Details for: TIMP2

Gene ID: 7077

Symbol: TIMP2

Ensembl ID: ENSG00000035862

Description: TIMP metallopeptidase inhibitor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.27
    Marker Score: 111330
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.77
    Marker Score: 3603
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.75
    Marker Score: 3774
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.54
    Marker Score: 6651
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.53
    Marker Score: 2153
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.52
    Marker Score: 2690
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.44
    Marker Score: 1017
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.36
    Marker Score: 26636
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.36
    Marker Score: 14025
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.32
    Marker Score: 59401
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.24
    Marker Score: 2568
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.24
    Marker Score: 516
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.19
    Marker Score: 9457
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.19
    Marker Score: 941
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.17
    Marker Score: 562
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.09
    Marker Score: 21046.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.06
    Marker Score: 1476
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.03
    Marker Score: 2500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.02
    Marker Score: 13126
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.99
    Marker Score: 1098
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.99
    Marker Score: 1923
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.95
    Marker Score: 439
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.92
    Marker Score: 1831
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.91
    Marker Score: 38048
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.91
    Marker Score: 1254
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.9
    Marker Score: 1354
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.9
    Marker Score: 1081
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.89
    Marker Score: 14521
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.89
    Marker Score: 1288
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.87
    Marker Score: 2248
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.86
    Marker Score: 2622.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.86
    Marker Score: 1858
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.85
    Marker Score: 7151
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.83
    Marker Score: 1037
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.83
    Marker Score: 69502
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.83
    Marker Score: 102080
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.79
    Marker Score: 66186
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.79
    Marker Score: 8293
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.79
    Marker Score: 446
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.78
    Marker Score: 446
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.77
    Marker Score: 4233
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.74
    Marker Score: 634
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.73
    Marker Score: 653
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.72
    Marker Score: 718
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 1.71
    Marker Score: 554
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.71
    Marker Score: 1816
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.7
    Marker Score: 3196
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.69
    Marker Score: 3366
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.68
    Marker Score: 1058
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.67
    Marker Score: 1101
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.66
    Marker Score: 10065
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.65
    Marker Score: 1715
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.64
    Marker Score: 465
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.62
    Marker Score: 3119
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.6
    Marker Score: 1797
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.58
    Marker Score: 3473
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.58
    Marker Score: 389
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.53
    Marker Score: 3116
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.53
    Marker Score: 763
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.52
    Marker Score: 1748
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.5
    Marker Score: 2307
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.48
    Marker Score: 11132
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.46
    Marker Score: 5964
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.46
    Marker Score: 911
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.45
    Marker Score: 1703
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166627
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.43
    Marker Score: 3569.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.42
    Marker Score: 707
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.42
    Marker Score: 1525
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.41
    Marker Score: 14517
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.39
    Marker Score: 5153
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.39
    Marker Score: 5761
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.38
    Marker Score: 322
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.37
    Marker Score: 798
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.37
    Marker Score: 440
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.37
    Marker Score: 299
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.36
    Marker Score: 552
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.36
    Marker Score: 346
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.35
    Marker Score: 3683
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.35
    Marker Score: 3168
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.33
    Marker Score: 656
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.31
    Marker Score: 5496
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.25
    Marker Score: 2432
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.24
    Marker Score: 823
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.23
    Marker Score: 396
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.23
    Marker Score: 2833
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.23
    Marker Score: 2240
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.21
    Marker Score: 291
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.2
    Marker Score: 700
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.19
    Marker Score: 1328
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.17
    Marker Score: 15485
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.17
    Marker Score: 2824
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.15
    Marker Score: 1034
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.15
    Marker Score: 2897
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.15
    Marker Score: 385
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.14
    Marker Score: 70311
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 1.12
    Marker Score: 334
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.11
    Marker Score: 1046
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.11
    Marker Score: 10400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17241

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics** TIMP2 is a 330-amino acid protein that belongs to the TIMP family, which consists of four members: TIMP1, TIMP2, TIMP3, and TIMP4. TIMP2 is characterized by its ability to inhibit the activity of MMPs, which are a family of proteases that degrade the ECM. The protein has a conserved cysteine-rich domain that forms a zinc-binding site, which is essential for its inhibitory activity. TIMP2 is also known for its ability to regulate the activity of other proteases, such as cathepsins and aspartic proteases. **Pathways and Functions** TIMP2 regulates the activity of MMPs through a complex interaction with the MMPs' catalytic site. This interaction involves the binding of TIMP2 to the MMPs' active site, which prevents the enzyme from accessing its substrate, thereby inhibiting its activity. TIMP2 also regulates the activity of other proteases, such as cathepsins and aspartic proteases, by binding to their active sites or inhibiting their activity through a competitive mechanism. In addition to its role as a protease inhibitor, TIMP2 also regulates the activity of other signaling pathways, including the TGF-β (transforming growth factor-beta) and the PDGF (platelet-derived growth factor) pathways. These pathways are involved in regulating cell growth, differentiation, and survival, and TIMP2's inhibition of MMP activity helps to regulate the activity of these pathways. **Clinical Significance** Dysregulation of TIMP2 has been implicated in various diseases, including cancer, fibrosis, and inflammatory diseases. In cancer, TIMP2's inhibition of MMP activity can promote tumor growth and metastasis, while its overexpression can inhibit tumor growth. In fibrosis, TIMP2's inhibition of MMP activity can lead to the accumulation of extracellular matrix, which can cause tissue damage and dysfunction. In inflammatory diseases, TIMP2's regulation of protease activity can influence the severity of inflammation and tissue damage. Furthermore, TIMP2 has been identified as a biomarker for various diseases, including cancer and cardiovascular disease. Elevated levels of TIMP2 in the blood or tissue have been associated with poor prognosis and increased risk of disease progression. In conclusion, TIMP2 is a critical regulator of the extracellular matrix and plays a significant role in maintaining tissue homeostasis and preventing excessive matrix degradation. Its dysregulation has been implicated in various diseases, and its clinical significance makes it an important target for therapeutic intervention.

Genular Protein ID: 2092127797

Symbol: TIMP2_HUMAN

Name: Metalloproteinase inhibitor 2

UniProtKB Accession Codes:

P16035 Q16121 Q93006 Q9UDF7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 4 PIR 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2380196

Title: Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.

PubMed ID: 2380196

DOI: 10.1016/s0021-9258(18)77438-3

PubMed ID: 2157214

Title: cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.

PubMed ID: 2157214

DOI: 10.1073/pnas.87.7.2800

PubMed ID: 8810321

Title: Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene.

PubMed ID: 8810321

DOI: 10.1074/jbc.271.41.25498

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2793861

Title: Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family.

PubMed ID: 2793861

DOI: 10.1016/s0021-9258(18)71503-2

PubMed ID: 1480041

Title: TIMP-2: identification and characterization of a new member of the metalloproteinase inhibitor family.

PubMed ID: 1480041

PubMed ID: 2554304

Title: Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.

PubMed ID: 2554304

DOI: 10.1073/pnas.86.21.8207

PubMed ID: 1730286

Title: Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid.

PubMed ID: 1730286

DOI: 10.1016/0014-5793(92)80393-u

PubMed ID: 8112602

Title: Characterization of the promoter of the gene encoding human tissue inhibitor of metalloproteinases-2 (TIMP-2).

PubMed ID: 8112602

DOI: 10.1016/0378-1119(94)90753-6

PubMed ID: 1655733

Title: Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site.

PubMed ID: 1655733

DOI: 10.1016/s0021-9258(18)55224-8

PubMed ID: 11710594

Title: Human cervical tumor cell (SiHa) surface alphavbeta3 integrin receptor has associated matrix metalloproteinase (MMP-2) activity.

PubMed ID: 11710594

DOI: 10.1007/s004320100271

PubMed ID: 7918391

Title: Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family.

PubMed ID: 7918391

DOI: 10.1021/bi00205a010

PubMed ID: 9705310

Title: High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3.

PubMed ID: 9705310

DOI: 10.1074/jbc.273.34.21736

PubMed ID: 9837731

Title: Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1-A resolution.

PubMed ID: 9837731

DOI: 10.1006/jmbi.1998.2223

PubMed ID: 12032297

Title: Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2.

PubMed ID: 12032297

DOI: 10.1073/pnas.102185399

PubMed ID: 24073280

Title: Matrix metalloproteinase-10/TIMP-2 structure and analyses define conserved core interactions and diverse exosite interactions in MMP/TIMP complexes.

PubMed ID: 24073280

DOI: 10.1371/journal.pone.0075836

Sequence Information:

  • Length: 220
  • Mass: 24399
  • Checksum: 603E5B1C9F94735D
  • Sequence:
    • MGAAARTLRL ALGLLLLATL LRPADACSCS PVHPQQAFCN ADVVIRAKAV SEKEVDSGND 
IYGNPIKRIQ YEIKQIKMFK GPEKDIEFIY TAPSSAVCGV SLDVGGKKEY LIAGKAEGDG 
KMHITLCDFI VPWDTLSTTQ KKSLNHRYQM GCECKITRCP MIPCYISSPD ECLWMDWVTE 
KNINGHQAKF FACIKRSDGS CAWYRGAAPP KQEFLDIEDP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.