Details for: TEC
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 53.9393
Cell Significance Index: -8.3900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 27.4007
Cell Significance Index: -6.9500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 18.2889
Cell Significance Index: -7.4300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 8.0755
Cell Significance Index: -7.7100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 6.9346
Cell Significance Index: -8.5500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.9974
Cell Significance Index: -6.5600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.5899
Cell Significance Index: 302.5700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.2819
Cell Significance Index: 36.9400 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.0637
Cell Significance Index: 15.7000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.7599
Cell Significance Index: 58.3200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7520
Cell Significance Index: 34.0900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.7498
Cell Significance Index: 10.2300 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.7417
Cell Significance Index: 15.8600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7291
Cell Significance Index: 72.1200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7067
Cell Significance Index: 15.3100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5902
Cell Significance Index: 532.9400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4852
Cell Significance Index: 29.1300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4620
Cell Significance Index: 50.2600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.4524
Cell Significance Index: 11.3100 - Cell Name: peg cell (CL4033014)
Fold Change: 0.4250
Cell Significance Index: 9.8200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3854
Cell Significance Index: 62.6900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3645
Cell Significance Index: 72.3300 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.3471
Cell Significance Index: 4.0400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3086
Cell Significance Index: 19.9100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2844
Cell Significance Index: 33.5400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2780
Cell Significance Index: 7.7700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2434
Cell Significance Index: 16.8300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2404
Cell Significance Index: 6.4300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2085
Cell Significance Index: 41.8200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2008
Cell Significance Index: 10.4300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.1644
Cell Significance Index: 2.7700 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1559
Cell Significance Index: 4.1000 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.1261
Cell Significance Index: 1.7500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1244
Cell Significance Index: 2.6500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1178
Cell Significance Index: 4.1400 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.1059
Cell Significance Index: 1.3200 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.0645
Cell Significance Index: 0.8700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0637
Cell Significance Index: 34.8000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0617
Cell Significance Index: 1.5900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0551
Cell Significance Index: 9.9400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0527
Cell Significance Index: 6.4900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0490
Cell Significance Index: 31.1400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0461
Cell Significance Index: 20.4000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0458
Cell Significance Index: 2.5700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0329
Cell Significance Index: 61.9300 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0318
Cell Significance Index: 0.6200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0223
Cell Significance Index: 1.0400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0197
Cell Significance Index: 1.2400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0186
Cell Significance Index: 34.3800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0147
Cell Significance Index: 22.6800 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0099
Cell Significance Index: 1.2700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0054
Cell Significance Index: 7.4000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0034
Cell Significance Index: 0.0900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0034
Cell Significance Index: 2.3400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0010
Cell Significance Index: 0.4800 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0012
Cell Significance Index: -0.0100 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.0024
Cell Significance Index: -0.0300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0036
Cell Significance Index: -0.5200 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0061
Cell Significance Index: -0.0900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0085
Cell Significance Index: -6.2100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0095
Cell Significance Index: -7.1600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0107
Cell Significance Index: -6.0300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0107
Cell Significance Index: -7.9200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0114
Cell Significance Index: -4.1000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0154
Cell Significance Index: -9.6400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0189
Cell Significance Index: -5.4300 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0194
Cell Significance Index: -0.2900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0215
Cell Significance Index: -1.3200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0229
Cell Significance Index: -2.3400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0265
Cell Significance Index: -4.5300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0321
Cell Significance Index: -1.5100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0374
Cell Significance Index: -4.3600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0419
Cell Significance Index: -8.8300 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0436
Cell Significance Index: -0.6200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0449
Cell Significance Index: -6.1600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0459
Cell Significance Index: -1.2300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0509
Cell Significance Index: -5.8300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0558
Cell Significance Index: -5.8200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0585
Cell Significance Index: -7.5600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0595
Cell Significance Index: -1.5200 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0803
Cell Significance Index: -1.1500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0837
Cell Significance Index: -2.6800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0863
Cell Significance Index: -6.1100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0916
Cell Significance Index: -1.5700 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0989
Cell Significance Index: -1.4900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1010
Cell Significance Index: -8.0000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1037
Cell Significance Index: -0.9600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1090
Cell Significance Index: -8.1200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1098
Cell Significance Index: -2.9900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1253
Cell Significance Index: -7.7000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1285
Cell Significance Index: -8.6400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1377
Cell Significance Index: -7.1700 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.1384
Cell Significance Index: -2.2800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1596
Cell Significance Index: -8.0600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1623
Cell Significance Index: -8.5200 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.1759
Cell Significance Index: -2.2600 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1803
Cell Significance Index: -7.8400 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1803
Cell Significance Index: -6.6200 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.1824
Cell Significance Index: -4.4500 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1854
Cell Significance Index: -6.5000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2836338515
Symbol: TEC_HUMAN
Name: Tyrosine-protein kinase Tec
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7934162
Title: Molecular cloning and analysis of the human Tec protein-tyrosine kinase.
PubMed ID: 7934162
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12573241
Title: Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.
PubMed ID: 12573241
PubMed ID: 7526158
Title: Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding.
PubMed ID: 7526158
PubMed ID: 9299487
Title: Integrin-dependent tyrosine phosphorylation and cytoskeletal translocation of Tec in thrombin-activated platelets.
PubMed ID: 9299487
PubMed ID: 9341160
Title: SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase.
PubMed ID: 9341160
PubMed ID: 9753425
Title: Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase.
PubMed ID: 9753425
PubMed ID: 9652744
Title: Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets.
PubMed ID: 9652744
PubMed ID: 10518561
Title: Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase.
PubMed ID: 10518561
PubMed ID: 15492005
Title: SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase.
PubMed ID: 15492005
PubMed ID: 19807924
Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
PubMed ID: 19807924
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19883687
Title: Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte.
PubMed ID: 19883687
PubMed ID: 20230531
Title: Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion.
PubMed ID: 20230531
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 631
- Mass: 73581
- Checksum: F55DECBF9916E1F9
- Sequence:
MNFNTILEEI LIKRSQQKKK TSPLNYKERL FVLTKSMLTY YEGRAEKKYR KGFIDVSKIK CVEIVKNDDG VIPCQNKYPF QVVHDANTLY IFAPSPQSRD LWVKKLKEEI KNNNNIMIKY HPKFWTDGSY QCCRQTEKLA PGCEKYNLFE SSIRKALPPA PETKKRRPPP PIPLEEEDNS EEIVVAMYDF QAAEGHDLRL ERGQEYLILE KNDVHWWRAR DKYGNEGYIP SNYVTGKKSN NLDQYEWYCR NMNRSKAEQL LRSEDKEGGF MVRDSSQPGL YTVSLYTKFG GEGSSGFRHY HIKETTTSPK KYYLAEKHAF GSIPEIIEYH KHNAAGLVTR LRYPVSVKGK NAPTTAGFSY EKWEINPSEL TFMRELGSGL FGVVRLGKWR AQYKVAIKAI REGAMCEEDF IEEAKVMMKL THPKLVQLYG VCTQQKPIYI VTEFMERGCL LNFLRQRQGH FSRDVLLSMC QDVCEGMEYL ERNSFIHRDL AARNCLVSEA GVVKVSDFGM ARYVLDDQYT SSSGAKFPVK WCPPEVFNYS RFSSKSDVWS FGVLMWEVFT EGRMPFEKYT NYEVVTMVTR GHRLYQPKLA SNYVYEVMLR CWQEKPEGRP SFEDLLRTID ELVECEETFG R
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.