Details for: TYRO3

Gene ID: 7301

Symbol: TYRO3

Ensembl ID: ENSG00000092445

Description: TYRO3 protein tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 139.5093
    Cell Significance Index: -21.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.0012
    Cell Significance Index: -21.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.3561
    Cell Significance Index: -18.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.6081
    Cell Significance Index: -21.7100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.9040
    Cell Significance Index: 37.1900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.7415
    Cell Significance Index: -6.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4902
    Cell Significance Index: 298.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6681
    Cell Significance Index: 19.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6676
    Cell Significance Index: 19.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6542
    Cell Significance Index: 124.5000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6450
    Cell Significance Index: 5.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5182
    Cell Significance Index: 51.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5013
    Cell Significance Index: 10.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4826
    Cell Significance Index: 66.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2876
    Cell Significance Index: 7.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2852
    Cell Significance Index: 257.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2766
    Cell Significance Index: 44.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2036
    Cell Significance Index: 22.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2004
    Cell Significance Index: 39.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1517
    Cell Significance Index: 5.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1371
    Cell Significance Index: 2.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1163
    Cell Significance Index: 6.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1151
    Cell Significance Index: 14.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1117
    Cell Significance Index: 40.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1050
    Cell Significance Index: 5.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1023
    Cell Significance Index: 6.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0829
    Cell Significance Index: 2.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0752
    Cell Significance Index: 52.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0657
    Cell Significance Index: 0.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0607
    Cell Significance Index: 2.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0324
    Cell Significance Index: 1.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0069
    Cell Significance Index: 0.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0002
    Cell Significance Index: 0.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0078
    Cell Significance Index: -3.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0082
    Cell Significance Index: -0.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0099
    Cell Significance Index: -18.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0144
    Cell Significance Index: -26.5700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0147
    Cell Significance Index: -0.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0148
    Cell Significance Index: -22.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0175
    Cell Significance Index: -23.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0181
    Cell Significance Index: -11.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0214
    Cell Significance Index: -0.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0274
    Cell Significance Index: -20.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0282
    Cell Significance Index: -21.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0320
    Cell Significance Index: -14.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0322
    Cell Significance Index: -23.8400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0364
    Cell Significance Index: -0.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0400
    Cell Significance Index: -22.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0512
    Cell Significance Index: -5.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0533
    Cell Significance Index: -9.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0624
    Cell Significance Index: -17.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0646
    Cell Significance Index: -2.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0664
    Cell Significance Index: -11.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0683
    Cell Significance Index: -3.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0716
    Cell Significance Index: -2.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0809
    Cell Significance Index: -10.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0816
    Cell Significance Index: -3.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0895
    Cell Significance Index: -11.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0942
    Cell Significance Index: -13.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1109
    Cell Significance Index: -23.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1205
    Cell Significance Index: -13.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1284
    Cell Significance Index: -7.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1420
    Cell Significance Index: -8.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1427
    Cell Significance Index: -5.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1678
    Cell Significance Index: -17.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1849
    Cell Significance Index: -21.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2051
    Cell Significance Index: -21.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2218
    Cell Significance Index: -16.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2331
    Cell Significance Index: -10.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2411
    Cell Significance Index: -12.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2575
    Cell Significance Index: -16.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2611
    Cell Significance Index: -20.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2764
    Cell Significance Index: -19.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2857
    Cell Significance Index: -18.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2899
    Cell Significance Index: -15.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2983
    Cell Significance Index: -9.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3265
    Cell Significance Index: -10.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3283
    Cell Significance Index: -15.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3690
    Cell Significance Index: -5.0400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3710
    Cell Significance Index: -5.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3855
    Cell Significance Index: -8.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3908
    Cell Significance Index: -8.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3995
    Cell Significance Index: -14.0000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4020
    Cell Significance Index: -4.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4333
    Cell Significance Index: -11.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4780
    Cell Significance Index: -13.0100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5027
    Cell Significance Index: -5.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5119
    Cell Significance Index: -18.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5300
    Cell Significance Index: -13.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5456
    Cell Significance Index: -15.6400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5535
    Cell Significance Index: -9.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5587
    Cell Significance Index: -8.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5623
    Cell Significance Index: -12.9900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5628
    Cell Significance Index: -12.0300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5663
    Cell Significance Index: -14.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5941
    Cell Significance Index: -17.5000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.6009
    Cell Significance Index: -7.0100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6054
    Cell Significance Index: -12.1600
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.6363
    Cell Significance Index: -2.7700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6826
    Cell Significance Index: -16.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** TYRO3 is a transmembrane receptor tyrosine kinase, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain with tyrosine kinase activity. 2. **Expression:** TYRO3 is expressed in various cell types, including neural progenitor cells, interstitial cells of the ovary, and cells involved in immune response, such as natural killer cells. 3. **Function:** TYRO3 regulates multiple cellular processes, including apoptosis, cell migration, and immune response, through its tyrosine kinase activity and interactions with other signaling molecules. **Pathways and Functions:** TYRO3 is involved in several signaling pathways, including: 1. **Apoptotic cell clearance:** TYRO3 regulates apoptosis in neurons and other cell types, promoting the clearance of damaged or infected cells. 2. **Cell migration:** TYRO3 is involved in the regulation of cell migration, including the migration of neural progenitor cells and natural killer cells. 3. **Immune response regulation:** TYRO3 negatively regulates the immune response, inhibiting the activation of lymphocytes and the production of inflammatory cytokines. 4. **Neuron homeostasis:** TYRO3 regulates the balance between neuronal survival and death, maintaining the homeostasis of the nervous system. 5. **Neurotrophic signaling:** TYRO3 interacts with neurotrophic factors, such as nerve growth factor (NGF), to regulate neuronal survival and development. **Clinical Significance:** TYRO3 plays a critical role in various diseases and disorders, including: 1. **Immune disorders:** Dysregulation of TYRO3 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Neurological disorders:** TYRO3 is involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** TYRO3 is overexpressed in various types of cancer, including breast cancer and colon cancer, and is associated with poor prognosis. 4. **Reproductive disorders:** TYRO3 is involved in the regulation of ovulation and is associated with infertility in women. In conclusion, the TYRO3 gene is a multifaceted regulator of immune response and cellular homeostasis, with implications for various diseases and disorders. Further research is needed to fully elucidate the functions of TYRO3 and its role in human disease.

Genular Protein ID: 2487049144

Symbol: TYRO3_HUMAN

Name: Tyrosine-protein kinase receptor TYRO3

UniProtKB Accession Codes:

Q06418 O14953 Q86VR3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 40 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 Rhea 3 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7511603

Title: RSE, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain.

PubMed ID: 7511603

DOI: 10.1016/s0021-9258(17)34118-2

PubMed ID: 8108112

Title: Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain.

PubMed ID: 8108112

PubMed ID: 7857658

Title: Isolation and characterization of the human DTK receptor tyrosine kinase.

PubMed ID: 7857658

DOI: 10.3109/08977199409001055

PubMed ID: 9175267

Title: A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress.

PubMed ID: 9175267

DOI: 10.1016/s0248-4900(97)86830-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8262388

Title: The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25.

PubMed ID: 8262388

DOI: 10.1016/0378-1119(93)90109-g

PubMed ID: 7537495

Title: Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase.

PubMed ID: 7537495

DOI: 10.1006/bbrc.1995.1549

PubMed ID: 7634325

Title: Reevaluation of the roles of protein S and Gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3.

PubMed ID: 7634325

DOI: 10.1016/0092-8674(95)90424-7

PubMed ID: 16737840

Title: Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases.

PubMed ID: 16737840

DOI: 10.1016/j.cytogfr.2006.04.004

PubMed ID: 17005688

Title: Tyro3 family-mediated cell entry of Ebola and Marburg viruses.

PubMed ID: 17005688

DOI: 10.1128/jvi.01157-06

PubMed ID: 18421305

Title: Immunobiology of the TAM receptors.

PubMed ID: 18421305

DOI: 10.1038/nri2303

PubMed ID: 20546121

Title: Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization.

PubMed ID: 20546121

DOI: 10.1111/j.1538-7836.2010.03935.x

PubMed ID: 22156524

Title: Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry.

PubMed ID: 22156524

DOI: 10.1128/jvi.06451-11

PubMed ID: 22673088

Title: Cell surface molecules involved in infection mediated by lymphocytic choriomeningitis virus glycoprotein.

PubMed ID: 22673088

DOI: 10.1292/jvms.12-0176

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25277499

Title: Phosphatidylserine receptors: enhancers of enveloped virus entry and infection.

PubMed ID: 25277499

DOI: 10.1016/j.virol.2014.09.009

PubMed ID: 14623883

Title: Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family.

PubMed ID: 14623883

DOI: 10.1074/jbc.m311750200

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 890
  • Mass: 96905
  • Checksum: F9EC675077C4E8F1
  • Sequence:
    • MALRRSMGRP GLPPLPLPPP PRLGLLLAAL ASLLLPESAA AGLKLMGAPV KLTVSQGQPV 
KLNCSVEGME EPDIQWVKDG AVVQNLDQLY IPVSEQHWIG FLSLKSVERS DAGRYWCQVE 
DGGETEISQP VWLTVEGVPF FTVEPKDLAV PPNAPFQLSC EAVGPPEPVT IVWWRGTTKI 
GGPAPSPSVL NVTGVTQSTM FSCEAHNLKG LASSRTATVH LQALPAAPFN ITVTKLSSSN 
ASVAWMPGAD GRALLQSCTV QVTQAPGGWE VLAVVVPVPP FTCLLRDLVP ATNYSLRVRC 
ANALGPSPYA DWVPFQTKGL APASAPQNLH AIRTDSGLIL EWEEVIPEAP LEGPLGPYKL 
SWVQDNGTQD ELTVEGTRAN LTGWDPQKDL IVRVCVSNAV GCGPWSQPLV VSSHDRAGQQ 
GPPHSRTSWV PVVLGVLTAL VTAAALALIL LRKRRKETRF GQAFDSVMAR GEPAVHFRAA 
RSFNRERPER IEATLDSLGI SDELKEKLED VLIPEQQFTL GRMLGKGEFG SVREAQLKQE 
DGSFVKVAVK MLKADIIASS DIEEFLREAA CMKEFDHPHV AKLVGVSLRS RAKGRLPIPM 
VILPFMKHGD LHAFLLASRI GENPFNLPLQ TLIRFMVDIA CGMEYLSSRN FIHRDLAARN 
CMLAEDMTVC VADFGLSRKI YSGDYYRQGC ASKLPVKWLA LESLADNLYT VQSDVWAFGV 
TMWEIMTRGQ TPYAGIENAE IYNYLIGGNR LKQPPECMED VYDLMYQCWS ADPKQRPSFT 
CLRMELENIL GQLSVLSASQ DPLYINIERA EEPTAGGSLE LPGRDQPYSG AGDGSGMGAV 
GGTPSDCRYI LTPGGLAEQP GQAEHQPESP LNETQRLLLL QQGLLPHSSC

Genular Protein ID: 3922040767

Symbol: H0YNK6_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YNK6

Database IDs:

ARBA 18 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 9 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 15 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 1 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 3 SAM 2 SMART 4 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 845
  • Mass: 92316
  • Checksum: 01C6CE9367B8BCCF
  • Sequence:
    • MGAPVKLTVS QGQPVKLNCS VEGMEEPDIQ WVKDGAVVQN LDQLYIPVSE QHWIGFLSLK 
SVERSDAGRY WCQVEDGGET EISQPVWLTV EGVPFFTVEP KDLAVPPNAP FQLSCEAVGP 
PEPVTIVWWR GTTKIGGPAP SPSVLNVTGV TQSTMFSCEA HNLKGLASSR TATVHLQALP 
AAPFNITVTK LSSSNASVAW MPGADGRALL QSCTVQVTQA PGGWEVLAVV VPVPPFTCLL 
RDLVPATNYS LRVRCANALG PSPYADWVPF QTKGLAPASA PQNLHAIRTD SGLILEWEEV 
IPEAPLEGPL GPYKLSWVQD NGTQDELTVE GTRANLTGWD PQKDLIVRVC VSNAVGCGPW 
SQPLVVSSHD RAGQQGPPHS RTSWVPVVLG VLTALVTAAA LALILLRKRR KETRFGQAFD 
SVMARGEPAV HFRAARSFNR ERPERIEATL DSLGISDELK EKLEDVLIPE QQFTLGRMLG 
KGEFGSVREA QLKQEDGSFV KVAVKMLKAD IIASSDIEEF LREAACMKEF DHPHVAKLVG 
VSLRSRAKGR LPIPMVILPF MKHGDLHAFL LASRIGENPF NLPLQTLIRF MVDIACGMEY 
LSSRNFIHRD LAARNCMLAE DMTVCVADFG LSRKIYSGDY YRQGCASKLP VKWLALESLA 
DNLYTVQSDV WAFGVTMWEI MTRGQTPYAG IENAEIYNYL IGGNRLKQPP ECMEDVYDLM 
YQCWSADPKQ RPSFTCLRME LENILGQLSV LSASQDPLYI NIERAEEPTA GGSLELPGRD 
QPYSGAGDGS GMGAVGGTPS DCRYILTPGG LAEQPGQAEH QPESPLNETQ RLLLLQQGLL 
PHSSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.