TYK2 | ENSG00000105397 | NCBI 7297

Details for: TYK2

Gene ID: 7297

Symbol: TYK2

Ensembl ID: ENSG00000105397

Description: tyrosine kinase 2

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Evasion by rsv of host interferon responses
(R-HSA-9833109)
Il-6-type cytokine receptor ligand interactions
(R-HSA-6788467)
Immune system
(R-HSA-168256)
Inactivation of csf3 (g-csf) signaling
(R-HSA-9705462)
Infectious disease
(R-HSA-5663205)
Interferon alpha/beta signaling
(R-HSA-909733)
Interferon signaling
(R-HSA-913531)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-6 family signaling
(R-HSA-6783589)
Interleukin-6 signaling
(R-HSA-1059683)
Interleukin-10 signaling
(R-HSA-6783783)
Interleukin-12 family signaling
(R-HSA-447115)
Interleukin-12 signaling
(R-HSA-9020591)
Interleukin-20 family signaling
(R-HSA-8854691)
Interleukin-23 signaling
(R-HSA-9020933)
Interleukin-27 signaling
(R-HSA-9020956)
Interleukin-35 signalling
(R-HSA-8984722)
Mapk1 (erk2) activation
(R-HSA-112411)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk3 (erk1) activation
(R-HSA-110056)
Mapk family signaling cascades
(R-HSA-5683057)
Other interleukin signaling
(R-HSA-449836)
Potential therapeutics for sars
(R-HSA-9679191)
Raf-independent mapk1/3 activation
(R-HSA-112409)
Regulation of ifna/ifnb signaling
(R-HSA-912694)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rsv-host interactions
(R-HSA-9833110)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by csf3 (g-csf)
(R-HSA-9674555)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Cell differentiation
(GO:0030154)
Cell surface receptor signaling pathway via jak-stat
(GO:0007259)
Cellular response to virus
(GO:0098586)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytoplasm
(GO:0005737)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Extrinsic component of cytoplasmic side of plasma membrane
(GO:0031234)
Extrinsic component of plasma membrane
(GO:0019897)
Growth hormone receptor binding
(GO:0005131)
Growth hormone receptor signaling pathway via jak-stat
(GO:0060397)
Immune response
(GO:0006955)
Interleukin-10-mediated signaling pathway
(GO:0140105)
Interleukin-12 receptor complex
(GO:0042022)
Interleukin-12-mediated signaling pathway
(GO:0035722)
Interleukin-23 receptor complex
(GO:0072536)
Interleukin-23-mediated signaling pathway
(GO:0038155)
Intracellular signal transduction
(GO:0035556)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of natural killer cell proliferation
(GO:0032819)
Positive regulation of nk t cell proliferation
(GO:0051142)
Positive regulation of protein localization to nucleus
(GO:1900182)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Positive regulation of t-helper 17 type immune response
(GO:2000318)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of type ii interferon production
(GO:0032729)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Type 1 angiotensin receptor binding
(GO:0031702)
Type iii interferon-mediated signaling pathway
(GO:0038196)
Type ii interferon-mediated signaling pathway
(GO:0060333)
Type i interferon-mediated signaling pathway
(GO:0060337)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 101.7710
Cell Significance Index: -15.8300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 64.2832
Cell Significance Index: -16.3100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 40.7501
Cell Significance Index: -16.5600
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 40.7091
Cell Significance Index: -16.7700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 35.7563
Cell Significance Index: -18.3900
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 17.3450
Cell Significance Index: -16.5600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 14.0394
Cell Significance Index: -17.3100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.4654
Cell Significance Index: -17.3200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.1832
Cell Significance Index: -15.9200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.4830
Cell Significance Index: -17.6900
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.9752
Cell Significance Index: -8.7000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.3904
Cell Significance Index: 137.5400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.2118
Cell Significance Index: 197.0800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1357
Cell Significance Index: 1025.4500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.7412
Cell Significance Index: 13.7000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6096
Cell Significance Index: 36.6000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5958
Cell Significance Index: 16.6500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.5836
Cell Significance Index: 68.0100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.5703
Cell Significance Index: 15.2800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5333
Cell Significance Index: 106.9900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4469
Cell Significance Index: 88.6900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4437
Cell Significance Index: 52.3300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3923
Cell Significance Index: 8.5000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3905
Cell Significance Index: 27.0100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3177
Cell Significance Index: 57.2800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3162
Cell Significance Index: 9.1100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.2617
Cell Significance Index: 3.5700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2476
Cell Significance Index: 15.9800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2339
Cell Significance Index: 83.9100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2304
Cell Significance Index: 12.0000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1933
Cell Significance Index: 8.7600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1904
Cell Significance Index: 9.8900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1717
Cell Significance Index: 13.1800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1648
Cell Significance Index: 4.1200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1631
Cell Significance Index: 22.4000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1389
Cell Significance Index: 75.8700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1188
Cell Significance Index: 5.5400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0866
Cell Significance Index: 38.3000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0855
Cell Significance Index: 59.1300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0841
Cell Significance Index: 16.0000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0665
Cell Significance Index: 8.1800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0297
Cell Significance Index: 54.7700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0257
Cell Significance Index: 1.2100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0250
Cell Significance Index: 3.2000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0196
Cell Significance Index: 30.1400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0177
Cell Significance Index: 33.3200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0029
Cell Significance Index: 2.1100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0024
Cell Significance Index: 3.2500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0016
Cell Significance Index: 0.2700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0050
Cell Significance Index: -3.1600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0078
Cell Significance Index: -0.2200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0088
Cell Significance Index: -3.9800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0114
Cell Significance Index: -0.7700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0141
Cell Significance Index: -10.6600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0142
Cell Significance Index: -0.3800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0183
Cell Significance Index: -1.8700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0204
Cell Significance Index: -15.1300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0289
Cell Significance Index: -16.3200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0306
Cell Significance Index: -4.4500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0321
Cell Significance Index: -20.0700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0322
Cell Significance Index: -2.2800
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0329
Cell Significance Index: -0.7200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0373
Cell Significance Index: -4.8200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0528
Cell Significance Index: -15.2000
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0538
Cell Significance Index: -1.0500
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0560
Cell Significance Index: -1.6500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0628
Cell Significance Index: -3.8600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0663
Cell Significance Index: -3.7200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0880
Cell Significance Index: -6.5600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0880
Cell Significance Index: -2.3500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0928
Cell Significance Index: -19.5400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0989
Cell Significance Index: -11.3400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1058
Cell Significance Index: -1.7700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1092
Cell Significance Index: -4.8300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1174
Cell Significance Index: -7.4000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1392
Cell Significance Index: -3.6600
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1465
Cell Significance Index: -2.5100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1483
Cell Significance Index: -5.6200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1555
Cell Significance Index: -16.1900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1653
Cell Significance Index: -8.6800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1672
Cell Significance Index: -5.8100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1673
Cell Significance Index: -5.8800
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.1683
Cell Significance Index: -2.8400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1712
Cell Significance Index: -13.5600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1852
Cell Significance Index: -5.0400
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1869
Cell Significance Index: -2.7600
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.2195
Cell Significance Index: -3.1500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.2269
Cell Significance Index: -3.4000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2529
Cell Significance Index: -6.4600
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: -0.2600
Cell Significance Index: -2.1500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2651
Cell Significance Index: -8.4900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2910
Cell Significance Index: -7.4800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3008
Cell Significance Index: -18.4400
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.3094
Cell Significance Index: -2.6300
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3396
Cell Significance Index: -9.6900
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3484
Cell Significance Index: -5.2500
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3496
Cell Significance Index: -5.1600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3507
Cell Significance Index: -11.1700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3519
Cell Significance Index: -7.5000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3521
Cell Significance Index: -7.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** TYK2 is a non-receptor tyrosine-protein kinase that belongs to the Janus kinase (JAK) family. It is characterized by its ability to phosphorylate tyrosine residues on target proteins, leading to the activation of downstream signaling pathways. TYK2 is specifically involved in the signaling of cytokines, including interferons, interleukins, and interleukin-17. It is also activated by viral proteins, such as those from RSV and SARS-CoV-2. TYK2 has a broad tissue distribution, with significant expression in the immune system, epithelial cells, and neurons. **Pathways and Functions:** TYK2 is involved in multiple signaling pathways, including: 1. **Cytokine-mediated signaling pathway:** TYK2 is activated by cytokines, such as interferons, interleukins, and interleukin-17, leading to the activation of downstream signaling pathways. 2. **Cellular response to virus:** TYK2 is activated by viral proteins, such as those from RSV and SARS-CoV-2, leading to the activation of immune responses. 3. **Immune response pathways:** TYK2 is involved in the regulation of immune responses, including the production of cytokines, the activation of natural killer cells, and the proliferation of T cells. 4. **Interferon signaling pathway:** TYK2 is involved in the regulation of interferon signaling, including the production of type I and type III interferons. 5. **Interleukin signaling pathway:** TYK2 is involved in the regulation of interleukin signaling, including the production of interleukin-17. **Clinical Significance:** Dysregulation of the TYK2 gene has been implicated in various diseases, including: 1. **Respiratory syncytial virus (RSV) infections:** TYK2 has been shown to play a crucial role in the regulation of RSV-induced immune responses. 2. **SARS-CoV-2 infections:** TYK2 has been implicated in the regulation of SARS-CoV-2-induced immune responses and has been shown to be a potential therapeutic target. 3. **Autoimmune disorders:** TYK2 has been implicated in the regulation of autoimmune responses, including the production of cytokines and the activation of immune cells. 4. **Cancer:** TYK2 has been implicated in the regulation of cancer cell growth and survival, including the activation of signaling pathways involved in cell proliferation and apoptosis. In conclusion, the TYK2 gene plays a crucial role in the immune system's response to viral and cytokine signaling. Its dysregulation has been implicated in various diseases, including RSV infections, SARS-CoV-2 infections, autoimmune disorders, and cancer. Further research is needed to fully understand the role of TYK2 in the immune system and to identify potential therapeutic targets for the treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Non-receptor tyrosine-protein kinase TYK2

Genular Protein ID: 1543706591

Symbol: TYK2_HUMAN

Name: Non-receptor tyrosine-protein kinase TYK2

UniProtKB Accession Codes:

P29597 Q6QB10 Q96CH0

Database IDs:

Citations:

PubMed ID: 2216457

Title: TYK2, prototype of a novel class of non-receptor tyrosine kinase genes.

PubMed ID: 2216457

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1386289

Title: A protein tyrosine kinase in the interferon alpha/beta signaling pathway.

PubMed ID: 1386289

DOI: 10.1016/0092-8674(92)90105-l

PubMed ID: 2156206

Title: Identification and chromosomal mapping of new human tyrosine kinase genes.

PubMed ID: 2156206

PubMed ID: 2247464

Title: Putative tyrosine kinases expressed in K-562 human leukemia cells.

PubMed ID: 2247464

DOI: 10.1073/pnas.87.22.8913

PubMed ID: 8232552

Title: The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction.

PubMed ID: 8232552

DOI: 10.1038/366129a0

PubMed ID: 7813427

Title: Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta.

PubMed ID: 7813427

DOI: 10.1002/j.1460-2075.1994.tb06932.x

PubMed ID: 7526154

Title: Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.

PubMed ID: 7526154

DOI: 10.1128/mcb.14.12.8133-8142.1994

PubMed ID: 7657660

Title: Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor.

PubMed ID: 7657660

DOI: 10.1074/jbc.270.35.20775

PubMed ID: 7638186

Title: Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

PubMed ID: 7638186

DOI: 10.1073/pnas.92.16.7307

PubMed ID: 8702790

Title: Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase.

PubMed ID: 8702790

DOI: 10.1074/jbc.271.34.20494

PubMed ID: 10542297

Title: Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase.

PubMed ID: 10542297

DOI: 10.1074/jbc.274.45.32507

PubMed ID: 10523853

Title: The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-alpha.

PubMed ID: 10523853

DOI: 10.1038/sj.onc.1202960

PubMed ID: 10995743

Title: Urokinase stimulates human vascular smooth muscle cell migration via a phosphatidylinositol 3-kinase-Tyk2 interaction.

PubMed ID: 10995743

DOI: 10.1074/jbc.m003626200

PubMed ID: 15277531

Title: Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules.

PubMed ID: 15277531

DOI: 10.1074/jbc.m401915200

PubMed ID: 17088085

Title: Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity.

PubMed ID: 17088085

DOI: 10.1016/j.immuni.2006.09.009

PubMed ID: 16987978

Title: The Epstein-Barr virus-encoded LMP-1 oncoprotein negatively affects Tyk2 phosphorylation and interferon signaling in human B cells.

PubMed ID: 16987978

DOI: 10.1128/jvi.01570-06

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29162862

Title: TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity.

PubMed ID: 29162862

DOI: 10.1038/s41598-017-15912-6

PubMed ID: 32213613

Title: Epstein-Barr Virus (EBV) Tegument Protein BGLF2 Suppresses Type I Interferon Signaling To Promote EBV Reactivation.

PubMed ID: 32213613

DOI: 10.1128/jvi.00258-20

PubMed ID: 20478313

Title: Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.

PubMed ID: 20478313

DOI: 10.1016/j.jmb.2010.05.020

PubMed ID: 25762719

Title: Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.

PubMed ID: 25762719

DOI: 10.1074/jbc.m114.619502

PubMed ID: 24843152

Title: Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition.

PubMed ID: 24843152

DOI: 10.1073/pnas.1401180111

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 1187
Mass: 133650
Checksum: F76C25D6A919EDBC
Sequence:

MPLRHWGMAR GSKPVGDGAQ PMAAMGGLKV LLHWAGPGGG EPWVTFSESS LTAEEVCIHI 
AHKVGITPPC FNLFALFDAQ AQVWLPPNHI LEIPRDASLM LYFRIRFYFR NWHGMNPREP 
AVYRCGPPGT EASSDQTAQG MQLLDPASFE YLFEQGKHEF VNDVASLWEL STEEEIHHFK 
NESLGMAFLH LCHLALRHGI PLEEVAKKTS FKDCIPRSFR RHIRQHSALT RLRLRNVFRR 
FLRDFQPGRL SQQMVMVKYL ATLERLAPRF GTERVPVCHL RLLAQAEGEP CYIRDSGVAP 
TDPGPESAAG PPTHEVLVTG TGGIQWWPVE EEVNKEEGSS GSSGRNPQAS LFGKKAKAHK 
AVGQPADRPR EPLWAYFCDF RDITHVVLKE HCVSIHRQDN KCLELSLPSR AAALSFVSLV 
DGYFRLTADS SHYLCHEVAP PRLVMSIRDG IHGPLLEPFV QAKLRPEDGL YLIHWSTSHP 
YRLILTVAQR SQAPDGMQSL RLRKFPIEQQ DGAFVLEGWG RSFPSVRELG AALQGCLLRA 
GDDCFSLRRC CLPQPGETSN LIIMRGARAS PRTLNLSQLS FHRVDQKEIT QLSHLGQGTR 
TNVYEGRLRV EGSGDPEEGK MDDEDPLVPG RDRGQELRVV LKVLDPSHHD IALAFYETAS 
LMSQVSHTHL AFVHGVCVRG PENIMVTEYV EHGPLDVWLR RERGHVPMAW KMVVAQQLAS 
ALSYLENKNL VHGNVCGRNI LLARLGLAEG TSPFIKLSDP GVGLGALSRE ERVERIPWLA 
PECLPGGANS LSTAMDKWGF GATLLEICFD GEAPLQSRSP SEKEHFYQRQ HRLPEPSCPQ 
LATLTSQCLT YEPTQRPSFR TILRDLTRLQ PHNLADVLTV NPDSPASDPT VFHKRYLKKI 
RDLGEGHFGK VSLYCYDPTN DGTGEMVAVK ALKADCGPQH RSGWKQEIDI LRTLYHEHII 
KYKGCCEDQG EKSLQLVMEY VPLGSLRDYL PRHSIGLAQL LLFAQQICEG MAYLHAQHYI 
HRDLAARNVL LDNDRLVKIG DFGLAKAVPE GHEYYRVRED GDSPVFWYAP ECLKEYKFYY 
ASDVWSFGVT LYELLTHCDS SQSPPTKFLE LIGIAQGQMT VLRLTELLER GERLPRPDKC 
PCEVYHLMKN CWETEASFRP TFENLIPILK TVHEKYQGQA PSVFSVC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TYK2

Associated with

Cells (max top 100)

Other Information

TYK2, prototype of a novel class of non-receptor tyrosine kinase genes. PubMed ID: 2216457

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A protein tyrosine kinase in the interferon alpha/beta signaling pathway. PubMed ID: 1386289

Identification and chromosomal mapping of new human tyrosine kinase genes. PubMed ID: 2156206

Putative tyrosine kinases expressed in K-562 human leukemia cells. PubMed ID: 2247464

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. PubMed ID: 8232552

Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta. PubMed ID: 7813427

Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. PubMed ID: 7526154

Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor. PubMed ID: 7657660

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. PubMed ID: 7638186

Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. PubMed ID: 8702790

Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase. PubMed ID: 10542297

The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-alpha. PubMed ID: 10523853

Urokinase stimulates human vascular smooth muscle cell migration via a phosphatidylinositol 3-kinase-Tyk2 interaction. PubMed ID: 10995743

Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules. PubMed ID: 15277531

Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. PubMed ID: 17088085

The Epstein-Barr virus-encoded LMP-1 oncoprotein negatively affects Tyk2 phosphorylation and interferon signaling in human B cells. PubMed ID: 16987978

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity. PubMed ID: 29162862

Epstein-Barr Virus (EBV) Tegument Protein BGLF2 Suppresses Type I Interferon Signaling To Promote EBV Reactivation. PubMed ID: 32213613

Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6. PubMed ID: 20478313

Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain. PubMed ID: 25762719

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition. PubMed ID: 24843152

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846