Details for: THPO

Gene ID: 7066

Symbol: THPO

Ensembl ID: ENSG00000090534

Description: thrombopoietin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.2156
    Cell Significance Index: 37.2700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.2762
    Cell Significance Index: 16.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5429
    Cell Significance Index: 13.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2938
    Cell Significance Index: 58.3100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2597
    Cell Significance Index: 4.1200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1914
    Cell Significance Index: 3.0700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1668
    Cell Significance Index: 2.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1466
    Cell Significance Index: 3.2100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0774
    Cell Significance Index: 0.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0678
    Cell Significance Index: 13.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0623
    Cell Significance Index: 0.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0187
    Cell Significance Index: 6.7300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0166
    Cell Significance Index: 0.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0146
    Cell Significance Index: 0.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0126
    Cell Significance Index: 1.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0125
    Cell Significance Index: 1.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0110
    Cell Significance Index: 1.5100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0061
    Cell Significance Index: 0.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0006
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0013
    Cell Significance Index: -1.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0019
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0028
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0029
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0030
    Cell Significance Index: -0.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0031
    Cell Significance Index: -1.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0031
    Cell Significance Index: -1.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0040
    Cell Significance Index: -1.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0057
    Cell Significance Index: -1.6400
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0058
    Cell Significance Index: -0.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0085
    Cell Significance Index: -1.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0094
    Cell Significance Index: -1.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0104
    Cell Significance Index: -0.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0105
    Cell Significance Index: -0.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0114
    Cell Significance Index: -0.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0118
    Cell Significance Index: -1.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0137
    Cell Significance Index: -0.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0144
    Cell Significance Index: -1.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0146
    Cell Significance Index: -1.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0154
    Cell Significance Index: -0.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0176
    Cell Significance Index: -1.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0208
    Cell Significance Index: -0.5300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0216
    Cell Significance Index: -0.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0223
    Cell Significance Index: -0.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0227
    Cell Significance Index: -1.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0240
    Cell Significance Index: -1.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0240
    Cell Significance Index: -1.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0243
    Cell Significance Index: -0.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0255
    Cell Significance Index: -2.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0263
    Cell Significance Index: -0.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0265
    Cell Significance Index: -1.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0301
    Cell Significance Index: -1.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0312
    Cell Significance Index: -1.7500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0313
    Cell Significance Index: -0.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0364
    Cell Significance Index: -0.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0366
    Cell Significance Index: -0.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0367
    Cell Significance Index: -1.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0367
    Cell Significance Index: -1.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0369
    Cell Significance Index: -1.8700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0370
    Cell Significance Index: -0.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0374
    Cell Significance Index: -0.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0410
    Cell Significance Index: -1.4400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0412
    Cell Significance Index: -0.4300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0436
    Cell Significance Index: -0.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0444
    Cell Significance Index: -0.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0445
    Cell Significance Index: -1.9700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0450
    Cell Significance Index: -0.8800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0472
    Cell Significance Index: -0.6100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0508
    Cell Significance Index: -0.4900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0509
    Cell Significance Index: -1.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0512
    Cell Significance Index: -1.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0515
    Cell Significance Index: -1.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0527
    Cell Significance Index: -1.5100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0531
    Cell Significance Index: -1.0800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0532
    Cell Significance Index: -0.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0545
    Cell Significance Index: -1.3600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0547
    Cell Significance Index: -0.5200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0550
    Cell Significance Index: -0.7200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0574
    Cell Significance Index: -1.4000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0575
    Cell Significance Index: -0.7000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0578
    Cell Significance Index: -0.7700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0582
    Cell Significance Index: -1.8400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0583
    Cell Significance Index: -0.9600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0584
    Cell Significance Index: -1.4000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0599
    Cell Significance Index: -1.2500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0625
    Cell Significance Index: -1.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0628
    Cell Significance Index: -1.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0633
    Cell Significance Index: -1.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0635
    Cell Significance Index: -1.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0666
    Cell Significance Index: -1.7500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0677
    Cell Significance Index: -1.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0681
    Cell Significance Index: -1.3300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0682
    Cell Significance Index: -0.6600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0694
    Cell Significance Index: -2.8400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0701
    Cell Significance Index: -1.7900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0707
    Cell Significance Index: -0.6700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0709
    Cell Significance Index: -1.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** THPO is a glycoprotein hormone that belongs to the transforming growth factor-beta (TGF-β) superfamily. It is primarily produced by the liver and kidney and is involved in the regulation of megakaryocyte development and platelet production. THPO binds to its receptor, c-Mpl, which is expressed on the surface of megakaryocytes and platelets, triggering a signaling cascade that regulates cell proliferation, differentiation, and survival. THPO has also been shown to have anti-inflammatory and anti-angiogenic properties, making it a potential therapeutic target for various diseases. **Pathways and Functions:** The THPO signaling pathway involves the binding of THPO to its receptor, c-Mpl, which triggers a series of downstream signaling events that regulate megakaryocyte development and platelet production. The pathway involves the activation of the MAPK cascade, which regulates cell proliferation and differentiation, as well as the PI3K/Akt pathway, which regulates cell survival and anti-apoptotic signaling. THPO has also been implicated in other cellular processes, including cell proliferation, differentiation, and signaling pathways, such as the ERK1/2 cascade and the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway. **Clinical Significance:** THPO has been implicated in various diseases, including thrombocytopenia, a condition characterized by low platelet counts, as well as other hematological disorders, such as leukemia and lymphoma. THPO has also been shown to have anti-inflammatory and anti-angiogenic properties, making it a potential therapeutic target for various diseases, including cancer and cardiovascular disease. Additionally, THPO has been used as a biomarker for the diagnosis and monitoring of hematological disorders, such as thrombocytopenia and leukemia. **Significantly Expressed Cells:** THPO is expressed in various cell types, including kidney proximal convoluted tubule epithelial cells, goblet cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, intestinal crypt stem cells of colon, transit amplifying cells, abnormal cells, neoplastic cells, and mast cells. The expression of THPO in these cell types suggests that it plays a broader role in regulating cellular processes beyond hematopoiesis. **Proteins:** THPO has been associated with several proteins, including TPO_HUMAN (Thrombopoietin), F8W6L1_HUMAN (unknown), Q5FBX8_HUMAN (unknown), and A0A3B3ITS0_HUMAN (unknown). These proteins are involved in various cellular processes, including cell signaling and regulation of cellular processes. In conclusion, THPO is a critical regulator of hematopoiesis, particularly in the development and maturation of megakaryocytes, and has been implicated in various other cellular processes, including cell proliferation, differentiation, and signaling pathways. Its clinical significance extends beyond hematological disorders, making it a potential therapeutic target for various diseases, including cancer and cardiovascular disease.

Genular Protein ID: 1386966978

Symbol: TPO_HUMAN

Name: Thrombopoietin

UniProtKB Accession Codes:

P40225 A1L3Y0 B7ZLR8 B9EGA8 Q13020 Q15790 Q15791 Q15792

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 14 EMDB 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 7 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 10 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8202154

Title: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.

PubMed ID: 8202154

DOI: 10.1038/369533a0

PubMed ID: 8020099

Title: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl.

PubMed ID: 8020099

DOI: 10.1016/0092-8674(94)90450-2

PubMed ID: 7809166

Title: Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization.

PubMed ID: 7809166

DOI: 10.1073/pnas.91.26.13023

PubMed ID: 7926023

Title: Molecular cloning and chromosomal localization of the human thrombopoietin gene.

PubMed ID: 7926023

DOI: 10.1016/0014-5793(94)01008-0

PubMed ID: 7849319

Title: Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin.

PubMed ID: 7849319

PubMed ID: 8537317

Title: Purification and characterization of thrombopoietin.

PubMed ID: 8537317

DOI: 10.1093/oxfordjournals.jbchem.a124883

PubMed ID: 7822271

Title: Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene.

PubMed ID: 7822271

DOI: 10.1074/jbc.270.2.511

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9425899

Title: An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia.

PubMed ID: 9425899

DOI: 10.1038/ng0198-49

PubMed ID: 8942648

Title: Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246.

PubMed ID: 8942648

DOI: 10.1021/bi961075b

PubMed ID: 24085763

Title: Exome sequencing reveals a thrombopoietin ligand mutation in a Micronesian family with autosomal recessive aplastic anemia.

PubMed ID: 24085763

DOI: 10.1182/blood-2012-12-473538

PubMed ID: 28466964

Title: A new form of inherited thrombocytopenia due to monoallelic loss of function mutation in the thrombopoietin gene.

PubMed ID: 28466964

DOI: 10.1111/bjh.14694

PubMed ID: 29191945

Title: Thrombopoietin mutation in congenital amegakaryocytic thrombocytopenia treatable with romiplostim.

PubMed ID: 29191945

DOI: 10.15252/emmm.201708168

PubMed ID: 36226497

Title: Defective binding of ETS1 and STAT4 due to a mutation in the promoter region of THPO as a novel mechanism of congenital amegakaryocytic thrombocytopenia.

PubMed ID: 36226497

DOI: 10.3324/haematol.2022.281392

PubMed ID: 14769915

Title: Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment.

PubMed ID: 14769915

DOI: 10.1073/pnas.0308530100

PubMed ID: 28559357

Title: Bone marrow failure unresponsive to bone marrow transplant is caused by mutations in thrombopoietin.

PubMed ID: 28559357

DOI: 10.1182/blood-2017-02-768036

PubMed ID: 32150607

Title: Monoallelic loss-of-function THPO variants cause heritable thrombocytopenia.

PubMed ID: 32150607

DOI: 10.1182/bloodadvances.2019001293

Sequence Information:

  • Length: 353
  • Mass: 37823
  • Checksum: F0AB5449B72E5526
  • Sequence:
    • MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS HVLHSRLSQC PEVHPLPTPV 
LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG QLGPTCLSSL LGQLSGQVRL 
LLGALQSLLG TQLPPQGRTT AHKDPNAIFL SFQHLLRGKV RFLMLVGGST LCVRRAPPTT 
AVPSRTSLVL TLNELPNRTS GLLETNFTAS ARTTGSGLLK WQQGFRAKIP GLLNQTSRSL 
DQIPGYLNRI HELLNGTRGL FPGPSRRTLG APDISSGTSD TGSLPPNLQP GYSPSPTHPP 
TGQYTLFPLP PTLPTPVVQL HPLLPDPSAP TPTPTSPLLN TSYTHSQNLS QEG

Genular Protein ID: 3092648513

Symbol: A0A3B3ITS0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A3B3ITS0

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 493
  • Mass: 53239
  • Checksum: FF36F2ADBEF724DA
  • Sequence:
    • MDPPIQIFSV VCVGGGVDPG PGRGSREEKA SLPGAFTSVW WLPSLIGQKW PRQAYDLLLW 
RGCAPPPHVF LPICSPEGCL LCTWVLEPFS TRIDSSPLAR LCPTLLCPEV QEPKPPPWPQ 
EGFRGEAPNR EPRQPDTPAR MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS 
HVLHSRLSQC PEVHPLPTPV LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG 
QLGPTCLSSL LGQLSGQVRL LLGALQSLLG TQLPPQGRTT AHKDPNAIFL SFQHLLRGKV 
RFLMLVGGST LCVRRAPPTT AVPSRTSLVL TLNELPNRTS GLLETNFTAS ARTTGSGLLK 
WQQGFRAKIP GLLNQTSRSL DQIPGYLNRI HELLNGTRGL FPGPSRRTLG APDISSGTSD 
TGSLPPNLQP GYSPSPTHPP TGQYTLFPLP PTLPTPVVQL HPLLPDPSAP TPTPTSPLLN 
TSYTHSQNLS QEG

Genular Protein ID: 3190313244

Symbol: F8W6L1_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W6L1

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 2 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 286
  • Mass: 31544
  • Checksum: 477EAC4BE75442F6
  • Sequence:
    • MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS HVLHSRLSQC PEVHPLPTPV 
LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG QLGPTCLSSL LGQLSGQVRL 
LLGALQSLLG TQLPPQGRTT AHKDPNAIFL SFQHLLRGKD FWIVGDKLHC LSQNYWLWAS 
EVAAGIQSQD SWSAEPNLQV PGPNPRIPEQ DTRTLEWNSW TLSWTLTQDP RSPGHFLRNI 
RHRLPATQPP AWIFSFPNPS SYWTVYALPS STHLAHPCGP APPPAS

Genular Protein ID: 860215158

Symbol: Q5FBX8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5FBX8

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 PharmGKB 1 Proteomes 2 RefSeq 2 SAM 2 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 319
  • Mass: 35082
  • Checksum: 99274DA16BC8B531
  • Sequence:
    • MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS HVLHSRLSQC PEVHPLPTPV 
LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG QLGPTCLSSL LGQLSGQVRL 
LLGALQSLLG TQDHSSQGSQ CHLPELPTPA PRKGAFPDAC RRVHPLRQAG PTHHSCPQQN 
LSSPHTERAP KQDFWIVGDK LHCLSQNYWL WASEVAAGIQ SQDSWSAEPN LQVPGPNPRI 
PEQDTRTLEW NSWTLSWTLT QDPRSPGHFL RNIRHRLPAT QPPAWIFSFP NPSSYWTVYA 
LPSSTHLAHP CGPAPPPAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.