Details for: UQCRFS1
Gene ID: 7386
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: UQCRFS1
Ensembl ID: ENSG00000169021
Description: ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 74.47rCSI 67.25%PRS 13.14
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CSI 70.23rCSI 67.72%PRS 10.38
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CSI 66.41rCSI 69.57%PRS 13.73
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CSI 64.38rCSI 42.79%PRS 17.69
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CSI 63.45rCSI 74.52%PRS 17.29
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CSI 62.72rCSI 50.71%PRS 14.65
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CSI 61.46rCSI 64.24%PRS 15.43
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CSI 60.34rCSI 52.25%PRS 16.56
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CSI 58.75rCSI 56.56%PRS 15.27
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CSI 55.02rCSI 58.46%PRS 25.91
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CSI 51.85rCSI 40.79%PRS 17.63
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CSI 49.36rCSI 51.71%PRS 15.77
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CSI 45.75rCSI 57.42%PRS 18.9
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CSI 44.31rCSI 43.58%PRS 16.03
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CSI 40.91rCSI 65.96%PRS 23.3
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CSI 39.79rCSI 52.88%PRS 16.13
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CSI 36.45rCSI 32.35%PRS 14.74
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CSI 34.36rCSI 28.81%PRS 17.63
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CSI 33.69rCSI 48.59%PRS 20.57
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CSI 31.96rCSI 45.81%PRS 20.23
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CSI 31.5rCSI 27.7%PRS 10.7
-
CSI 31.36rCSI 35.9%PRS 30.04
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CSI 30.01rCSI 71.35%PRS 22.14
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CSI 29.7rCSI 45.89%PRS 13.81
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CSI 29.52rCSI 45.15%PRS 23.93
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CSI 27.5rCSI 24.15%PRS 16.68
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CSI 27rCSI 25.51%PRS 15.4
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CSI 26.5rCSI 36.11%PRS 13.16
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CSI 25.76rCSI 44.12%PRS 19.92
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CSI 24.55rCSI 37.43%PRS 13.75
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CSI 24.11rCSI 34.74%PRS 23.56
-
CSI 23.79rCSI 24.25%PRS 21.05
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CSI 22.66rCSI 48.24%PRS 23.69
-
CSI 21.22rCSI 21.17%PRS 12.6
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CSI 21.21rCSI 27.2%PRS 17.04
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CSI 18.78rCSI 14.47%PRS 13.47
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CSI 18.32rCSI 26.8%PRS 15.58
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CSI 17.71rCSI 37.67%PRS 24.57
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CSI 17.5rCSI 14.49%PRS 14.8
-
CSI 17.48rCSI 47.13%PRS 18.99
-
CSI 17.43rCSI 33.89%PRS 15.09
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CSI 17.22rCSI 15.88%PRS 15.05
-
CSI 16.55rCSI 22.61%PRS 16.35
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CSI 15.61rCSI 29.46%PRS 18.42
-
CSI 15.52rCSI 68.14%PRS 27.4
-
CSI 15.26rCSI 33.72%PRS 10.62
-
CSI 15.23rCSI 23.4%PRS 20.75
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CSI 15.01rCSI 42.87%PRS 25.22
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CSI 14.44rCSI 48.83%PRS 24.28
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CSI 14.04rCSI 20.03%PRS 16.61
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CSI 13.57rCSI 15.28%PRS 23.68
-
CSI 13.23rCSI 9.2%PRS 17.38
-
CSI 13.12rCSI 17.94%PRS 16.72
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CSI 13.03rCSI 13.97%PRS 13.57
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CSI 12.74rCSI 36.87%PRS 16.74
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CSI 12.69rCSI 16.97%PRS 19.51
-
CSI 12.66rCSI 44.42%PRS 26.45
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CSI 11.89rCSI 9.86%PRS 13.9
-
CSI 11.77rCSI 25.7%PRS 29.49
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CSI 11.74rCSI 40.21%PRS 53.52
-
CSI 11.53rCSI 13.33%PRS 10.79
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CSI 11.47rCSI 45.64%PRS 25.81
-
CSI 10.96rCSI 11.27%PRS 24.06
-
CSI 10.93rCSI 31.63%PRS 32.42
-
CSI 10.85rCSI 22.28%PRS 33.46
-
CSI 10.83rCSI 50.76%PRS 38.28
-
CSI 10.69rCSI 80.28%PRS 26.81
-
CSI 10.55rCSI 15.48%PRS 19.37
-
CSI 10.47rCSI 56.51%PRS 27.03
-
CSI 10.17rCSI 13.91%PRS 23.78
-
CSI 10.09rCSI 10.53%PRS 15.12
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CSI 9.93rCSI 18.95%PRS 33.58
-
CSI 9.9rCSI 7.86%PRS 26.14
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CSI 9.78rCSI 12.1%PRS 12.94
-
CSI 9.72rCSI 5.74%PRS 20.36
-
CSI 9.63rCSI 21.33%PRS 13.72
-
CSI 9.6rCSI 55.85%PRS 22.13
-
CSI 9.51rCSI 28.07%PRS 17.9
-
CSI 9.29rCSI 7.34%PRS 10.14
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CSI 9.12rCSI 20.82%PRS 12.87
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CSI 9.03rCSI 6.35%PRS 36.94
-
CSI 9.02rCSI 6.27%PRS 20.93
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CSI 8.98rCSI 12%PRS 28.12
-
CSI 8.97rCSI 8.23%PRS 17.01
-
CSI 8.93rCSI 23.51%PRS 28.72
-
CSI 8.72rCSI 11.19%PRS 14.36
-
CSI 8.69rCSI 44.89%PRS 28.77
-
CSI 8.62rCSI 21.33%PRS 13.62
-
CSI 8.41rCSI 20.53%PRS 14.64
-
CSI 8.37rCSI 12.35%PRS 23.17
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CSI 8.32rCSI 33.26%PRS 31.8
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CSI 8.17rCSI 16.29%PRS 24.64
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CSI 7.68rCSI 27.29%PRS 44.96
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CSI 7.67rCSI 40.29%PRS 25.82
-
CSI 7.65rCSI 10.03%PRS 58.36
-
CSI 7.62rCSI 5.91%PRS 14.06
-
CSI 7.43rCSI 5.65%PRS 19.37
-
CSI 7.4rCSI 23.83%PRS 15.63
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CSI 7.31rCSI 17.16%PRS 21.91
-
CSI 7.26rCSI 9.03%PRS 15.57
-
CSI -10.2rCSI -12.2%PRS 25.7%
-
CSI -3.8rCSI -12.3%PRS 18.0%
-
CSI -2.8rCSI -6.3%PRS 30.2%
-
CSI -2.2rCSI -6.6%PRS 21.2%
-
CSI -1.6rCSI -1.9%PRS 19.7%
-
CSI -1.5rCSI -3.0%PRS 14.7%
-
CSI -1.4rCSI -2.4%PRS 10.9%
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CSI -1.0rCSI -6.1%PRS 53.6%
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CSI -1.0rCSI -5.8%PRS 9.1%
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CSI -0.9rCSI -2.4%PRS 21.6%
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CSI -0.7rCSI -1.6%PRS 16.4%
-
CSI -0.4rCSI -0.6%PRS 17.0%
-
CSI -0.4rCSI -0.7%PRS 16.2%
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CSI -0.4rCSI -0.7%PRS 10.7%
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CSI -0.3rCSI -0.5%PRS 19.5%
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CSI -0.2rCSI -0.4%PRS 8.7%
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CSI -0.2rCSI -0.7%PRS 8.1%
-
CSI -0.2rCSI -0.4%PRS 8.5%
-
CSI 0.1rCSI 0.2%PRS 20.5%
-
CSI 0.1rCSI 2.6%PRS 66.1%
-
CSI 0.1rCSI 0.4%PRS 9.3%
-
CSI 0.2rCSI 4.3%PRS 60.1%
-
CSI 0.2rCSI 5.2%PRS 62.3%
-
CSI 0.3rCSI 1.4%PRS 21.5%
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CSI 0.3rCSI 4.8%PRS 68.6%
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CSI 0.3rCSI 3.5%PRS 36.0%
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CSI 0.3rCSI 0.7%PRS 9.1%
-
CSI 0.3rCSI 3.1%PRS 56.7%
-
CSI 0.4rCSI 0.6%PRS 12.6%
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CSI 0.4rCSI 2.6%PRS 11.6%
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CSI 0.4rCSI 0.9%PRS 22.5%
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CSI 0.5rCSI 1.7%PRS 25.3%
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CSI 0.5rCSI 0.6%PRS 22.6%
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CSI 0.5rCSI 5.7%PRS 53.4%
-
CSI 0.5rCSI 1.0%PRS 32.9%
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CSI 0.5rCSI 4.2%PRS 55.2%
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CSI 0.6rCSI 0.8%PRS 14.8%
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CSI 0.6rCSI 1.6%PRS 55.0%
-
CSI 0.6rCSI 0.9%PRS 11.4%
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CSI 0.6rCSI 1.1%PRS 8.7%
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CSI 0.6rCSI 1.9%PRS 10.0%
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CSI 0.7rCSI 1.7%PRS 14.5%
-
CSI 0.7rCSI 1.9%PRS 24.4%
-
CSI 0.7rCSI 0.9%PRS 19.2%
-
CSI 0.7rCSI 1.0%PRS 20.8%
-
CSI 0.7rCSI 3.3%PRS 61.1%
-
CSI 0.8rCSI 1.6%PRS 29.9%
-
CSI 0.8rCSI 7.5%PRS 40.1%
-
CSI 0.9rCSI 2.4%PRS 20.7%
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CSI 0.9rCSI 1.6%PRS 13.7%
-
CSI 0.9rCSI 1.3%PRS 13.6%
-
CSI 0.9rCSI 1.4%PRS 9.5%
-
CSI 0.9rCSI 7.4%PRS 15.1%
-
CSI 0.9rCSI 1.6%PRS 11.2%
-
CSI 0.9rCSI 21.9%PRS 26.9%
-
CSI 1.0rCSI 3.7%PRS 8.9%
-
CSI 1.0rCSI 1.6%PRS 25.9%
-
CSI 1.0rCSI 1.0%PRS 23.1%
-
CSI 1.0rCSI 2.7%PRS 23.1%
-
CSI 1.0rCSI 7.6%PRS 39.4%
-
CSI 1.1rCSI 0.9%PRS 15.6%
-
CSI 1.1rCSI 7.1%PRS 45.3%
-
CSI 1.1rCSI 1.5%PRS 13.8%
-
CSI 1.1rCSI 25.8%PRS 77.3%
-
CSI 1.1rCSI 2.2%PRS 42.2%
-
CSI 1.1rCSI 6.9%PRS 32.7%
-
CSI 1.2rCSI 2.4%PRS 22.3%
-
CSI 1.2rCSI 5.3%PRS 14.2%
-
CSI 1.2rCSI 2.1%PRS 29.5%
-
CSI 1.4rCSI 1.3%PRS 30.2%
-
CSI 1.4rCSI 7.6%PRS 48.0%
-
CSI 1.4rCSI 9.6%PRS 28.7%
-
CSI 1.5rCSI 19.4%PRS 59.1%
-
CSI 1.5rCSI 1.6%PRS 16.9%
-
CSI 1.6rCSI 7.8%PRS 19.4%
-
CSI 1.6rCSI 17.4%PRS 26.6%
-
CSI 1.6rCSI 9.1%PRS 45.5%
-
CSI 1.6rCSI 9.3%PRS 22.7%
-
CSI 1.6rCSI 2.0%PRS 8.1%
-
CSI 1.6rCSI 3.0%PRS 12.3%
-
CSI 1.7rCSI 1.5%PRS 22.4%
-
CSI 1.7rCSI 40.8%PRS 47.5%
-
CSI 1.8rCSI 5.0%PRS 26.0%
-
CSI 1.8rCSI 3.3%PRS 31.9%
-
CSI 1.8rCSI 7.8%PRS 14.5%
-
CSI 1.8rCSI 4.9%PRS 53.5%
-
CSI 1.8rCSI 2.6%PRS 21.9%
-
CSI 1.9rCSI 5.2%PRS 22.8%
-
CSI 1.9rCSI 3.7%PRS 15.7%
-
CSI 1.9rCSI 7.1%PRS 12.5%
-
CSI 1.9rCSI 29.0%PRS 44.3%
-
CSI 2.0rCSI 2.5%PRS 9.1%
-
CSI 2.0rCSI 3.0%PRS 14.8%
-
CSI 2.0rCSI 8.7%PRS 26.2%
-
CSI 2.0rCSI 5.1%PRS 41.7%
-
CSI 2.0rCSI 7.9%PRS 30.1%
-
CSI 2.1rCSI 1.5%PRS 21.8%
-
CSI 2.1rCSI 18.4%PRS 78.2%
-
CSI 2.1rCSI 4.7%PRS 16.9%
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CSI 2.2rCSI 5.8%PRS 17.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 790462512
Symbol: UCRI_HUMAN
Name: Cytochrome b-c1 complex subunit Rieske, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2158323
Title: The primary structure of human Rieske iron-sulfur protein of mitochondrial cytochrome bc1 complex deduced from cDNA analysis.
PubMed ID: 2158323
PubMed ID: 7721092
Title: Structure, sequence and location of the UQCRFS1 gene for the human Rieske Fe-S protein.
PubMed ID: 7721092
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9150947
Title: Renal cell carcinoma and normal kidney protein expression.
PubMed ID: 9150947
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28673544
Title: TTC19 plays a husbandry role on UQCRFS1 turnover in the biogenesis of mitochondrial respiratory complex III.
PubMed ID: 28673544
PubMed ID: 28380382
Title: A single adaptable cochaperone-scaffold complex delivers nascent iron-sulfur clusters to mammalian respiratory chain complexes I-III.
PubMed ID: 28380382
PubMed ID: 31883641
Title: Bi-allelic UQCRFS1 variants are associated with mitochondrial complex III deficiency, cardiomyopathy, and alopecia totalis.
PubMed ID: 31883641
PubMed ID: 28844695
Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.
PubMed ID: 28844695
Sequence Information:
- Length: 274
- Mass: 29668
- Checksum: 8DB51634DEB039B0
- Sequence:
MLSVASRSGP FAPVLSATSR GVAGALRPLV QATVPATPEQ PVLDLKRPFL SRESLSGQAV RRPLVASVGL NVPASVCYSH TDIKVPDFSE YRRLEVLDST KSSRESSEAR KGFSYLVTGV TTVGVAYAAK NAVTQFVSSM SASADVLALA KIEIKLSDIP EGKNMAFKWR GKPLFVRHRT QKEIEQEAAV ELSQLRDPQH DLDRVKKPEW VILIGVCTHL GCVPIANAGD FGGYYCPCHG SHYDASGRIR LGPAPLNLEV PTYEFTSDDM VIVG