Details for: THOP1

Gene ID: 7064

Symbol: THOP1

Ensembl ID: ENSG00000172009

Description: thimet oligopeptidase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 81.5197
    Cell Significance Index: -12.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 54.2494
    Cell Significance Index: -13.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.5102
    Cell Significance Index: -14.0200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 23.4120
    Cell Significance Index: -15.7100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.6951
    Cell Significance Index: -14.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.8066
    Cell Significance Index: -15.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7786
    Cell Significance Index: -15.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1485
    Cell Significance Index: -16.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4148
    Cell Significance Index: 153.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2691
    Cell Significance Index: 36.5700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0718
    Cell Significance Index: 16.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0710
    Cell Significance Index: 967.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9232
    Cell Significance Index: 24.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7482
    Cell Significance Index: 51.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7373
    Cell Significance Index: 33.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7210
    Cell Significance Index: 15.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6802
    Cell Significance Index: 42.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.6580
    Cell Significance Index: 16.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6058
    Cell Significance Index: 120.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5610
    Cell Significance Index: 112.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5297
    Cell Significance Index: 14.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4773
    Cell Significance Index: 56.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4362
    Cell Significance Index: 12.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4249
    Cell Significance Index: 152.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3605
    Cell Significance Index: 68.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3185
    Cell Significance Index: 173.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3090
    Cell Significance Index: 9.1000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2686
    Cell Significance Index: 2.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2243
    Cell Significance Index: 7.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2164
    Cell Significance Index: 13.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2131
    Cell Significance Index: 2.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2089
    Cell Significance Index: 10.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1986
    Cell Significance Index: 4.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1856
    Cell Significance Index: 6.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1819
    Cell Significance Index: 4.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1770
    Cell Significance Index: 6.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1664
    Cell Significance Index: 7.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1595
    Cell Significance Index: 15.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1406
    Cell Significance Index: 10.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1401
    Cell Significance Index: 7.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1343
    Cell Significance Index: 59.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1334
    Cell Significance Index: 3.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1291
    Cell Significance Index: 16.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1283
    Cell Significance Index: 1.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1242
    Cell Significance Index: 17.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1163
    Cell Significance Index: 7.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1047
    Cell Significance Index: 8.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1039
    Cell Significance Index: 12.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0972
    Cell Significance Index: 17.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0519
    Cell Significance Index: 2.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0487
    Cell Significance Index: 1.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0371
    Cell Significance Index: 4.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0156
    Cell Significance Index: 1.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0066
    Cell Significance Index: 12.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0012
    Cell Significance Index: -0.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0030
    Cell Significance Index: -5.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0046
    Cell Significance Index: -7.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0077
    Cell Significance Index: -5.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0104
    Cell Significance Index: -14.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0117
    Cell Significance Index: -8.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0124
    Cell Significance Index: -7.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0154
    Cell Significance Index: -11.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0204
    Cell Significance Index: -0.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0207
    Cell Significance Index: -9.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0233
    Cell Significance Index: -13.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0234
    Cell Significance Index: -4.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0284
    Cell Significance Index: -17.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0312
    Cell Significance Index: -1.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0318
    Cell Significance Index: -3.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0371
    Cell Significance Index: -2.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0463
    Cell Significance Index: -13.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0499
    Cell Significance Index: -0.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0523
    Cell Significance Index: -6.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0601
    Cell Significance Index: -1.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0613
    Cell Significance Index: -2.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0759
    Cell Significance Index: -4.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0783
    Cell Significance Index: -8.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0828
    Cell Significance Index: -17.4500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1112
    Cell Significance Index: -1.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1233
    Cell Significance Index: -2.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1486
    Cell Significance Index: -15.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1723
    Cell Significance Index: -5.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1784
    Cell Significance Index: -14.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1960
    Cell Significance Index: -10.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2329
    Cell Significance Index: -14.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2796
    Cell Significance Index: -4.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3039
    Cell Significance Index: -9.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3052
    Cell Significance Index: -8.7500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3152
    Cell Significance Index: -3.9100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3220
    Cell Significance Index: -4.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3235
    Cell Significance Index: -6.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3247
    Cell Significance Index: -10.6300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3382
    Cell Significance Index: -8.1100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3467
    Cell Significance Index: -4.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3505
    Cell Significance Index: -12.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3696
    Cell Significance Index: -9.5000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3701
    Cell Significance Index: -5.3000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3726
    Cell Significance Index: -5.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3750
    Cell Significance Index: -7.9600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3769
    Cell Significance Index: -5.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** THOP1 is a member of the dipeptidyl peptidase (DPP) family, characterized by its metalloendopeptidase activity, which involves the cleavage of peptide bonds in proteins. The enzyme is primarily expressed in various cell types, including germ cells, enterocytes, osteoclasts, and cardiac muscle myoblasts. THOP1 has a unique ability to bind to metal ions, which is essential for its catalytic activity. The enzyme is also involved in the ubiquitination and proteasome degradation of proteins, highlighting its role in protein regulation and quality control. **Pathways and Functions:** THOP1 is involved in several key pathways, including: 1. **Adaptive Immune System:** THOP1 plays a crucial role in the presentation of antigens to class I MHC molecules, which is essential for the recognition and elimination of pathogens. 2. **Antigen Processing: Ubiquitination & Proteasome Degradation:** THOP1 is involved in the ubiquitination and proteasome degradation of proteins, which is essential for protein regulation and quality control. 3. **Class I MHC Mediated Antigen Processing & Presentation:** THOP1 is involved in the processing and presentation of antigens to class I MHC molecules, which is essential for the recognition and elimination of pathogens. 4. **Cytosol:** THOP1 is involved in various cytosolic processes, including protein regulation and quality control. 5. **Immune System:** THOP1 plays a crucial role in the immune system, including the regulation of immune responses and the elimination of pathogens. **Clinical Significance:** THOP1 has significant clinical implications, particularly in the context of immune-related disorders. Dysregulation of THOP1 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** THOP1 has been implicated in the pathogenesis of autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** THOP1 has been implicated in the progression of various cancers, including breast cancer and lung cancer. 3. **Neurodegenerative Disorders:** THOP1 has been implicated in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, THOP1 is a complex enzyme that plays a crucial role in antigen processing and immune regulation. Its dysregulation has significant clinical implications, particularly in the context of immune-related disorders. Further research is necessary to fully elucidate the mechanisms by which THOP1 regulates immune responses and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 445680910

Symbol: THOP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P52888 B3KSE2 Q9UCB3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7639763

Title: Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a beta-APP substrate peptide.

PubMed ID: 7639763

DOI: 10.1006/bbrc.1995.2099

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8286339

Title: Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.

PubMed ID: 8286339

DOI: 10.1021/bi00167a025

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17251185

Title: Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase.

PubMed ID: 17251185

DOI: 10.1074/jbc.m609897200

Sequence Information:

  • Length: 689
  • Mass: 78840
  • Checksum: 092D53DD63B322DE
  • Sequence:
    • MKPPAACAGD MADAASPCSV VNDLRWDLSA QQIEERTREL IEQTKRVYDQ VGTQEFEDVS 
YESTLKALAD VEVTYTVQRN ILDFPQHVSP SKDIRTASTE ADKKLSEFDV EMSMREDVYQ 
RIVWLQEKVQ KDSLRPEAAR YLERLIKLGR RNGLHLPRET QENIKRIKKK LSLLCIDFNK 
NLNEDTTFLP FTLQELGGLP EDFLNSLEKM EDGKLKVTLK YPHYFPLLKK CHVPETRRKV 
EEAFNCRCKE ENCAILKELV TLRAQKSRLL GFHTHADYVL EMNMAKTSQT VATFLDELAQ 
KLKPLGEQER AVILELKRAE CERRGLPFDG RIRAWDMRYY MNQVEETRYC VDQNLLKEYF 
PVQVVTHGLL GIYQELLGLA FHHEEGASAW HEDVRLYTAR DAASGEVVGK FYLDLYPREG 
KYGHAACFGL QPGCLRQDGS RQIAIAAMVA NFTKPTADAP SLLQHDEVET YFHEFGHVMH 
QLCSQAEFAM FSGTHVERDF VEAPSQMLEN WVWEQEPLLR MSRHYRTGSA VPRELLEKLI 
ESRQANTGLF NLRQIVLAKV DQALHTQTDA DPAEEYARLC QEILGVPATP GTNMPATFGH 
LAGGYDAQYY GYLWSEVYSM DMFHTRFKQE GVLNSKVGMD YRSCILRPGG SEDASAMLRR 
FLGRDPKQDA FLLSKGLQVG GCEPEPQVC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.