Details for: TRGC2

Gene ID: 6967

Symbol: TRGC2

Ensembl ID: ENSG00000227191

Description: T cell receptor gamma constant 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.5871
    Cell Significance Index: 114.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.6758
    Cell Significance Index: 105.9100
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.1401
    Cell Significance Index: 18.2100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.9332
    Cell Significance Index: 23.7600
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.8652
    Cell Significance Index: 34.6300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.2642
    Cell Significance Index: 35.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.7777
    Cell Significance Index: -5.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6324
    Cell Significance Index: 73.9900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.5995
    Cell Significance Index: 4.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2059
    Cell Significance Index: 26.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1358
    Cell Significance Index: 216.1500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.9838
    Cell Significance Index: 10.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9749
    Cell Significance Index: 96.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7890
    Cell Significance Index: 712.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3425
    Cell Significance Index: 7.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3396
    Cell Significance Index: 36.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3262
    Cell Significance Index: 53.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1662
    Cell Significance Index: 11.5000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1254
    Cell Significance Index: 1.8900
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.1062
    Cell Significance Index: 1.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0542
    Cell Significance Index: 1.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0013
    Cell Significance Index: -1.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0034
    Cell Significance Index: -0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0038
    Cell Significance Index: -7.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0050
    Cell Significance Index: -9.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0059
    Cell Significance Index: -0.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0059
    Cell Significance Index: -9.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0071
    Cell Significance Index: -9.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0125
    Cell Significance Index: -9.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0133
    Cell Significance Index: -8.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0162
    Cell Significance Index: -0.5200
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0181
    Cell Significance Index: -0.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0200
    Cell Significance Index: -9.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0234
    Cell Significance Index: -8.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0276
    Cell Significance Index: -5.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0278
    Cell Significance Index: -7.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0355
    Cell Significance Index: -3.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0436
    Cell Significance Index: -8.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0440
    Cell Significance Index: -7.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0492
    Cell Significance Index: -8.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0525
    Cell Significance Index: -6.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0561
    Cell Significance Index: -8.1500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0637
    Cell Significance Index: -2.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0640
    Cell Significance Index: -8.7900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0656
    Cell Significance Index: -1.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0677
    Cell Significance Index: -8.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0695
    Cell Significance Index: -4.1800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0701
    Cell Significance Index: -2.8700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0732
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0747
    Cell Significance Index: -8.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0748
    Cell Significance Index: -9.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0788
    Cell Significance Index: -9.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0810
    Cell Significance Index: -3.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0816
    Cell Significance Index: -8.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0911
    Cell Significance Index: -5.8800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0912
    Cell Significance Index: -0.7700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0928
    Cell Significance Index: -0.8800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1004
    Cell Significance Index: -1.7100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1110
    Cell Significance Index: -1.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1183
    Cell Significance Index: -9.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1283
    Cell Significance Index: -9.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1292
    Cell Significance Index: -8.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1461
    Cell Significance Index: -8.9800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1503
    Cell Significance Index: -2.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1734
    Cell Significance Index: -9.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1829
    Cell Significance Index: -9.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1920
    Cell Significance Index: -8.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2019
    Cell Significance Index: -5.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2103
    Cell Significance Index: -9.3000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2129
    Cell Significance Index: -2.6900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.2150
    Cell Significance Index: -1.9900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2156
    Cell Significance Index: -2.5500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2174
    Cell Significance Index: -2.2500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2229
    Cell Significance Index: -4.5400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2324
    Cell Significance Index: -5.6300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2448
    Cell Significance Index: -4.2200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2451
    Cell Significance Index: -4.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2453
    Cell Significance Index: -9.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2520
    Cell Significance Index: -9.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2561
    Cell Significance Index: -8.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2704
    Cell Significance Index: -5.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2776
    Cell Significance Index: -8.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2784
    Cell Significance Index: -9.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3038
    Cell Significance Index: -8.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3138
    Cell Significance Index: -8.3800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3167
    Cell Significance Index: -7.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3168
    Cell Significance Index: -9.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3182
    Cell Significance Index: -9.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3183
    Cell Significance Index: -8.5300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3232
    Cell Significance Index: -3.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3384
    Cell Significance Index: -9.7000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3402
    Cell Significance Index: -10.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3495
    Cell Significance Index: -9.1900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3496
    Cell Significance Index: -8.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3591
    Cell Significance Index: -9.1500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3629
    Cell Significance Index: -9.0500
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3663
    Cell Significance Index: -5.2100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3664
    Cell Significance Index: -9.1400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.3676
    Cell Significance Index: -2.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRGC2 is a gene that encodes a protein, T cell receptor gamma constant 2, which is a component of the gamma-delta T cell receptor complex. This complex is responsible for recognizing and responding to a wide range of antigens, including those derived from pathogens, tumor cells, and other foreign substances. TRGC2 is specifically expressed in gamma-delta intraepithelial T cells, which are a subset of T cells that reside in epithelial tissues, such as the skin, lungs, and gastrointestinal tract. These cells are critical for the surveillance of the external environment and the prevention of infections. **Pathways and Functions:** TRGC2 is involved in several key pathways that regulate immune responses. Firstly, it is a component of the adaptive immune response, which is a highly specific and targeted response to specific antigens. TRGC2 is also involved in the transmembrane signaling pathway, which is a complex network of molecular interactions that allows for the transmission of signals from the cell surface to the nucleus. This signaling pathway is essential for the activation and proliferation of T cells, as well as the production of cytokines and other immune molecules. In addition to its role in the adaptive immune response, TRGC2 is also involved in the regulation of immune homeostasis. Gamma-delta T cells are essential for the maintenance of immune tolerance and the prevention of autoimmune diseases. TRGC2 is also involved in the regulation of the expression of other immune-related genes, such as those involved in the production of cytokines and the activation of immune cells. **Clinical Significance:** TRGC2 is of significant clinical importance, particularly in the context of immune-related disorders. Dysregulation of TRGC2 has been implicated in a range of diseases, including autoimmune disorders, such as multiple sclerosis and type 1 diabetes. Gamma-delta T cells have also been shown to play a critical role in the clearance of tumors and the prevention of infections. Furthermore, TRGC2 has been identified as a potential target for the development of immunotherapies, such as cancer vaccines and immunomodulatory therapies. By modulating the expression of TRGC2, it may be possible to enhance the function of gamma-delta T cells and improve the efficacy of immunotherapies. In conclusion, TRGC2 is a gene of significant importance in the field of immunology. Its role in the adaptive immune response, immune homeostasis, and the regulation of immune-related genes makes it a critical component of the immune system. Further research into the functions and clinical significance of TRGC2 is necessary to fully understand its role in human health and disease. **Significantly expressed cells:** - Early promyelocyte - CD8-alpha alpha positive - Gamma-delta intraepithelial T cell - Late promyelocyte - Enterocyte of epithelium of large intestine - Effector CD8-positive, alpha-beta T cell - CD8-alpha-beta-positive, alpha-beta intraepithelial T cell - Activated CD8-positive, alpha-beta T cell - Colon goblet cell - Effector memory CD8-positive, alpha-beta T cell

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.