Details for: TCOF1

Gene ID: 6949

Symbol: TCOF1

Ensembl ID: ENSG00000070814

Description: treacle ribosome biogenesis factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 135.0733
    Cell Significance Index: -21.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.1342
    Cell Significance Index: -18.5500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 54.1037
    Cell Significance Index: -21.9800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 53.9632
    Cell Significance Index: -22.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 53.0582
    Cell Significance Index: -25.0500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 47.9602
    Cell Significance Index: -24.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.1057
    Cell Significance Index: -22.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.7598
    Cell Significance Index: -23.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4924
    Cell Significance Index: -22.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.5897
    Cell Significance Index: -20.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9807
    Cell Significance Index: -23.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0254
    Cell Significance Index: -8.8100
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.4732
    Cell Significance Index: 11.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0987
    Cell Significance Index: 70.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8971
    Cell Significance Index: 12.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7741
    Cell Significance Index: 90.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6927
    Cell Significance Index: 112.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6778
    Cell Significance Index: 73.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6630
    Cell Significance Index: 131.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6576
    Cell Significance Index: 17.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6230
    Cell Significance Index: 37.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5231
    Cell Significance Index: 51.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5150
    Cell Significance Index: 60.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5051
    Cell Significance Index: 96.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5049
    Cell Significance Index: 23.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4969
    Cell Significance Index: 99.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3668
    Cell Significance Index: 331.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3423
    Cell Significance Index: 61.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3013
    Cell Significance Index: 8.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2950
    Cell Significance Index: 10.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2839
    Cell Significance Index: 34.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2757
    Cell Significance Index: 150.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2557
    Cell Significance Index: 35.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2473
    Cell Significance Index: 6.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2464
    Cell Significance Index: 12.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2436
    Cell Significance Index: 16.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2328
    Cell Significance Index: 5.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2158
    Cell Significance Index: 95.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2025
    Cell Significance Index: 72.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1948
    Cell Significance Index: 4.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1833
    Cell Significance Index: 8.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1695
    Cell Significance Index: 10.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1262
    Cell Significance Index: 87.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0920
    Cell Significance Index: 11.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0824
    Cell Significance Index: 10.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0819
    Cell Significance Index: 1.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0712
    Cell Significance Index: 3.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0530
    Cell Significance Index: 0.9800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0494
    Cell Significance Index: 1.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0464
    Cell Significance Index: 3.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0358
    Cell Significance Index: 2.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0165
    Cell Significance Index: 0.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0090
    Cell Significance Index: 0.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0045
    Cell Significance Index: 0.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0044
    Cell Significance Index: 0.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0015
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0039
    Cell Significance Index: -7.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0047
    Cell Significance Index: -0.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0066
    Cell Significance Index: -10.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0091
    Cell Significance Index: -12.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0141
    Cell Significance Index: -10.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0190
    Cell Significance Index: -13.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0248
    Cell Significance Index: -15.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0286
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0307
    Cell Significance Index: -22.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0351
    Cell Significance Index: -3.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0403
    Cell Significance Index: -18.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0423
    Cell Significance Index: -23.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0454
    Cell Significance Index: -28.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0483
    Cell Significance Index: -3.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0687
    Cell Significance Index: -3.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0702
    Cell Significance Index: -20.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0892
    Cell Significance Index: -12.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0912
    Cell Significance Index: -7.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1185
    Cell Significance Index: -2.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1344
    Cell Significance Index: -28.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1380
    Cell Significance Index: -15.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1512
    Cell Significance Index: -1.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1615
    Cell Significance Index: -10.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1746
    Cell Significance Index: -4.4600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1831
    Cell Significance Index: -1.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1873
    Cell Significance Index: -5.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1876
    Cell Significance Index: -8.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1933
    Cell Significance Index: -11.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2073
    Cell Significance Index: -6.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2199
    Cell Significance Index: -22.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2414
    Cell Significance Index: -7.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2668
    Cell Significance Index: -6.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2681
    Cell Significance Index: -7.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2765
    Cell Significance Index: -10.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2872
    Cell Significance Index: -22.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3340
    Cell Significance Index: -20.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3370
    Cell Significance Index: -7.3800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4010
    Cell Significance Index: -3.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4131
    Cell Significance Index: -7.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4188
    Cell Significance Index: -11.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4396
    Cell Significance Index: -5.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4921
    Cell Significance Index: -5.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5046
    Cell Significance Index: -12.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TCOF1 is a highly expressed gene that is widely distributed across different cell types. It is a scaffold protein that interacts with various partners, including RNA-binding proteins, to regulate ribosome biogenesis and translation. The gene encodes for a protein known as treacle protein, which is involved in the regulation of ribosomal RNA transcription and translation. TCOF1 is also involved in the regulation of cell growth and differentiation, particularly in neural crest cells and B cells. **Pathways and Functions** TCOF1 is involved in several cellular pathways, including: 1. **Ribosome biogenesis**: TCOF1 regulates ribosome biogenesis by interacting with RNA polymerase I and other ribosomal proteins to modulate the transcription of ribosomal RNA. 2. **Translation regulation**: TCOF1 regulates translation by interacting with translation initiation factors and other proteins to modulate the initiation of translation. 3. **Cell growth and differentiation**: TCOF1 is involved in the regulation of cell growth and differentiation, particularly in neural crest cells and B cells. 4. **Neural crest development**: TCOF1 is involved in the development of neural crest cells, which are a group of cells that give rise to various cell types, including neurons and glial cells. **Clinical Significance** TCOF1 has been implicated in several diseases, including: 1. **Cancer**: TCOF1 has been overexpressed in various types of cancer, including leukemia and lymphoma, and has been associated with poor prognosis. 2. **Neurological disorders**: TCOF1 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Immunodeficiency**: TCOF1 has been implicated in immunodeficiency diseases, including X-linked agammaglobulinemia, a disorder characterized by impaired B cell development and function. Overall, TCOF1 is a critical gene that plays a key role in regulating ribosome biogenesis, translation, and cell growth and differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and mechanisms of this gene.

Genular Protein ID: 148940866

Symbol: TCOF_HUMAN

Name: Treacle protein

UniProtKB Accession Codes:

Q13428 A0JLU0 B4E111 Q6SC72 Q7Z5W9 Q96A52 Q99408 Q99860

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 7 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 50 Ensembl 8 ExpressionAtlas 1 GO 13 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 RefSeq 7 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8563749

Title: Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome.

PubMed ID: 8563749

DOI: 10.1038/ng0296-130

PubMed ID: 9074926

Title: Identification of the complete coding sequence and genomic organization of the Treacher Collins syndrome gene.

PubMed ID: 9074926

DOI: 10.1101/gr.7.3.223

PubMed ID: 9096354

Title: TCOF1 gene encodes a putative nucleolar phosphoprotein that exhibits mutations in Treacher Collins syndrome throughout its coding region.

PubMed ID: 9096354

DOI: 10.1073/pnas.94.7.3110

PubMed ID: 15019983

Title: Another face of the Treacher Collins syndrome (TCOF1) gene: identification of additional exons.

PubMed ID: 15019983

DOI: 10.1016/j.gene.2003.11.027

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12777385

Title: Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome.

PubMed ID: 12777385

DOI: 10.1074/jbc.m304304200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 26399832

Title: Cell-fate determination by ubiquitin-dependent regulation of translation.

PubMed ID: 26399832

DOI: 10.1038/nature14978

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 9042910

Title: The mutational spectrum in Treacher Collins syndrome reveals a predominance of mutations that create a premature-termination codon.

PubMed ID: 9042910

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1488
  • Mass: 152106
  • Checksum: 6348306D0479790B
  • Sequence:
    • MAEARKRREL LPLIYHHLLR AGYVRAAREV KEQSGQKCFL AQPVTLLDIY THWQQTSELG 
RKRKAEEDAA LQAKKTRVSD PISTSESSEE EEEAEAETAK ATPRLASTNS SVLGADLPSS 
MKEKAKAETE KAGKTGNSMP HPATGKTVAN LLSGKSPRKS AEPSANTTLV SETEEEGSVP 
AFGAAAKPGM VSAGQADSSS EDTSSSSDET DVEGKPSVKP AQVKASSVST KESPARKAAP 
APGKVGDVTP QVKGGALPPA KRAKKPEEES ESSEEGSESE EEAPAGTRSQ VKASEKILQV 
RAASAPAKGT PGKGATPAPP GKAGAVASQT KAGKPEEDSE SSSEESSDSE EETPAAKALL 
QAKASGKTSQ VGAASAPAKE SPRKGAAPAP PGKTGPAVAK AQAGKREEDS QSSSEESDSE 
EEAPAQAKPS GKAPQVRAAS APAKESPRKG AAPAPPRKTG PAAAQVQVGK QEEDSRSSSE 
ESDSDREALA AMNAAQVKPL GKSPQVKPAS TMGMGPLGKG AGPVPPGKVG PATPSAQVGK 
WEEDSESSSE ESSDSSDGEV PTAVAPAQEK SLGNILQAKP TSSPAKGPPQ KAGPVAVQVK 
AEKPMDNSES SEESSDSADS EEAPAAMTAA QAKPALKIPQ TKACPKKTNT TASAKVAPVR 
VGTQAPRKAG TATSPAGSSP AVAGGTQRPA EDSSSSEESD SEEEKTGLAV TVGQAKSVGK 
GLQVKAASVP VKGSLGQGTA PVLPGKTGPT VTQVKAEKQE DSESSEEESD SEEAAASPAQ 
VKTSVKKTQA KANPAAARAP SAKGTISAPG KVVTAAAQAK QRSPSKVKPP VRNPQNSTVL 
ARGPASVPSV GKAVATAAQA QTGPEEDSGS SEEESDSEEE AETLAQVKPS GKTHQIRAAL 
APAKESPRKG AAPTPPGKTG PSAAQAGKQD DSGSSSEESD SDGEAPAAVT SAQVIKPPLI 
FVDPNRSPAG PAATPAQAQA ASTPRKARAS ESTARSSSSE SEDEDVIPAT QCLTPGIRTN 
VVTMPTAHPR IAPKASMAGA SSSKESSRIS DGKKQEGPAT QVSKKNPASL PLTQAALKVL 
AQKASEAQPP VARTQPSSGV DSAVGTLPAT SPQSTSVQAK GTNKLRKPKL PEVQQATKAP 
ESSDDSEDSS DSSSGSEEDG EGPQGAKSAH TLGPTPSRTE TLVEETAAES SEDDVVAPSQ 
SLLSGYMTPG LTPANSQASK ATPKLDSSPS VSSTLAAKDD PDGKQEAKPQ QAAGMLSPKT 
GGKEAASGTT PQKSRKPKKG AGNPQASTLA LQSNITQCLL GQPWPLNEAQ VQASVVKVLT 
ELLEQERKKV VDTTKESSRK GWESRKRKLS GDQPAARTPR SKKKKKLGAG EGGEASVSPE 
KTSTTSKGKA KRDKASGDVK EKKGKGSLGS QGAKDEPEEE LQKGMGTVEG GDQSNPKSKK 
EKKKSDKRKK DKEKKEKKKK AKKASTKDSE SPSQKKKKKK KKTAEQTV

Genular Protein ID: 184874299

Symbol: B4DRA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DRA2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 923
  • Mass: 93769
  • Checksum: EAFDFB1C4BC4658C
  • Sequence:
    • MNAAQVKPLG KSPQVKPAST MGMGPLGKGA GPVPPGKVGP ATPSAQVGKW EEDSESSSEE 
SSDSSDGEVP TAVAPAQEKS LGNILQAKPT SSPAKGPPQK AGPVAVQVKA EKPMDNSESS 
EESSDSADSE EAPAAMTAAQ AKPALKIPQT KACPKKTNTT ASAKVAPVRV GTQAPRKAGT 
ATSPAGSSPA VAGGTQRPAE DSSSSEESDS EEEKTGLAVT VGQAKSVGKG LQVKAASVPV 
KGSLGQGTAP VLPGKTGPTV TQVKAEKQED SESSEEESDS EEAAASPAQV KTSVKKTQAK 
ANPAAARAPS AKGTISAPGK VVTAAAQAKQ RSPSKVKPPV RNPQNSTVLA RGPASVPSVG 
KAVATAAQAQ TGPEEDSGSS EEESDSEEEA ETLAQVKPSG KTHQIRAALA PAKESPRKGA 
APTPPGKTGP SAAQAGKQDD SGSSSEESDS DGEAPAAVTS AQVIKPPLIF VDPNRSPAGP 
AATPAQAQAA STPRKARASE STARSSSSES EDEDVIPATQ CLTPGIRTNV VTMPTAHPRI 
APKASMAGAS SSKESSRISD GKKQEGPATQ VDSAVGTLPA TSPQSTSVQA KGTNKLRKPK 
LPEVQQATKA PESSDDSEDS SDSSSGSEED GEGPQGAKSA HTLVGPTRSR TETLVEETAA 
ESSEDDVVAP SQSLLSGYMT PGLTPANSQA SKATPKLDSS PSVSSTLAAK DDPDGKQEAK 
PQQAAGMLSP KTGGKEAASG TTPQKSRKPK KGAGNPQAST LALQSNITQC LLGQPWPLNE 
AQVQASVVKV LTELLEQERK KVVDTTKESS RKGWESRKRK LSGDQPAART PRSKKKKKLG 
AGEGGEASVS PEKTSTTSKG KAKRDKASGD VKEKKGKGSL GSQGAKDEPE EELQKGMGTV 
EGGDQSNPKS KKEKKKSDKR KKD

Genular Protein ID: 3407355351

Symbol: E7ETY2_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7ETY2

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 GeneTree 1 HGNC 1 IntAct 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1488
  • Mass: 152304
  • Checksum: 4FC162CCA7AE6659
  • Sequence:
    • MAEARKRREL LPLIYHHLLR AGYVRAAREV KEQSGQKCFL AQPVTLLDIY THWQQTSELG 
RKRKAEEDAA LQAKKTRVSD PISTSESSEE EEEAEAETAK ATPRLASTNS SVLGADLPSS 
MKEKAKAETE KAGKTGNSMP HPATGKTVAN LLSGKSPRKS AEPSANTTLV SETEEEGSVP 
AFGAAAKPGM VSAGQADSSS EDTSSSSDET DVEGKPSVKP AQVKASSVST KESPARKAAP 
APGKVGDVTP QVKGGALPPA KRAKKPEEES ESSEEGSESE EEAPAGTRSQ VKASEKILQV 
RAASAPAKGT PGKGATPAPP GKAGAVASQT KAGKPEEDSE SSSEESSDSE EETPAAKALL 
QAKASGKTSQ VGAASAPAKE SPRKGAAPAP PGKTGPAVAK AQAGKREEDS QSSSEESDSE 
EEAPAQAKPS GKAPQVRAAS APAKESPRKG AAPAPPRKTG PAAAQVQVGK QEEDSRSSSE 
ESDSDREALA AMNAAQVKPL GKSPQVKPAS TMGMGPLGKG AGPVPPGKVG PATPSAQVGK 
WEEDSESSSE ESSDSSDGEV PTAVAPAQEK SLGNILQAKP TSSPAKGPPQ KAGPVAVQVK 
AEKPMDNSES SEESSDSADS EEAPAAMTAA QAKPALKIPQ TKACPKKTNT TASAKVAPVR 
VGTQAPRKAG TATSPAGSSP AVAGGTQRPA EDSSSSEESD SEEEKTGLAV TVGQAKSVGK 
GLQVKAASVP VKGSLGQGTA PVLPGKTGPT VTQVKAEKQE DSESSEEESD SEEAAASPAQ 
VKTSVKKTQA KANPAAARAP SAKGTISAPG KVVTAAAQAK QRSPSKVKPP VRNPQNSTVL 
ARGPASVPSV GKAVATAAQA QTGPEEDSGS SEEESDSEEE AETLAQVKPS GKTHQIRAAL 
APAKESPRKG AAPTPPGKTG PSAAQAGKQD DSGSSSEESD SDGEAPAAVT SAQKDSNSKP 
ARSKTLAPAP PERNTEGSSE SSEEELPLTQ VIKPPLIFVD PNRSPAGPAA TPAQAQAAST 
PRKARASEST ARSSSSESED EDVIPATQCL TPGIRTNVVT MPTAHPRIAP KASMAGASSS 
KESSRISDGK KQEGPATQVD SAVGTLPATS PQSTSVQAKG TNKLRKPKLP EVQQATKAPE 
SSDDSEDSSD SSSGSEEDGE GPQGAKSAHT LVGPTPSRTE TLVEETAAES SEDDVVAPSQ 
SLLSGYMTPG LTPANSQASK ATPKLDSSPS VSSTLAAKDD PDGKQEAKPQ QAAGMLSPKT 
GGKEAASGTT PQKSRKPKKG AGNPQASTLA LQSNITQCLL GQPWPLNEAQ VQASVVKVLT 
ELLEQERKKV VDTTKESSRK GWESRKRKLS GDQPAARTPR SKKKKKLGAG EGGEASVSPE 
KTSTTSKGKA KRDKASGDVK EKKGKGSLGS QGAKDEPEEE LQKGMGTVEG GDQSNPKSKK 
EKKKSDKRKK DKEKKEKKKK AKKASTKDSE SPSQKKKKKK KKTAEQTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.