Details for: TEC

Gene ID: 7006

Symbol: TEC

Ensembl ID: ENSG00000135605

Description: tec protein tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 53.9393
    Cell Significance Index: -8.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.4007
    Cell Significance Index: -6.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.2889
    Cell Significance Index: -7.4300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.0755
    Cell Significance Index: -7.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.9346
    Cell Significance Index: -8.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.9974
    Cell Significance Index: -6.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.5899
    Cell Significance Index: 302.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2819
    Cell Significance Index: 36.9400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.0637
    Cell Significance Index: 15.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7599
    Cell Significance Index: 58.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7520
    Cell Significance Index: 34.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7498
    Cell Significance Index: 10.2300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7417
    Cell Significance Index: 15.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7291
    Cell Significance Index: 72.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7067
    Cell Significance Index: 15.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5902
    Cell Significance Index: 532.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4852
    Cell Significance Index: 29.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4620
    Cell Significance Index: 50.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4524
    Cell Significance Index: 11.3100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4250
    Cell Significance Index: 9.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3854
    Cell Significance Index: 62.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3645
    Cell Significance Index: 72.3300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.3471
    Cell Significance Index: 4.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3086
    Cell Significance Index: 19.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2844
    Cell Significance Index: 33.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2780
    Cell Significance Index: 7.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2434
    Cell Significance Index: 16.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2404
    Cell Significance Index: 6.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2085
    Cell Significance Index: 41.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2008
    Cell Significance Index: 10.4300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1644
    Cell Significance Index: 2.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1559
    Cell Significance Index: 4.1000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1261
    Cell Significance Index: 1.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1244
    Cell Significance Index: 2.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1178
    Cell Significance Index: 4.1400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1059
    Cell Significance Index: 1.3200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.0645
    Cell Significance Index: 0.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0637
    Cell Significance Index: 34.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0617
    Cell Significance Index: 1.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0551
    Cell Significance Index: 9.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0527
    Cell Significance Index: 6.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0490
    Cell Significance Index: 31.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0461
    Cell Significance Index: 20.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0458
    Cell Significance Index: 2.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0329
    Cell Significance Index: 61.9300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0318
    Cell Significance Index: 0.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0223
    Cell Significance Index: 1.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0197
    Cell Significance Index: 1.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0186
    Cell Significance Index: 34.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0147
    Cell Significance Index: 22.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0099
    Cell Significance Index: 1.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0054
    Cell Significance Index: 7.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0034
    Cell Significance Index: 0.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0034
    Cell Significance Index: 2.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0010
    Cell Significance Index: 0.4800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0036
    Cell Significance Index: -0.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0061
    Cell Significance Index: -0.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0085
    Cell Significance Index: -6.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0095
    Cell Significance Index: -7.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0107
    Cell Significance Index: -6.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0107
    Cell Significance Index: -7.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0114
    Cell Significance Index: -4.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0154
    Cell Significance Index: -9.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0189
    Cell Significance Index: -5.4300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0194
    Cell Significance Index: -0.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0215
    Cell Significance Index: -1.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0229
    Cell Significance Index: -2.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0265
    Cell Significance Index: -4.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0321
    Cell Significance Index: -1.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0374
    Cell Significance Index: -4.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0419
    Cell Significance Index: -8.8300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0436
    Cell Significance Index: -0.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0449
    Cell Significance Index: -6.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0459
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0509
    Cell Significance Index: -5.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0558
    Cell Significance Index: -5.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0585
    Cell Significance Index: -7.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0595
    Cell Significance Index: -1.5200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0803
    Cell Significance Index: -1.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0837
    Cell Significance Index: -2.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0863
    Cell Significance Index: -6.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0916
    Cell Significance Index: -1.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0989
    Cell Significance Index: -1.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1010
    Cell Significance Index: -8.0000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1037
    Cell Significance Index: -0.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1090
    Cell Significance Index: -8.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1098
    Cell Significance Index: -2.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1253
    Cell Significance Index: -7.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1285
    Cell Significance Index: -8.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1377
    Cell Significance Index: -7.1700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1384
    Cell Significance Index: -2.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1596
    Cell Significance Index: -8.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1623
    Cell Significance Index: -8.5200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1759
    Cell Significance Index: -2.2600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1803
    Cell Significance Index: -7.8400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1803
    Cell Significance Index: -6.6200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1824
    Cell Significance Index: -4.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1854
    Cell Significance Index: -6.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-receptor tyrosine kinase:** The Tec protein tyrosine kinase is a non-receptor tyrosine kinase, meaning it does not have an extracellular ligand-binding domain. 2. **Signaling versatility:** Tec kinase is involved in multiple signaling pathways, including adaptive and innate immune responses, cytokine signaling, and cell proliferation. 3. **Cell type-specific expression:** The Tec kinase is significantly expressed in various cell types, including immune cells, epithelial cells, and neurons. 4. **Phosphorylation activity:** Tec kinase exhibits phosphotyrosine kinase activity, which is essential for its signaling function. **Pathways and Functions:** 1. **Adaptive immune response:** Tec kinase is involved in the activation of immune cells, including T cells and B cells, through the signaling of T cell receptors and B cell receptors. 2. **Cytokine signaling:** Tec kinase is a key player in cytokine signaling, including the signaling of interleukins, such as IL-3, IL-5, and GM-CSF. 3. **Cell proliferation:** Tec kinase is involved in cell proliferation and survival, particularly in the context of immune cells and epithelial cells. 4. **Tissue regeneration:** Tec kinase is also involved in tissue regeneration, including the regeneration of the cornea and the retina. **Clinical Significance:** 1. **Cancer:** Dysregulation of the Tec kinase has been implicated in various cancers, including leukemia and lymphoma. 2. **Autoimmune disorders:** Tec kinase is involved in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological disorders:** Tec kinase is also involved in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases:** Tec kinase is involved in the immune response to infectious diseases, including HIV and tuberculosis. In conclusion, the Tec protein tyrosine kinase is a versatile and essential kinase that plays a crucial role in various cellular processes, including immune response, cell signaling, and tissue regeneration. Its dysregulation has been implicated in various diseases, making it a promising target for therapeutic interventions. Further research is needed to fully elucidate the mechanisms of Tec kinase and its role in human disease.

Genular Protein ID: 2836338515

Symbol: TEC_HUMAN

Name: Tyrosine-protein kinase Tec

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7934162

Title: Molecular cloning and analysis of the human Tec protein-tyrosine kinase.

PubMed ID: 7934162

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12573241

Title: Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.

PubMed ID: 12573241

DOI: 10.1016/s1570-9639(02)00524-1

PubMed ID: 7526158

Title: Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding.

PubMed ID: 7526158

DOI: 10.1128/mcb.14.12.8432-8437.1994

PubMed ID: 9299487

Title: Integrin-dependent tyrosine phosphorylation and cytoskeletal translocation of Tec in thrombin-activated platelets.

PubMed ID: 9299487

DOI: 10.1006/bbrc.1997.7269

PubMed ID: 9341160

Title: SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase.

PubMed ID: 9341160

DOI: 10.1074/jbc.272.43.27178

PubMed ID: 9753425

Title: Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase.

PubMed ID: 9753425

DOI: 10.1046/j.1365-2443.1998.00201.x

PubMed ID: 9652744

Title: Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets.

PubMed ID: 9652744

DOI: 10.1038/sj.onc.1201799

PubMed ID: 10518561

Title: Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase.

PubMed ID: 10518561

DOI: 10.1073/pnas.96.21.11976

PubMed ID: 15492005

Title: SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase.

PubMed ID: 15492005

DOI: 10.1074/jbc.m408141200

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19883687

Title: Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte.

PubMed ID: 19883687

DOI: 10.1016/j.imlet.2009.10.009

PubMed ID: 20230531

Title: Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion.

PubMed ID: 20230531

DOI: 10.1111/j.1600-0854.2010.01059.x

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 631
  • Mass: 73581
  • Checksum: F55DECBF9916E1F9
  • Sequence:
  • MNFNTILEEI LIKRSQQKKK TSPLNYKERL FVLTKSMLTY YEGRAEKKYR KGFIDVSKIK 
    CVEIVKNDDG VIPCQNKYPF QVVHDANTLY IFAPSPQSRD LWVKKLKEEI KNNNNIMIKY 
    HPKFWTDGSY QCCRQTEKLA PGCEKYNLFE SSIRKALPPA PETKKRRPPP PIPLEEEDNS 
    EEIVVAMYDF QAAEGHDLRL ERGQEYLILE KNDVHWWRAR DKYGNEGYIP SNYVTGKKSN 
    NLDQYEWYCR NMNRSKAEQL LRSEDKEGGF MVRDSSQPGL YTVSLYTKFG GEGSSGFRHY 
    HIKETTTSPK KYYLAEKHAF GSIPEIIEYH KHNAAGLVTR LRYPVSVKGK NAPTTAGFSY 
    EKWEINPSEL TFMRELGSGL FGVVRLGKWR AQYKVAIKAI REGAMCEEDF IEEAKVMMKL 
    THPKLVQLYG VCTQQKPIYI VTEFMERGCL LNFLRQRQGH FSRDVLLSMC QDVCEGMEYL 
    ERNSFIHRDL AARNCLVSEA GVVKVSDFGM ARYVLDDQYT SSSGAKFPVK WCPPEVFNYS 
    RFSSKSDVWS FGVLMWEVFT EGRMPFEKYT NYEVVTMVTR GHRLYQPKLA SNYVYEVMLR 
    CWQEKPEGRP SFEDLLRTID ELVECEETFG R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.