Details for: TCOF1

Gene ID: 6949

Symbol: TCOF1

Ensembl ID: ENSG00000070814

Description: treacle ribosome biogenesis factor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.12
    Marker Score: 2089
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.89
    Marker Score: 603
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.79
    Marker Score: 1077
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.55
    Marker Score: 548
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.17
    Marker Score: 11906
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.1
    Marker Score: 1377
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.06
    Marker Score: 262
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.03
    Marker Score: 5077
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71669
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47894
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30386
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.96
    Marker Score: 967
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.96
    Marker Score: 1380
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2388
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.93
    Marker Score: 635
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.92
    Marker Score: 2510
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 473
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5152
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2688
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.87
    Marker Score: 1417
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.87
    Marker Score: 2585
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.87
    Marker Score: 936
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.87
    Marker Score: 657
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.84
    Marker Score: 1989
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.84
    Marker Score: 242
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.84
    Marker Score: 7181
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.83
    Marker Score: 526
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.83
    Marker Score: 1000.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.82
    Marker Score: 881
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.82
    Marker Score: 1084
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.81
    Marker Score: 804
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.81
    Marker Score: 403
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.81
    Marker Score: 8325
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.81
    Marker Score: 49562
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.79
    Marker Score: 746
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 317
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.79
    Marker Score: 590
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.79
    Marker Score: 573
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.78
    Marker Score: 1364
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.78
    Marker Score: 2889
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.78
    Marker Score: 3191
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.77
    Marker Score: 12058
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.77
    Marker Score: 42944
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.77
    Marker Score: 1087
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.77
    Marker Score: 1185
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.76
    Marker Score: 2142
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.76
    Marker Score: 263
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.76
    Marker Score: 1589
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.76
    Marker Score: 371
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 579
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.75
    Marker Score: 7090
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.74
    Marker Score: 1254
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.74
    Marker Score: 233
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.74
    Marker Score: 237
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.73
    Marker Score: 779
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.73
    Marker Score: 417
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.72
    Marker Score: 610
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.72
    Marker Score: 251
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.72
    Marker Score: 190
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 369
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.71
    Marker Score: 213
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.71
    Marker Score: 169
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.7
    Marker Score: 1913
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.7
    Marker Score: 291
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.7
    Marker Score: 674
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.7
    Marker Score: 621
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.69
    Marker Score: 508
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.69
    Marker Score: 715
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.68
    Marker Score: 427
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2868.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.68
    Marker Score: 633
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.68
    Marker Score: 463
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.67
    Marker Score: 451
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.67
    Marker Score: 1597
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 444
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.67
    Marker Score: 147
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.67
    Marker Score: 1571.5
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.67
    Marker Score: 142
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 609
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.66
    Marker Score: 134
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.66
    Marker Score: 777.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.66
    Marker Score: 6173
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.66
    Marker Score: 448
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.65
    Marker Score: 160
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.65
    Marker Score: 508
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.65
    Marker Score: 460
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.65
    Marker Score: 316
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.64
    Marker Score: 325
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.64
    Marker Score: 605
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.64
    Marker Score: 8626
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.64
    Marker Score: 941
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.64
    Marker Score: 569
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.63
    Marker Score: 291
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.63
    Marker Score: 174
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.63
    Marker Score: 167

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Other Information

**Key Characteristics** TCOF1 is a highly expressed gene that is widely distributed across different cell types. It is a scaffold protein that interacts with various partners, including RNA-binding proteins, to regulate ribosome biogenesis and translation. The gene encodes for a protein known as treacle protein, which is involved in the regulation of ribosomal RNA transcription and translation. TCOF1 is also involved in the regulation of cell growth and differentiation, particularly in neural crest cells and B cells. **Pathways and Functions** TCOF1 is involved in several cellular pathways, including: 1. **Ribosome biogenesis**: TCOF1 regulates ribosome biogenesis by interacting with RNA polymerase I and other ribosomal proteins to modulate the transcription of ribosomal RNA. 2. **Translation regulation**: TCOF1 regulates translation by interacting with translation initiation factors and other proteins to modulate the initiation of translation. 3. **Cell growth and differentiation**: TCOF1 is involved in the regulation of cell growth and differentiation, particularly in neural crest cells and B cells. 4. **Neural crest development**: TCOF1 is involved in the development of neural crest cells, which are a group of cells that give rise to various cell types, including neurons and glial cells. **Clinical Significance** TCOF1 has been implicated in several diseases, including: 1. **Cancer**: TCOF1 has been overexpressed in various types of cancer, including leukemia and lymphoma, and has been associated with poor prognosis. 2. **Neurological disorders**: TCOF1 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Immunodeficiency**: TCOF1 has been implicated in immunodeficiency diseases, including X-linked agammaglobulinemia, a disorder characterized by impaired B cell development and function. Overall, TCOF1 is a critical gene that plays a key role in regulating ribosome biogenesis, translation, and cell growth and differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and mechanisms of this gene.

Genular Protein ID: 148940866

Symbol: TCOF_HUMAN

Name: Treacle protein

UniProtKB Accession Codes:

Q13428 A0JLU0 B4E111 Q6SC72 Q7Z5W9 Q96A52 Q99408 Q99860

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 7 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 50 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 13 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 RefSeq 7 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8563749

Title: Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome.

PubMed ID: 8563749

DOI: 10.1038/ng0296-130

PubMed ID: 9074926

Title: Identification of the complete coding sequence and genomic organization of the Treacher Collins syndrome gene.

PubMed ID: 9074926

DOI: 10.1101/gr.7.3.223

PubMed ID: 9096354

Title: TCOF1 gene encodes a putative nucleolar phosphoprotein that exhibits mutations in Treacher Collins syndrome throughout its coding region.

PubMed ID: 9096354

DOI: 10.1073/pnas.94.7.3110

PubMed ID: 15019983

Title: Another face of the Treacher Collins syndrome (TCOF1) gene: identification of additional exons.

PubMed ID: 15019983

DOI: 10.1016/j.gene.2003.11.027

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12777385

Title: Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome.

PubMed ID: 12777385

DOI: 10.1074/jbc.m304304200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 26399832

Title: Cell-fate determination by ubiquitin-dependent regulation of translation.

PubMed ID: 26399832

DOI: 10.1038/nature14978

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 9042910

Title: The mutational spectrum in Treacher Collins syndrome reveals a predominance of mutations that create a premature-termination codon.

PubMed ID: 9042910

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1488
  • Mass: 152106
  • Checksum: 6348306D0479790B
  • Sequence:
    • MAEARKRREL LPLIYHHLLR AGYVRAAREV KEQSGQKCFL AQPVTLLDIY THWQQTSELG 
RKRKAEEDAA LQAKKTRVSD PISTSESSEE EEEAEAETAK ATPRLASTNS SVLGADLPSS 
MKEKAKAETE KAGKTGNSMP HPATGKTVAN LLSGKSPRKS AEPSANTTLV SETEEEGSVP 
AFGAAAKPGM VSAGQADSSS EDTSSSSDET DVEGKPSVKP AQVKASSVST KESPARKAAP 
APGKVGDVTP QVKGGALPPA KRAKKPEEES ESSEEGSESE EEAPAGTRSQ VKASEKILQV 
RAASAPAKGT PGKGATPAPP GKAGAVASQT KAGKPEEDSE SSSEESSDSE EETPAAKALL 
QAKASGKTSQ VGAASAPAKE SPRKGAAPAP PGKTGPAVAK AQAGKREEDS QSSSEESDSE 
EEAPAQAKPS GKAPQVRAAS APAKESPRKG AAPAPPRKTG PAAAQVQVGK QEEDSRSSSE 
ESDSDREALA AMNAAQVKPL GKSPQVKPAS TMGMGPLGKG AGPVPPGKVG PATPSAQVGK 
WEEDSESSSE ESSDSSDGEV PTAVAPAQEK SLGNILQAKP TSSPAKGPPQ KAGPVAVQVK 
AEKPMDNSES SEESSDSADS EEAPAAMTAA QAKPALKIPQ TKACPKKTNT TASAKVAPVR 
VGTQAPRKAG TATSPAGSSP AVAGGTQRPA EDSSSSEESD SEEEKTGLAV TVGQAKSVGK 
GLQVKAASVP VKGSLGQGTA PVLPGKTGPT VTQVKAEKQE DSESSEEESD SEEAAASPAQ 
VKTSVKKTQA KANPAAARAP SAKGTISAPG KVVTAAAQAK QRSPSKVKPP VRNPQNSTVL 
ARGPASVPSV GKAVATAAQA QTGPEEDSGS SEEESDSEEE AETLAQVKPS GKTHQIRAAL 
APAKESPRKG AAPTPPGKTG PSAAQAGKQD DSGSSSEESD SDGEAPAAVT SAQVIKPPLI 
FVDPNRSPAG PAATPAQAQA ASTPRKARAS ESTARSSSSE SEDEDVIPAT QCLTPGIRTN 
VVTMPTAHPR IAPKASMAGA SSSKESSRIS DGKKQEGPAT QVSKKNPASL PLTQAALKVL 
AQKASEAQPP VARTQPSSGV DSAVGTLPAT SPQSTSVQAK GTNKLRKPKL PEVQQATKAP 
ESSDDSEDSS DSSSGSEEDG EGPQGAKSAH TLGPTPSRTE TLVEETAAES SEDDVVAPSQ 
SLLSGYMTPG LTPANSQASK ATPKLDSSPS VSSTLAAKDD PDGKQEAKPQ QAAGMLSPKT 
GGKEAASGTT PQKSRKPKKG AGNPQASTLA LQSNITQCLL GQPWPLNEAQ VQASVVKVLT 
ELLEQERKKV VDTTKESSRK GWESRKRKLS GDQPAARTPR SKKKKKLGAG EGGEASVSPE 
KTSTTSKGKA KRDKASGDVK EKKGKGSLGS QGAKDEPEEE LQKGMGTVEG GDQSNPKSKK 
EKKKSDKRKK DKEKKEKKKK AKKASTKDSE SPSQKKKKKK KKTAEQTV

Genular Protein ID: 3407355351

Symbol: E7ETY2_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7ETY2

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 3 GeneTree 1 GenomeRNAi 1 HGNC 1 IntAct 1 InterPro 3 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1488
  • Mass: 152304
  • Checksum: 4FC162CCA7AE6659
  • Sequence:
    • MAEARKRREL LPLIYHHLLR AGYVRAAREV KEQSGQKCFL AQPVTLLDIY THWQQTSELG 
RKRKAEEDAA LQAKKTRVSD PISTSESSEE EEEAEAETAK ATPRLASTNS SVLGADLPSS 
MKEKAKAETE KAGKTGNSMP HPATGKTVAN LLSGKSPRKS AEPSANTTLV SETEEEGSVP 
AFGAAAKPGM VSAGQADSSS EDTSSSSDET DVEGKPSVKP AQVKASSVST KESPARKAAP 
APGKVGDVTP QVKGGALPPA KRAKKPEEES ESSEEGSESE EEAPAGTRSQ VKASEKILQV 
RAASAPAKGT PGKGATPAPP GKAGAVASQT KAGKPEEDSE SSSEESSDSE EETPAAKALL 
QAKASGKTSQ VGAASAPAKE SPRKGAAPAP PGKTGPAVAK AQAGKREEDS QSSSEESDSE 
EEAPAQAKPS GKAPQVRAAS APAKESPRKG AAPAPPRKTG PAAAQVQVGK QEEDSRSSSE 
ESDSDREALA AMNAAQVKPL GKSPQVKPAS TMGMGPLGKG AGPVPPGKVG PATPSAQVGK 
WEEDSESSSE ESSDSSDGEV PTAVAPAQEK SLGNILQAKP TSSPAKGPPQ KAGPVAVQVK 
AEKPMDNSES SEESSDSADS EEAPAAMTAA QAKPALKIPQ TKACPKKTNT TASAKVAPVR 
VGTQAPRKAG TATSPAGSSP AVAGGTQRPA EDSSSSEESD SEEEKTGLAV TVGQAKSVGK 
GLQVKAASVP VKGSLGQGTA PVLPGKTGPT VTQVKAEKQE DSESSEEESD SEEAAASPAQ 
VKTSVKKTQA KANPAAARAP SAKGTISAPG KVVTAAAQAK QRSPSKVKPP VRNPQNSTVL 
ARGPASVPSV GKAVATAAQA QTGPEEDSGS SEEESDSEEE AETLAQVKPS GKTHQIRAAL 
APAKESPRKG AAPTPPGKTG PSAAQAGKQD DSGSSSEESD SDGEAPAAVT SAQKDSNSKP 
ARSKTLAPAP PERNTEGSSE SSEEELPLTQ VIKPPLIFVD PNRSPAGPAA TPAQAQAAST 
PRKARASEST ARSSSSESED EDVIPATQCL TPGIRTNVVT MPTAHPRIAP KASMAGASSS 
KESSRISDGK KQEGPATQVD SAVGTLPATS PQSTSVQAKG TNKLRKPKLP EVQQATKAPE 
SSDDSEDSSD SSSGSEEDGE GPQGAKSAHT LVGPTPSRTE TLVEETAAES SEDDVVAPSQ 
SLLSGYMTPG LTPANSQASK ATPKLDSSPS VSSTLAAKDD PDGKQEAKPQ QAAGMLSPKT 
GGKEAASGTT PQKSRKPKKG AGNPQASTLA LQSNITQCLL GQPWPLNEAQ VQASVVKVLT 
ELLEQERKKV VDTTKESSRK GWESRKRKLS GDQPAARTPR SKKKKKLGAG EGGEASVSPE 
KTSTTSKGKA KRDKASGDVK EKKGKGSLGS QGAKDEPEEE LQKGMGTVEG GDQSNPKSKK 
EKKKSDKRKK DKEKKEKKKK AKKASTKDSE SPSQKKKKKK KKTAEQTV

Genular Protein ID: 184874299

Symbol: B4DRA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DRA2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Genevisible 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 923
  • Mass: 93769
  • Checksum: EAFDFB1C4BC4658C
  • Sequence:
    • MNAAQVKPLG KSPQVKPAST MGMGPLGKGA GPVPPGKVGP ATPSAQVGKW EEDSESSSEE 
SSDSSDGEVP TAVAPAQEKS LGNILQAKPT SSPAKGPPQK AGPVAVQVKA EKPMDNSESS 
EESSDSADSE EAPAAMTAAQ AKPALKIPQT KACPKKTNTT ASAKVAPVRV GTQAPRKAGT 
ATSPAGSSPA VAGGTQRPAE DSSSSEESDS EEEKTGLAVT VGQAKSVGKG LQVKAASVPV 
KGSLGQGTAP VLPGKTGPTV TQVKAEKQED SESSEEESDS EEAAASPAQV KTSVKKTQAK 
ANPAAARAPS AKGTISAPGK VVTAAAQAKQ RSPSKVKPPV RNPQNSTVLA RGPASVPSVG 
KAVATAAQAQ TGPEEDSGSS EEESDSEEEA ETLAQVKPSG KTHQIRAALA PAKESPRKGA 
APTPPGKTGP SAAQAGKQDD SGSSSEESDS DGEAPAAVTS AQVIKPPLIF VDPNRSPAGP 
AATPAQAQAA STPRKARASE STARSSSSES EDEDVIPATQ CLTPGIRTNV VTMPTAHPRI 
APKASMAGAS SSKESSRISD GKKQEGPATQ VDSAVGTLPA TSPQSTSVQA KGTNKLRKPK 
LPEVQQATKA PESSDDSEDS SDSSSGSEED GEGPQGAKSA HTLVGPTRSR TETLVEETAA 
ESSEDDVVAP SQSLLSGYMT PGLTPANSQA SKATPKLDSS PSVSSTLAAK DDPDGKQEAK 
PQQAAGMLSP KTGGKEAASG TTPQKSRKPK KGAGNPQAST LALQSNITQC LLGQPWPLNE 
AQVQASVVKV LTELLEQERK KVVDTTKESS RKGWESRKRK LSGDQPAART PRSKKKKKLG 
AGEGGEASVS PEKTSTTSKG KAKRDKASGD VKEKKGKGSL GSQGAKDEPE EELQKGMGTV 
EGGDQSNPKS KKEKKKSDKR KKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.