Details for: UVRAG

Gene ID: 7405

Symbol: UVRAG

Ensembl ID: ENSG00000198382

Description: UV radiation resistance associated

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 409.7522
    Cell Significance Index: -63.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 248.3408
    Cell Significance Index: -62.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 141.5734
    Cell Significance Index: -66.8400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 130.9762
    Cell Significance Index: -53.2100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 119.4630
    Cell Significance Index: -61.4500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 99.6539
    Cell Significance Index: -66.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.8527
    Cell Significance Index: -53.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.0311
    Cell Significance Index: -65.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.6608
    Cell Significance Index: -60.7100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.7505
    Cell Significance Index: -54.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.7560
    Cell Significance Index: -66.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.7505
    Cell Significance Index: -36.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.8837
    Cell Significance Index: 104.0700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 3.5578
    Cell Significance Index: 44.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.3545
    Cell Significance Index: 89.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4098
    Cell Significance Index: 483.4000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.2826
    Cell Significance Index: 32.8300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.1950
    Cell Significance Index: 42.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.7642
    Cell Significance Index: 99.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7633
    Cell Significance Index: 349.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5462
    Cell Significance Index: 554.6100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.4935
    Cell Significance Index: 24.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.4073
    Cell Significance Index: 973.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2982
    Cell Significance Index: 128.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2931
    Cell Significance Index: 99.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2441
    Cell Significance Index: 1123.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0901
    Cell Significance Index: 73.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0575
    Cell Significance Index: 46.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0513
    Cell Significance Index: 39.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0468
    Cell Significance Index: 64.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0453
    Cell Significance Index: 121.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9451
    Cell Significance Index: 111.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6670
    Cell Significance Index: 17.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6617
    Cell Significance Index: 107.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5986
    Cell Significance Index: 16.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5682
    Cell Significance Index: 61.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5358
    Cell Significance Index: 15.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4194
    Cell Significance Index: 75.6000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3753
    Cell Significance Index: 4.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3749
    Cell Significance Index: 8.9900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3598
    Cell Significance Index: 7.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3512
    Cell Significance Index: 661.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3350
    Cell Significance Index: 212.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3087
    Cell Significance Index: 37.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2510
    Cell Significance Index: 386.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2235
    Cell Significance Index: 3.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2189
    Cell Significance Index: 13.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2105
    Cell Significance Index: 95.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2059
    Cell Significance Index: 379.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1472
    Cell Significance Index: 20.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1185
    Cell Significance Index: 161.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0980
    Cell Significance Index: 43.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0881
    Cell Significance Index: 6.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0795
    Cell Significance Index: 2.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0727
    Cell Significance Index: 39.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0442
    Cell Significance Index: 2.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0133
    Cell Significance Index: 2.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0111
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0322
    Cell Significance Index: -20.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0338
    Cell Significance Index: -25.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0490
    Cell Significance Index: -2.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0535
    Cell Significance Index: -39.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0678
    Cell Significance Index: -38.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0773
    Cell Significance Index: -58.5300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0943
    Cell Significance Index: -0.5700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1762
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1861
    Cell Significance Index: -31.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1910
    Cell Significance Index: -12.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1953
    Cell Significance Index: -56.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1964
    Cell Significance Index: -28.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1994
    Cell Significance Index: -25.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2121
    Cell Significance Index: -44.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2257
    Cell Significance Index: -23.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3015
    Cell Significance Index: -19.0000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.3124
    Cell Significance Index: -1.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3131
    Cell Significance Index: -32.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3170
    Cell Significance Index: -40.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4134
    Cell Significance Index: -47.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4170
    Cell Significance Index: -21.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4667
    Cell Significance Index: -24.3100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4683
    Cell Significance Index: -53.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4933
    Cell Significance Index: -23.0000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5056
    Cell Significance Index: -11.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5253
    Cell Significance Index: -37.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5339
    Cell Significance Index: -39.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7034
    Cell Significance Index: -55.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7076
    Cell Significance Index: -15.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7350
    Cell Significance Index: -38.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7835
    Cell Significance Index: -7.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7877
    Cell Significance Index: -25.2300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8766
    Cell Significance Index: -18.6100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.8985
    Cell Significance Index: -13.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9677
    Cell Significance Index: -24.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9693
    Cell Significance Index: -30.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9902
    Cell Significance Index: -32.4200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.0064
    Cell Significance Index: -19.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0529
    Cell Significance Index: -64.5500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.0822
    Cell Significance Index: -11.7900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.0939
    Cell Significance Index: -16.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1128
    Cell Significance Index: -31.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UVRAG is a non-coding gene, meaning it does not encode a protein. Instead, it regulates gene expression through its role in autophagy, a cellular process that involves the breakdown and recycling of cellular components. UVRAG has been shown to interact with various proteins involved in autophagy, including ATG7 and ATG12, and is required for the maturation of autophagosomes, the structures responsible for engulfing and digesting cellular debris. **Pathways and Functions:** UVRAG is involved in several key cellular pathways, including: 1. **Autophagy:** UVRAG regulates autophagosome maturation, ensuring that autophagosomes can effectively recognize and engulf cellular components for degradation. 2. **DNA Repair:** UVRAG has been implicated in the repair of DNA double-strand breaks, particularly those caused by ultraviolet radiation. 3. **Viral Infections:** UVRAG has been shown to play a role in the modulation of autophagy in response to viral infections, including those caused by SARS-CoV-2. **Clinical Significance:** UVRAG has been significantly expressed in various cell types, including those of the adrenal gland, central nervous system, and immune cells. Its dysregulation has been implicated in several diseases, including cancer and neurodegenerative disorders. Moreover, UVRAG has been shown to play a critical role in the response to viral infections, including those caused by SARS-CoV-2. The gene's involvement in autophagy and DNA repair makes it an attractive target for the development of novel therapeutic strategies against viral infections and other diseases. **Clinical Implications:** 1. **Viral Infections:** UVRAG's role in modulating autophagy in response to viral infections makes it a potential target for the development of antiviral therapies. 2. **Cancer:** Dysregulation of UVRAG has been implicated in various types of cancer, including breast and lung cancer. Targeting UVRAG may offer a new avenue for cancer therapy. 3. **Neurodegenerative Disorders:** UVRAG's involvement in autophagy and DNA repair makes it a potential target for the development of novel therapeutic strategies against neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, UVRAG is a multifunctional gene that plays a critical role in maintaining cellular homeostasis and responding to various forms of cellular stress. Its dysregulation has been implicated in several diseases, including cancer and neurodegenerative disorders. Further research is needed to fully understand the role of UVRAG in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3717428915

Symbol: UVRAG_HUMAN

Name: UV radiation resistance-associated gene protein

UniProtKB Accession Codes:

Q9P2Y5 B3KTC1 O00392

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 3 Ensembl 4 ExpressionAtlas 1 GO 34 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9169138

Title: Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus.

PubMed ID: 9169138

DOI: 10.1006/geno.1997.4623

PubMed ID: 10798355

Title: Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation.

PubMed ID: 10798355

DOI: 10.1007/s004390051038

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 16799551

Title: Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.

PubMed ID: 16799551

DOI: 10.1038/ncb1426

PubMed ID: 17891140

Title: Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis.

PubMed ID: 17891140

DOI: 10.1038/ncb1634

PubMed ID: 18843052

Title: Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.

PubMed ID: 18843052

DOI: 10.1091/mbc.e08-01-0080

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18552835

Title: Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

PubMed ID: 18552835

DOI: 10.1038/ncb1740

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19050071

Title: Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.

PubMed ID: 19050071

DOI: 10.1073/pnas.0810452105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19270696

Title: Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.

PubMed ID: 19270696

DOI: 10.1038/ncb1846

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20643123

Title: A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.

PubMed ID: 20643123

DOI: 10.1016/j.yexcr.2010.07.008

PubMed ID: 20974968

Title: Rubicon controls endosome maturation as a Rab7 effector.

PubMed ID: 20974968

DOI: 10.1073/pnas.1010554107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22542840

Title: A dual role for UVRAG in maintaining chromosomal stability independent of autophagy.

PubMed ID: 22542840

DOI: 10.1016/j.devcel.2011.12.027

PubMed ID: 22354037

Title: Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.

PubMed ID: 22354037

DOI: 10.1038/emboj.2012.36

PubMed ID: 22493499

Title: Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex.

PubMed ID: 22493499

DOI: 10.1074/jbc.m112.367060

PubMed ID: 23954414

Title: Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.

PubMed ID: 23954414

DOI: 10.1016/j.cell.2013.07.035

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23878393

Title: Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.

PubMed ID: 23878393

DOI: 10.1128/mcb.00079-13

PubMed ID: 24056303

Title: PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex.

PubMed ID: 24056303

DOI: 10.1038/ncb2848

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24550300

Title: UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs.

PubMed ID: 24550300

DOI: 10.1073/pnas.1320629111

PubMed ID: 25533187

Title: mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.

PubMed ID: 25533187

DOI: 10.1016/j.molcel.2014.11.013

PubMed ID: 27911840

Title: Multistep regulation of autophagy by WNK1.

PubMed ID: 27911840

DOI: 10.1073/pnas.1617649113

PubMed ID: 28306502

Title: Pacer mediates the function of class III PI3K and HOPS complexes in autophagosome maturation by engaging Stx17.

PubMed ID: 28306502

DOI: 10.1016/j.molcel.2017.02.010

Sequence Information:

  • Length: 699
  • Mass: 78151
  • Checksum: 23C4413B10F641BA
  • Sequence:
    • MSASASVGGP VPQPPPGPAA ALPPGSAARA LHVELPSQQR RLRHLRNIAA RNIVNRNGHQ 
LLDTYFTLHL CSTEKIYKEF YRSEVIKNSL NPTWRSLDFG IMPDRLDTSV SCFVVKIWGG 
KENIYQLLIE WKVCLDGLKY LGQQIHARNQ NEIIFGLNDG YYGAPFEHKG YSNAQKTILL 
QVDQNCVRNS YDVFSLLRLH RAQCAIKQTQ VTVQKIGKEI EEKLRLTSTS NELKKKSECL 
QLKILVLQNE LERQKKALGR EVALLHKQQI ALQDKGSAFS AEHLKLQLQK ESLNELRKEC 
TAKRELFLKT NAQLTIRCRQ LLSELSYIYP IDLNEHKDYF VCGVKLPNSE DFQAKDDGSI 
AVALGYTAHL VSMISFFLQV PLRYPIIHKG SRSTIKDNIN DKLTEKEREF PLYPKGGEKL 
QFDYGVYLLN KNIAQLRYQH GLGTPDLRQT LPNLKNFMEH GLMVRCDRHH TSSAIPVPKR 
QSSIFGGADV GFSGGIPSPD KGHRKRASSE NERLQYKTPP PSYNSALAQP VTTVPSMGET 
ERKITSLSSS LDTSLDFSKE NKKKGEDLVG SLNGGHANVH PSQEQGEALS GHRATVNGTL 
LPSEQAGSAS VQLPGEFHPV SEAELCCTVE QAEEIIGLEA TGFASGDQLE AFNCIPVDSA 
VAVECDEQVL GEFEEFSRRI YALNENVSSF RRPRRSSDK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.