Details for: THPO

Gene ID: 7066

Symbol: THPO

Ensembl ID: ENSG00000090534

Description: thrombopoietin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.45
    Marker Score: 3009
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48059
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 492
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.78
    Marker Score: 2483
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 469
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.53
    Marker Score: 1244
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.51
    Marker Score: 245
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.47
    Marker Score: 898
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.46
    Marker Score: 741
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.46
    Marker Score: 314
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.43
    Marker Score: 883
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.42
    Marker Score: 6544
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.39
    Marker Score: 373
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.21
    Marker Score: 331
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.21
    Marker Score: 823
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.2
    Marker Score: 883
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.19
    Marker Score: 1210
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.18
    Marker Score: 272
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.17
    Marker Score: 45
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.17
    Marker Score: 101
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.15
    Marker Score: 58
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.14
    Marker Score: 151
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.14
    Marker Score: 74
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.14
    Marker Score: 745
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.13
    Marker Score: 1155
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.13
    Marker Score: 439
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.13
    Marker Score: 131
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.13
    Marker Score: 7917
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.11
    Marker Score: 125
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.11
    Marker Score: 43
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.11
    Marker Score: 77
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.11
    Marker Score: 30
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.1
    Marker Score: 943
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.1
    Marker Score: 167
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.09
    Marker Score: 3352
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.09
    Marker Score: 364
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.09
    Marker Score: 92
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.09
    Marker Score: 66
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.08
    Marker Score: 472
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 78
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 60
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.07
    Marker Score: 66
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.06
    Marker Score: 164
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 67
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.05
    Marker Score: 15.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.05
    Marker Score: 63
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.05
    Marker Score: 381
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.05
    Marker Score: 76
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.05
    Marker Score: 210
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.05
    Marker Score: 186
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 43
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.05
    Marker Score: 76
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.04
    Marker Score: 106
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.04
    Marker Score: 157
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.04
    Marker Score: 643
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.04
    Marker Score: 482
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.04
    Marker Score: 1607
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.04
    Marker Score: 50
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.04
    Marker Score: 15

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Other Information

**Key Characteristics:** THPO is a glycoprotein hormone that belongs to the transforming growth factor-beta (TGF-β) superfamily. It is primarily produced by the liver and kidney and is involved in the regulation of megakaryocyte development and platelet production. THPO binds to its receptor, c-Mpl, which is expressed on the surface of megakaryocytes and platelets, triggering a signaling cascade that regulates cell proliferation, differentiation, and survival. THPO has also been shown to have anti-inflammatory and anti-angiogenic properties, making it a potential therapeutic target for various diseases. **Pathways and Functions:** The THPO signaling pathway involves the binding of THPO to its receptor, c-Mpl, which triggers a series of downstream signaling events that regulate megakaryocyte development and platelet production. The pathway involves the activation of the MAPK cascade, which regulates cell proliferation and differentiation, as well as the PI3K/Akt pathway, which regulates cell survival and anti-apoptotic signaling. THPO has also been implicated in other cellular processes, including cell proliferation, differentiation, and signaling pathways, such as the ERK1/2 cascade and the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway. **Clinical Significance:** THPO has been implicated in various diseases, including thrombocytopenia, a condition characterized by low platelet counts, as well as other hematological disorders, such as leukemia and lymphoma. THPO has also been shown to have anti-inflammatory and anti-angiogenic properties, making it a potential therapeutic target for various diseases, including cancer and cardiovascular disease. Additionally, THPO has been used as a biomarker for the diagnosis and monitoring of hematological disorders, such as thrombocytopenia and leukemia. **Significantly Expressed Cells:** THPO is expressed in various cell types, including kidney proximal convoluted tubule epithelial cells, goblet cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, intestinal crypt stem cells of colon, transit amplifying cells, abnormal cells, neoplastic cells, and mast cells. The expression of THPO in these cell types suggests that it plays a broader role in regulating cellular processes beyond hematopoiesis. **Proteins:** THPO has been associated with several proteins, including TPO_HUMAN (Thrombopoietin), F8W6L1_HUMAN (unknown), Q5FBX8_HUMAN (unknown), and A0A3B3ITS0_HUMAN (unknown). These proteins are involved in various cellular processes, including cell signaling and regulation of cellular processes. In conclusion, THPO is a critical regulator of hematopoiesis, particularly in the development and maturation of megakaryocytes, and has been implicated in various other cellular processes, including cell proliferation, differentiation, and signaling pathways. Its clinical significance extends beyond hematological disorders, making it a potential therapeutic target for various diseases, including cancer and cardiovascular disease.

Genular Protein ID: 1386966978

Symbol: TPO_HUMAN

Name: Thrombopoietin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8202154

Title: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.

PubMed ID: 8202154

DOI: 10.1038/369533a0

PubMed ID: 8020099

Title: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl.

PubMed ID: 8020099

DOI: 10.1016/0092-8674(94)90450-2

PubMed ID: 7809166

Title: Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization.

PubMed ID: 7809166

DOI: 10.1073/pnas.91.26.13023

PubMed ID: 7926023

Title: Molecular cloning and chromosomal localization of the human thrombopoietin gene.

PubMed ID: 7926023

DOI: 10.1016/0014-5793(94)01008-0

PubMed ID: 7849319

Title: Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin.

PubMed ID: 7849319

PubMed ID: 8537317

Title: Purification and characterization of thrombopoietin.

PubMed ID: 8537317

DOI: 10.1093/oxfordjournals.jbchem.a124883

PubMed ID: 7822271

Title: Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene.

PubMed ID: 7822271

DOI: 10.1074/jbc.270.2.511

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9425899

Title: An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia.

PubMed ID: 9425899

DOI: 10.1038/ng0198-49

PubMed ID: 8942648

Title: Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246.

PubMed ID: 8942648

DOI: 10.1021/bi961075b

PubMed ID: 14769915

Title: Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment.

PubMed ID: 14769915

DOI: 10.1073/pnas.0308530100

Sequence Information:

  • Length: 353
  • Mass: 37823
  • Checksum: F0AB5449B72E5526
  • Sequence:
  • MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS HVLHSRLSQC PEVHPLPTPV 
    LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG QLGPTCLSSL LGQLSGQVRL 
    LLGALQSLLG TQLPPQGRTT AHKDPNAIFL SFQHLLRGKV RFLMLVGGST LCVRRAPPTT 
    AVPSRTSLVL TLNELPNRTS GLLETNFTAS ARTTGSGLLK WQQGFRAKIP GLLNQTSRSL 
    DQIPGYLNRI HELLNGTRGL FPGPSRRTLG APDISSGTSD TGSLPPNLQP GYSPSPTHPP 
    TGQYTLFPLP PTLPTPVVQL HPLLPDPSAP TPTPTSPLLN TSYTHSQNLS QEG

Genular Protein ID: 3190313244

Symbol: F8W6L1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 286
  • Mass: 31544
  • Checksum: 477EAC4BE75442F6
  • Sequence:
  • MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS HVLHSRLSQC PEVHPLPTPV 
    LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG QLGPTCLSSL LGQLSGQVRL 
    LLGALQSLLG TQLPPQGRTT AHKDPNAIFL SFQHLLRGKD FWIVGDKLHC LSQNYWLWAS 
    EVAAGIQSQD SWSAEPNLQV PGPNPRIPEQ DTRTLEWNSW TLSWTLTQDP RSPGHFLRNI 
    RHRLPATQPP AWIFSFPNPS SYWTVYALPS STHLAHPCGP APPPAS

Genular Protein ID: 860215158

Symbol: Q5FBX8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 319
  • Mass: 35082
  • Checksum: 99274DA16BC8B531
  • Sequence:
  • MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS HVLHSRLSQC PEVHPLPTPV 
    LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG QLGPTCLSSL LGQLSGQVRL 
    LLGALQSLLG TQDHSSQGSQ CHLPELPTPA PRKGAFPDAC RRVHPLRQAG PTHHSCPQQN 
    LSSPHTERAP KQDFWIVGDK LHCLSQNYWL WASEVAAGIQ SQDSWSAEPN LQVPGPNPRI 
    PEQDTRTLEW NSWTLSWTLT QDPRSPGHFL RNIRHRLPAT QPPAWIFSFP NPSSYWTVYA 
    LPSSTHLAHP CGPAPPPAS

Genular Protein ID: 3092648513

Symbol: A0A3B3ITS0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 493
  • Mass: 53239
  • Checksum: FF36F2ADBEF724DA
  • Sequence:
  • MDPPIQIFSV VCVGGGVDPG PGRGSREEKA SLPGAFTSVW WLPSLIGQKW PRQAYDLLLW 
    RGCAPPPHVF LPICSPEGCL LCTWVLEPFS TRIDSSPLAR LCPTLLCPEV QEPKPPPWPQ 
    EGFRGEAPNR EPRQPDTPAR MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS 
    HVLHSRLSQC PEVHPLPTPV LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG 
    QLGPTCLSSL LGQLSGQVRL LLGALQSLLG TQLPPQGRTT AHKDPNAIFL SFQHLLRGKV 
    RFLMLVGGST LCVRRAPPTT AVPSRTSLVL TLNELPNRTS GLLETNFTAS ARTTGSGLLK 
    WQQGFRAKIP GLLNQTSRSL DQIPGYLNRI HELLNGTRGL FPGPSRRTLG APDISSGTSD 
    TGSLPPNLQP GYSPSPTHPP TGQYTLFPLP PTLPTPVVQL HPLLPDPSAP TPTPTSPLLN 
    TSYTHSQNLS QEG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.