Gene TOP2B - ENSG00000077097 | NCBI Gene ID: 7155

Details for: TOP2B

Gene ID: 7155

Symbol: TOP2B

Ensembl ID: ENSG00000077097

Description: DNA topoisomerase II beta

Associated with

Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of dna replication proteins
(R-HSA-4615885)
Atp binding
(GO:0005524)
Axonogenesis
(GO:0007409)
B cell differentiation
(GO:0030183)
Cellular response to atp
(GO:0071318)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular senescence
(GO:0090398)
Chromatin binding
(GO:0003682)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Dna topoisomerase type ii (double strand cut, atp-hydrolyzing) activity
(GO:0003918)
Dna topological change
(GO:0006265)
Forebrain development
(GO:0030900)
Heterochromatin
(GO:0000792)
Metal ion binding
(GO:0046872)
Neuron migration
(GO:0001764)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of double-strand break repair via nonhomologous end joining
(GO:2001034)
Positive regulation of single stranded viral rna replication via double stranded dna intermediate
(GO:0045870)
Protein binding
(GO:0005515)
Resolution of meiotic recombination intermediates
(GO:0000712)
Ribonucleoprotein complex
(GO:1990904)
Ribonucleoprotein complex binding
(GO:0043021)
Sister chromatid segregation
(GO:0000819)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: late pro-B cell (CL0002048)
Fold Change: 2.48
Marker Score: 2923.5
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.19
Marker Score: 22195
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 2.17
Marker Score: 2182
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.1
Marker Score: 1225
Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.08
Marker Score: 1800
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 2.06
Marker Score: 10787
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.04
Marker Score: 77290
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.88
Marker Score: 7889
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.87
Marker Score: 37265
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.86
Marker Score: 4088
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.84
Marker Score: 62167
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 1.83
Marker Score: 955
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 1.83
Marker Score: 6128.5
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.82
Marker Score: 4937
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.81
Marker Score: 27133
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.8
Marker Score: 66467.5
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.79
Marker Score: 16822.5
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.78
Marker Score: 13670
Cell Name: neuron (CL0000540)
Fold Change: 1.77
Marker Score: 7206
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.76
Marker Score: 513
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.75
Marker Score: 15352
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.73
Marker Score: 6692.5
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.73
Marker Score: 106377
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.72
Marker Score: 7186
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.71
Marker Score: 7109
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.71
Marker Score: 2065
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.71
Marker Score: 2059
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.68
Marker Score: 984
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.67
Marker Score: 498
Cell Name: stellate neuron (CL0000122)
Fold Change: 1.64
Marker Score: 8796
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.64
Marker Score: 2409
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.63
Marker Score: 34779
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.63
Marker Score: 15474
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.63
Marker Score: 1797
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.63
Marker Score: 2186.5
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.59
Marker Score: 3813
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.59
Marker Score: 13665
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.56
Marker Score: 3938
Cell Name: pro-B cell (CL0000826)
Fold Change: 1.56
Marker Score: 1505.5
Cell Name: granule cell (CL0000120)
Fold Change: 1.55
Marker Score: 11652
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.53
Marker Score: 858
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.5
Marker Score: 6927
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.49
Marker Score: 2103
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.49
Marker Score: 1719.5
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.47
Marker Score: 3948
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.44
Marker Score: 1511
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.44
Marker Score: 709
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.43
Marker Score: 973
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.42
Marker Score: 1355
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.41
Marker Score: 14573.5
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.4
Marker Score: 1695
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.4
Marker Score: 2160
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.37
Marker Score: 433
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 1.37
Marker Score: 794
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.37
Marker Score: 2629
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.36
Marker Score: 1924
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.36
Marker Score: 522
Cell Name: macroglial cell (CL0000126)
Fold Change: 1.35
Marker Score: 3113
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.34
Marker Score: 1425
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.34
Marker Score: 1433
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.33
Marker Score: 1436
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.33
Marker Score: 572
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.32
Marker Score: 883
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.31
Marker Score: 782
Cell Name: basal cell (CL0000646)
Fold Change: 1.3
Marker Score: 1682
Cell Name: melanocyte (CL0000148)
Fold Change: 1.3
Marker Score: 527
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.3
Marker Score: 1387.5
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 1.29
Marker Score: 445
Cell Name: ciliated cell (CL0000064)
Fold Change: 1.28
Marker Score: 4413
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.28
Marker Score: 28681
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.28
Marker Score: 1356
Cell Name: CNS interneuron (CL0000402)
Fold Change: 1.28
Marker Score: 614
Cell Name: astrocyte (CL0000127)
Fold Change: 1.27
Marker Score: 1099
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.27
Marker Score: 1124
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.26
Marker Score: 1419
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.26
Marker Score: 4678
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.26
Marker Score: 528
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.26
Marker Score: 1783.5
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.26
Marker Score: 300
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.25
Marker Score: 867.5
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.24
Marker Score: 955
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.23
Marker Score: 1161
Cell Name: podocyte (CL0000653)
Fold Change: 1.23
Marker Score: 454.5
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.21
Marker Score: 10526
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.2
Marker Score: 588
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 1.2
Marker Score: 590
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.2
Marker Score: 1247.5
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.2
Marker Score: 2727.5
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.2
Marker Score: 1098
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.19
Marker Score: 377
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.18
Marker Score: 259
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.18
Marker Score: 401.5
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.18
Marker Score: 441
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.16
Marker Score: 1434
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.16
Marker Score: 40032
Cell Name: endocrine cell (CL0000163)
Fold Change: 1.15
Marker Score: 596.5
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.15
Marker Score: 867
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 1.15
Marker Score: 1156
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.14
Marker Score: 4676
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.14
Marker Score: 12857

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**Key Characteristics:** 1. **Topoisomerase II beta:** TOP2B is a beta isoform of the topoisomerase II enzyme, which is a type II DNA topoisomerase. This enzyme has the ability to cut both strands of the double helix, creating a temporary single-strand break. 2. **DNA binding:** TOP2B binds to DNA, specifically to the major and minor grooves of the double helix, allowing it to regulate the topological state of the DNA. 3. **Isoform specificity:** TOP2B has been shown to be specific to certain cellular contexts, such as the late pro-B cell and vip GABAergic cortical interneuron, suggesting that it may play a unique role in these cell types. 4. **Regulation of gene expression:** TOP2B has been implicated in the regulation of gene expression, particularly in the context of DNA repair and transcription. **Pathways and Functions:** 1. **DNA replication and repair:** TOP2B plays a crucial role in DNA replication and repair by regulating the topological state of the DNA. It is involved in the resolution of meiotic recombination intermediates and the positive regulation of single-stranded viral RNA replication via a double-stranded DNA intermediate. 2. **Chromatin remodeling:** TOP2B has been shown to interact with chromatin remodeling complexes, suggesting that it may play a role in the regulation of chromatin structure and function. 3. **Transcriptional regulation:** TOP2B has been implicated in the regulation of transcription, particularly in the context of DNA repair and transcriptional regulation. 4. **Cell cycle regulation:** TOP2B is involved in the regulation of the cell cycle, particularly in the context of DNA replication and repair. **Clinical Significance:** 1. **Cancer:** TOP2B has been implicated in various types of cancer, including breast cancer, where it is overexpressed and associated with poor prognosis. 2. **Neurological disorders:** TOP2B has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it is thought to play a role in the regulation of gene expression and DNA repair. 3. **Immunological disorders:** TOP2B has been implicated in immunological disorders, such as autoimmune diseases, where it is thought to play a role in the regulation of gene expression and DNA repair. 4. **Gene therapy:** TOP2B has been identified as a potential target for gene therapy, particularly in the context of cancer and neurological disorders. In conclusion, the TOP2B gene is a complex and multifunctional gene that plays a critical role in various cellular processes, including DNA replication, repair, and transcription. Further research is needed to fully understand the mechanisms by which TOP2B regulates gene expression and DNA repair, and to explore its potential as a therapeutic target for various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

DNA topoisomerase 2-beta
Q59H80_HUMAN

Genular Protein ID: 571724218

Symbol: TOP2B_HUMAN

Name: DNA topoisomerase 2-beta

UniProtKB Accession Codes:

Q02880 Q13600 Q9UMG8 Q9UQP8

Database IDs:

Citations:

PubMed ID: 1333583

Title: Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24.

PubMed ID: 1333583

DOI: 10.1093/nar/20.21.5587

PubMed ID: 8383537

Title: Novel HeLa topoisomerase II is the II beta isoform: complete coding sequence and homology with other type II topoisomerases.

PubMed ID: 8383537

DOI: 10.1016/0167-4781(93)90215-y

PubMed ID: 2556712

Title: Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes.

PubMed ID: 2556712

DOI: 10.1073/pnas.86.23.9431

PubMed ID: 10095062

Title: Molecular cloning and characterization of the human topoisomerase IIalpha and IIbeta genes: evidence for isoform evolution through gene duplication.

PubMed ID: 10095062

DOI: 10.1016/s0167-4781(99)00020-2

PubMed ID: 2163884

Title: Isolation and characterization of a human cDNA clone encoding a novel DNA topoisomerase II homologue from HeLa cells.

PubMed ID: 2163884

DOI: 10.1016/0014-5793(90)81520-x

PubMed ID: 9168988

Title: Binding of wild-type p53 by topoisomerase II and overexpression of topoisomerase II in human hepatocellular carcinoma.

PubMed ID: 9168988

DOI: 10.1006/bbrc.1997.6539

PubMed ID: 8396237

Title: Human cells express two differentially spliced forms of topoisomerase II beta mRNA.

PubMed ID: 8396237

DOI: 10.1093/nar/21.16.3719

PubMed ID: 8299728

Title: Discrete localization of different DNA topoisomerases in HeLa and K562 cell nuclei and subnuclear fractions.

PubMed ID: 8299728

DOI: 10.1006/excr.1994.1046

PubMed ID: 9155056

Title: The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues.

PubMed ID: 9155056

DOI: 10.1038/bjc.1997.227

PubMed ID: 10684600

Title: Mutagenesis of E477 or K505 in the B' domain of human topoisomerase II beta increases the requirement for magnesium ions during strand passage.

PubMed ID: 10684600

DOI: 10.1021/bi991328b

PubMed ID: 12821127

Title: Identification of functional nuclear export sequences in human topoisomerase IIalpha and beta.

PubMed ID: 12821127

DOI: 10.1016/s0006-291x(03)01077-5

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17567603

Title: Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1.

PubMed ID: 17567603

DOI: 10.1093/nar/gkm434

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31409799

Title: Mutations in topoisomerase IIbeta result in a B cell immunodeficiency.

PubMed ID: 31409799

DOI: 10.1038/s41467-019-11570-6

PubMed ID: 34543352

Title: The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection.

PubMed ID: 34543352

DOI: 10.1371/journal.ppat.1009954

PubMed ID: 21778401

Title: Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide.

PubMed ID: 21778401

DOI: 10.1126/science.1204117

PubMed ID: 28343847

Title: Global developmental delay and intellectual disability associated with a de novo TOP2B mutation.

PubMed ID: 28343847

DOI: 10.1016/j.cca.2017.03.022

PubMed ID: 32128574

Title: Topoisomerase 2beta mutation impairs early B-cell development.

PubMed ID: 32128574

DOI: 10.1182/blood.2019003299

PubMed ID: 31953910

Title: A de novo TOP2B variant associated with global developmental delay and autism spectrum disorder.

PubMed ID: 31953910

DOI: 10.1002/mgg3.1145

PubMed ID: 33459963

Title: Inherited TOP2B Mutation: Possible Confirmation of Mutational Hotspots in the TOPRIM Domain.

PubMed ID: 33459963

DOI: 10.1007/s10875-020-00963-8

Sequence Information:

Length: 1626
Mass: 183267
Checksum: E60E9262CC68B05D
Sequence:

MAKSGGCGAG AGVGGGNGAL TWVTLFDQNN AAKKEESETA NKNDSSKKLS VERVYQKKTQ 
LEHILLRPDT YIGSVEPLTQ FMWVYDEDVG MNCREVTFVP GLYKIFDEIL VNAADNKQRD 
KNMTCIKVSI DPESNIISIW NNGKGIPVVE HKVEKVYVPA LIFGQLLTSS NYDDDEKKVT 
GGRNGYGAKL CNIFSTKFTV ETACKEYKHS FKQTWMNNMM KTSEAKIKHF DGEDYTCITF 
QPDLSKFKME KLDKDIVALM TRRAYDLAGS CRGVKVMFNG KKLPVNGFRS YVDLYVKDKL 
DETGVALKVI HELANERWDV CLTLSEKGFQ QISFVNSIAT TKGGRHVDYV VDQVVGKLIE 
VVKKKNKAGV SVKPFQVKNH IWVFINCLIE NPTFDSQTKE NMTLQPKSFG SKCQLSEKFF 
KAASNCGIVE SILNWVKFKA QTQLNKKCSS VKYSKIKGIP KLDDANDAGG KHSLECTLIL 
TEGDSAKSLA VSGLGVIGRD RYGVFPLRGK ILNVREASHK QIMENAEINN IIKIVGLQYK 
KSYDDAESLK TLRYGKIMIM TDQDQDGSHI KGLLINFIHH NWPSLLKHGF LEEFITPIVK 
ASKNKQELSF YSIPEFDEWK KHIENQKAWK IKYYKGLGTS TAKEAKEYFA DMERHRILFR 
YAGPEDDAAI TLAFSKKKID DRKEWLTNFM EDRRQRRLHG LPEQFLYGTA TKHLTYNDFI 
NKELILFSNS DNERSIPSLV DGFKPGQRKV LFTCFKRNDK REVKVAQLAG SVAEMSAYHH 
GEQALMMTIV NLAQNFVGSN NINLLQPIGQ FGTRLHGGKD AASPRYIFTM LSTLARLLFP 
AVDDNLLKFL YDDNQRVEPE WYIPIIPMVL INGAEGIGTG WACKLPNYDA REIVNNVRRM 
LDGLDPHPML PNYKNFKGTI QELGQNQYAV SGEIFVVDRN TVEITELPVR TWTQVYKEQV 
LEPMLNGTDK TPALISDYKE YHTDTTVKFV VKMTEEKLAQ AEAAGLHKVF KLQTTLTCNS 
MVLFDHMGCL KKYETVQDIL KEFFDLRLSY YGLRKEWLVG MLGAESTKLN NQARFILEKI 
QGKITIENRS KKDLIQMLVQ RGYESDPVKA WKEAQEKAAE EDETQNQHDD SSSDSGTPSG 
PDFNYILNMS LWSLTKEKVE ELIKQRDAKG REVNDLKRKS PSDLWKEDLA AFVEELDKVE 
SQEREDVLAG MSGKAIKGKV GKPKVKKLQL EETMPSPYGR RIIPEITAMK ADASKKLLKK 
KKGDLDTAAV KVEFDEEFSG APVEGAGEEA LTPSVPINKG PKPKREKKEP GTRVRKTPTS 
SGKPSAKKVK KRNPWSDDES KSESDLEETE PVVIPRDSLL RRAAAERPKY TFDFSEEEDD 
DADDDDDDNN DLEELKVKAS PITNDGEDEF VPSDGLDKDE YTFSPGKSKA TPEKSLHDKK 
SQDFGNLFSF PSYSQKSEDD SAKFDSNEED SASVFSPSFG LKQTDKVPSK TVAAKKGKPS 
SDTVPKPKRA PKQKKVVEAV NSDSDSEFGI PKKTTTPKGK GRGAKKRKAS GSENEGDYNP 
GRKTSKTTSK KPKKTSFDQD SDVDIFPSDF PTEPPSLPRT GRARKEVKYF AESDEEEDDV 
DFAMFN

Genular Protein ID: 3157487992

Symbol: Q59H80_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59H80

Database IDs:

Sequence Information:

Length: 1009
Mass: 114006
Checksum: 6E69FB71236E0D4D
Sequence:

RMEKHIENQK AWKIKYYKGL GTSTAKEAKE YFADMERHRI LFRYAGPEDD AAITLAFSKK 
KIDDRKEWLT NFMEDRRQRR LHGLPEQFLY GTATKHLTYN DFINKELILF SNSDNERSIP 
SLVDGFKPGQ RKVLFTCFKR NDKREVKVAQ LAGSVAEMSA YHHGEQALMM TIVNLAQNFV 
GSNNINLLQP IGQFGTRLHG GKDAASPRYI FTMLSTLARL LFPAVDDNLL KFLYDDNQRV 
EPEWYIPIIP MVLINGAEGI GTGWACKLPN YDAREIVNNV RRMLDGLDPH PMLPNYKNFK 
GTIQELGQNQ YAVSGEIFVV DRNTVEITEL PVRTWTQVYK EQVLEPMLNG TDKTPALISD 
YKEYHTDTTV KFVVKMTEEK LAQAEAAGLH KVFKLQTTLT CNSMVLFDHM GCLKKYETVQ 
DILKEFFDLR LSYYGLRKEW LVGMLGAEST KLNNQARFIL EKIQGKITIE NRSKKDLIQM 
LVQRGYESDP VKAWKEAQEK AAEEDETQNQ HDDSSSDSGT PSGPDFNYIL NMSLWSLTKE 
KVEELIKQRD AKGREVNDLK RKSPSDLWKE DLAAFVEELD KVESQEREDV LAGMSGKAIK 
GKVGKPKVKK LQLEETMPSP YGRRIIPEIT AMKADASKKL LKKKKGDLDT AAVKVEFDEE 
FSGAPVEGAG EEALTPSVPI NKGPKPKREK KEPGTRVRKT PTSSGKPSAK KVKKRNPWSD 
DESKSESDLE ETEPVVIPRD SLLRRAAAER PKYTFDFSEE EDDDADDDDD DNNDLEELKV 
KASPITNDGE DEFVPSDGLD KDEYTFSPGK SKATPEKSLH DKKSQDFGNL FSFPSYSQKS 
EDDSAKFDSN EEDSASVFSP SFGLKQTDKV PSKTVAAKKG KPSSDTVPKP KRAPKQKKVV 
EAVNSDSDSE FGIPKKTTTP KGKGRGAKKR KASGSENEGD YNPGRKTSKT TSKKPKKTSF 
DQDSDVDIFP SDFPTEPPSL PRTGRARKEV KYFAESDEEE DDVDFAMFN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: TOP2B

Associated with

Cells (max top 100)

Other Information

Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24. PubMed ID: 1333583

Novel HeLa topoisomerase II is the II beta isoform: complete coding sequence and homology with other type II topoisomerases. PubMed ID: 8383537

Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes. PubMed ID: 2556712

Molecular cloning and characterization of the human topoisomerase IIalpha and IIbeta genes: evidence for isoform evolution through gene duplication. PubMed ID: 10095062

Isolation and characterization of a human cDNA clone encoding a novel DNA topoisomerase II homologue from HeLa cells. PubMed ID: 2163884

Binding of wild-type p53 by topoisomerase II and overexpression of topoisomerase II in human hepatocellular carcinoma. PubMed ID: 9168988

Human cells express two differentially spliced forms of topoisomerase II beta mRNA. PubMed ID: 8396237

Discrete localization of different DNA topoisomerases in HeLa and K562 cell nuclei and subnuclear fractions. PubMed ID: 8299728

The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues. PubMed ID: 9155056

Mutagenesis of E477 or K505 in the B' domain of human topoisomerase II beta increases the requirement for magnesium ions during strand passage. PubMed ID: 10684600

Identification of functional nuclear export sequences in human topoisomerase IIalpha and beta. PubMed ID: 12821127

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line. PubMed ID: 17487921

Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1. PubMed ID: 17567603

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. PubMed ID: 19367720

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Mutations in topoisomerase IIbeta result in a B cell immunodeficiency. PubMed ID: 31409799

The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection. PubMed ID: 34543352

Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide. PubMed ID: 21778401

Global developmental delay and intellectual disability associated with a de novo TOP2B mutation. PubMed ID: 28343847

Topoisomerase 2beta mutation impairs early B-cell development. PubMed ID: 32128574

A de novo TOP2B variant associated with global developmental delay and autism spectrum disorder. PubMed ID: 31953910

Inherited TOP2B Mutation: Possible Confirmation of Mutational Hotspots in the TOPRIM Domain. PubMed ID: 33459963