Details for: TP53BP1

Gene ID: 7158

Symbol: TP53BP1

Ensembl ID: ENSG00000067369

Description: tumor protein p53 binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 280.2400
    Cell Significance Index: -43.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 163.2607
    Cell Significance Index: -41.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 87.0631
    Cell Significance Index: -35.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.9838
    Cell Significance Index: -35.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.5731
    Cell Significance Index: -43.8600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.8314
    Cell Significance Index: -42.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.2064
    Cell Significance Index: -34.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.1631
    Cell Significance Index: -44.0500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 11.1351
    Cell Significance Index: 183.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.0430
    Cell Significance Index: -21.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0211
    Cell Significance Index: 405.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.7420
    Cell Significance Index: 1204.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4527
    Cell Significance Index: 521.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1671
    Cell Significance Index: 231.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0173
    Cell Significance Index: 57.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9742
    Cell Significance Index: 105.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9417
    Cell Significance Index: 153.1700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8096
    Cell Significance Index: 17.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8040
    Cell Significance Index: 61.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7919
    Cell Significance Index: 53.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7738
    Cell Significance Index: 46.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7691
    Cell Significance Index: 34.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7583
    Cell Significance Index: 33.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7106
    Cell Significance Index: 26.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6325
    Cell Significance Index: 8.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5325
    Cell Significance Index: 95.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5005
    Cell Significance Index: 273.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4537
    Cell Significance Index: 62.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4422
    Cell Significance Index: 8.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4288
    Cell Significance Index: 29.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4245
    Cell Significance Index: 52.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3931
    Cell Significance Index: 11.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3669
    Cell Significance Index: 19.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3494
    Cell Significance Index: 4.1700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2628
    Cell Significance Index: 3.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2443
    Cell Significance Index: 15.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2441
    Cell Significance Index: 12.6800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2381
    Cell Significance Index: 4.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2301
    Cell Significance Index: 6.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2080
    Cell Significance Index: 391.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1889
    Cell Significance Index: 5.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1770
    Cell Significance Index: 112.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1260
    Cell Significance Index: 55.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1218
    Cell Significance Index: 187.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1110
    Cell Significance Index: 204.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0946
    Cell Significance Index: 2.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0587
    Cell Significance Index: 79.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0547
    Cell Significance Index: 5.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0480
    Cell Significance Index: 2.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0396
    Cell Significance Index: 1.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0323
    Cell Significance Index: 14.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0303
    Cell Significance Index: 3.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0160
    Cell Significance Index: 14.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0005
    Cell Significance Index: 0.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0052
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0209
    Cell Significance Index: -15.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0242
    Cell Significance Index: -3.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0244
    Cell Significance Index: -17.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0320
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0331
    Cell Significance Index: -20.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0433
    Cell Significance Index: -7.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0493
    Cell Significance Index: -27.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0530
    Cell Significance Index: -40.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0600
    Cell Significance Index: -7.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0727
    Cell Significance Index: -4.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1067
    Cell Significance Index: -22.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1298
    Cell Significance Index: -37.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1376
    Cell Significance Index: -14.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1466
    Cell Significance Index: -17.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1470
    Cell Significance Index: -3.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1677
    Cell Significance Index: -21.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2176
    Cell Significance Index: -24.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2193
    Cell Significance Index: -10.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2260
    Cell Significance Index: -6.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2301
    Cell Significance Index: -4.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2862
    Cell Significance Index: -21.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2990
    Cell Significance Index: -8.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3023
    Cell Significance Index: -21.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3095
    Cell Significance Index: -16.2500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3129
    Cell Significance Index: -35.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3191
    Cell Significance Index: -6.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3200
    Cell Significance Index: -11.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3239
    Cell Significance Index: -6.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3352
    Cell Significance Index: -34.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3546
    Cell Significance Index: -10.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3994
    Cell Significance Index: -24.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4598
    Cell Significance Index: -11.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4642
    Cell Significance Index: -36.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5013
    Cell Significance Index: -8.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5288
    Cell Significance Index: -32.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5334
    Cell Significance Index: -14.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5649
    Cell Significance Index: -8.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5911
    Cell Significance Index: -8.4700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5997
    Cell Significance Index: -8.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6129
    Cell Significance Index: -14.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6197
    Cell Significance Index: -20.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6239
    Cell Significance Index: -16.6900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6276
    Cell Significance Index: -12.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6547
    Cell Significance Index: -20.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6822
    Cell Significance Index: -14.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Interactions with p53:** TP53BP1 binds to p53, modulating its activity and influencing its ability to regulate cell cycle arrest, DNA repair, and apoptosis. 2. **DNA damage response:** TP53BP1 participates in the DNA damage response, working in conjunction with other proteins to repair DNA double-strand breaks and maintain genome stability. 3. **Cell cycle regulation:** TP53BP1 helps regulate the cell cycle, ensuring that damaged cells undergo apoptosis or repair mechanisms rather than continue to proliferate. 4. **Histone modification:** TP53BP1 interacts with histones, influencing chromatin organization and gene expression. 5. **Neurological specificity:** TP53BP1 is highly expressed in GABAergic cortical interneurons, suggesting a role in maintaining neuronal function and integrity. **Pathways and Functions:** 1. **DNA damage response:** TP53BP1 is involved in the repair of DNA double-strand breaks via classical nonhomologous end joining and homology-directed repair. 2. **Cell cycle checkpoints:** TP53BP1 helps regulate the cell cycle, ensuring that damaged cells undergo apoptosis or repair mechanisms. 3. **Histone modification:** TP53BP1 interacts with histones, influencing chromatin organization and gene expression. 4. **Apoptosis regulation:** TP53BP1 modulates apoptosis, allowing for the elimination of damaged cells. 5. **Transcriptional regulation:** TP53BP1 influences transcriptional activity, regulating the expression of genes involved in DNA repair and cell cycle regulation. **Clinical Significance:** 1. **Cancer:** TP53BP1 dysregulation has been implicated in various cancers, including breast, lung, and colon cancer, where it may contribute to tumorigenesis and cancer progression. 2. **Neurological disorders:** TP53BP1 has been associated with neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, where it may play a role in maintaining neuronal function and integrity. 3. **Genome instability:** TP53BP1 dysregulation may contribute to genome instability, increasing the risk of cancer and other diseases. 4. **Therapeutic targeting:** TP53BP1 may serve as a therapeutic target for cancer and neurological disorders, particularly in combination with other treatments. In conclusion, TP53BP1 is a critical regulator of genome stability, interacting with p53 and influencing various cellular processes. Its dysregulation has been implicated in various diseases, including cancer and neurological disorders. Further research is needed to fully understand the role of TP53BP1 in maintaining genome stability and its therapeutic potential.

Genular Protein ID: 58511089

Symbol: TP53B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9748285

Title: Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2.

PubMed ID: 9748285

DOI: 10.1074/jbc.273.40.26061

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8016121

Title: Two cellular proteins that bind to wild-type but not mutant p53.

PubMed ID: 8016121

DOI: 10.1073/pnas.91.13.6098

PubMed ID: 11042216

Title: Negative cell cycle regulation and DNA-damage inducible phosphorylation of the BRCT protein 53BP1.

PubMed ID: 11042216

DOI: 10.1074/jbc.m007665200

PubMed ID: 11331310

Title: Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways.

PubMed ID: 11331310

DOI: 10.1083/jcb.153.3.613

PubMed ID: 12364621

Title: 53BP1, a mediator of the DNA damage checkpoint.

PubMed ID: 12364621

DOI: 10.1126/science.1076182

PubMed ID: 12824158

Title: Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA.

PubMed ID: 12824158

DOI: 10.1074/jbc.m304066200

PubMed ID: 12607005

Title: MDC1 is a mediator of the mammalian DNA damage checkpoint.

PubMed ID: 12607005

DOI: 10.1038/nature01446

PubMed ID: 15492236

Title: p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder.

PubMed ID: 15492236

DOI: 10.1158/0008-5472.can-04-2005

PubMed ID: 15574327

Title: A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

PubMed ID: 15574327

DOI: 10.1016/j.molcel.2004.10.029

PubMed ID: 16294045

Title: The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity.

PubMed ID: 16294045

DOI: 10.4161/cc.4.12.2250

PubMed ID: 16294047

Title: 53BP1 oligomerization is independent of its methylation by PRMT1.

PubMed ID: 16294047

DOI: 10.4161/cc.4.12.2282

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17553757

Title: Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR.

PubMed ID: 17553757

DOI: 10.1016/j.dnarep.2007.04.011

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19176521

Title: Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage.

PubMed ID: 19176521

DOI: 10.1074/jbc.m809272200

PubMed ID: 19656881

Title: Functional interaction between Epstein-Barr virus replication protein Zta and host DNA damage response protein 53BP1.

PubMed ID: 19656881

DOI: 10.1128/jvi.00512-09

PubMed ID: 19650074

Title: p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage.

PubMed ID: 19650074

DOI: 10.1002/jcp.21889

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20347427

Title: Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1.

PubMed ID: 20347427

DOI: 10.1016/j.molcel.2009.12.040

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21144835

Title: Protein phosphatase 5 is necessary for ATR-mediated DNA repair.

PubMed ID: 21144835

DOI: 10.1016/j.bbrc.2010.12.005

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22553214

Title: BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair.

PubMed ID: 22553214

DOI: 10.1242/jcs.105353

PubMed ID: 23727112

Title: 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

PubMed ID: 23727112

DOI: 10.1016/j.cell.2013.05.023

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23333306

Title: A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.

PubMed ID: 23333306

DOI: 10.1016/j.molcel.2013.01.001

PubMed ID: 23760478

Title: 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.

PubMed ID: 23760478

DOI: 10.1038/nature12318

PubMed ID: 23874665

Title: Msl2 is a novel component of the vertebrate DNA damage response.

PubMed ID: 23874665

DOI: 10.1371/journal.pone.0068549

PubMed ID: 23345425

Title: Role of 53BP1 oligomerization in regulating double-strand break repair.

PubMed ID: 23345425

DOI: 10.1073/pnas.1222617110

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24703952

Title: Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks.

PubMed ID: 24703952

DOI: 10.1016/j.molcel.2014.03.020

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 27153538

Title: The TIP60 complex regulates bivalent chromatin recognition by 53BP1 through direct H4K20me binding and H2AK15 acetylation.

PubMed ID: 27153538

DOI: 10.1016/j.molcel.2016.03.031

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28241136

Title: TIRR regulates 53BP1 by masking its histone methyl-lysine binding function.

PubMed ID: 28241136

DOI: 10.1038/nature21358

PubMed ID: 29789392

Title: FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells.

PubMed ID: 29789392

DOI: 10.15252/embj.201899543

PubMed ID: 29651020

Title: GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1.

PubMed ID: 29651020

DOI: 10.1038/s41467-018-03817-5

PubMed ID: 31527692

Title: VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes.

PubMed ID: 31527692

DOI: 10.1038/s41598-019-49821-7

PubMed ID: 37696958

Title: Dynamics of the DYNLL1-MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs.

PubMed ID: 37696958

DOI: 10.1038/s41594-023-01074-9

PubMed ID: 12110597

Title: Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor.

PubMed ID: 12110597

DOI: 10.1093/emboj/cdf383

PubMed ID: 11877378

Title: Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.

PubMed ID: 11877378

DOI: 10.1101/gad.959202

PubMed ID: 15525939

Title: Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.

PubMed ID: 15525939

DOI: 10.1038/nature03114

PubMed ID: 17190600

Title: Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.

PubMed ID: 17190600

DOI: 10.1016/j.cell.2006.10.043

PubMed ID: 31135337

Title: Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.

PubMed ID: 31135337

DOI: 10.7554/elife.44353

Sequence Information:

  • Length: 1972
  • Mass: 213574
  • Checksum: 13E2CC8A265F9D2A
  • Sequence:
  • MDPTGSQLDS DFSQQDTPCL IIEDSQPESQ VLEDDSGSHF SMLSRHLPNL QTHKENPVLD 
    VVSNPEQTAG EERGDGNSGF NEHLKENKVA DPVDSSNLDT CGSISQVIEQ LPQPNRTSSV 
    LGMSVESAPA VEEEKGEELE QKEKEKEEDT SGNTTHSLGA EDTASSQLGF GVLELSQSQD 
    VEENTVPYEV DKEQLQSVTT NSGYTRLSDV DANTAIKHEE QSNEDIPIAE QSSKDIPVTA 
    QPSKDVHVVK EQNPPPARSE DMPFSPKASV AAMEAKEQLS AQELMESGLQ IQKSPEPEVL 
    STQEDLFDQS NKTVSSDGCS TPSREEGGCS LASTPATTLH LLQLSGQRSL VQDSLSTNSS 
    DLVAPSPDAF RSTPFIVPSS PTEQEGRQDK PMDTSVLSEE GGEPFQKKLQ SGEPVELENP 
    PLLPESTVSP QASTPISQST PVFPPGSLPI PSQPQFSHDI FIPSPSLEEQ SNDGKKDGDM 
    HSSSLTVECS KTSEIEPKNS PEDLGLSLTG DSCKLMLSTS EYSQSPKMES LSSHRIDEDG 
    ENTQIEDTEP MSPVLNSKFV PAENDSILMN PAQDGEVQLS QNDDKTKGDD TDTRDDISIL 
    ATGCKGREET VAEDVCIDLT CDSGSQAVPS PATRSEALSS VLDQEEAMEI KEHHPEEGSS 
    GSEVEEIPET PCESQGEELK EENMESVPLH LSLTETQSQG LCLQKEMPKK ECSEAMEVET 
    SVISIDSPQK LAILDQELEH KEQEAWEEAT SEDSSVVIVD VKEPSPRVDV SCEPLEGVEK 
    CSDSQSWEDI APEIEPCAEN RLDTKEEKSV EYEGDLKSGT AETEPVEQDS SQPSLPLVRA 
    DDPLRLDQEL QQPQTQEKTS NSLTEDSKMA NAKQLSSDAE AQKLGKPSAH ASQSFCESSS 
    ETPFHFTLPK EGDIIPPLTG ATPPLIGHLK LEPKRHSTPI GISNYPESTI ATSDVMSESM 
    VETHDPILGS GKGDSGAAPD VDDKLCLRMK LVSPETEASE ESLQFNLEKP ATGERKNGST 
    AVAESVASPQ KTMSVLSCIC EARQENEARS EDPPTTPIRG NLLHFPSSQG EEEKEKLEGD 
    HTIRQSQQPM KPISPVKDPV SPASQKMVIQ GPSSPQGEAM VTDVLEDQKE GRSTNKENPS 
    KALIERPSQN NIGIQTMECS LRVPETVSAA TQTIKNVCEQ GTSTVDQNFG KQDATVQTER 
    GSGEKPVSAP GDDTESLHSQ GEEEFDMPQP PHGHVLHRHM RTIREVRTLV TRVITDVYYV 
    DGTEVERKVT EETEEPIVEC QECETEVSPS QTGGSSGDLG DISSFSSKAS SLHRTSSGTS 
    LSAMHSSGSS GKGAGPLRGK TSGTEPADFA LPSSRGGPGK LSPRKGVSQT GTPVCEEDGD 
    AGLGIRQGGK APVTPRGRGR RGRPPSRTTG TRETAVPGPL GIEDISPNLS PDDKSFSRVV 
    PRVPDSTRRT DVGAGALRRS DSPEIPFQAA AGPSDGLDAS SPGNSFVGLR VVAKWSSNGY 
    FYSGKITRDV GAGKYKLLFD DGYECDVLGK DILLCDPIPL DTEVTALSED EYFSAGVVKG 
    HRKESGELYY SIEKEGQRKW YKRMAVILSL EQGNRLREQY GLGPYEAVTP LTKAADISLD 
    NLVEGKRKRR SNVSSPATPT ASSSSSTTPT RKITESPRAS MGVLSGKRKL ITSEEERSPA 
    KRGRKSATVK PGAVGAGEFV SPCESGDNTG EPSALEEQRG PLPLNKTLFL GYAFLLTMAT 
    TSDKLASRSK LPDGPTGSSE EEEEFLEIPP FNKQYTESQL RAGAGYILED FNEAQCNTAY 
    QCLLIADQHC RTRKYFLCLA SGIPCVSHVW VHDSCHANQL QNYRNYLLPA GYSLEEQRIL 
    DWQPRENPFQ NLKVLLVSDQ QQNFLELWSE ILMTGGAASV KQHHSSAHNK DIALGVFDVV 
    VTDPSCPASV LKCAEALQLP VVSQEWVIQC LIVGERIGFK QHPKYKHDYV SH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.