Details for: DYNLT3

Gene ID: 6990

Symbol: DYNLT3

Ensembl ID: ENSG00000165169

Description: dynein light chain Tctex-type 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.63
    Marker Score: 6453.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.21
    Marker Score: 1847
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.16
    Marker Score: 16890
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.06
    Marker Score: 17769
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.75
    Marker Score: 59435
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.71
    Marker Score: 3034
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.71
    Marker Score: 2836
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.69
    Marker Score: 602
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.63
    Marker Score: 837
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.61
    Marker Score: 6198
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.58
    Marker Score: 6812
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.57
    Marker Score: 631
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.52
    Marker Score: 631
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.51
    Marker Score: 376
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.5
    Marker Score: 376
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.49
    Marker Score: 1269
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.46
    Marker Score: 2155
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.45
    Marker Score: 3539.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.42
    Marker Score: 3571
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.4
    Marker Score: 997
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.34
    Marker Score: 1430
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.33
    Marker Score: 1051
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.33
    Marker Score: 34047
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.32
    Marker Score: 2487
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.31
    Marker Score: 827
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.27
    Marker Score: 14288
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.27
    Marker Score: 43824
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.25
    Marker Score: 711
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.2
    Marker Score: 641.5
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.19
    Marker Score: 269
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.19
    Marker Score: 1441
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.18
    Marker Score: 511
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.16
    Marker Score: 1108
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.16
    Marker Score: 1093
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.13
    Marker Score: 320
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.13
    Marker Score: 741
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.12
    Marker Score: 11565
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.12
    Marker Score: 532
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.12
    Marker Score: 6788
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.09
    Marker Score: 1546
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.07
    Marker Score: 670.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.04
    Marker Score: 686
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.04
    Marker Score: 323
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.04
    Marker Score: 294
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.04
    Marker Score: 475
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.02
    Marker Score: 530
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.02
    Marker Score: 905
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.01
    Marker Score: 257
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.01
    Marker Score: 300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1
    Marker Score: 585
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71618
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47842
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.99
    Marker Score: 221
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.99
    Marker Score: 368
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.99
    Marker Score: 227
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.98
    Marker Score: 2809
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.98
    Marker Score: 1511
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30380
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.97
    Marker Score: 247
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.97
    Marker Score: 981
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.97
    Marker Score: 564
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.96
    Marker Score: 288
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.96
    Marker Score: 372
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.95
    Marker Score: 648
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.95
    Marker Score: 3357.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.94
    Marker Score: 2606
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.94
    Marker Score: 1454
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.94
    Marker Score: 316
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.94
    Marker Score: 57796
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.94
    Marker Score: 1222
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2381
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.93
    Marker Score: 238
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.93
    Marker Score: 1279
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.93
    Marker Score: 498
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.92
    Marker Score: 954
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.92
    Marker Score: 999
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.91
    Marker Score: 2566
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.91
    Marker Score: 315
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.91
    Marker Score: 218
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.9
    Marker Score: 907
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.9
    Marker Score: 260
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.9
    Marker Score: 950
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9
    Marker Score: 945
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.89
    Marker Score: 424
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.89
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2672
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.88
    Marker Score: 436
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.88
    Marker Score: 825
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.88
    Marker Score: 541
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.88
    Marker Score: 850
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.88
    Marker Score: 505
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.88
    Marker Score: 398
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.87
    Marker Score: 8642
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.87
    Marker Score: 1429
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.86
    Marker Score: 215
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.86
    Marker Score: 775
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.86
    Marker Score: 363

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Other Information

**Key Characteristics:** 1. **Dynein Light Chain Tctex-type 3 (DYLT3)**: The DYNLT3 gene encodes for a 30-kDa protein with a high degree of sequence similarity to other dynein light chains. 2. **Cytoplasmic Dynein Complex**: DYLT3 is a key component of the cytoplasmic dynein complex, which is responsible for microtubule-based movement and transport of cargo within the cell. 3. **Regulation of Mitotic Cell Cycle**: DYLT3 is involved in the regulation of the mitotic cell cycle, including positive regulation of mitotic entry and progression. 4. **Cell Cycle Regulation**: DYLT3 is also involved in the regulation of the cell cycle, particularly in the G2/M phase transition. **Pathways and Functions:** 1. **Cell Cycle Regulation**: DYLT3 is involved in the regulation of the mitotic cell cycle, including positive regulation of mitotic entry and progression. 2. **Microtubule-Based Movement**: DYLT3 is a key component of the cytoplasmic dynein complex, which is responsible for microtubule-based movement and transport of cargo within the cell. 3. **Kinetochore Formation**: DYLT3 is involved in the formation of the kinetochore, a protein structure that plays a crucial role in the separation of chromosomes during mitosis. 4. **Regulation of Microtubule Dynamics**: DYLT3 regulates the dynamics of microtubules, which is essential for maintaining cellular homeostasis and preventing aberrant cell division. **Clinical Significance:** DYSLT3 dysregulation has been implicated in various diseases, including: 1. **Cancer**: DYLT3 mutations have been associated with certain types of cancer, such as breast cancer and ovarian cancer. 2. **Neurodegenerative Diseases**: DYLT3 dysregulation has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Reproductive Disorders**: DYLT3 dysregulation has been implicated in reproductive disorders, such as infertility and miscarriage. In conclusion, the DYNLT3 gene plays a crucial role in maintaining cellular homeostasis and regulating various cellular processes, including cell cycle regulation, microtubule-based movement, and kinetochore formation. Dysregulation of this gene has been implicated in various diseases, highlighting the importance of further research into the functions and mechanisms of DYNLT3.

Genular Protein ID: 3871755104

Symbol: DYLT3_HUMAN

Name: Dynein light chain Tctex-type 3

UniProtKB Accession Codes:

P51808 Q6ICS3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8004092

Title: Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex.

PubMed ID: 8004092

DOI: 10.1093/hmg/3.2.257

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16079286

Title: Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway.

PubMed ID: 16079286

DOI: 10.1242/jcs.02472

PubMed ID: 17289665

Title: The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3.

PubMed ID: 17289665

DOI: 10.1074/jbc.m611279200

Sequence Information:

  • Length: 116
  • Mass: 13062
  • Checksum: 7DEB2A8B9D989632
  • Sequence:
    • MEEYHRHCDE VGFNAEEAHN IVKECVDGVL GGEDYNHNNI NQWTASIVEQ SLTHLVKLGK 
AYKYIVTCAV VQKSAYGFHT ASSCFWDTTS DGTCTVRWEN RTMNCIVNVF AIAIVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.