Gene TRH - ENSG00000170893 | NCBI Gene ID: 7200

Details for: TRH

Gene ID: 7200

Symbol: TRH

Ensembl ID: ENSG00000170893

Description: thyrotropin releasing hormone

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Adult walking behavior
(GO:0007628)
Cell-cell signaling
(GO:0007267)
Eating behavior
(GO:0042755)
Extracellular region
(GO:0005576)
Histamine metabolic process
(GO:0001692)
Hormone-mediated signaling pathway
(GO:0009755)
Negative regulation of glutamate secretion
(GO:0014050)
Positive regulation of gamma-aminobutyric acid secretion
(GO:0014054)
Positive regulation of insulin secretion
(GO:0032024)
Protein binding
(GO:0005515)
Secretory granule
(GO:0030141)
Signal transduction
(GO:0007165)
Thyrotropin-releasing hormone activity
(GO:0008437)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 3.78
Marker Score: 19821
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 2.35
Marker Score: 3249.5
Cell Name: granule cell (CL0000120)
Fold Change: 2.1
Marker Score: 15859
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.49
Marker Score: 3021
Cell Name: macroglial cell (CL0000126)
Fold Change: 1.48
Marker Score: 3397
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.19
Marker Score: 2263
Cell Name: thymocyte (CL0000893)
Fold Change: 1.15
Marker Score: 1200
Cell Name: goblet cell (CL0000160)
Fold Change: 1.14
Marker Score: 7609
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.06
Marker Score: 2700
Cell Name: Mueller cell (CL0000636)
Fold Change: 1.04
Marker Score: 1439
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71832
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48057
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5351
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.88
Marker Score: 1789
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.85
Marker Score: 653
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.81
Marker Score: 12652
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1268
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 398
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.6
Marker Score: 215
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.59
Marker Score: 468
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.57
Marker Score: 238
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.57
Marker Score: 374
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.55
Marker Score: 515
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.54
Marker Score: 2207
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 0.53
Marker Score: 1788
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.53
Marker Score: 363
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.53
Marker Score: 259
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.51
Marker Score: 308
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.49
Marker Score: 963.5
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.43
Marker Score: 515
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.42
Marker Score: 201
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.39
Marker Score: 103
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.39
Marker Score: 405
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.38
Marker Score: 186
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 377
Cell Name: stellate neuron (CL0000122)
Fold Change: 0.36
Marker Score: 1921
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.33
Marker Score: 109
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.33
Marker Score: 186.5
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.31
Marker Score: 494
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.3
Marker Score: 193
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.3
Marker Score: 132
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.28
Marker Score: 1020
Cell Name: pre-conventional dendritic cell (CL0002010)
Fold Change: 0.27
Marker Score: 79
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.27
Marker Score: 8985
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.26
Marker Score: 2614
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.25
Marker Score: 626.5
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.25
Marker Score: 254
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.25
Marker Score: 88
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.24
Marker Score: 945
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.24
Marker Score: 2142
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 0.24
Marker Score: 179
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.23
Marker Score: 220
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.21
Marker Score: 604
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.21
Marker Score: 138
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 0.2
Marker Score: 84
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 0.2
Marker Score: 56
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.19
Marker Score: 577
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.18
Marker Score: 224.5
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.16
Marker Score: 83
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.16
Marker Score: 121
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.16
Marker Score: 77
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.15
Marker Score: 38
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.15
Marker Score: 427
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.15
Marker Score: 89
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.14
Marker Score: 138
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.13
Marker Score: 71
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.13
Marker Score: 378
Cell Name: male germ cell (CL0000015)
Fold Change: 0.13
Marker Score: 38
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.12
Marker Score: 47
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.12
Marker Score: 250
Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
Fold Change: 0.12
Marker Score: 33
Cell Name: germ cell (CL0000586)
Fold Change: 0.12
Marker Score: 205
Cell Name: astrocyte (CL0000127)
Fold Change: 0.12
Marker Score: 100
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.11
Marker Score: 81
Cell Name: glial cell (CL0000125)
Fold Change: 0.11
Marker Score: 122
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.11
Marker Score: 231
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.11
Marker Score: 295
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.11
Marker Score: 276
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.11
Marker Score: 31
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.1
Marker Score: 111
Cell Name: promonocyte (CL0000559)
Fold Change: 0.1
Marker Score: 66
Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.1
Marker Score: 82
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.1
Marker Score: 41
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.1
Marker Score: 22
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.1
Marker Score: 33
Cell Name: stromal cell (CL0000499)
Fold Change: 0.09
Marker Score: 111
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.09
Marker Score: 32
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.09
Marker Score: 46
Cell Name: neural cell (CL0002319)
Fold Change: 0.09
Marker Score: 44
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.09
Marker Score: 59
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.09
Marker Score: 64.5
Cell Name: neuron (CL0000540)
Fold Change: 0.09
Marker Score: 349
Cell Name: ganglion interneuron (CL0000397)
Fold Change: 0.09
Marker Score: 26
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.08
Marker Score: 40
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.08
Marker Score: 71.5

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**Key characteristics:** * TRH is a glycoprotein that is expressed in the thyroid gland and certain other cells. * It is a member of the G protein-coupled receptor (GPCR) superfamily. * TRH is a ligand for the G protein-coupled receptor for thyrotropin (TRH-R). * TRH-R is expressed in neurons and other cells throughout the body. **Pathways and functions:** * TRH binds to its receptor, TRH-R, on the surface of target cells. * This binding activates the TRH-R, which in turn activates the G protein. * The G protein activates the enzyme adenylate cyclase, which converts cyclic AMP (cAMP) to cyclic GMP (cGMP). * cGMP acts on the guanylyl cyclase enzyme, which increases the production of cyclic GMP (cGMP). * cGMP binds to its target proteins, which leads to the activation of downstream signaling pathways. **Clinical significance:** * Mutations in the TRH gene have been linked to a number of endocrine disorders, including hyperthyroidism, hypothyroidism, and cretinism. * TRH is also a therapeutic target for thyroid cancer. * The development of drugs that target TRH signaling has led to the development of new treatments for thyroid disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Pro-thyrotropin-releasing hormone

Genular Protein ID: 71059553

Symbol: TRH_HUMAN

Name: Pro-thyrotropin-releasing hormone

UniProtKB Accession Codes:

P20396 B2R8R1 Q2TB83

Database IDs:

Citations:

PubMed ID: 2126343

Title: Cloning and structure of human genomic DNA and hypothalamic cDNA encoding human prepro thyrotropin-releasing hormone.

PubMed ID: 2126343

DOI: 10.1210/mend-4-4-551

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19825978

Title: Thyrotropin releasing hormone (TRH): a new player in human hair-growth control.

PubMed ID: 19825978

DOI: 10.1096/fj.08-126417

Sequence Information:

Length: 242
Mass: 27404
Checksum: 8C0F9D915B32F29F
Sequence:

MPGPWLLLAL ALTLNLTGVP GGRAQPEAAQ QEAVTAAEHP GLDDFLRQVE RLLFLRENIQ 
RLQGDQGEHS ASQIFQSDWL SKRQHPGKRE EEEEEGVEEE EEEEGGAVGP HKRQHPGRRE 
DEASWSVDVT QHKRQHPGRR SPWLAYAVPK RQHPGRRLAD PKAQRSWEEE EEEEEREEDL 
MPEKRQHPGK RALGGPCGPQ GAYGQAGLLL GLLDDLSRSQ GAEEKRQHPG RRAAWVREPL 
EE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: TRH

Associated with

Cells (max top 100)

Other Information

Cloning and structure of human genomic DNA and hypothalamic cDNA encoding human prepro thyrotropin-releasing hormone. PubMed ID: 2126343

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Thyrotropin releasing hormone (TRH): a new player in human hair-growth control. PubMed ID: 19825978

Database document:

PubMed ID: 2126343

PubMed ID: 14702039

PubMed ID: 15489334

PubMed ID: 19825978