Details for: USF2

Gene ID: 7392

Symbol: USF2

Ensembl ID: ENSG00000105698

Description: upstream transcription factor 2, c-fos interacting

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 271.8823
    Cell Significance Index: -42.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 156.9921
    Cell Significance Index: -39.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.9399
    Cell Significance Index: -36.9500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 81.9619
    Cell Significance Index: -42.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 67.2705
    Cell Significance Index: -45.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.4818
    Cell Significance Index: -37.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.0272
    Cell Significance Index: -44.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.3125
    Cell Significance Index: -41.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.3911
    Cell Significance Index: -44.9500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.8385
    Cell Significance Index: -33.2900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.3616
    Cell Significance Index: -18.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.3375
    Cell Significance Index: 272.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.7316
    Cell Significance Index: 23.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5866
    Cell Significance Index: 172.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9761
    Cell Significance Index: 62.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9333
    Cell Significance Index: 168.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8443
    Cell Significance Index: 58.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8439
    Cell Significance Index: 43.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8311
    Cell Significance Index: 166.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8307
    Cell Significance Index: 102.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7618
    Cell Significance Index: 35.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7269
    Cell Significance Index: 99.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5933
    Cell Significance Index: 58.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5884
    Cell Significance Index: 260.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5814
    Cell Significance Index: 68.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5737
    Cell Significance Index: 12.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5224
    Cell Significance Index: 27.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4953
    Cell Significance Index: 31.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4918
    Cell Significance Index: 25.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4716
    Cell Significance Index: 257.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3989
    Cell Significance Index: 79.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3983
    Cell Significance Index: 142.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3884
    Cell Significance Index: 350.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3846
    Cell Significance Index: 11.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3590
    Cell Significance Index: 25.3900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3409
    Cell Significance Index: 6.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3337
    Cell Significance Index: 15.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3226
    Cell Significance Index: 61.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2736
    Cell Significance Index: 12.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1896
    Cell Significance Index: 4.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1853
    Cell Significance Index: 128.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1829
    Cell Significance Index: 13.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1417
    Cell Significance Index: 18.1700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1220
    Cell Significance Index: 0.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0637
    Cell Significance Index: 8.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0615
    Cell Significance Index: 1.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0368
    Cell Significance Index: 5.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0333
    Cell Significance Index: 1.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0073
    Cell Significance Index: 13.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0087
    Cell Significance Index: -6.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0128
    Cell Significance Index: -23.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0168
    Cell Significance Index: -25.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0277
    Cell Significance Index: -20.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0290
    Cell Significance Index: -18.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0302
    Cell Significance Index: -41.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0336
    Cell Significance Index: -3.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0360
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0373
    Cell Significance Index: -6.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0456
    Cell Significance Index: -33.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0543
    Cell Significance Index: -24.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0734
    Cell Significance Index: -41.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0837
    Cell Significance Index: -52.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0920
    Cell Significance Index: -1.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0948
    Cell Significance Index: -2.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1235
    Cell Significance Index: -35.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1614
    Cell Significance Index: -5.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1886
    Cell Significance Index: -4.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2022
    Cell Significance Index: -29.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2073
    Cell Significance Index: -13.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2133
    Cell Significance Index: -13.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2369
    Cell Significance Index: -49.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2523
    Cell Significance Index: -28.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2549
    Cell Significance Index: -19.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2629
    Cell Significance Index: -8.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2847
    Cell Significance Index: -5.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3304
    Cell Significance Index: -8.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3551
    Cell Significance Index: -3.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3842
    Cell Significance Index: -6.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4000
    Cell Significance Index: -31.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4046
    Cell Significance Index: -42.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4836
    Cell Significance Index: -21.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5143
    Cell Significance Index: -28.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5392
    Cell Significance Index: -9.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5832
    Cell Significance Index: -14.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5880
    Cell Significance Index: -17.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6171
    Cell Significance Index: -7.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6451
    Cell Significance Index: -24.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6488
    Cell Significance Index: -17.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6912
    Cell Significance Index: -8.2400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7182
    Cell Significance Index: -7.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7247
    Cell Significance Index: -44.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7314
    Cell Significance Index: -18.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7779
    Cell Significance Index: -22.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8199
    Cell Significance Index: -41.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8689
    Cell Significance Index: -13.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9192
    Cell Significance Index: -26.2300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.9495
    Cell Significance Index: -14.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9808
    Cell Significance Index: -28.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9834
    Cell Significance Index: -31.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9985
    Cell Significance Index: -34.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** USF2 is a member of the Basic Helix-Loop-Helix (bHLH) transcription factor family, which plays a pivotal role in regulating gene expression in response to various stimuli. The gene encodes a protein that exhibits homodimerization and heterodimerization capabilities, allowing it to interact with other transcription factors and influence gene expression. USF2 is also involved in glucose-dependent regulation of transcription, suggesting its role in metabolic processes. The gene's expression is tightly regulated, with its levels modulated by various signaling pathways, including those mediated by nuclear receptors and the estrogen receptor. **Pathways and Functions** USF2 is involved in multiple signaling pathways, including: 1. **Estrogen-dependent gene expression**: USF2 interacts with estrogen receptors to regulate the expression of genes involved in reproductive and developmental processes. 2. **Lipid homeostasis**: USF2 modulates the expression of genes involved in lipid metabolism, suggesting its role in maintaining cellular lipid balance. 3. **Regulation of transcription by RNA polymerase II**: USF2 interacts with RNA polymerase II to regulate the expression of genes involved in various biological processes. 4. **Glucose-dependent regulation of transcription**: USF2 is involved in the regulation of transcription in response to glucose availability, suggesting its role in metabolic processes. 5. **Intracellular signaling**: USF2 is involved in signaling pathways mediated by nuclear receptors, such as the estrogen receptor and the glucocorticoid receptor. **Clinical Significance** The USF2 gene's expression is significant in various diseases, including: 1. **Immunological disorders**: USF2 is involved in the regulation of immune cell function, and its dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: USF2 is involved in the regulation of gene expression in cancer cells, and its dysregulation has been implicated in various types of cancer, including breast cancer and lung cancer. 3. **Neurological disorders**: USF2 is involved in the regulation of gene expression in neurons, and its dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the USF2 gene is a crucial regulator of gene expression in various cell types, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of USF2 in human health and disease.

Genular Protein ID: 368201657

Symbol: USF2_HUMAN

Name: Upstream stimulatory factor 2

UniProtKB Accession Codes:

Q15853 O00671 O00709 Q05750 Q07952 Q15851 Q15852 Q6FI33 Q6YI47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 4 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8576131

Title: Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms.

PubMed ID: 8576131

DOI: 10.1074/jbc.271.3.1405

PubMed ID: 8954795

Title: Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia.

PubMed ID: 8954795

DOI: 10.1006/geno.1996.0609

PubMed ID: 15276216

Title: Isolation of a novel USF2 isoform: repressor of cathepsin B expression.

PubMed ID: 15276216

DOI: 10.1016/j.gene.2004.05.005

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1450663

Title: Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers.

PubMed ID: 1450663

PubMed ID: 1589769

Title: Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos.

PubMed ID: 1589769

DOI: 10.1126/science.1589769

Sequence Information:

  • Length: 346
  • Mass: 36955
  • Checksum: 78CEFE97AC4C10CF
  • Sequence:
    • MDMLDPGLDP AASATAAAAA SHDKGPEAEE GVELQEGGDG PGAEEQTAVA ITSVQQAAFG 
DHNIQYQFRT ETNGGQVTYR VVQVTDGQLD GQGDTAGAVS VVSTAAFAGG QQAVTQVGVD 
GAAQRPGPAA ASVPPGPAAP FPLAVIQNPF SNGGSPAAEA VSGEARFAYF PASSVGDTTA 
VSVQTTDQSL QAGGQFYVMM TPQDVLQTGT QRTIAPRTHP YSPKIDGTRT PRDERRRAQH 
NEVERRRRDK INNWIVQLSK IIPDCNADNS KTGASKGGIL SKACDYIREL RQTNQRMQET 
FKEAERLQMD NELLRQQIEE LKNENALLRA QLQQHNLEMV GEGTRQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.