Details for: TRGV10

Gene ID: 6984

Symbol: TRGV10

Ensembl ID: ENSG00000211694

Description: T cell receptor gamma variable 10 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.7079
    Cell Significance Index: 3.8600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1844
    Cell Significance Index: 2.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1243
    Cell Significance Index: 3.3300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0955
    Cell Significance Index: 0.9900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.0616
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0056
    Cell Significance Index: -4.2200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0062
    Cell Significance Index: -0.0900
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0083
    Cell Significance Index: -0.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0109
    Cell Significance Index: -4.9300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0154
    Cell Significance Index: -0.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0204
    Cell Significance Index: -4.0900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0212
    Cell Significance Index: -0.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0215
    Cell Significance Index: -2.6400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0246
    Cell Significance Index: -1.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0251
    Cell Significance Index: -4.9800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0275
    Cell Significance Index: -0.2900
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0306
    Cell Significance Index: -0.3500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0323
    Cell Significance Index: -0.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0330
    Cell Significance Index: -4.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0372
    Cell Significance Index: -1.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0504
    Cell Significance Index: -5.1500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0635
    Cell Significance Index: -0.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0778
    Cell Significance Index: -5.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0901
    Cell Significance Index: -4.2000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0917
    Cell Significance Index: -2.2900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0956
    Cell Significance Index: -1.1300
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1034
    Cell Significance Index: -1.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1081
    Cell Significance Index: -4.9000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1115
    Cell Significance Index: -0.9500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1239
    Cell Significance Index: -3.0000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1251
    Cell Significance Index: -1.0000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1308
    Cell Significance Index: -1.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1371
    Cell Significance Index: -1.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1425
    Cell Significance Index: -3.6400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1482
    Cell Significance Index: -5.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1498
    Cell Significance Index: -4.2800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1504
    Cell Significance Index: -1.1700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1513
    Cell Significance Index: -1.5400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1740
    Cell Significance Index: -2.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1786
    Cell Significance Index: -4.8600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1790
    Cell Significance Index: -4.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1898
    Cell Significance Index: -5.4400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1926
    Cell Significance Index: -1.6300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2048
    Cell Significance Index: -2.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2116
    Cell Significance Index: -2.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2164
    Cell Significance Index: -5.0000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2168
    Cell Significance Index: -3.0800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2216
    Cell Significance Index: -3.8200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2247
    Cell Significance Index: -2.7800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.2260
    Cell Significance Index: -1.8300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2267
    Cell Significance Index: -2.2900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2317
    Cell Significance Index: -2.5900
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.2369
    Cell Significance Index: -2.3200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2389
    Cell Significance Index: -4.6700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2404
    Cell Significance Index: -3.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2418
    Cell Significance Index: -4.7200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2431
    Cell Significance Index: -2.3700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2431
    Cell Significance Index: -2.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2528
    Cell Significance Index: -4.2300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2538
    Cell Significance Index: -3.4800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2543
    Cell Significance Index: -4.0800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2546
    Cell Significance Index: -3.5200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2572
    Cell Significance Index: -4.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2635
    Cell Significance Index: -4.8700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.2650
    Cell Significance Index: -2.6500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2719
    Cell Significance Index: -4.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2747
    Cell Significance Index: -2.6400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2755
    Cell Significance Index: -4.7100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.2774
    Cell Significance Index: -2.4700
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.2809
    Cell Significance Index: -2.9700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2822
    Cell Significance Index: -2.6400
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.2848
    Cell Significance Index: -2.3600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2872
    Cell Significance Index: -2.8800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2892
    Cell Significance Index: -4.6500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2910
    Cell Significance Index: -3.4700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.2987
    Cell Significance Index: -4.0900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3033
    Cell Significance Index: -3.9800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3043
    Cell Significance Index: -4.4400
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.3083
    Cell Significance Index: -2.7400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3102
    Cell Significance Index: -4.4600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3111
    Cell Significance Index: -3.5800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3130
    Cell Significance Index: -5.0500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3132
    Cell Significance Index: -3.5300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3133
    Cell Significance Index: -3.4700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3134
    Cell Significance Index: -3.3700
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.3212
    Cell Significance Index: -2.3900
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.3217
    Cell Significance Index: -3.0800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3229
    Cell Significance Index: -3.4300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3238
    Cell Significance Index: -5.0100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.3243
    Cell Significance Index: -3.0800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3245
    Cell Significance Index: -4.7900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3266
    Cell Significance Index: -4.0800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.3281
    Cell Significance Index: -1.0000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3293
    Cell Significance Index: -5.0100
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: -0.3318
    Cell Significance Index: -2.5600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3346
    Cell Significance Index: -4.2400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3346
    Cell Significance Index: -4.0700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3363
    Cell Significance Index: -4.3200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.3369
    Cell Significance Index: -5.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRGV10 is a non-functional gene, meaning it does not encode a protein that plays a critical role in the immune response. Despite its non-functional status, TRGV10 is significantly expressed in various cell types, including mature alpha-beta T cells, thymocytes, neutrophil progenitor cells, and hematopoietic cells. This widespread expression suggests that TRGV10 may have a regulatory or modulatory function, influencing the behavior of these cells in response to immune stimuli. The TRGV10 gene is part of the T cell receptor gamma (TRG) locus, which is crucial for the development and function of alpha-beta T cells. The TRG locus is composed of multiple genes that encode the gamma chain of the T cell receptor, which is essential for recognizing and binding to antigen-presenting molecules. While TRGV10 does not encode a functional gamma chain, its expression in various cell types implies that it may be involved in the regulation of T cell development, activation, or differentiation. **Pathways and Functions** TRGV10 is associated with several key pathways involved in the adaptive immune response, including: 1. **Adaptive immune response**: TRGV10 is expressed in mature alpha-beta T cells, which are central to the adaptive immune response. The expression of TRGV10 in these cells may help regulate their activation, proliferation, and differentiation in response to antigen presentation. 2. **T cell receptor complex**: TRGV10 is part of the TRG locus, which is essential for the development and function of alpha-beta T cells. The expression of TRGV10 in thymocytes and other cell types may help regulate the assembly and function of the T cell receptor complex. 3. **Cell signaling pathways**: TRGV10 may be involved in regulating cell signaling pathways that control T cell activation, proliferation, and differentiation. For example, TRGV10 may interact with other genes or proteins to modulate the activity of key signaling molecules, such as STAT5 or NF-κB. **Clinical Significance** The clinical significance of TRGV10 is an area of ongoing research. While its non-functional status may limit its direct involvement in the immune response, its expression in various cell types suggests that it may play a regulatory or modulatory role in immune function. Further studies are needed to fully understand the clinical implications of TRGV10 and its potential role in immune-related diseases. Some potential areas of investigation include: 1. **Immunodeficiency disorders**: The expression of TRGV10 in hematopoietic cells suggests that it may be involved in the development of immunodeficiency disorders. Further studies may help identify the role of TRGV10 in these disorders. 2. **Autoimmune diseases**: TRGV10's expression in mature alpha-beta T cells may be relevant to the development and progression of autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis. 3. **Cancer immunotherapy**: The expression of TRGV10 in various cell types may be relevant to the development of cancer immunotherapies, such as checkpoint inhibitors or adoptive T cell therapies. In conclusion, the TRGV10 gene is a complex and enigmatic component of the human immune system. Further research is needed to fully understand its key characteristics, pathways, and clinical significance. By unraveling the mysteries of TRGV10, we can gain a deeper understanding of the intricate relationships between the immune system and its various cells, ultimately leading to improved treatments for immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.