TLR2 | ENSG00000137462 | NCBI 7097

Details for: TLR2

Gene ID: 7097

Symbol: TLR2

Ensembl ID: ENSG00000137462

Description: toll like receptor 2

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Antimicrobial peptides
(R-HSA-6803157)
Bacterial infection pathways
(R-HSA-9824439)
Beta defensins
(R-HSA-1461957)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Defensins
(R-HSA-1461973)
Disease
(R-HSA-1643685)
Diseases associated with the tlr signaling cascade
(R-HSA-5602358)
Diseases of immune system
(R-HSA-5260271)
Er-phagosome pathway
(R-HSA-1236974)
Immune system
(R-HSA-168256)
Infection with mycobacterium tuberculosis
(R-HSA-9635486)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Irak4 deficiency (tlr2/4)
(R-HSA-5603041)
Modulation by mtb of host immune system
(R-HSA-9637628)
Myd88 deficiency (tlr2/4)
(R-HSA-5602498)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Neutrophil degranulation
(R-HSA-6798695)
Regulation of tlr by endogenous ligand
(R-HSA-5686938)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rsv-host interactions
(R-HSA-9833110)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Viral infection pathways
(R-HSA-9824446)
Amyloid-beta binding
(GO:0001540)
Apoptotic process
(GO:0006915)
Cellular response to bacterial lipopeptide
(GO:0071221)
Cellular response to lipoteichoic acid
(GO:0071223)
Central nervous system myelin formation
(GO:0032289)
Defense response to gram-positive bacterium
(GO:0050830)
Defense response to virus
(GO:0051607)
Detection of diacyl bacterial lipopeptide
(GO:0042496)
Detection of triacyl bacterial lipopeptide
(GO:0042495)
I-kappab phosphorylation
(GO:0007252)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Learning
(GO:0007612)
Leukotriene metabolic process
(GO:0006691)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Lipopolysaccharide binding
(GO:0001530)
Lipopolysaccharide immune receptor activity
(GO:0001875)
Microglia development
(GO:0014005)
Microglial cell activation
(GO:0001774)
Nad+ nucleotidase, cyclic adp-ribose generating
(GO:0061809)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of phagocytosis
(GO:0050765)
Negative regulation of synapse assembly
(GO:0051964)
Nitric oxide metabolic process
(GO:0046209)
Pattern recognition receptor activity
(GO:0038187)
Peptidoglycan binding
(GO:0042834)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of interleukin-18 production
(GO:0032741)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of nitric-oxide synthase biosynthetic process
(GO:0051770)
Positive regulation of oligodendrocyte differentiation
(GO:0048714)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of wnt signaling pathway
(GO:0030177)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Response to fatty acid
(GO:0070542)
Response to hypoxia
(GO:0001666)
Response to insulin
(GO:0032868)
Response to progesterone
(GO:0032570)
Response to toxic substance
(GO:0009636)
Signaling receptor activity
(GO:0038023)
Signal transduction
(GO:0007165)
Toll-like receptor 2 signaling pathway
(GO:0034134)
Toll-like receptor binding
(GO:0035325)
Toll-like receptor signaling pathway
(GO:0002224)
Toll-like receptor tlr6:tlr2 signaling pathway
(GO:0038124)
Transmembrane signaling receptor activity
(GO:0004888)
Triacyl lipopeptide binding
(GO:0042497)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 77.6623
Cell Significance Index: -12.0800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 47.8230
Cell Significance Index: -12.1300
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 35.9512
Cell Significance Index: -14.8100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 27.3718
Cell Significance Index: -11.1200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 24.7674
Cell Significance Index: -12.7400
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 11.6262
Cell Significance Index: -11.1000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 9.7895
Cell Significance Index: -12.0700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 4.9337
Cell Significance Index: 158.0200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.0892
Cell Significance Index: -12.1900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.8919
Cell Significance Index: 53.4500
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.2378
Cell Significance Index: 19.1500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7317
Cell Significance Index: 139.2500
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.6475
Cell Significance Index: 5.2800
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.5650
Cell Significance Index: 7.9300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5349
Cell Significance Index: 25.1400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.4510
Cell Significance Index: 12.0700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4222
Cell Significance Index: 83.7800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3750
Cell Significance Index: 37.1000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3186
Cell Significance Index: 287.6800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2595
Cell Significance Index: 15.5800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2272
Cell Significance Index: 24.7200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1972
Cell Significance Index: 32.0700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1369
Cell Significance Index: 4.8100
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.1254
Cell Significance Index: 1.8900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0700
Cell Significance Index: 4.8400
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0566
Cell Significance Index: 7.3100
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0312
Cell Significance Index: 3.1900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0276
Cell Significance Index: 20.9200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0156
Cell Significance Index: 0.4500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0128
Cell Significance Index: 0.3200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0071
Cell Significance Index: 10.9600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0058
Cell Significance Index: 0.6800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0036
Cell Significance Index: 1.5700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0019
Cell Significance Index: 0.0900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0003
Cell Significance Index: 0.0600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0045
Cell Significance Index: -8.5100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0055
Cell Significance Index: -3.4800
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0070
Cell Significance Index: -3.8100
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0075
Cell Significance Index: -13.8700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0120
Cell Significance Index: -8.8300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0128
Cell Significance Index: -17.3900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0204
Cell Significance Index: -12.7600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0208
Cell Significance Index: -15.4100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0212
Cell Significance Index: -0.4600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0220
Cell Significance Index: -7.8900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0229
Cell Significance Index: -10.3800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0240
Cell Significance Index: -1.0900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0273
Cell Significance Index: -15.4000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0292
Cell Significance Index: -4.2400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0354
Cell Significance Index: -10.2000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0378
Cell Significance Index: -4.6500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0503
Cell Significance Index: -10.1000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0742
Cell Significance Index: -15.6300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0744
Cell Significance Index: -12.7100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0835
Cell Significance Index: -11.4700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0907
Cell Significance Index: -10.7000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0969
Cell Significance Index: -2.0100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1010
Cell Significance Index: -6.5200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1075
Cell Significance Index: -12.3200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1132
Cell Significance Index: -8.4400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1161
Cell Significance Index: -12.0900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1164
Cell Significance Index: -7.1400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1229
Cell Significance Index: -9.4300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1339
Cell Significance Index: -9.4700
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.1361
Cell Significance Index: -1.1500
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1398
Cell Significance Index: -6.0800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1403
Cell Significance Index: -3.9200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1464
Cell Significance Index: -3.1200
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1495
Cell Significance Index: -19.1700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1519
Cell Significance Index: -12.0300
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.1520
Cell Significance Index: -2.0200
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.1574
Cell Significance Index: -1.2800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1663
Cell Significance Index: -10.2200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1746
Cell Significance Index: -8.8200
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1814
Cell Significance Index: -9.4500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1883
Cell Significance Index: -12.6600
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.1887
Cell Significance Index: -2.7600
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1892
Cell Significance Index: -3.7000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1902
Cell Significance Index: -9.8800
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.1908
Cell Significance Index: -2.3600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2120
Cell Significance Index: -5.7700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2151
Cell Significance Index: -12.0700
Cell Name: leukocyte (CL0000738)
Fold Change: -0.2638
Cell Significance Index: -4.4800
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: -0.2660
Cell Significance Index: -3.2000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2898
Cell Significance Index: -7.4500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2922
Cell Significance Index: -15.3400
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.2980
Cell Significance Index: -4.9100
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2995
Cell Significance Index: -7.2600
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.3093
Cell Significance Index: -4.4900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3130
Cell Significance Index: -11.4900
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3197
Cell Significance Index: -11.2000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3271
Cell Significance Index: -14.4700
Cell Name: macrophage (CL0000235)
Fold Change: -0.3477
Cell Significance Index: -3.5500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3488
Cell Significance Index: -12.1200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3532
Cell Significance Index: -9.4300
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.3731
Cell Significance Index: -5.2300
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.3759
Cell Significance Index: -3.5000
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3801
Cell Significance Index: -12.4500
Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.3868
Cell Significance Index: -3.5400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3869
Cell Significance Index: -14.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** TLR2 is a type II transmembrane receptor, composed of an extracellular Toll/interleukin-1 receptor-like domain and an intracellular Toll/interleukin-1 receptor-like domain. It is expressed on various immune cells, including classical monocytes, macrophages, and microglia, as well as on epithelial cells and endothelial cells. TLR2 is unique in that it can recognize a wide range of ligands, including lipopeptides, peptidoglycan, and other microbial components. This broad recognition capacity allows TLR2 to respond to various pathogens and to play a key role in the defense against infections. **Pathways and Functions** The activation of TLR2 by its ligands triggers a signaling cascade that involves the recruitment of adaptor proteins, such as MyD88, and the activation of downstream kinases, including IRAK4 and IRAK1. This cascade ultimately leads to the activation of transcription factors, such as NF-κB and IRF3, which regulate the expression of pro-inflammatory genes. The production of pro-inflammatory cytokines, such as IL-6, IL-8, and TNF-α, is a key outcome of TLR2 activation, and plays a crucial role in the defense against infections. TLR2 also plays a role in the regulation of immune cell function, including the activation of neutrophils, macrophages, and dendritic cells, and the production of antimicrobial peptides and proteins. Additionally, TLR2 has been implicated in the regulation of immune responses in the central nervous system, where it plays a role in the development and activation of microglia. **Clinical Significance** Dysregulation of TLR2 has been implicated in a wide range of diseases, including autoimmune disorders, such as rheumatoid arthritis and lupus, and inflammatory diseases, such as asthma and Crohn's disease. TLR2 has also been implicated in the pathogenesis of infections, such as tuberculosis and Lyme disease, and has been used as a target for the development of therapeutic strategies to prevent and treat these diseases. Furthermore, TLR2 has been shown to play a role in the regulation of immune responses in the central nervous system, where it has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and multiple sclerosis. The use of TLR2 as a therapeutic target for the treatment of these diseases is an area of active research. In addition, TLR2 has been shown to play a role in the regulation of immune responses in the context of cancer, where it has been implicated in the promotion of tumor growth and metastasis. The use of TLR2 as a therapeutic target for the treatment of cancer is an area of active research. In conclusion, TLR2 is a critical component of the innate immune system, playing a key role in the recognition and response to pathogens. Its dysregulation has been implicated in a wide range of diseases, and its therapeutic targeting is an area of active research.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Toll/interleukin-1 receptor-like protein 4
B3KWR9_HUMAN

Genular Protein ID: 4107451121

Symbol: TLR2_HUMAN

Name: Toll/interleukin-1 receptor-like protein 4

UniProtKB Accession Codes:

O60603 B3Y612 D1CS45 D1CS48 D1CS49 O15454 Q8NI00

Database IDs:

Citations:

PubMed ID: 9596645

Title: Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans.

PubMed ID: 9596645

PubMed ID: 9435236

Title: A family of human receptors structurally related to Drosophila Toll.

PubMed ID: 9435236

DOI: 10.1073/pnas.95.2.588

PubMed ID: 9751057

Title: Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling.

PubMed ID: 9751057

DOI: 10.1038/26239

PubMed ID: 18810425

Title: Natural selection in the TLR-related genes in the course of primate evolution.

PubMed ID: 18810425

DOI: 10.1007/s00251-008-0332-0

PubMed ID: 19924287

Title: The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes.

PubMed ID: 19924287

DOI: 10.1371/journal.pone.0007803

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10426995

Title: Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors.

PubMed ID: 10426995

DOI: 10.1126/science.285.5428.732

PubMed ID: 10426996

Title: Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2.

PubMed ID: 10426996

DOI: 10.1126/science.285.5428.736

PubMed ID: 11441107

Title: Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.

PubMed ID: 11441107

DOI: 10.4049/jimmunol.167.2.987

PubMed ID: 12471095

Title: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.

PubMed ID: 12471095

DOI: 10.4049/jimmunol.169.12.6668

PubMed ID: 16880211

Title: Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.

PubMed ID: 16880211

DOI: 10.1074/jbc.m602794200

PubMed ID: 15173186

Title: Four N-linked glycosylation sites in human toll-like receptor 2 cooperate to direct efficient biosynthesis and secretion.

PubMed ID: 15173186

DOI: 10.1074/jbc.m403830200

PubMed ID: 15809303

Title: Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signals.

PubMed ID: 15809303

DOI: 10.1074/jbc.m411379200

PubMed ID: 16622205

Title: The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes.

PubMed ID: 16622205

DOI: 10.1128/iai.74.5.2686-2696.2006

PubMed ID: 17322885

Title: A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.

PubMed ID: 17322885

DOI: 10.1038/ng1976

PubMed ID: 19362712

Title: TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.

PubMed ID: 19362712

DOI: 10.1016/j.cellimm.2009.03.008

PubMed ID: 20800577

Title: Non-acylated Mycobacterium bovis glycoprotein MPB83 binds to TLR1/2 and stimulates production of matrix metalloproteinase 9.

PubMed ID: 20800577

DOI: 10.1016/j.bbrc.2010.08.085

PubMed ID: 21078852

Title: Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4(+) T cell activation via Toll-like receptors 1 and 2.

PubMed ID: 21078852

DOI: 10.1128/iai.00806-10

PubMed ID: 22665377

Title: Staphylococcal superantigen-like protein 3 binds to the Toll-like receptor 2 extracellular domain and inhibits cytokine production induced by Staphylococcus aureus, cell wall component, or lipopeptides in murine macrophages.

PubMed ID: 22665377

DOI: 10.1128/iai.00399-12

PubMed ID: 23376921

Title: TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3.

PubMed ID: 23376921

DOI: 10.1038/emboj.2013.8

PubMed ID: 25385819

Title: TRAM is required for TLR2 endosomal signaling to type I IFN induction.

PubMed ID: 25385819

DOI: 10.4049/jimmunol.1401605

PubMed ID: 27805901

Title: RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity.

PubMed ID: 27805901

DOI: 10.7554/elife.18496

PubMed ID: 34133077

Title: Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19.

PubMed ID: 34133077

DOI: 10.15252/emmm.202114150

PubMed ID: 11081518

Title: Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.

PubMed ID: 11081518

DOI: 10.1038/35040600

PubMed ID: 17889651

Title: Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide.

PubMed ID: 17889651

DOI: 10.1016/j.cell.2007.09.008

PubMed ID: 11476982

Title: Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients.

PubMed ID: 11476982

DOI: 10.1111/j.1574-695x.2001.tb01586.x

PubMed ID: 12646604

Title: A Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling.

PubMed ID: 12646604

DOI: 10.4049/jimmunol.170.7.3451

PubMed ID: 21618349

Title: Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family.

PubMed ID: 21618349

DOI: 10.1002/humu.21486

Sequence Information:

Length: 784
Mass: 89838
Checksum: 7DBE6B24CF1FAF8B
Sequence:

MPHTLWMVWV LGVIISLSKE ESSNQASLSC DRNGICKGSS GSLNSIPSGL TEAVKSLDLS 
NNRITYISNS DLQRCVNLQA LVLTSNGINT IEEDSFSSLG SLEHLDLSYN YLSNLSSSWF 
KPLSSLTFLN LLGNPYKTLG ETSLFSHLTK LQILRVGNMD TFTKIQRKDF AGLTFLEELE 
IDASDLQSYE PKSLKSIQNV SHLILHMKQH ILLLEIFVDV TSSVECLELR DTDLDTFHFS 
ELSTGETNSL IKKFTFRNVK ITDESLFQVM KLLNQISGLL ELEFDDCTLN GVGNFRASDN 
DRVIDPGKVE TLTIRRLHIP RFYLFYDLST LYSLTERVKR ITVENSKVFL VPCLLSQHLK 
SLEYLDLSEN LMVEEYLKNS ACEDAWPSLQ TLILRQNHLA SLEKTGETLL TLKNLTNIDI 
SKNSFHSMPE TCQWPEKMKY LNLSSTRIHS VTGCIPKTLE ILDVSNNNLN LFSLNLPQLK 
ELYISRNKLM TLPDASLLPM LLVLKISRNA ITTFSKEQLD SFHTLKTLEA GGNNFICSCE 
FLSFTQEQQA LAKVLIDWPA NYLCDSPSHV RGQQVQDVRL SVSECHRTAL VSGMCCALFL 
LILLTGVLCH RFHGLWYMKM MWAWLQAKRK PRKAPSRNIC YDAFVSYSER DAYWVENLMV 
QELENFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTV FVLSENFVKS EWCKYELDFS 
HFRLFDENND AAILILLEPI EKKAIPQRFC KLRKIMNTKT YLEWPMDEAQ REGFWVNLRA 
AIKS

Genular Protein ID: 1994509236

Symbol: B3KWR9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KWR9

Database IDs:

Sequence Information:

Length: 784
Mass: 89826
Checksum: 10CBBD878AE70CBB
Sequence:

MPHTLWMVWV LGVIISLSKE ESSNQASLSC DRNGICKGSS GSLNSTPSGL TEAVKSLDLS 
NNRITYISNS DLQRCVNLQA LVLTSNGINT IEEDSFSSLG SLEHLDLSYN YLSNLSSSWF 
KPLSSLTFLN LLGNPYKTLG ETSLFSHLTK LQILRVGNMD TFTKIQRKDF AGLTFLEELE 
IDASDLQSYE PKSLKSIQNV SHLILHMKQH ILLLEIFVDV TSSVECLELR DTDLDTFHFS 
ELSTGETNSL IKKFTFRNVK ITDESLFQVM KLLNQISGLL ELEFDDCTLN GVGNFRASDN 
DRVIDPGKVE TLTIRRLHIP RFYLFYDLST LYSLTERVKR ITVENSKVFL VPCLLSQHLK 
SLEYLDLSEN LMVEEYLKNS ACEDAWPSLQ TLILRQNHLA SLEKTGETLL TLKNLTNIDI 
SKNSFHSMPE TCQWPEKMKY LNLSSTRIHS VTGCIPKTLE ILDVSNNNLN LFSLNLPQLK 
ELYISRNKLM TLPDASLLPM LLVLKISRNA ITTFSKEQLD SFHTLKTLEA GGNNFICSCE 
FLSFTQEQQA LAKVLIDWPA NYLCDSPSHV RGQQVQDVRL SVSECHRTAL VSGMCCALFL 
LILLTGVLCH RFHGLWYMKM MWAWLQAKRK PRKAPSRNIC YDAFVSYSER DAYWVENLMV 
QELENFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTV FVLSENFVKS EWCKYELDFS 
HFRLFDENND AAILILLEPI EKKAIPQRFC KLRKIMNTKT YLEWPMDEAQ REGFWVNLRA 
AIKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TLR2

Associated with

Cells (max top 100)

Other Information

Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. PubMed ID: 9596645

A family of human receptors structurally related to Drosophila Toll. PubMed ID: 9435236

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. PubMed ID: 9751057

Natural selection in the TLR-related genes in the course of primate evolution. PubMed ID: 18810425

The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes. PubMed ID: 19924287

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors. PubMed ID: 10426995

Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2. PubMed ID: 10426996

Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. PubMed ID: 11441107

A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. PubMed ID: 12471095

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. PubMed ID: 16880211

Four N-linked glycosylation sites in human toll-like receptor 2 cooperate to direct efficient biosynthesis and secretion. PubMed ID: 15173186

Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signals. PubMed ID: 15809303

The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes. PubMed ID: 16622205

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. PubMed ID: 17322885

TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis. PubMed ID: 19362712

Non-acylated Mycobacterium bovis glycoprotein MPB83 binds to TLR1/2 and stimulates production of matrix metalloproteinase 9. PubMed ID: 20800577

Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4(+) T cell activation via Toll-like receptors 1 and 2. PubMed ID: 21078852

Staphylococcal superantigen-like protein 3 binds to the Toll-like receptor 2 extracellular domain and inhibits cytokine production induced by Staphylococcus aureus, cell wall component, or lipopeptides in murine macrophages. PubMed ID: 22665377

TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3. PubMed ID: 23376921

TRAM is required for TLR2 endosomal signaling to type I IFN induction. PubMed ID: 25385819

RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity. PubMed ID: 27805901

Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19. PubMed ID: 34133077

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. PubMed ID: 11081518

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. PubMed ID: 17889651

Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. PubMed ID: 11476982

A Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling. PubMed ID: 12646604

Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family. PubMed ID: 21618349