Details for: THOP1

Gene ID: 7064

Symbol: THOP1

Ensembl ID: ENSG00000172009

Description: thimet oligopeptidase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.17
    Marker Score: 3795
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.71
    Marker Score: 8187
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.69
    Marker Score: 2607.5
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.49
    Marker Score: 740
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.17
    Marker Score: 1684
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17486
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.03
    Marker Score: 701
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71748
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47972
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.94
    Marker Score: 1776
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5234
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.91
    Marker Score: 1848
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2715
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.9
    Marker Score: 677
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.9
    Marker Score: 718
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.88
    Marker Score: 848
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.87
    Marker Score: 7438
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.82
    Marker Score: 7835
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.81
    Marker Score: 2212.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.81
    Marker Score: 2393
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.8
    Marker Score: 1232
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.79
    Marker Score: 2493.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.77
    Marker Score: 47153
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.76
    Marker Score: 768
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.75
    Marker Score: 2950
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 567
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.73
    Marker Score: 176
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.72
    Marker Score: 1698
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 288.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.72
    Marker Score: 659
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.72
    Marker Score: 7392
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 642
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.7
    Marker Score: 202
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.68
    Marker Score: 1621
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.68
    Marker Score: 6398
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.66
    Marker Score: 2704
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.66
    Marker Score: 693
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.64
    Marker Score: 1339
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.64
    Marker Score: 200
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.63
    Marker Score: 203
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.63
    Marker Score: 786.5
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.62
    Marker Score: 826
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.61
    Marker Score: 1044
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.61
    Marker Score: 577
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 398
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.59
    Marker Score: 1255.5
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.59
    Marker Score: 146
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.59
    Marker Score: 354
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.57
    Marker Score: 419
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.57
    Marker Score: 612
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.57
    Marker Score: 3440
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.57
    Marker Score: 2116
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.57
    Marker Score: 19775
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.56
    Marker Score: 600
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.55
    Marker Score: 20941
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.55
    Marker Score: 262
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.55
    Marker Score: 20228
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.55
    Marker Score: 400
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.54
    Marker Score: 300
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.54
    Marker Score: 269
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.54
    Marker Score: 190
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.54
    Marker Score: 362
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.54
    Marker Score: 156
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.54
    Marker Score: 1096
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 427
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.53
    Marker Score: 2057
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.53
    Marker Score: 200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.53
    Marker Score: 10559
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.53
    Marker Score: 184
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.53
    Marker Score: 258
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.52
    Marker Score: 357
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.52
    Marker Score: 3095.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.51
    Marker Score: 7666
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.51
    Marker Score: 1378
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.51
    Marker Score: 134
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 322
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.5
    Marker Score: 293
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.5
    Marker Score: 161
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.5
    Marker Score: 142
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.49
    Marker Score: 3792
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.49
    Marker Score: 437
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.49
    Marker Score: 199
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.48
    Marker Score: 130
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.47
    Marker Score: 259
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.47
    Marker Score: 139
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.47
    Marker Score: 195
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.46
    Marker Score: 2003
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.46
    Marker Score: 316.5
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.46
    Marker Score: 211

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** THOP1 is a member of the dipeptidyl peptidase (DPP) family, characterized by its metalloendopeptidase activity, which involves the cleavage of peptide bonds in proteins. The enzyme is primarily expressed in various cell types, including germ cells, enterocytes, osteoclasts, and cardiac muscle myoblasts. THOP1 has a unique ability to bind to metal ions, which is essential for its catalytic activity. The enzyme is also involved in the ubiquitination and proteasome degradation of proteins, highlighting its role in protein regulation and quality control. **Pathways and Functions:** THOP1 is involved in several key pathways, including: 1. **Adaptive Immune System:** THOP1 plays a crucial role in the presentation of antigens to class I MHC molecules, which is essential for the recognition and elimination of pathogens. 2. **Antigen Processing: Ubiquitination & Proteasome Degradation:** THOP1 is involved in the ubiquitination and proteasome degradation of proteins, which is essential for protein regulation and quality control. 3. **Class I MHC Mediated Antigen Processing & Presentation:** THOP1 is involved in the processing and presentation of antigens to class I MHC molecules, which is essential for the recognition and elimination of pathogens. 4. **Cytosol:** THOP1 is involved in various cytosolic processes, including protein regulation and quality control. 5. **Immune System:** THOP1 plays a crucial role in the immune system, including the regulation of immune responses and the elimination of pathogens. **Clinical Significance:** THOP1 has significant clinical implications, particularly in the context of immune-related disorders. Dysregulation of THOP1 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** THOP1 has been implicated in the pathogenesis of autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** THOP1 has been implicated in the progression of various cancers, including breast cancer and lung cancer. 3. **Neurodegenerative Disorders:** THOP1 has been implicated in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, THOP1 is a complex enzyme that plays a crucial role in antigen processing and immune regulation. Its dysregulation has significant clinical implications, particularly in the context of immune-related disorders. Further research is necessary to fully elucidate the mechanisms by which THOP1 regulates immune responses and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 445680910

Symbol: THOP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P52888 B3KSE2 Q9UCB3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7639763

Title: Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a beta-APP substrate peptide.

PubMed ID: 7639763

DOI: 10.1006/bbrc.1995.2099

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8286339

Title: Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.

PubMed ID: 8286339

DOI: 10.1021/bi00167a025

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17251185

Title: Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase.

PubMed ID: 17251185

DOI: 10.1074/jbc.m609897200

Sequence Information:

  • Length: 689
  • Mass: 78840
  • Checksum: 092D53DD63B322DE
  • Sequence:
    • MKPPAACAGD MADAASPCSV VNDLRWDLSA QQIEERTREL IEQTKRVYDQ VGTQEFEDVS 
YESTLKALAD VEVTYTVQRN ILDFPQHVSP SKDIRTASTE ADKKLSEFDV EMSMREDVYQ 
RIVWLQEKVQ KDSLRPEAAR YLERLIKLGR RNGLHLPRET QENIKRIKKK LSLLCIDFNK 
NLNEDTTFLP FTLQELGGLP EDFLNSLEKM EDGKLKVTLK YPHYFPLLKK CHVPETRRKV 
EEAFNCRCKE ENCAILKELV TLRAQKSRLL GFHTHADYVL EMNMAKTSQT VATFLDELAQ 
KLKPLGEQER AVILELKRAE CERRGLPFDG RIRAWDMRYY MNQVEETRYC VDQNLLKEYF 
PVQVVTHGLL GIYQELLGLA FHHEEGASAW HEDVRLYTAR DAASGEVVGK FYLDLYPREG 
KYGHAACFGL QPGCLRQDGS RQIAIAAMVA NFTKPTADAP SLLQHDEVET YFHEFGHVMH 
QLCSQAEFAM FSGTHVERDF VEAPSQMLEN WVWEQEPLLR MSRHYRTGSA VPRELLEKLI 
ESRQANTGLF NLRQIVLAKV DQALHTQTDA DPAEEYARLC QEILGVPATP GTNMPATFGH 
LAGGYDAQYY GYLWSEVYSM DMFHTRFKQE GVLNSKVGMD YRSCILRPGG SEDASAMLRR 
FLGRDPKQDA FLLSKGLQVG GCEPEPQVC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.