Details for: TSPAN8

Gene ID: 7103

Symbol: TSPAN8

Ensembl ID: ENSG00000127324

Description: tetraspanin 8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.99
    Marker Score: 12522
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.73
    Marker Score: 23805
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.67
    Marker Score: 17636
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.52
    Marker Score: 7989
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.21
    Marker Score: 3078
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 3.17
    Marker Score: 868
  • Cell Name: stem cell (CL0000034)
    Fold Change: 3
    Marker Score: 7134
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.7
    Marker Score: 4165
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.65
    Marker Score: 1397
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.44
    Marker Score: 1021
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.4
    Marker Score: 6442.5
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.4
    Marker Score: 694
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.35
    Marker Score: 1370
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.3
    Marker Score: 1135
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.09
    Marker Score: 602
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.06
    Marker Score: 709
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2008
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2
    Marker Score: 752
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.84
    Marker Score: 686
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.81
    Marker Score: 1876
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.81
    Marker Score: 448
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6
    Marker Score: 2358
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.59
    Marker Score: 405
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.54
    Marker Score: 644.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.51
    Marker Score: 3964
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.44
    Marker Score: 349
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.44
    Marker Score: 1678
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.4
    Marker Score: 443
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.34
    Marker Score: 848
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.33
    Marker Score: 11264
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 1.28
    Marker Score: 368
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.22
    Marker Score: 2311
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.22
    Marker Score: 2479
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.21
    Marker Score: 1228.5
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.16
    Marker Score: 333
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.15
    Marker Score: 688
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.07
    Marker Score: 232
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.03
    Marker Score: 298
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71769.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47993
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.97
    Marker Score: 227
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.95
    Marker Score: 1741
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.95
    Marker Score: 691
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.95
    Marker Score: 346
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 446
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1514
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5310
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.9
    Marker Score: 605
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.9
    Marker Score: 235
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.9
    Marker Score: 465
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.88
    Marker Score: 240
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13369
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.85
    Marker Score: 592
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.81
    Marker Score: 257
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8
    Marker Score: 534
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.8
    Marker Score: 680
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.78
    Marker Score: 405
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 309
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 562
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.73
    Marker Score: 1714
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.71
    Marker Score: 284
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.71
    Marker Score: 228
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.71
    Marker Score: 187
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.7
    Marker Score: 9446
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.69
    Marker Score: 203
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 629
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.69
    Marker Score: 1674
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2874
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.66
    Marker Score: 413
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.66
    Marker Score: 374
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.65
    Marker Score: 170
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.63
    Marker Score: 175
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.63
    Marker Score: 293
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.62
    Marker Score: 267
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.62
    Marker Score: 284
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.62
    Marker Score: 1020
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.61
    Marker Score: 1138
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.58
    Marker Score: 3064
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.58
    Marker Score: 278
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.57
    Marker Score: 603
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.55
    Marker Score: 537.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.54
    Marker Score: 269
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.53
    Marker Score: 166
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 0.51
    Marker Score: 164
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.49
    Marker Score: 148
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.49
    Marker Score: 434

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Other Information

**Key Characteristics:** TSPAN8 is a relatively small protein, consisting of 92 amino acids, with a molecular weight of approximately 9.5 kDa. It belongs to the tetraspanin superfamily, characterized by its four transmembrane domains and a cytoplasmic C-terminal tail. TSPAN8 is highly expressed in various cell types, including stem cells, epithelial cells, and hematopoietic stem cells, suggesting its broad involvement in cellular processes. **Pathways and Functions:** TSPAN8 is implicated in multiple cellular pathways, including: 1. **Integrin binding**: TSPAN8 interacts with integrins, transmembrane receptors that facilitate cell-cell and cell-extracellular matrix interactions. This interaction is crucial for cell adhesion, migration, and signaling. 2. **Regulation of gene expression**: TSPAN8 has been shown to modulate the expression of genes involved in cellular differentiation, proliferation, and survival. Its role in regulating gene expression is mediated through its interaction with transcription factors and other signaling molecules. 3. **Negative regulation of blood coagulation**: TSPAN8 has been implicated in the regulation of blood coagulation, with studies suggesting that it inhibits the activation of coagulation factors. 4. **Spermatogenesis**: TSPAN8 is highly expressed in the testes, where it plays a crucial role in the regulation of spermatogenesis, the process of sperm production. **Clinical Significance:** Dysregulation of TSPAN8 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of TSPAN8 has been observed in various types of cancer, including breast, lung, and colon cancer. Its role in cancer progression is thought to be mediated through its ability to regulate cell adhesion, migration, and signaling. 2. **Cardiovascular disease**: TSPAN8 has been implicated in the regulation of blood coagulation, with studies suggesting that its dysregulation may contribute to the development of cardiovascular disease. 3. **Neurological disorders**: TSPAN8 has been shown to play a role in the regulation of gene expression in the central nervous system, with its dysregulation potentially contributing to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TSPAN8 is a multifaceted gene involved in various cellular processes, including cell adhesion, migration, and signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms underlying its function and its role in human disease.

Genular Protein ID: 2443744733

Symbol: TSN8_HUMAN

Name: Tetraspanin-8

UniProtKB Accession Codes:

P19075 B2R7T7 Q9BS78

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2395876

Title: Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens.

PubMed ID: 2395876

DOI: 10.1073/pnas.87.17.6833

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 237
  • Mass: 26044
  • Checksum: D1058F054EE8C14E
  • Sequence:
    • MAGVSACIKY SMFTFNFLFW LCGILILALA IWVRVSNDSQ AIFGSEDVGS SSYVAVDILI 
AVGAIIMILG FLGCCGAIKE SRCMLLLFFI GLLLILLLQV ATGILGAVFK SKSDRIVNET 
LYENTKLLSA TGESEKQFQE AIIVFQEEFK CCGLVNGAAD WGNNFQHYPE LCACLDKQRP 
CQSYNGKQVY KETCISFIKD FLAKNLIIVI GISFGLAVIE ILGLVFSMVL YCQIGNK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.