Details for: DYNLT3

Gene ID: 6990

Symbol: DYNLT3

Ensembl ID: ENSG00000165169

Description: dynein light chain Tctex-type 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 208.6210
    Cell Significance Index: -32.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 118.1580
    Cell Significance Index: -29.9700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.2388
    Cell Significance Index: -26.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 65.7244
    Cell Significance Index: -31.0300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 59.8384
    Cell Significance Index: -30.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.3637
    Cell Significance Index: -27.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.4405
    Cell Significance Index: -32.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.7799
    Cell Significance Index: -23.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3222
    Cell Significance Index: -32.8400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.1916
    Cell Significance Index: -25.1600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.3668
    Cell Significance Index: 36.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.4314
    Cell Significance Index: -7.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5989
    Cell Significance Index: 43.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5681
    Cell Significance Index: 44.9500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.5105
    Cell Significance Index: 13.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.4491
    Cell Significance Index: 76.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2874
    Cell Significance Index: 95.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0460
    Cell Significance Index: 170.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0305
    Cell Significance Index: 141.5100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.0001
    Cell Significance Index: 6.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9251
    Cell Significance Index: 48.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8750
    Cell Significance Index: 107.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8203
    Cell Significance Index: 447.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8114
    Cell Significance Index: 38.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7798
    Cell Significance Index: 140.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7337
    Cell Significance Index: 94.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7043
    Cell Significance Index: 141.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6266
    Cell Significance Index: 32.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6069
    Cell Significance Index: 38.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5491
    Cell Significance Index: 37.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5450
    Cell Significance Index: 70.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3394
    Cell Significance Index: 9.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3188
    Cell Significance Index: 114.3500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.2664
    Cell Significance Index: 1.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2366
    Cell Significance Index: 2.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2156
    Cell Significance Index: 10.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1898
    Cell Significance Index: 83.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1889
    Cell Significance Index: 12.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1737
    Cell Significance Index: 33.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1516
    Cell Significance Index: 25.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1442
    Cell Significance Index: 3.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1336
    Cell Significance Index: 26.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1188
    Cell Significance Index: 11.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0835
    Cell Significance Index: 2.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0811
    Cell Significance Index: 2.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0778
    Cell Significance Index: 9.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0688
    Cell Significance Index: 1.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0441
    Cell Significance Index: 1.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0293
    Cell Significance Index: 1.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0062
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0008
    Cell Significance Index: 1.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0046
    Cell Significance Index: -0.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0067
    Cell Significance Index: -9.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0109
    Cell Significance Index: -8.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0120
    Cell Significance Index: -18.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0132
    Cell Significance Index: -10.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0137
    Cell Significance Index: -25.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0139
    Cell Significance Index: -8.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0177
    Cell Significance Index: -11.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0341
    Cell Significance Index: -19.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0349
    Cell Significance Index: -3.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0377
    Cell Significance Index: -17.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0449
    Cell Significance Index: -1.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0509
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0540
    Cell Significance Index: -11.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0679
    Cell Significance Index: -7.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0696
    Cell Significance Index: -20.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0975
    Cell Significance Index: -11.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1084
    Cell Significance Index: -7.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1262
    Cell Significance Index: -18.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1352
    Cell Significance Index: -15.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1506
    Cell Significance Index: -4.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1544
    Cell Significance Index: -9.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1633
    Cell Significance Index: -4.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1692
    Cell Significance Index: -11.9700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1737
    Cell Significance Index: -3.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1859
    Cell Significance Index: -3.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2232
    Cell Significance Index: -17.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2360
    Cell Significance Index: -7.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2553
    Cell Significance Index: -5.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2630
    Cell Significance Index: -20.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3011
    Cell Significance Index: -31.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3208
    Cell Significance Index: -8.5800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.3311
    Cell Significance Index: -3.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3613
    Cell Significance Index: -4.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3657
    Cell Significance Index: -6.1200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3892
    Cell Significance Index: -6.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3945
    Cell Significance Index: -22.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4214
    Cell Significance Index: -18.6400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4372
    Cell Significance Index: -11.1700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4546
    Cell Significance Index: -3.0800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.4555
    Cell Significance Index: -4.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4592
    Cell Significance Index: -7.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4742
    Cell Significance Index: -17.9600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4870
    Cell Significance Index: -10.4100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5076
    Cell Significance Index: -14.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5149
    Cell Significance Index: -31.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5734
    Cell Significance Index: -21.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6192
    Cell Significance Index: -14.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dynein Light Chain Tctex-type 3 (DYLT3)**: The DYNLT3 gene encodes for a 30-kDa protein with a high degree of sequence similarity to other dynein light chains. 2. **Cytoplasmic Dynein Complex**: DYLT3 is a key component of the cytoplasmic dynein complex, which is responsible for microtubule-based movement and transport of cargo within the cell. 3. **Regulation of Mitotic Cell Cycle**: DYLT3 is involved in the regulation of the mitotic cell cycle, including positive regulation of mitotic entry and progression. 4. **Cell Cycle Regulation**: DYLT3 is also involved in the regulation of the cell cycle, particularly in the G2/M phase transition. **Pathways and Functions:** 1. **Cell Cycle Regulation**: DYLT3 is involved in the regulation of the mitotic cell cycle, including positive regulation of mitotic entry and progression. 2. **Microtubule-Based Movement**: DYLT3 is a key component of the cytoplasmic dynein complex, which is responsible for microtubule-based movement and transport of cargo within the cell. 3. **Kinetochore Formation**: DYLT3 is involved in the formation of the kinetochore, a protein structure that plays a crucial role in the separation of chromosomes during mitosis. 4. **Regulation of Microtubule Dynamics**: DYLT3 regulates the dynamics of microtubules, which is essential for maintaining cellular homeostasis and preventing aberrant cell division. **Clinical Significance:** DYSLT3 dysregulation has been implicated in various diseases, including: 1. **Cancer**: DYLT3 mutations have been associated with certain types of cancer, such as breast cancer and ovarian cancer. 2. **Neurodegenerative Diseases**: DYLT3 dysregulation has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Reproductive Disorders**: DYLT3 dysregulation has been implicated in reproductive disorders, such as infertility and miscarriage. In conclusion, the DYNLT3 gene plays a crucial role in maintaining cellular homeostasis and regulating various cellular processes, including cell cycle regulation, microtubule-based movement, and kinetochore formation. Dysregulation of this gene has been implicated in various diseases, highlighting the importance of further research into the functions and mechanisms of DYNLT3.

Genular Protein ID: 3871755104

Symbol: DYLT3_HUMAN

Name: Dynein light chain Tctex-type 3

UniProtKB Accession Codes:

P51808 Q6ICS3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8004092

Title: Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex.

PubMed ID: 8004092

DOI: 10.1093/hmg/3.2.257

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16079286

Title: Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway.

PubMed ID: 16079286

DOI: 10.1242/jcs.02472

PubMed ID: 17289665

Title: The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3.

PubMed ID: 17289665

DOI: 10.1074/jbc.m611279200

Sequence Information:

  • Length: 116
  • Mass: 13062
  • Checksum: 7DEB2A8B9D989632
  • Sequence:
    • MEEYHRHCDE VGFNAEEAHN IVKECVDGVL GGEDYNHNNI NQWTASIVEQ SLTHLVKLGK 
AYKYIVTCAV VQKSAYGFHT ASSCFWDTTS DGTCTVRWEN RTMNCIVNVF AIAIVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.