Details for: TLR2

Gene ID: 7097

Symbol: TLR2

Ensembl ID: ENSG00000137462

Description: toll like receptor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.01
    Marker Score: 112233
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.84
    Marker Score: 2104
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.67
    Marker Score: 3259.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1158
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168905
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.46
    Marker Score: 727
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.3
    Marker Score: 1301
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.28
    Marker Score: 3182
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.25
    Marker Score: 5176
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.16
    Marker Score: 2110
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.12
    Marker Score: 2696
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.06
    Marker Score: 1285
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251785
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48029
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.99
    Marker Score: 667
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.92
    Marker Score: 932
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5189
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.9
    Marker Score: 1439
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.87
    Marker Score: 5303
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.87
    Marker Score: 400
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.87
    Marker Score: 10057
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.86
    Marker Score: 961
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.84
    Marker Score: 5481
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 625
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.81
    Marker Score: 2095
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8
    Marker Score: 3369
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.75
    Marker Score: 1334
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.75
    Marker Score: 270
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1182
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.69
    Marker Score: 1562
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.62
    Marker Score: 434
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.6
    Marker Score: 279
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.59
    Marker Score: 244
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 373.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.55
    Marker Score: 354
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.54
    Marker Score: 990
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.54
    Marker Score: 329
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.54
    Marker Score: 2240
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.54
    Marker Score: 696
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.52
    Marker Score: 13344
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.51
    Marker Score: 175
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.47
    Marker Score: 134
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.45
    Marker Score: 7286
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.45
    Marker Score: 433
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.45
    Marker Score: 283
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.43
    Marker Score: 667
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.42
    Marker Score: 424
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.42
    Marker Score: 2185
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.41
    Marker Score: 103
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.39
    Marker Score: 122
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.38
    Marker Score: 198
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.37
    Marker Score: 211
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.36
    Marker Score: 128
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 237
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.36
    Marker Score: 244
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.35
    Marker Score: 203
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.35
    Marker Score: 334
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.34
    Marker Score: 157
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.34
    Marker Score: 99
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.33
    Marker Score: 191
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.32
    Marker Score: 223
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.32
    Marker Score: 178
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.31
    Marker Score: 213
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.31
    Marker Score: 403
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.31
    Marker Score: 81
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3
    Marker Score: 126
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3
    Marker Score: 163
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.29
    Marker Score: 344
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.29
    Marker Score: 718
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.29
    Marker Score: 941
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.29
    Marker Score: 144.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.29
    Marker Score: 257
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.28
    Marker Score: 279
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.28
    Marker Score: 124
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.27
    Marker Score: 85
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.27
    Marker Score: 74
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.26
    Marker Score: 82
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.26
    Marker Score: 80
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.26
    Marker Score: 311
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.25
    Marker Score: 126
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.25
    Marker Score: 123
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.25
    Marker Score: 438
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 148.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.24
    Marker Score: 511
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.24
    Marker Score: 83

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Other Information

**Key Characteristics** TLR2 is a type II transmembrane receptor, composed of an extracellular Toll/interleukin-1 receptor-like domain and an intracellular Toll/interleukin-1 receptor-like domain. It is expressed on various immune cells, including classical monocytes, macrophages, and microglia, as well as on epithelial cells and endothelial cells. TLR2 is unique in that it can recognize a wide range of ligands, including lipopeptides, peptidoglycan, and other microbial components. This broad recognition capacity allows TLR2 to respond to various pathogens and to play a key role in the defense against infections. **Pathways and Functions** The activation of TLR2 by its ligands triggers a signaling cascade that involves the recruitment of adaptor proteins, such as MyD88, and the activation of downstream kinases, including IRAK4 and IRAK1. This cascade ultimately leads to the activation of transcription factors, such as NF-κB and IRF3, which regulate the expression of pro-inflammatory genes. The production of pro-inflammatory cytokines, such as IL-6, IL-8, and TNF-α, is a key outcome of TLR2 activation, and plays a crucial role in the defense against infections. TLR2 also plays a role in the regulation of immune cell function, including the activation of neutrophils, macrophages, and dendritic cells, and the production of antimicrobial peptides and proteins. Additionally, TLR2 has been implicated in the regulation of immune responses in the central nervous system, where it plays a role in the development and activation of microglia. **Clinical Significance** Dysregulation of TLR2 has been implicated in a wide range of diseases, including autoimmune disorders, such as rheumatoid arthritis and lupus, and inflammatory diseases, such as asthma and Crohn's disease. TLR2 has also been implicated in the pathogenesis of infections, such as tuberculosis and Lyme disease, and has been used as a target for the development of therapeutic strategies to prevent and treat these diseases. Furthermore, TLR2 has been shown to play a role in the regulation of immune responses in the central nervous system, where it has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and multiple sclerosis. The use of TLR2 as a therapeutic target for the treatment of these diseases is an area of active research. In addition, TLR2 has been shown to play a role in the regulation of immune responses in the context of cancer, where it has been implicated in the promotion of tumor growth and metastasis. The use of TLR2 as a therapeutic target for the treatment of cancer is an area of active research. In conclusion, TLR2 is a critical component of the innate immune system, playing a key role in the recognition and response to pathogens. Its dysregulation has been implicated in a wide range of diseases, and its therapeutic targeting is an area of active research.

Genular Protein ID: 4107451121

Symbol: TLR2_HUMAN

Name: Toll/interleukin-1 receptor-like protein 4

UniProtKB Accession Codes:

O60603 B3Y612 D1CS45 D1CS48 D1CS49 O15454 Q8NI00

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ComplexPortal 3 DIP 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 14 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 75 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 7 PIRSF 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 11 RefSeq 14 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9596645

Title: Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans.

PubMed ID: 9596645

PubMed ID: 9435236

Title: A family of human receptors structurally related to Drosophila Toll.

PubMed ID: 9435236

DOI: 10.1073/pnas.95.2.588

PubMed ID: 9751057

Title: Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling.

PubMed ID: 9751057

DOI: 10.1038/26239

PubMed ID: 18810425

Title: Natural selection in the TLR-related genes in the course of primate evolution.

PubMed ID: 18810425

DOI: 10.1007/s00251-008-0332-0

PubMed ID: 19924287

Title: The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes.

PubMed ID: 19924287

DOI: 10.1371/journal.pone.0007803

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10426995

Title: Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors.

PubMed ID: 10426995

DOI: 10.1126/science.285.5428.732

PubMed ID: 10426996

Title: Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2.

PubMed ID: 10426996

DOI: 10.1126/science.285.5428.736

PubMed ID: 11441107

Title: Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.

PubMed ID: 11441107

DOI: 10.4049/jimmunol.167.2.987

PubMed ID: 12471095

Title: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.

PubMed ID: 12471095

DOI: 10.4049/jimmunol.169.12.6668

PubMed ID: 16880211

Title: Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.

PubMed ID: 16880211

DOI: 10.1074/jbc.m602794200

PubMed ID: 15173186

Title: Four N-linked glycosylation sites in human toll-like receptor 2 cooperate to direct efficient biosynthesis and secretion.

PubMed ID: 15173186

DOI: 10.1074/jbc.m403830200

PubMed ID: 15809303

Title: Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signals.

PubMed ID: 15809303

DOI: 10.1074/jbc.m411379200

PubMed ID: 16622205

Title: The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes.

PubMed ID: 16622205

DOI: 10.1128/iai.74.5.2686-2696.2006

PubMed ID: 17322885

Title: A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.

PubMed ID: 17322885

DOI: 10.1038/ng1976

PubMed ID: 19362712

Title: TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.

PubMed ID: 19362712

DOI: 10.1016/j.cellimm.2009.03.008

PubMed ID: 20800577

Title: Non-acylated Mycobacterium bovis glycoprotein MPB83 binds to TLR1/2 and stimulates production of matrix metalloproteinase 9.

PubMed ID: 20800577

DOI: 10.1016/j.bbrc.2010.08.085

PubMed ID: 21078852

Title: Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4(+) T cell activation via Toll-like receptors 1 and 2.

PubMed ID: 21078852

DOI: 10.1128/iai.00806-10

PubMed ID: 22665377

Title: Staphylococcal superantigen-like protein 3 binds to the Toll-like receptor 2 extracellular domain and inhibits cytokine production induced by Staphylococcus aureus, cell wall component, or lipopeptides in murine macrophages.

PubMed ID: 22665377

DOI: 10.1128/iai.00399-12

PubMed ID: 23376921

Title: TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3.

PubMed ID: 23376921

DOI: 10.1038/emboj.2013.8

PubMed ID: 25385819

Title: TRAM is required for TLR2 endosomal signaling to type I IFN induction.

PubMed ID: 25385819

DOI: 10.4049/jimmunol.1401605

PubMed ID: 27805901

Title: RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity.

PubMed ID: 27805901

DOI: 10.7554/elife.18496

PubMed ID: 34133077

Title: Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19.

PubMed ID: 34133077

DOI: 10.15252/emmm.202114150

PubMed ID: 11081518

Title: Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.

PubMed ID: 11081518

DOI: 10.1038/35040600

PubMed ID: 17889651

Title: Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide.

PubMed ID: 17889651

DOI: 10.1016/j.cell.2007.09.008

PubMed ID: 11476982

Title: Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients.

PubMed ID: 11476982

DOI: 10.1111/j.1574-695x.2001.tb01586.x

PubMed ID: 12646604

Title: A Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling.

PubMed ID: 12646604

DOI: 10.4049/jimmunol.170.7.3451

PubMed ID: 21618349

Title: Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family.

PubMed ID: 21618349

DOI: 10.1002/humu.21486

Sequence Information:

  • Length: 784
  • Mass: 89838
  • Checksum: 7DBE6B24CF1FAF8B
  • Sequence:
    • MPHTLWMVWV LGVIISLSKE ESSNQASLSC DRNGICKGSS GSLNSIPSGL TEAVKSLDLS 
NNRITYISNS DLQRCVNLQA LVLTSNGINT IEEDSFSSLG SLEHLDLSYN YLSNLSSSWF 
KPLSSLTFLN LLGNPYKTLG ETSLFSHLTK LQILRVGNMD TFTKIQRKDF AGLTFLEELE 
IDASDLQSYE PKSLKSIQNV SHLILHMKQH ILLLEIFVDV TSSVECLELR DTDLDTFHFS 
ELSTGETNSL IKKFTFRNVK ITDESLFQVM KLLNQISGLL ELEFDDCTLN GVGNFRASDN 
DRVIDPGKVE TLTIRRLHIP RFYLFYDLST LYSLTERVKR ITVENSKVFL VPCLLSQHLK 
SLEYLDLSEN LMVEEYLKNS ACEDAWPSLQ TLILRQNHLA SLEKTGETLL TLKNLTNIDI 
SKNSFHSMPE TCQWPEKMKY LNLSSTRIHS VTGCIPKTLE ILDVSNNNLN LFSLNLPQLK 
ELYISRNKLM TLPDASLLPM LLVLKISRNA ITTFSKEQLD SFHTLKTLEA GGNNFICSCE 
FLSFTQEQQA LAKVLIDWPA NYLCDSPSHV RGQQVQDVRL SVSECHRTAL VSGMCCALFL 
LILLTGVLCH RFHGLWYMKM MWAWLQAKRK PRKAPSRNIC YDAFVSYSER DAYWVENLMV 
QELENFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTV FVLSENFVKS EWCKYELDFS 
HFRLFDENND AAILILLEPI EKKAIPQRFC KLRKIMNTKT YLEWPMDEAQ REGFWVNLRA 
AIKS

Genular Protein ID: 1994509236

Symbol: B3KWR9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KWR9

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PRINTS 2 PROSITE 3 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 7 RuleBase 1 SMART 4 SUPFAM 3

Sequence Information:

  • Length: 784
  • Mass: 89826
  • Checksum: 10CBBD878AE70CBB
  • Sequence:
    • MPHTLWMVWV LGVIISLSKE ESSNQASLSC DRNGICKGSS GSLNSTPSGL TEAVKSLDLS 
NNRITYISNS DLQRCVNLQA LVLTSNGINT IEEDSFSSLG SLEHLDLSYN YLSNLSSSWF 
KPLSSLTFLN LLGNPYKTLG ETSLFSHLTK LQILRVGNMD TFTKIQRKDF AGLTFLEELE 
IDASDLQSYE PKSLKSIQNV SHLILHMKQH ILLLEIFVDV TSSVECLELR DTDLDTFHFS 
ELSTGETNSL IKKFTFRNVK ITDESLFQVM KLLNQISGLL ELEFDDCTLN GVGNFRASDN 
DRVIDPGKVE TLTIRRLHIP RFYLFYDLST LYSLTERVKR ITVENSKVFL VPCLLSQHLK 
SLEYLDLSEN LMVEEYLKNS ACEDAWPSLQ TLILRQNHLA SLEKTGETLL TLKNLTNIDI 
SKNSFHSMPE TCQWPEKMKY LNLSSTRIHS VTGCIPKTLE ILDVSNNNLN LFSLNLPQLK 
ELYISRNKLM TLPDASLLPM LLVLKISRNA ITTFSKEQLD SFHTLKTLEA GGNNFICSCE 
FLSFTQEQQA LAKVLIDWPA NYLCDSPSHV RGQQVQDVRL SVSECHRTAL VSGMCCALFL 
LILLTGVLCH RFHGLWYMKM MWAWLQAKRK PRKAPSRNIC YDAFVSYSER DAYWVENLMV 
QELENFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTV FVLSENFVKS EWCKYELDFS 
HFRLFDENND AAILILLEPI EKKAIPQRFC KLRKIMNTKT YLEWPMDEAQ REGFWVNLRA 
AIKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.