Details for: TUBG1

Gene ID: 7283

Symbol: TUBG1

Ensembl ID: ENSG00000131462

Description: tubulin gamma 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 64.4606
    Cell Significance Index: -16.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 36.7747
    Cell Significance Index: -14.9400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.7267
    Cell Significance Index: -15.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.7012
    Cell Significance Index: -15.6600
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 10.8365
    Cell Significance Index: 4.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.2527
    Cell Significance Index: -16.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6223
    Cell Significance Index: -18.2400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.6825
    Cell Significance Index: 20.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8865
    Cell Significance Index: 359.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0801
    Cell Significance Index: 106.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0391
    Cell Significance Index: 121.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8384
    Cell Significance Index: 43.5500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8223
    Cell Significance Index: 8.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.7759
    Cell Significance Index: 12.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7190
    Cell Significance Index: 9.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7013
    Cell Significance Index: 76.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6168
    Cell Significance Index: 21.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6039
    Cell Significance Index: 98.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5595
    Cell Significance Index: 65.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5059
    Cell Significance Index: 456.7500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4853
    Cell Significance Index: 3.8800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4691
    Cell Significance Index: 3.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4161
    Cell Significance Index: 51.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3781
    Cell Significance Index: 206.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3576
    Cell Significance Index: 70.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3564
    Cell Significance Index: 64.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3329
    Cell Significance Index: 8.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3287
    Cell Significance Index: 6.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2904
    Cell Significance Index: 20.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2894
    Cell Significance Index: 127.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2599
    Cell Significance Index: 12.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2476
    Cell Significance Index: 13.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2408
    Cell Significance Index: 17.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2263
    Cell Significance Index: 5.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2195
    Cell Significance Index: 7.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1986
    Cell Significance Index: 14.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1945
    Cell Significance Index: 5.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1879
    Cell Significance Index: 4.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1768
    Cell Significance Index: 5.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1663
    Cell Significance Index: 7.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1640
    Cell Significance Index: 32.8900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.1293
    Cell Significance Index: 0.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1071
    Cell Significance Index: 2.8600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1039
    Cell Significance Index: 1.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1025
    Cell Significance Index: 14.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1004
    Cell Significance Index: 17.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0919
    Cell Significance Index: 4.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0781
    Cell Significance Index: 4.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0729
    Cell Significance Index: 1.9900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0695
    Cell Significance Index: 2.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0605
    Cell Significance Index: 1.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0526
    Cell Significance Index: 6.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0426
    Cell Significance Index: 5.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0377
    Cell Significance Index: 13.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0261
    Cell Significance Index: 0.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0023
    Cell Significance Index: 0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0004
    Cell Significance Index: 0.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0021
    Cell Significance Index: -1.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0031
    Cell Significance Index: -5.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0053
    Cell Significance Index: -0.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0064
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0095
    Cell Significance Index: -5.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0096
    Cell Significance Index: -14.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0121
    Cell Significance Index: -8.8600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0140
    Cell Significance Index: -0.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0145
    Cell Significance Index: -19.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0147
    Cell Significance Index: -9.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0171
    Cell Significance Index: -9.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0236
    Cell Significance Index: -2.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0295
    Cell Significance Index: -13.3700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0317
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0354
    Cell Significance Index: -7.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0378
    Cell Significance Index: -4.3300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0471
    Cell Significance Index: -0.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0521
    Cell Significance Index: -14.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0586
    Cell Significance Index: -2.0600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0711
    Cell Significance Index: -1.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0934
    Cell Significance Index: -13.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1120
    Cell Significance Index: -1.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1185
    Cell Significance Index: -3.1700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1214
    Cell Significance Index: -0.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1327
    Cell Significance Index: -6.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1638
    Cell Significance Index: -12.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1647
    Cell Significance Index: -10.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1705
    Cell Significance Index: -10.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1707
    Cell Significance Index: -9.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1710
    Cell Significance Index: -17.8000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1721
    Cell Significance Index: -1.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1765
    Cell Significance Index: -13.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1849
    Cell Significance Index: -12.4300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2811
    Cell Significance Index: -3.6000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3109
    Cell Significance Index: -3.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3291
    Cell Significance Index: -8.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3522
    Cell Significance Index: -10.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3601
    Cell Significance Index: -15.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3663
    Cell Significance Index: -10.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3817
    Cell Significance Index: -5.7200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3856
    Cell Significance Index: -9.6300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3895
    Cell Significance Index: -8.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TUBG1 is a gene that encodes a gamma subunit of tubulin, which is a key component of microtubules. The gamma subunit is essential for the assembly and disassembly of microtubules, and it interacts with other tubulin subunits to form the microtubule lattice. TUBG1 is a highly conserved gene, with high sequence similarity across species. The protein product of TUBG1, Gamma-1-tubulin, is a small, acidic protein that is highly abundant in cells. **Pathways and Functions** TUBG1 is involved in various cellular pathways, including: 1. **Cell cycle regulation**: TUBG1 is involved in the regulation of the cell cycle, particularly during the G2/M phase. It interacts with other proteins to form the gamma-tubulin complex, which is essential for the formation of the mitotic spindle. 2. **Centrosome maturation**: TUBG1 is involved in the maturation of the centrosome, which is the primary microtubule organizing center in cells. It interacts with other proteins to form the pericentriolar material, which is essential for the formation of the centrosome. 3. **Microtubule nucleation**: TUBG1 is involved in the nucleation of microtubules, which is the process of forming new microtubules from the centrosome. 4. **Ciliary assembly**: TUBG1 is involved in the assembly of cilia, which are microtubule-based structures that protrude from the cell surface. 5. **Mitotic spindle organization**: TUBG1 is involved in the organization of the mitotic spindle, which is the structure that separates chromosomes during cell division. **Clinical Significance** TUBG1 has been implicated in various diseases, including: 1. **Cancer**: TUBG1 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer. 2. **Neurological disorders**: TUBG1 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Ciliopathies**: TUBG1 has been shown to be mutated in certain ciliopathies, which are a group of disorders that affect the function of cilia. 4. **Reproductive disorders**: TUBG1 has been implicated in various reproductive disorders, including infertility and miscarriage. In summary, TUBG1 is a gene that plays a critical role in various cellular processes, including cell cycle regulation, centrosome maturation, and microtubule nucleation. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and ciliopathies. Further research is needed to fully understand the role of TUBG1 in human disease.

Genular Protein ID: 1576077157

Symbol: TBG1_HUMAN

Name: Gamma-1-tubulin

UniProtKB Accession Codes:

P23258 Q53X79 Q9BW59

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 EMDB 24 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 26 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1904010

Title: Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome.

PubMed ID: 1904010

DOI: 10.1016/0092-8674(91)90389-g

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 9566967

Title: The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p.

PubMed ID: 9566967

DOI: 10.1083/jcb.141.3.663

PubMed ID: 9566969

Title: Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin.

PubMed ID: 9566969

DOI: 10.1083/jcb.141.3.689

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17959831

Title: CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex.

PubMed ID: 17959831

DOI: 10.1091/mbc.e07-04-0371

PubMed ID: 20643351

Title: Pitchfork regulates primary cilia disassembly and left-right asymmetry.

PubMed ID: 20643351

DOI: 10.1016/j.devcel.2010.06.005

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24107630

Title: Nucleoporin Nup62 maintains centrosome homeostasis.

PubMed ID: 24107630

DOI: 10.4161/cc.26671

PubMed ID: 30723163

Title: The microtubule-associated protein EML3 regulates mitotic spindle assembly by recruiting the Augmin complex to spindle microtubules.

PubMed ID: 30723163

DOI: 10.1074/jbc.ra118.007164

PubMed ID: 23603762

Title: Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.

PubMed ID: 23603762

DOI: 10.1038/ng.2613

Sequence Information:

  • Length: 451
  • Mass: 51170
  • Checksum: E2A4C0179ED0CFE8
  • Sequence:
    • MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV FFYQADDEHY 
IPRAVLLDLE PRVIHSILNS PYAKLYNPEN IYLSEHGGGA GNNWASGFSQ GEKIHEDIFD 
IIDREADGSD SLEGFVLCHS IAGGTGSGLG SYLLERLNDR YPKKLVQTYS VFPNQDEMSD 
VVVQPYNSLL TLKRLTQNAD CVVVLDNTAL NRIATDRLHI QNPSFSQINQ LVSTIMSAST 
TTLRYPGYMN NDLIGLIASL IPTPRLHFLM TGYTPLTTDQ SVASVRKTTV LDVMRRLLQP 
KNVMVSTGRD RQTNHCYIAI LNIIQGEVDP TQVHKSLQRI RERKLANFIP WGPASIQVAL 
SRKSPYLPSA HRVSGLMMAN HTSISSLFER TCRQYDKLRK REAFLEQFRK EDMFKDNFDE 
MDTSREIVQQ LIDEYHAATR PDYISWGTQE Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.