Details for: TGM4

Gene ID: 7047

Symbol: TGM4

Ensembl ID: ENSG00000163810

Description: transglutaminase 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 3.86
    Marker Score: 2139
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.86
    Marker Score: 1057
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.08
    Marker Score: 7159
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.06
    Marker Score: 2704
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71838
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48062
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.8
    Marker Score: 3088
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.74
    Marker Score: 308
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 476.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.42
    Marker Score: 872.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.28
    Marker Score: 148
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.27
    Marker Score: 160
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.22
    Marker Score: 172.5
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.19
    Marker Score: 273
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.17
    Marker Score: 96
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.13
    Marker Score: 67
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.12
    Marker Score: 86
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.09
    Marker Score: 65
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.08
    Marker Score: 204
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.08
    Marker Score: 193
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.08
    Marker Score: 1043
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 86
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.07
    Marker Score: 73
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 60
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.07
    Marker Score: 67
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.06
    Marker Score: 12
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 53
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.06
    Marker Score: 143
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.05
    Marker Score: 59
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.05
    Marker Score: 157
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.05
    Marker Score: 84
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.05
    Marker Score: 63
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.05
    Marker Score: 75
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.04
    Marker Score: 270
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.04
    Marker Score: 33
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.04
    Marker Score: 45
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.04
    Marker Score: 153
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.04
    Marker Score: 8
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.04
    Marker Score: 55
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.04
    Marker Score: 36
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.03
    Marker Score: 56
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.03
    Marker Score: 56
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.03
    Marker Score: 42
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.03
    Marker Score: 33.5
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.03
    Marker Score: 86
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 39
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.03
    Marker Score: 102
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.03
    Marker Score: 53
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 13

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Other Information

**Key characteristics:** * TGM4 is a glycoprotein that is encoded by the TGM4 gene. * It is a transmembrane protein that is expressed on the surface of cells. * It is a member of the transglutaminase family of enzymes. * It is highly expressed in cells of the immune system, particularly in erythrocytes, macrophages, and dendritic cells. **Pathways and functions:** * TGM4 is involved in the assembly of the ECM. It is a key component of the integrin-linked collagen (ILC) complex, which is responsible for the adhesion of cells to the ECM. * It is also involved in the regulation of cell migration, proliferation, and differentiation. * In endothelial cells, TGM4 is essential for the formation of new blood vessels. * In immune cells, TGM4 is involved in the formation of immune complexes and the trafficking of immune cells to sites of inflammation. **Clinical significance:** * Mutations in the TGM4 gene have been linked to several human diseases, including rheumatoid arthritis, osteoarthritis, and atherosclerosis. * TGM4 inhibitors are being investigated as potential treatments for these diseases. * TGM4 is a promising target for the development of new drugs that are used to treat cancer and other diseases that are characterized by abnormal cell migration and proliferation.

Genular Protein ID: 3330518426

Symbol: TGM4_HUMAN

Name: Protein-glutamine gamma-glutamyltransferase 4

UniProtKB Accession Codes:

P49221 Q16707 Q96QN4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 9 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 Rhea 4 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7916568

Title: Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library.

PubMed ID: 7916568

DOI: 10.1006/bbrc.1994.2298

PubMed ID: 8645175

Title: Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase.

PubMed ID: 8645175

DOI: 10.1042/bj3150901

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 684
  • Mass: 77145
  • Checksum: 64A3E754EA46BFEC
  • Sequence:
    • MMDASKELQV LHIDFLNQDN AVSHHTWEFQ TSSPVFRRGQ VFHLRLVLNQ PLQSYHQLKL 
EFSTGPNPSI AKHTLVVLDP RTPSDHYNWQ ATLQNESGKE VTVAVTSSPN AILGKYQLNV 
KTGNHILKSE ENILYLLFNP WCKEDMVFMP DEDERKEYIL NDTGCHYVGA ARSIKCKPWN 
FGQFEKNVLD CCISLLTESS LKPTDRRDPV LVCRAMCAMM SFEKGQGVLI GNWTGDYEGG 
TAPYKWTGSA PILQQYYNTK QAVCFGQCWV FAGILTTVLR ALGIPARSVT GFDSAHDTER 
NLTVDTYVNE NGEKITSMTH DSVWNFHVWT DAWMKRPDLP KGYDGWQAVD ATPQERSQGV 
FCCGPSPLTA IRKGDIFIVY DTRFVFSEVN GDRLIWLVKM VNGQEELHVI SMETTSIGKN 
ISTKAVGQDR RRDITYEYKY PEGSSEERQV MDHAFLLLSS EREHRRPVKE NFLHMSVQSD 
DVLLGNSVNF TVILKRKTAA LQNVNILGSF ELQLYTGKKM AKLCDLNKTS QIQGQVSEVT 
LTLDSKTYIN SLAILDDEPV IRGFIIAEIV ESKEIMASEV FTSFQYPEFS IELPNTGRIG 
QLLVCNCIFK NTLAIPLTDV KFSLESLGIS SLQTSDHGTV QPGETIQSQI KCTPIKTGPK 
KFIVKLSSKQ VKEINAQKIV LITK

Genular Protein ID: 1032082111

Symbol: A0A994J576_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A994J576

Database IDs:

ARBA 1 CTD 1 ChEBI 5 EMBL 3 Ensembl 2 GO 2 Gene3D 2 GeneTree 1 HGNC 1 InterPro 10 NCBI Taxonomy 1 PANTHER 2 PIRSF 1 PIRSR 2 PROSITE 1 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 2 SUPFAM 3

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 729
  • Mass: 81869
  • Checksum: 7AC2082C7EDA1506
  • Sequence:
    • MMDASKELRS HFVAQAGVLW LFTAAIIAHC SLKLLGSSDS PTSVSRVTGI TELQVLHIDF 
LNQDNAVSHH TWEFQTSSPV FRRGQVFHLR LVLNQPLQSY HQLKLEFSTG PNPSIAKHTL 
VVLDPRTPSD HYNWQATLQN ESGKEVTVAV TSSPNAILGK YQLNVKTGNH ILKSEENILY 
LLFNPWCKED MVFMPDEDER KEYILNDTGC HYVGAARSIK CKPWNFGQFE KNVLDCCISL 
LTESSLKPTD RRDPVLVCRA MCAMMSFEKG QGVLIGNWTG DYEGGTAPYK WTGSAPILQQ 
YYNTKQAVCF GQCWVFAGIL TTVLRALGIP ARSVTGFDSA HDTERNLTVD TYVNENGEKI 
TSMTHDSVWN FHVWTDAWMK RPDLPKGYDG WQAVDATPQE RSQGVFCCGP SPLTAIRKGD 
IFIVYDTRFV FSEVNGDRLI WLVKMVNGQE ELHVISMETT SIGKNISTKA VGQDRRRDIT 
YEYKYPEGSS EERQVMDHAF LLLSSEREHR RPVKENFLHM SVQSDDVLLG NSVNFTVILK 
RKTAALQNVN ILGSFELQLY TGKKMAKLCD LNKTSQIQGQ VSEVTLTLDS KTYINSLAIL 
DDEPVIRGFI IAEIVESKEI MASEVFTSFQ YPEFSIELPN TGRIGQLLVC NCIFKNTLAI 
PLTDVKFSLE SLGISSLQTS DHGTVQPGET IQSQIKCTPI KTGPKKFIVK LSSKQVKEIN 
AQKIVLITK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.