TNF | ENSG00000232810 | NCBI 7124

Details for: TNF

Gene ID: 7124

Symbol: TNF

Ensembl ID: ENSG00000232810

Description: tumor necrosis factor

Associated with

Adipogenesis
(R-HSA-9843745)
Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Developmental biology
(R-HSA-1266738)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-10 signaling
(R-HSA-6783783)
Regulation of tnfr1 signaling
(R-HSA-5357905)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Tnfr1-induced nf-kappa-b signaling pathway
(R-HSA-5357956)
Tnfr1-induced proapoptotic signaling
(R-HSA-5357786)
Tnfr1-mediated ceramide production
(R-HSA-5626978)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Tnf signaling
(R-HSA-75893)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Calcium-mediated signaling
(GO:0019722)
Cell surface receptor signaling pathway via jak-stat
(GO:0007259)
Chronic inflammatory response to antigenic stimulus
(GO:0002439)
Circadian rhythm
(GO:0007623)
Cortical actin cytoskeleton organization
(GO:0030866)
Cytokine activity
(GO:0005125)
Death receptor agonist activity
(GO:0038177)
Extracellular matrix organization
(GO:0030198)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Glucose metabolic process
(GO:0006006)
Humoral immune response
(GO:0006959)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Jnk cascade
(GO:0007254)
Leukocyte migration involved in inflammatory response
(GO:0002523)
Macrophage activation involved in immune response
(GO:0002281)
Microglial cell activation
(GO:0001774)
Negative regulation of alkaline phosphatase activity
(GO:0010693)
Negative regulation of cytokine production involved in immune response
(GO:0002719)
Negative regulation of endothelial cell proliferation
(GO:0001937)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of heart rate
(GO:0010459)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of l-glutamate import across plasma membrane
(GO:0002037)
Negative regulation of lipid storage
(GO:0010888)
Negative regulation of myelination
(GO:0031642)
Negative regulation of systemic arterial blood pressure
(GO:0003085)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Osteoclast differentiation
(GO:0030316)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of chronic inflammatory response to antigenic stimulus
(GO:0002876)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of fever generation
(GO:0031622)
Positive regulation of fractalkine production
(GO:0032724)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of humoral immune response mediated by circulating immunoglobulin
(GO:0002925)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of interleukin-18 production
(GO:0032741)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of type ii interferon production
(GO:0032729)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Regulation of immunoglobulin production
(GO:0002637)
Regulation of metabolic process
(GO:0019222)
Response to activity
(GO:0014823)
Response to fructose
(GO:0009750)
Response to hypoxia
(GO:0001666)
Response to nutrient levels
(GO:0031667)
Response to salt stress
(GO:0009651)
Response to virus
(GO:0009615)
Response to xenobiotic stimulus
(GO:0009410)
Sequestering of triglyceride
(GO:0030730)
Skeletal muscle contraction
(GO:0003009)
Transcription cis-regulatory region binding
(GO:0000976)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Tumor necrosis factor receptor binding
(GO:0005164)
Vascular endothelial growth factor production
(GO:0010573)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 75.7336
Cell Significance Index: -11.7800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 46.9951
Cell Significance Index: -11.9200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 31.3595
Cell Significance Index: -12.7400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 27.2170
Cell Significance Index: -14.0000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 9.5381
Cell Significance Index: -11.7600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.0243
Cell Significance Index: 88.8200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 2.5272
Cell Significance Index: -6.7700
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 2.3474
Cell Significance Index: -7.2100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.3402
Cell Significance Index: 62.9900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.8265
Cell Significance Index: 15.2800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7742
Cell Significance Index: 20.7100
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.7459
Cell Significance Index: 4.4700
Cell Name: lactocyte (CL0002325)
Fold Change: 0.6790
Cell Significance Index: 87.7200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6393
Cell Significance Index: 349.1500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5423
Cell Significance Index: 103.2000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4266
Cell Significance Index: 42.2000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3876
Cell Significance Index: 349.9900
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.2367
Cell Significance Index: 1.9300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2355
Cell Significance Index: 15.2000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2151
Cell Significance Index: 25.3700
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.1970
Cell Significance Index: 0.8200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1337
Cell Significance Index: 21.7500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1276
Cell Significance Index: 9.5100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0918
Cell Significance Index: 9.9900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0634
Cell Significance Index: 28.0500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0573
Cell Significance Index: 35.8000
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0330
Cell Significance Index: 0.5100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0024
Cell Significance Index: 0.1100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0060
Cell Significance Index: -11.2800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0067
Cell Significance Index: -4.9300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0091
Cell Significance Index: -0.3200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0093
Cell Significance Index: -5.2400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0103
Cell Significance Index: -0.7200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0115
Cell Significance Index: -8.7000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0137
Cell Significance Index: -1.6000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0161
Cell Significance Index: -3.3900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0163
Cell Significance Index: -0.8200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0178
Cell Significance Index: -13.0800
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0191
Cell Significance Index: -2.4500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0196
Cell Significance Index: -0.4900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0201
Cell Significance Index: -0.5800
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0202
Cell Significance Index: -0.8300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0207
Cell Significance Index: -13.1300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0241
Cell Significance Index: -4.1100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0254
Cell Significance Index: -2.9100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0277
Cell Significance Index: -12.5500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0364
Cell Significance Index: -5.0000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0405
Cell Significance Index: -4.1400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0446
Cell Significance Index: -2.0800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0493
Cell Significance Index: -8.8800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0508
Cell Significance Index: -1.1000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0558
Cell Significance Index: -11.2000
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0559
Cell Significance Index: -11.0900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0573
Cell Significance Index: -6.5400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0783
Cell Significance Index: -9.6300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0807
Cell Significance Index: -4.1900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0899
Cell Significance Index: -13.0700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0915
Cell Significance Index: -2.9300
Cell Name: thymocyte (CL0000893)
Fold Change: -0.0952
Cell Significance Index: -1.2000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1004
Cell Significance Index: -7.1000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1083
Cell Significance Index: -11.2800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1140
Cell Significance Index: -6.9900
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1311
Cell Significance Index: -2.7200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1344
Cell Significance Index: -10.3100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1388
Cell Significance Index: -2.9600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1769
Cell Significance Index: -10.6200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1793
Cell Significance Index: -5.0100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1996
Cell Significance Index: -5.1300
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.2006
Cell Significance Index: -2.0800
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.2069
Cell Significance Index: -2.8700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2071
Cell Significance Index: -5.5300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2128
Cell Significance Index: -11.9400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2225
Cell Significance Index: -11.6800
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.2229
Cell Significance Index: -3.2600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2280
Cell Significance Index: -8.3700
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2322
Cell Significance Index: -5.7900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2442
Cell Significance Index: -12.7200
Cell Name: leukocyte (CL0000738)
Fold Change: -0.2567
Cell Significance Index: -4.3600
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: -0.2573
Cell Significance Index: -3.8500
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2613
Cell Significance Index: -11.3600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2645
Cell Significance Index: -11.7000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2688
Cell Significance Index: -9.4200
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.2737
Cell Significance Index: -5.5700
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2834
Cell Significance Index: -4.2700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3104
Cell Significance Index: -11.7600
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.3237
Cell Significance Index: -4.7000
Cell Name: peg cell (CL4033014)
Fold Change: -0.3419
Cell Significance Index: -7.9000
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.3472
Cell Significance Index: -4.4000
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3638
Cell Significance Index: -11.9100
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.3660
Cell Significance Index: -7.1600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3707
Cell Significance Index: -9.4700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3716
Cell Significance Index: -11.8400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3744
Cell Significance Index: -10.1900
Cell Name: decidual cell (CL2000002)
Fold Change: -0.3808
Cell Significance Index: -6.1100
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.3932
Cell Significance Index: -9.8200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3955
Cell Significance Index: -11.6500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3966
Cell Significance Index: -11.3700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3984
Cell Significance Index: -8.3400
Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: -0.4028
Cell Significance Index: -6.9200
Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.4416
Cell Significance Index: -4.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** TNF is a 156 amino acid protein that belongs to the tumor necrosis factor family. It is characterized by its ability to induce apoptosis in various cell types, including tumor cells, immune cells, and normal cells. TNF is also known for its role in inflammation, as it can induce the production of pro-inflammatory cytokines and chemokines. The TNF receptor, TNFR1, is a type II transmembrane receptor that is expressed on the surface of many cell types and is capable of binding to TNF. TNF has several distinct isoforms, including TNF-alpha, TNF-beta, and lymphotoxin-alpha, each with unique biological activities. TNF-alpha is the most well-studied isoform and is involved in the regulation of immune responses, inflammation, and cell survival. **Pathways and Functions:** TNF signaling involves the activation of the TNFR1 receptor, which triggers a cascade of intracellular signaling events that regulate various cellular processes. The TNF signaling pathway is involved in: 1. **Apoptosis:** TNF induces apoptosis in various cell types, including tumor cells, immune cells, and normal cells. 2. **Inflammation:** TNF induces the production of pro-inflammatory cytokines and chemokines, which contribute to the development of inflammation. 3. **Immune Response:** TNF plays a critical role in the regulation of immune responses, including the activation of immune cells, such as macrophages and T cells. 4. **Cell Survival:** TNF can also regulate cell survival pathways, including the activation of anti-apoptotic proteins. 5. **Cytokine Production:** TNF induces the production of various cytokines, including TNF-alpha, IL-1beta, and IL-6. **Clinical Significance:** TNF is involved in various diseases, including: 1. **Rheumatoid Arthritis:** TNF-alpha is a key mediator of the inflammatory response in rheumatoid arthritis, and blocking TNF-alpha with monoclonal antibodies has been shown to be effective in treating the disease. 2. **Multiple Sclerosis:** TNF-alpha is also involved in the pathogenesis of multiple sclerosis, and blocking TNF-alpha has been shown to slow disease progression. 3. **Cancer:** TNF-alpha can induce apoptosis in tumor cells, and has been used as a therapeutic agent in cancer treatment. 4. **Infectious Diseases:** TNF plays a critical role in the regulation of immune responses to infections, and is involved in the pathogenesis of diseases such as tuberculosis and sepsis. In conclusion, TNF is a multifunctional cytokine that plays a critical role in the regulation of immune responses, inflammation, and cell survival. Its dysregulation is involved in various diseases, and targeting TNF with monoclonal antibodies has shown promise in treating several conditions. Further research is needed to fully understand the biology of TNF and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Tumor necrosis factor

Genular Protein ID: 2576552063

Symbol: TNFA_HUMAN

Name: Tumor necrosis factor

UniProtKB Accession Codes:

P01375 O43647 Q9P1Q2 Q9UIV3

Database IDs:

Citations:

PubMed ID: 3555974

Title: Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome.

PubMed ID: 3555974

DOI: 10.1101/sqb.1986.051.01.073

PubMed ID: 6392892

Title: Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.

PubMed ID: 6392892

DOI: 10.1038/312724a0

PubMed ID: 3883195

Title: Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor.

PubMed ID: 3883195

DOI: 10.1038/313803a0

PubMed ID: 2995927

Title: Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization.

PubMed ID: 2995927

DOI: 10.1093/nar/13.17.6361

PubMed ID: 3856324

Title: Molecular cloning of the complementary DNA for human tumor necrosis factor.

PubMed ID: 3856324

DOI: 10.1126/science.3856324

PubMed ID: 3932069

Title: Molecular cloning and expression of human tumor necrosis factor and comparison with mouse tumor necrosis factor.

PubMed ID: 3932069

DOI: 10.1111/j.1432-1033.1985.tb09226.x

PubMed ID: 8499947

Title: Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment.

PubMed ID: 8499947

DOI: 10.1038/ng0293-137

PubMed ID: 10202016

Title: A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.

PubMed ID: 10202016

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8631363

Title: O-glycosylated species of natural human tumor-necrosis factor-alpha.

PubMed ID: 8631363

DOI: 10.1111/j.1432-1033.1996.00431.x

PubMed ID: 8597870

Title: Phosphorylation of the 26 kDa TNF precursor in monocytic cells and in transfected HeLa cells.

PubMed ID: 8597870

PubMed ID: 10205166

Title: A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in 'reverse signalling'.

PubMed ID: 10205166

DOI: 10.1093/emboj/18.8.2119

PubMed ID: 2009860

Title: Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis.

PubMed ID: 2009860

DOI: 10.1002/j.1460-2075.1991.tb08015.x

PubMed ID: 1402651

Title: Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues.

PubMed ID: 1402651

DOI: 10.1084/jem.176.4.1053

PubMed ID: 9034191

Title: Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.

PubMed ID: 9034191

DOI: 10.1038/385733a0

PubMed ID: 10369255

Title: A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria.

PubMed ID: 10369255

DOI: 10.1038/9649

PubMed ID: 12746914

Title: Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity.

PubMed ID: 12746914

DOI: 10.1002/art.10935

PubMed ID: 12794819

Title: Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.

PubMed ID: 12794819

DOI: 10.1002/art.11143

PubMed ID: 12915457

Title: Association of TNF-alpha promoter polymorphisms with the clearance of hepatitis B virus infection.

PubMed ID: 12915457

DOI: 10.1093/hmg/ddg262

PubMed ID: 16829952

Title: SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production.

PubMed ID: 16829952

DOI: 10.1038/ncb1440

PubMed ID: 16829951

Title: A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b.

PubMed ID: 16829951

DOI: 10.1038/ncb1450

PubMed ID: 22517918

Title: Smac mimetic enables the anticancer action of BCG-stimulated neutrophils through TNF-alpha but not through TRAIL and FasL.

PubMed ID: 22517918

DOI: 10.1189/jlb.1211623

PubMed ID: 23552949

Title: SIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysine.

PubMed ID: 23552949

DOI: 10.1038/nature12038

PubMed ID: 23396208

Title: Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis.

PubMed ID: 23396208

DOI: 10.1038/nm.3085

PubMed ID: 2922050

Title: Structure of tumour necrosis factor.

PubMed ID: 2922050

DOI: 10.1038/338225a0

PubMed ID: 1964681

Title: The structure of tumour necrosis factor -- implications for biological function.

PubMed ID: 1964681

DOI: 10.1242/jcs.1990.supplement_13.3

PubMed ID: 2551905

Title: The structure of tumor necrosis factor-alpha at 2.6-A resolution. Implications for receptor binding.

PubMed ID: 2551905

DOI: 10.2210/pdb1tnf/pdb

PubMed ID: 9488135

Title: Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2.

PubMed ID: 9488135

DOI: 10.1093/protein/10.10.1101

PubMed ID: 9442056

Title: High resolution crystal structure of a human tumor necrosis factor-alpha mutant with low systemic toxicity.

PubMed ID: 9442056

DOI: 10.1074/jbc.273.4.2153

Sequence Information:

Length: 233
Mass: 25644
Checksum: 3DF90F96C9031FFE
Sequence:

MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL LHFGVIGPQR 
EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG QLQWLNRRAN ALLANGVELR 
DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV LLTHTISRIA VSYQTKVNLL SAIKSPCQRE 
TPEGAEAKPW YEPIYLGGVF QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TNF

Associated with

Cells (max top 100)

Other Information

Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome. PubMed ID: 3555974

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. PubMed ID: 6392892

Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor. PubMed ID: 3883195

Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. PubMed ID: 2995927

Molecular cloning of the complementary DNA for human tumor necrosis factor. PubMed ID: 3856324

Molecular cloning and expression of human tumor necrosis factor and comparison with mouse tumor necrosis factor. PubMed ID: 3932069

Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment. PubMed ID: 8499947

A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. PubMed ID: 10202016

Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. PubMed ID: 14656967

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

O-glycosylated species of natural human tumor-necrosis factor-alpha. PubMed ID: 8631363

Phosphorylation of the 26 kDa TNF precursor in monocytic cells and in transfected HeLa cells. PubMed ID: 8597870

A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in 'reverse signalling'. PubMed ID: 10205166

Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis. PubMed ID: 2009860

Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues. PubMed ID: 1402651

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. PubMed ID: 9034191

A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria. PubMed ID: 10369255

Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity. PubMed ID: 12746914

Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. PubMed ID: 12794819

Association of TNF-alpha promoter polymorphisms with the clearance of hepatitis B virus infection. PubMed ID: 12915457

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. PubMed ID: 16829952

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. PubMed ID: 16829951

Smac mimetic enables the anticancer action of BCG-stimulated neutrophils through TNF-alpha but not through TRAIL and FasL. PubMed ID: 22517918

SIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysine. PubMed ID: 23552949

Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis. PubMed ID: 23396208

Structure of tumour necrosis factor. PubMed ID: 2922050

The structure of tumour necrosis factor -- implications for biological function. PubMed ID: 1964681

The structure of tumor necrosis factor-alpha at 2.6-A resolution. Implications for receptor binding. PubMed ID: 2551905

Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2. PubMed ID: 9488135

High resolution crystal structure of a human tumor necrosis factor-alpha mutant with low systemic toxicity. PubMed ID: 9442056