Details for: UMPS

Gene ID: 7372

Symbol: UMPS

Ensembl ID: ENSG00000114491

Description: uridine monophosphate synthetase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 106.8500
    Cell Significance Index: -16.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 63.6129
    Cell Significance Index: -16.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.8400
    Cell Significance Index: -21.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.7316
    Cell Significance Index: -17.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.3610
    Cell Significance Index: -17.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.7994
    Cell Significance Index: -19.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.8425
    Cell Significance Index: -18.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0684
    Cell Significance Index: -20.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5907
    Cell Significance Index: -5.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6035
    Cell Significance Index: 158.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5958
    Cell Significance Index: 259.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4717
    Cell Significance Index: 20.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3576
    Cell Significance Index: 81.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2268
    Cell Significance Index: 243.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9794
    Cell Significance Index: 114.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9359
    Cell Significance Index: 24.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6929
    Cell Significance Index: 19.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6866
    Cell Significance Index: 18.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6132
    Cell Significance Index: 16.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5946
    Cell Significance Index: 536.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5632
    Cell Significance Index: 39.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5475
    Cell Significance Index: 37.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5015
    Cell Significance Index: 26.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4472
    Cell Significance Index: 89.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4262
    Cell Significance Index: 11.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4172
    Cell Significance Index: 18.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3945
    Cell Significance Index: 48.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3917
    Cell Significance Index: 21.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3863
    Cell Significance Index: 69.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3560
    Cell Significance Index: 194.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3425
    Cell Significance Index: 151.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3150
    Cell Significance Index: 43.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2888
    Cell Significance Index: 7.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2481
    Cell Significance Index: 89.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2085
    Cell Significance Index: 13.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2035
    Cell Significance Index: 26.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1800
    Cell Significance Index: 124.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1761
    Cell Significance Index: 8.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1312
    Cell Significance Index: 9.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1302
    Cell Significance Index: 18.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1280
    Cell Significance Index: 15.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1203
    Cell Significance Index: 4.1800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1152
    Cell Significance Index: 1.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1005
    Cell Significance Index: 12.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0991
    Cell Significance Index: 7.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0953
    Cell Significance Index: 2.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0732
    Cell Significance Index: 3.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0652
    Cell Significance Index: 7.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0515
    Cell Significance Index: 1.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0480
    Cell Significance Index: 2.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0288
    Cell Significance Index: 1.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0285
    Cell Significance Index: 0.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0282
    Cell Significance Index: 0.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0275
    Cell Significance Index: 0.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0195
    Cell Significance Index: 3.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0049
    Cell Significance Index: 9.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -5.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0071
    Cell Significance Index: -13.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0074
    Cell Significance Index: -4.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0088
    Cell Significance Index: -0.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0089
    Cell Significance Index: -13.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0100
    Cell Significance Index: -6.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0100
    Cell Significance Index: -7.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0109
    Cell Significance Index: -8.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0120
    Cell Significance Index: -16.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0179
    Cell Significance Index: -10.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0188
    Cell Significance Index: -3.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0207
    Cell Significance Index: -9.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0392
    Cell Significance Index: -4.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0475
    Cell Significance Index: -10.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0515
    Cell Significance Index: -14.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0607
    Cell Significance Index: -0.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0608
    Cell Significance Index: -2.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0720
    Cell Significance Index: -1.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0744
    Cell Significance Index: -5.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0799
    Cell Significance Index: -9.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0845
    Cell Significance Index: -3.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0993
    Cell Significance Index: -3.1800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1150
    Cell Significance Index: -1.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1421
    Cell Significance Index: -3.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1855
    Cell Significance Index: -19.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1961
    Cell Significance Index: -15.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2179
    Cell Significance Index: -3.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2210
    Cell Significance Index: -6.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2221
    Cell Significance Index: -5.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2292
    Cell Significance Index: -12.0400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2360
    Cell Significance Index: -1.9800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2419
    Cell Significance Index: -3.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2550
    Cell Significance Index: -6.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2774
    Cell Significance Index: -6.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2823
    Cell Significance Index: -17.3100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2997
    Cell Significance Index: -2.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3611
    Cell Significance Index: -8.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3652
    Cell Significance Index: -10.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3658
    Cell Significance Index: -8.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3752
    Cell Significance Index: -11.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4000
    Cell Significance Index: -12.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4053
    Cell Significance Index: -13.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4242
    Cell Significance Index: -14.8600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4249
    Cell Significance Index: -12.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UMPS is a cytosolic enzyme, belonging to the pyrimidine biosynthesis pathway. It exhibits high substrate specificity, with a preference for orotate over other pyrimidine analogs. The enzyme is also notable for its ability to regulate its own activity through feedback inhibition by OMP. This regulatory mechanism ensures that UMPS is only active when necessary, preventing excessive pyrimidine nucleotide synthesis. **Pathways and Functions:** UMPS is integral to the de novo pyrimidine biosynthesis pathway, which is responsible for the production of pyrimidine nucleotides from scratch. This process involves the conversion of orotate into OMP, followed by the addition of ribose-1-phosphate and the subsequent formation of cytidine monophosphate (CMP) and uridine monophosphate (UMP). UMPS is also involved in the biosynthesis of orotidine-5'-phosphate decarboxylase (OMP decarboxylase), a key enzyme in the pyrimidine nucleotide salvage pathway. In addition to its role in pyrimidine biosynthesis, UMPS is also implicated in the cellular response to xenobiotics. Studies have shown that UMPS expression is upregulated in response to exposure to certain environmental toxins, suggesting a potential role in protecting cells against oxidative stress. **Clinical Significance:** Dysregulation of UMPS has been implicated in various diseases, including cancer, where impaired pyrimidine biosynthesis can contribute to tumorigenesis. Mutations in the UMPS gene have been associated with certain cancer types, including leukemia and lymphoma. Furthermore, UMPS has been shown to play a critical role in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. The enzyme's involvement in pyrimidine biosynthesis suggests that dysregulation of UMPS may contribute to the accumulation of toxic pyrimidine metabolites in the brain, leading to neurodegeneration. In conclusion, UMPS is a vital enzyme in the de novo pyrimidine biosynthesis pathway, playing a crucial role in maintaining cellular homeostasis. Further research is needed to fully elucidate the mechanisms by which UMPS regulates pyrimidine biosynthesis and to explore its potential as a therapeutic target in various diseases. **Significantly Expressed Cells:** UMPS is expressed in a wide range of cell types, including germ cells, erythroid progenitor cells, placental villous trophoblasts, proerythroblasts, cardiac muscle myoblasts, oogonial cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, and intestinal crypt stem cells of the colon. **Proteins:** UMPS_HUMAN (OMPdecase) is the human protein encoded by the UMPS gene. This protein is a cytosolic enzyme with a molecular weight of approximately 50 kDa, and is characterized by its ability to catalyze the conversion of orotate into OMP.

Genular Protein ID: 3361027835

Symbol: UMPS_HUMAN

Name: OMPdecase

UniProtKB Accession Codes:

P11172 B5LY68 B5LY72 O00758 O00759 O00760 Q16862 Q9H3Q2 Q9UG49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 24 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 15 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 62 PDBsum 62 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3279416

Title: Molecular cloning and nucleotide sequence for the complete coding region of human UMP synthase.

PubMed ID: 3279416

DOI: 10.1073/pnas.85.6.1754

PubMed ID: 2624233

Title: Molecular cloning of human UMP synthase.

PubMed ID: 2624233

DOI: 10.1007/978-1-4684-5673-8_83

PubMed ID: 9042911

Title: Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families.

PubMed ID: 9042911

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18184586

Title: Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design.

PubMed ID: 18184586

DOI: 10.1016/j.str.2007.10.020

Sequence Information:

  • Length: 480
  • Mass: 52222
  • Checksum: D985CD566B72F5CA
  • Sequence:
    • MAVARAALGP LVTGLYDVQA FKFGDFVLKS GLSSPIYIDL RGIVSRPRLL SQVADILFQT 
AQNAGISFDT VCGVPYTALP LATVICSTNQ IPMLIRRKET KDYGTKRLVE GTINPGETCL 
IIEDVVTSGS SVLETVEVLQ KEGLKVTDAI VLLDREQGGK DKLQAHGIRL HSVCTLSKML 
EILEQQKKVD AETVGRVKRF IQENVFVAAN HNGSPLSIKE APKELSFGAR AELPRIHPVA 
SKLLRLMQKK ETNLCLSADV SLARELLQLA DALGPSICML KTHVDILNDF TLDVMKELIT 
LAKCHEFLIF EDRKFADIGN TVKKQYEGGI FKIASWADLV NAHVVPGSGV VKGLQEVGLP 
LHRGCLLIAE MSSTGSLATG DYTRAAVRMA EEHSEFVVGF ISGSRVSMKP EFLHLTPGVQ 
LEAGGDNLGQ QYNSPQEVIG KRGSDIIIVG RGIISAADRL EAAEMYRKAA WEAYLSRLGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.