Details for: TIMP2

Gene ID: 7077

Symbol: TIMP2

Ensembl ID: ENSG00000035862

Description: TIMP metallopeptidase inhibitor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 419.2993
    Cell Significance Index: -65.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 251.3371
    Cell Significance Index: -63.7500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 159.5955
    Cell Significance Index: -65.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 141.2898
    Cell Significance Index: -57.4000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 138.0997
    Cell Significance Index: -65.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 121.5723
    Cell Significance Index: -62.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 60.1680
    Cell Significance Index: -57.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.0777
    Cell Significance Index: -65.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.2529
    Cell Significance Index: -64.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.1222
    Cell Significance Index: -52.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.5685
    Cell Significance Index: -65.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.5971
    Cell Significance Index: 131.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.1710
    Cell Significance Index: 435.4600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.8187
    Cell Significance Index: 16.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.4076
    Cell Significance Index: 46.9900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.8637
    Cell Significance Index: 11.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5975
    Cell Significance Index: 573.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0557
    Cell Significance Index: 135.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8633
    Cell Significance Index: 22.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8083
    Cell Significance Index: 14.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7297
    Cell Significance Index: 44.8500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.7242
    Cell Significance Index: 9.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6164
    Cell Significance Index: 556.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6103
    Cell Significance Index: 422.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3724
    Cell Significance Index: 73.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3509
    Cell Significance Index: 191.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2589
    Cell Significance Index: 51.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2543
    Cell Significance Index: 25.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1569
    Cell Significance Index: 26.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1563
    Cell Significance Index: 25.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0902
    Cell Significance Index: 169.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0535
    Cell Significance Index: 1.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0336
    Cell Significance Index: 6.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0175
    Cell Significance Index: 7.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0142
    Cell Significance Index: 19.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0085
    Cell Significance Index: 3.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0003
    Cell Significance Index: 0.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0038
    Cell Significance Index: -5.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0239
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0403
    Cell Significance Index: -29.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0424
    Cell Significance Index: -26.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0506
    Cell Significance Index: -1.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0550
    Cell Significance Index: -34.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0589
    Cell Significance Index: -43.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0754
    Cell Significance Index: -42.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0763
    Cell Significance Index: -57.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0964
    Cell Significance Index: -11.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1021
    Cell Significance Index: -11.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1079
    Cell Significance Index: -11.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1459
    Cell Significance Index: -30.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1590
    Cell Significance Index: -28.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1877
    Cell Significance Index: -54.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2073
    Cell Significance Index: -24.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2078
    Cell Significance Index: -23.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2424
    Cell Significance Index: -18.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2443
    Cell Significance Index: -30.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2633
    Cell Significance Index: -11.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2802
    Cell Significance Index: -40.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3091
    Cell Significance Index: -19.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3560
    Cell Significance Index: -24.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3872
    Cell Significance Index: -21.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3890
    Cell Significance Index: -9.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4519
    Cell Significance Index: -58.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5150
    Cell Significance Index: -13.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5351
    Cell Significance Index: -24.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5389
    Cell Significance Index: -32.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5410
    Cell Significance Index: -56.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5483
    Cell Significance Index: -27.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5524
    Cell Significance Index: -65.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5704
    Cell Significance Index: -15.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6022
    Cell Significance Index: -17.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6541
    Cell Significance Index: -14.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6630
    Cell Significance Index: -31.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7173
    Cell Significance Index: -37.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7318
    Cell Significance Index: -54.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7396
    Cell Significance Index: -15.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7516
    Cell Significance Index: -59.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7686
    Cell Significance Index: -54.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9761
    Cell Significance Index: -65.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0468
    Cell Significance Index: -65.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0553
    Cell Significance Index: -54.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.0887
    Cell Significance Index: -56.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1016
    Cell Significance Index: -67.5400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.1412
    Cell Significance Index: -24.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1476
    Cell Significance Index: -39.8800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.2610
    Cell Significance Index: -26.9600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.3157
    Cell Significance Index: -28.8100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.3728
    Cell Significance Index: -27.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.4267
    Cell Significance Index: -28.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.4816
    Cell Significance Index: -65.5400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.5305
    Cell Significance Index: -12.4800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.5477
    Cell Significance Index: -22.2300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.5500
    Cell Significance Index: -13.0200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.6003
    Cell Significance Index: -56.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.6124
    Cell Significance Index: -59.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.6181
    Cell Significance Index: -45.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.7107
    Cell Significance Index: -56.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.7153
    Cell Significance Index: -24.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.7160
    Cell Significance Index: -54.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.7302
    Cell Significance Index: -65.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TIMP2 is a 330-amino acid protein that belongs to the TIMP family, which consists of four members: TIMP1, TIMP2, TIMP3, and TIMP4. TIMP2 is characterized by its ability to inhibit the activity of MMPs, which are a family of proteases that degrade the ECM. The protein has a conserved cysteine-rich domain that forms a zinc-binding site, which is essential for its inhibitory activity. TIMP2 is also known for its ability to regulate the activity of other proteases, such as cathepsins and aspartic proteases. **Pathways and Functions** TIMP2 regulates the activity of MMPs through a complex interaction with the MMPs' catalytic site. This interaction involves the binding of TIMP2 to the MMPs' active site, which prevents the enzyme from accessing its substrate, thereby inhibiting its activity. TIMP2 also regulates the activity of other proteases, such as cathepsins and aspartic proteases, by binding to their active sites or inhibiting their activity through a competitive mechanism. In addition to its role as a protease inhibitor, TIMP2 also regulates the activity of other signaling pathways, including the TGF-β (transforming growth factor-beta) and the PDGF (platelet-derived growth factor) pathways. These pathways are involved in regulating cell growth, differentiation, and survival, and TIMP2's inhibition of MMP activity helps to regulate the activity of these pathways. **Clinical Significance** Dysregulation of TIMP2 has been implicated in various diseases, including cancer, fibrosis, and inflammatory diseases. In cancer, TIMP2's inhibition of MMP activity can promote tumor growth and metastasis, while its overexpression can inhibit tumor growth. In fibrosis, TIMP2's inhibition of MMP activity can lead to the accumulation of extracellular matrix, which can cause tissue damage and dysfunction. In inflammatory diseases, TIMP2's regulation of protease activity can influence the severity of inflammation and tissue damage. Furthermore, TIMP2 has been identified as a biomarker for various diseases, including cancer and cardiovascular disease. Elevated levels of TIMP2 in the blood or tissue have been associated with poor prognosis and increased risk of disease progression. In conclusion, TIMP2 is a critical regulator of the extracellular matrix and plays a significant role in maintaining tissue homeostasis and preventing excessive matrix degradation. Its dysregulation has been implicated in various diseases, and its clinical significance makes it an important target for therapeutic intervention.

Genular Protein ID: 2092127797

Symbol: TIMP2_HUMAN

Name: Metalloproteinase inhibitor 2

UniProtKB Accession Codes:

P16035 Q16121 Q93006 Q9UDF7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2380196

Title: Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.

PubMed ID: 2380196

DOI: 10.1016/s0021-9258(18)77438-3

PubMed ID: 2157214

Title: cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.

PubMed ID: 2157214

DOI: 10.1073/pnas.87.7.2800

PubMed ID: 8810321

Title: Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene.

PubMed ID: 8810321

DOI: 10.1074/jbc.271.41.25498

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2793861

Title: Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family.

PubMed ID: 2793861

DOI: 10.1016/s0021-9258(18)71503-2

PubMed ID: 1480041

Title: TIMP-2: identification and characterization of a new member of the metalloproteinase inhibitor family.

PubMed ID: 1480041

PubMed ID: 2554304

Title: Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.

PubMed ID: 2554304

DOI: 10.1073/pnas.86.21.8207

PubMed ID: 1730286

Title: Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid.

PubMed ID: 1730286

DOI: 10.1016/0014-5793(92)80393-u

PubMed ID: 8112602

Title: Characterization of the promoter of the gene encoding human tissue inhibitor of metalloproteinases-2 (TIMP-2).

PubMed ID: 8112602

DOI: 10.1016/0378-1119(94)90753-6

PubMed ID: 1655733

Title: Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site.

PubMed ID: 1655733

DOI: 10.1016/s0021-9258(18)55224-8

PubMed ID: 11710594

Title: Human cervical tumor cell (SiHa) surface alphavbeta3 integrin receptor has associated matrix metalloproteinase (MMP-2) activity.

PubMed ID: 11710594

DOI: 10.1007/s004320100271

PubMed ID: 7918391

Title: Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family.

PubMed ID: 7918391

DOI: 10.1021/bi00205a010

PubMed ID: 9705310

Title: High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3.

PubMed ID: 9705310

DOI: 10.1074/jbc.273.34.21736

PubMed ID: 9837731

Title: Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1-A resolution.

PubMed ID: 9837731

DOI: 10.1006/jmbi.1998.2223

PubMed ID: 12032297

Title: Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2.

PubMed ID: 12032297

DOI: 10.1073/pnas.102185399

PubMed ID: 24073280

Title: Matrix metalloproteinase-10/TIMP-2 structure and analyses define conserved core interactions and diverse exosite interactions in MMP/TIMP complexes.

PubMed ID: 24073280

DOI: 10.1371/journal.pone.0075836

Sequence Information:

  • Length: 220
  • Mass: 24399
  • Checksum: 603E5B1C9F94735D
  • Sequence:
    • MGAAARTLRL ALGLLLLATL LRPADACSCS PVHPQQAFCN ADVVIRAKAV SEKEVDSGND 
IYGNPIKRIQ YEIKQIKMFK GPEKDIEFIY TAPSSAVCGV SLDVGGKKEY LIAGKAEGDG 
KMHITLCDFI VPWDTLSTTQ KKSLNHRYQM GCECKITRCP MIPCYISSPD ECLWMDWVTE 
KNINGHQAKF FACIKRSDGS CAWYRGAAPP KQEFLDIEDP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.