommendations:** 1. **Further Research:** Investigate the mechanisms by which TCF21 regulates gene expression and its role in disease pathogenesis. 2. **Therapeutic Targeting:** Explore the potential of TCF21 as a therapeutic target for various diseases, including respiratory disorders, kidney disease, and reproductive disorders. 3. **Immunological Studies:** Investigate the role of TCF21 in the regulation of immune responses and its implications for immune-related diseases. By advancing our understanding of TCF21 and its role in human health and disease, we can unlock new avenues for therapeutic intervention and improve patient outcomes.

Genular Protein ID: 286084457

Symbol: TCF21_HUMAN

Name: Transcription factor 21

UniProtKB Accession Codes:

O43680 E1P581 O43545 Q6ICV0 Q9BZ14

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 GO 42 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9733105

Title: Epicardin: a novel basic helix-loop-helix transcription factor gene expressed in epicardium, branchial arch myoblasts, and mesenchyme of developing lung, gut, kidney, and gonads.

PubMed ID: 9733105

DOI: 10.1002/(sici)1097-0177(199809)213:1<105::aid-aja10>3.0.co;2-1

PubMed ID: 10572052

Title: The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis.

PubMed ID: 10572052

DOI: 10.1242/dev.126.24.5771

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 179
  • Mass: 19715
  • Checksum: A26F496C536B6F04
  • Sequence:
    • MSTGSLSDVE DLQEVEMLEC DGLKMDSNKE FVTSNESTEE SSNCENGSPQ KGRGGLGKRR 
KAPTKKSPLS GVSQEGKQVQ RNAANARERA RMRVLSKAFS RLKTTLPWVP PDTKLSKLDT 
LRLASSYIAH LRQILANDKY ENGYIHPVNL TWPFMVAGKP ESDLKEVVTA SRLCGTTAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.