Details for: TSPAN8

Gene ID: 7103

Symbol: TSPAN8

Ensembl ID: ENSG00000127324

Description: tetraspanin 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 48.8533
    Cell Significance Index: -20.1300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 37.1989
    Cell Significance Index: 282.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 25.2823
    Cell Significance Index: -16.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 12.4997
    Cell Significance Index: 566.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 8.2373
    Cell Significance Index: 178.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.5998
    Cell Significance Index: -17.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 5.4575
    Cell Significance Index: 4927.7500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 3.9835
    Cell Significance Index: 40.1900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.8817
    Cell Significance Index: 40.1700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.8461
    Cell Significance Index: 57.6300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 3.6005
    Cell Significance Index: 37.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.6481
    Cell Significance Index: 137.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.5786
    Cell Significance Index: -7.9200
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 1.9887
    Cell Significance Index: 13.2800
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.8175
    Cell Significance Index: 12.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.7834
    Cell Significance Index: 57.1200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.7309
    Cell Significance Index: 13.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1959
    Cell Significance Index: 118.3100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8968
    Cell Significance Index: 20.7200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.8066
    Cell Significance Index: 8.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7273
    Cell Significance Index: 20.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.7255
    Cell Significance Index: 83.1200
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.7133
    Cell Significance Index: 7.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6630
    Cell Significance Index: 14.1200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4527
    Cell Significance Index: 10.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4000
    Cell Significance Index: 79.3900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3793
    Cell Significance Index: 43.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3736
    Cell Significance Index: 71.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3529
    Cell Significance Index: 9.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3491
    Cell Significance Index: 50.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2176
    Cell Significance Index: 159.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1480
    Cell Significance Index: 5.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1442
    Cell Significance Index: 9.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1296
    Cell Significance Index: 80.9300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1280
    Cell Significance Index: 2.1100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0885
    Cell Significance Index: 1.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0319
    Cell Significance Index: 5.4400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0278
    Cell Significance Index: 0.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0146
    Cell Significance Index: 1.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0122
    Cell Significance Index: 5.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0047
    Cell Significance Index: 0.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0043
    Cell Significance Index: 0.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0012
    Cell Significance Index: 0.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0008
    Cell Significance Index: -0.6000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0055
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0056
    Cell Significance Index: -10.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0094
    Cell Significance Index: -5.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0099
    Cell Significance Index: -5.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0112
    Cell Significance Index: -20.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0113
    Cell Significance Index: -2.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0140
    Cell Significance Index: -21.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0162
    Cell Significance Index: -22.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0238
    Cell Significance Index: -15.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0262
    Cell Significance Index: -2.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0288
    Cell Significance Index: -0.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0301
    Cell Significance Index: -10.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0408
    Cell Significance Index: -11.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0428
    Cell Significance Index: -19.4200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0451
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0496
    Cell Significance Index: -10.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0649
    Cell Significance Index: -8.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0652
    Cell Significance Index: -7.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0698
    Cell Significance Index: -1.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0726
    Cell Significance Index: -14.5600
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.1071
    Cell Significance Index: -0.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1222
    Cell Significance Index: -1.7500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1279
    Cell Significance Index: -3.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1422
    Cell Significance Index: -10.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1462
    Cell Significance Index: -5.9900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1546
    Cell Significance Index: -2.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1601
    Cell Significance Index: -16.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1616
    Cell Significance Index: -16.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1631
    Cell Significance Index: -9.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1669
    Cell Significance Index: -7.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1692
    Cell Significance Index: -12.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1733
    Cell Significance Index: -22.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1822
    Cell Significance Index: -3.7800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1884
    Cell Significance Index: -3.0400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1948
    Cell Significance Index: -1.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1968
    Cell Significance Index: -12.0700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2137
    Cell Significance Index: -1.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2304
    Cell Significance Index: -12.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2374
    Cell Significance Index: -15.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2566
    Cell Significance Index: -6.8500
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.2589
    Cell Significance Index: -1.5200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2635
    Cell Significance Index: -2.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2675
    Cell Significance Index: -20.5300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2700
    Cell Significance Index: -1.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2984
    Cell Significance Index: -18.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3001
    Cell Significance Index: -8.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3061
    Cell Significance Index: -7.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3096
    Cell Significance Index: -6.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3233
    Cell Significance Index: -8.8000
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.3367
    Cell Significance Index: -2.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3374
    Cell Significance Index: -20.7400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3524
    Cell Significance Index: -2.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3567
    Cell Significance Index: -5.9700
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.3671
    Cell Significance Index: -3.3200
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.3809
    Cell Significance Index: -2.9000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3945
    Cell Significance Index: -17.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TSPAN8 is a relatively small protein, consisting of 92 amino acids, with a molecular weight of approximately 9.5 kDa. It belongs to the tetraspanin superfamily, characterized by its four transmembrane domains and a cytoplasmic C-terminal tail. TSPAN8 is highly expressed in various cell types, including stem cells, epithelial cells, and hematopoietic stem cells, suggesting its broad involvement in cellular processes. **Pathways and Functions:** TSPAN8 is implicated in multiple cellular pathways, including: 1. **Integrin binding**: TSPAN8 interacts with integrins, transmembrane receptors that facilitate cell-cell and cell-extracellular matrix interactions. This interaction is crucial for cell adhesion, migration, and signaling. 2. **Regulation of gene expression**: TSPAN8 has been shown to modulate the expression of genes involved in cellular differentiation, proliferation, and survival. Its role in regulating gene expression is mediated through its interaction with transcription factors and other signaling molecules. 3. **Negative regulation of blood coagulation**: TSPAN8 has been implicated in the regulation of blood coagulation, with studies suggesting that it inhibits the activation of coagulation factors. 4. **Spermatogenesis**: TSPAN8 is highly expressed in the testes, where it plays a crucial role in the regulation of spermatogenesis, the process of sperm production. **Clinical Significance:** Dysregulation of TSPAN8 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of TSPAN8 has been observed in various types of cancer, including breast, lung, and colon cancer. Its role in cancer progression is thought to be mediated through its ability to regulate cell adhesion, migration, and signaling. 2. **Cardiovascular disease**: TSPAN8 has been implicated in the regulation of blood coagulation, with studies suggesting that its dysregulation may contribute to the development of cardiovascular disease. 3. **Neurological disorders**: TSPAN8 has been shown to play a role in the regulation of gene expression in the central nervous system, with its dysregulation potentially contributing to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TSPAN8 is a multifaceted gene involved in various cellular processes, including cell adhesion, migration, and signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms underlying its function and its role in human disease.

Genular Protein ID: 2443744733

Symbol: TSN8_HUMAN

Name: Tetraspanin-8

UniProtKB Accession Codes:

P19075 B2R7T7 Q9BS78

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2395876

Title: Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens.

PubMed ID: 2395876

DOI: 10.1073/pnas.87.17.6833

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 25761241

Title: Tetraspanin 8-rictor-integrin alpha3 complex is required for glioma cell migration.

PubMed ID: 25761241

DOI: 10.3390/ijms16035363

PubMed ID: 27180357

Title: Tetraspanin 8 is an interactor of the metalloprotease meprin beta within tetraspanin-enriched microdomains.

PubMed ID: 27180357

DOI: 10.1515/hsz-20-2016-0126

PubMed ID: 34524408

Title: Quantitative characterization of tetraspanin 8 homointeractions in the plasma membrane.

PubMed ID: 34524408

DOI: 10.1042/bcj20210459

PubMed ID: 35904232

Title: TSPAN8 alleviates high glucose-induced apoptosis and autophagy via targeting mTORC2.

PubMed ID: 35904232

DOI: 10.1002/cbin.11870

PubMed ID: 36078095

Title: Tetraspanin 8 Subfamily Members Regulate Substrate-Specificity of a Disintegrin and Metalloprotease 17.

PubMed ID: 36078095

DOI: 10.3390/cells11172683

PubMed ID: 37835445

Title: The Tetraspanin Tspan8 Associates with Endothelin Converting Enzyme ECE1 and Regulates Its Activity.

PubMed ID: 37835445

DOI: 10.3390/cancers15194751

PubMed ID: 37204469

Title: Tetraspanin Tspan8 restrains interferon signaling to stabilize intestinal epithelium by directing endocytosis of interferon receptor.

PubMed ID: 37204469

DOI: 10.1007/s00018-023-04803-x

Sequence Information:

  • Length: 237
  • Mass: 26044
  • Checksum: D1058F054EE8C14E
  • Sequence:
    • MAGVSACIKY SMFTFNFLFW LCGILILALA IWVRVSNDSQ AIFGSEDVGS SSYVAVDILI 
AVGAIIMILG FLGCCGAIKE SRCMLLLFFI GLLLILLLQV ATGILGAVFK SKSDRIVNET 
LYENTKLLSA TGESEKQFQE AIIVFQEEFK CCGLVNGAAD WGNNFQHYPE LCACLDKQRP 
CQSYNGKQVY KETCISFIKD FLAKNLIIVI GISFGLAVIE ILGLVFSMVL YCQIGNK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.