Gene TRGC2 - ENSG00000227191 | NCBI Gene ID: 6967

Details for: TRGC2

Gene ID: 6967

Symbol: TRGC2

Ensembl ID: ENSG00000227191

Description: T cell receptor gamma constant 2

Associated with

Adaptive immune response
(GO:0002250)
External side of plasma membrane
(GO:0009897)
Gamma-delta t cell receptor complex
(GO:0042106)
Immune response
(GO:0006955)
Plasma membrane
(GO:0005886)
T cell receptor signaling pathway
(GO:0050852)
Transmembrane signaling receptor activity
(GO:0004888)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: early promyelocyte (CL0002154)
Fold Change: 4.01
Marker Score: 3206.5
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 3.96
Marker Score: 1286.5
Cell Name: late promyelocyte (CL0002151)
Fold Change: 2.76
Marker Score: 691
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.99
Marker Score: 1987
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.77
Marker Score: 1486
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 1.73
Marker Score: 532
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.71
Marker Score: 387
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 1.7
Marker Score: 1234
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1163.5
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 1.49
Marker Score: 918
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.37
Marker Score: 3845
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.29
Marker Score: 5285
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 850
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 1.22
Marker Score: 625
Cell Name: myelocyte (CL0002193)
Fold Change: 1.17
Marker Score: 503.5
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.16
Marker Score: 483
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7690
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4808
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.04
Marker Score: 321
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71819
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48044
Cell Name: memory T cell (CL0000813)
Fold Change: 0.99
Marker Score: 427
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.99
Marker Score: 3123
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407.5
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 505
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 458
Cell Name: mature T cell (CL0002419)
Fold Change: 0.96
Marker Score: 9547
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.95
Marker Score: 1405
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.94
Marker Score: 594
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5299
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 370
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 322
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.87
Marker Score: 402
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5289
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.81
Marker Score: 684
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1267
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 706
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.77
Marker Score: 1093
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 589
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 393
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.75
Marker Score: 430.5
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 0.74
Marker Score: 2171
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.73
Marker Score: 315
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 458
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.68
Marker Score: 460
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.66
Marker Score: 1819
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.59
Marker Score: 298
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.58
Marker Score: 452
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.56
Marker Score: 335
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.56
Marker Score: 431
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 173
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.51
Marker Score: 1242
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.5
Marker Score: 444
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 0.5
Marker Score: 163
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.48
Marker Score: 12373
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.47
Marker Score: 283
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.46
Marker Score: 352
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.45
Marker Score: 221
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.44
Marker Score: 426
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.41
Marker Score: 143
Cell Name: Unknown (CL0000548)
Fold Change: 0.4
Marker Score: 288
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.35
Marker Score: 335
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.32
Marker Score: 277
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.31
Marker Score: 155
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.3
Marker Score: 177
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.3
Marker Score: 175
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.3
Marker Score: 474
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.29
Marker Score: 314
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.28
Marker Score: 75
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.28
Marker Score: 97
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.28
Marker Score: 260
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.26
Marker Score: 415
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.25
Marker Score: 56
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.25
Marker Score: 220
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.25
Marker Score: 81
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.25
Marker Score: 321
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.24
Marker Score: 88
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.23
Marker Score: 108
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.23
Marker Score: 1486
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: pneumocyte (CL0000322)
Fold Change: 0.22
Marker Score: 359
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.22
Marker Score: 123
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.22
Marker Score: 429
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74
Cell Name: promonocyte (CL0000559)
Fold Change: 0.22
Marker Score: 139
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.21
Marker Score: 109
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.21
Marker Score: 88
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.2
Marker Score: 106
Cell Name: mast cell (CL0000097)
Fold Change: 0.2
Marker Score: 118
Cell Name: neutrophil (CL0000775)
Fold Change: 0.2
Marker Score: 122
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.2
Marker Score: 131
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 0.2
Marker Score: 45
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.2
Marker Score: 112
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.19
Marker Score: 159
Cell Name: leukocyte (CL0000738)
Fold Change: 0.19
Marker Score: 108
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.19
Marker Score: 68

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Other Information

Description

**Key Characteristics:** TRGC2 is a gene that encodes a protein, T cell receptor gamma constant 2, which is a component of the gamma-delta T cell receptor complex. This complex is responsible for recognizing and responding to a wide range of antigens, including those derived from pathogens, tumor cells, and other foreign substances. TRGC2 is specifically expressed in gamma-delta intraepithelial T cells, which are a subset of T cells that reside in epithelial tissues, such as the skin, lungs, and gastrointestinal tract. These cells are critical for the surveillance of the external environment and the prevention of infections. **Pathways and Functions:** TRGC2 is involved in several key pathways that regulate immune responses. Firstly, it is a component of the adaptive immune response, which is a highly specific and targeted response to specific antigens. TRGC2 is also involved in the transmembrane signaling pathway, which is a complex network of molecular interactions that allows for the transmission of signals from the cell surface to the nucleus. This signaling pathway is essential for the activation and proliferation of T cells, as well as the production of cytokines and other immune molecules. In addition to its role in the adaptive immune response, TRGC2 is also involved in the regulation of immune homeostasis. Gamma-delta T cells are essential for the maintenance of immune tolerance and the prevention of autoimmune diseases. TRGC2 is also involved in the regulation of the expression of other immune-related genes, such as those involved in the production of cytokines and the activation of immune cells. **Clinical Significance:** TRGC2 is of significant clinical importance, particularly in the context of immune-related disorders. Dysregulation of TRGC2 has been implicated in a range of diseases, including autoimmune disorders, such as multiple sclerosis and type 1 diabetes. Gamma-delta T cells have also been shown to play a critical role in the clearance of tumors and the prevention of infections. Furthermore, TRGC2 has been identified as a potential target for the development of immunotherapies, such as cancer vaccines and immunomodulatory therapies. By modulating the expression of TRGC2, it may be possible to enhance the function of gamma-delta T cells and improve the efficacy of immunotherapies. In conclusion, TRGC2 is a gene of significant importance in the field of immunology. Its role in the adaptive immune response, immune homeostasis, and the regulation of immune-related genes makes it a critical component of the immune system. Further research into the functions and clinical significance of TRGC2 is necessary to fully understand its role in human health and disease. **Significantly expressed cells:** - Early promyelocyte - CD8-alpha alpha positive - Gamma-delta intraepithelial T cell - Late promyelocyte - Enterocyte of epithelium of large intestine - Effector CD8-positive, alpha-beta T cell - CD8-alpha-beta-positive, alpha-beta intraepithelial T cell - Activated CD8-positive, alpha-beta T cell - Colon goblet cell - Effector memory CD8-positive, alpha-beta T cell

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.