Details for: VASP

Gene ID: 7408

Symbol: VASP

Ensembl ID: ENSG00000125753

Description: vasodilator stimulated phosphoprotein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 207.6566
    Cell Significance Index: -32.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 102.5850
    Cell Significance Index: -26.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 85.4877
    Cell Significance Index: -34.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 76.6962
    Cell Significance Index: -36.2100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 73.6802
    Cell Significance Index: -37.9000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 54.2158
    Cell Significance Index: -36.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.5494
    Cell Significance Index: -35.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.0123
    Cell Significance Index: -33.3100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.6568
    Cell Significance Index: -34.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.1037
    Cell Significance Index: -24.8900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.5476
    Cell Significance Index: -14.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.2489
    Cell Significance Index: 78.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5276
    Cell Significance Index: -9.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.4034
    Cell Significance Index: 261.4200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.2824
    Cell Significance Index: 34.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.2779
    Cell Significance Index: 66.9000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.0311
    Cell Significance Index: 12.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7252
    Cell Significance Index: 1557.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6762
    Cell Significance Index: 197.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5761
    Cell Significance Index: 74.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5185
    Cell Significance Index: 78.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2825
    Cell Significance Index: 95.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0699
    Cell Significance Index: 55.7300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.0464
    Cell Significance Index: 6.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9276
    Cell Significance Index: 26.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8781
    Cell Significance Index: 142.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7909
    Cell Significance Index: 35.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7732
    Cell Significance Index: 95.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7599
    Cell Significance Index: 136.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6947
    Cell Significance Index: 18.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6558
    Cell Significance Index: 84.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5362
    Cell Significance Index: 292.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5343
    Cell Significance Index: 236.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5310
    Cell Significance Index: 34.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5000
    Cell Significance Index: 5.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3391
    Cell Significance Index: 9.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3015
    Cell Significance Index: 41.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2566
    Cell Significance Index: 32.9000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2357
    Cell Significance Index: 4.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2241
    Cell Significance Index: 44.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2132
    Cell Significance Index: 21.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1819
    Cell Significance Index: 1.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1799
    Cell Significance Index: 34.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1678
    Cell Significance Index: 11.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0659
    Cell Significance Index: 2.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0276
    Cell Significance Index: 5.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0181
    Cell Significance Index: 6.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0111
    Cell Significance Index: 17.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0091
    Cell Significance Index: 16.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0016
    Cell Significance Index: 3.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0009
    Cell Significance Index: -0.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0098
    Cell Significance Index: -13.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0113
    Cell Significance Index: -8.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0152
    Cell Significance Index: -2.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0169
    Cell Significance Index: -7.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0172
    Cell Significance Index: -10.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0209
    Cell Significance Index: -2.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0305
    Cell Significance Index: -2.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0335
    Cell Significance Index: -21.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0358
    Cell Significance Index: -26.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0482
    Cell Significance Index: -27.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0553
    Cell Significance Index: -2.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0771
    Cell Significance Index: -11.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0910
    Cell Significance Index: -0.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0958
    Cell Significance Index: -27.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1066
    Cell Significance Index: -12.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1105
    Cell Significance Index: -12.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1130
    Cell Significance Index: -23.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1712
    Cell Significance Index: -2.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1744
    Cell Significance Index: -4.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1913
    Cell Significance Index: -5.0300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1983
    Cell Significance Index: -22.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2023
    Cell Significance Index: -2.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2168
    Cell Significance Index: -5.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2190
    Cell Significance Index: -6.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2321
    Cell Significance Index: -6.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2699
    Cell Significance Index: -28.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2715
    Cell Significance Index: -13.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2900
    Cell Significance Index: -6.7000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2976
    Cell Significance Index: -2.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3032
    Cell Significance Index: -7.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3510
    Cell Significance Index: -22.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3531
    Cell Significance Index: -7.6500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3836
    Cell Significance Index: -15.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3929
    Cell Significance Index: -20.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4343
    Cell Significance Index: -34.4000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.4742
    Cell Significance Index: -2.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4774
    Cell Significance Index: -16.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4841
    Cell Significance Index: -32.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5075
    Cell Significance Index: -28.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5192
    Cell Significance Index: -31.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5358
    Cell Significance Index: -32.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5528
    Cell Significance Index: -11.5700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5675
    Cell Significance Index: -5.8800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6421
    Cell Significance Index: -9.1400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.7471
    Cell Significance Index: -12.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7641
    Cell Significance Index: -33.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7872
    Cell Significance Index: -22.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7979
    Cell Significance Index: -29.2900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8193
    Cell Significance Index: -21.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** VASP is a phosphoprotein that belongs to the 4.1 protein family, which is characterized by the presence of a 4.1R domain. VASP is composed of three domains: the N-terminal domain, the central domain, and the C-terminal domain. The central domain is the most conserved region and contains the actin-binding site, which is essential for its function. VASP is phosphorylated by various kinases, including LIM kinase 1 (LIMK1), which regulates its activity and localization. **Pathways and Functions:** VASP is involved in several signaling pathways that regulate actin dynamics, cell adhesion, and immune cell function. Some of the key pathways include: 1. **Actin polymerization and depolymerization:** VASP regulates actin filament polymerization and depolymerization by binding to actin filaments and modulating their dynamics. 2. **Adhesion and migration:** VASP is involved in cell adhesion and migration by regulating the formation of focal adhesions and filopodia. 3. **Immune cell development and function:** VASP is expressed in various immune cells, including myeloid leukocytes, monocytes, and natural killer cells, where it regulates their development, migration, and function. 4. **Signaling pathways:** VASP interacts with various signaling molecules, including G-proteins, MAP kinases, and transcription factors, to regulate immune responses. **Clinical Significance:** VASP has been implicated in various diseases, including: 1. **Immunodeficiency disorders:** VASP mutations have been associated with immunodeficiency disorders, such as Wiskott-Aldrich syndrome and X-linked lymphoproliferative disease. 2. **Cancer:** VASP has been shown to be overexpressed in various types of cancer, including leukemia, lymphoma, and breast cancer, where it promotes tumor progression and metastasis. 3. **Inflammatory diseases:** VASP has been implicated in inflammatory diseases, such as rheumatoid arthritis and atherosclerosis, where it regulates immune cell function and inflammation. 4. **Neurological disorders:** VASP has been shown to play a role in neurological disorders, such as multiple sclerosis and Alzheimer's disease, where it regulates axon guidance and synapse formation. In conclusion, VASP is a crucial regulator of actin dynamics and immune cell function. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and regulation. Further research is needed to elucidate the complex roles of VASP in immune cell development, function, and disease.

Genular Protein ID: 464690959

Symbol: VASP_HUMAN

Name: Vasodilator-stimulated phosphoprotein

UniProtKB Accession Codes:

P50552 B2RBT9 Q6PIZ1 Q93035

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7828592

Title: Molecular cloning, structural analysis and functional expression of the proline-rich focal adhesion and microfilament-associated protein VASP.

PubMed ID: 7828592

DOI: 10.1002/j.1460-2075.1995.tb06971.x

PubMed ID: 10087267

Title: Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes.

PubMed ID: 10087267

DOI: 10.1083/jcb.144.6.1245

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 8812448

Title: Cloning of the VASP (vasodilator-stimulated phosphoprotein) genes in human and mouse: structure, sequence, and chromosomal localization.

PubMed ID: 8812448

DOI: 10.1006/geno.1996.0457

PubMed ID: 8182057

Title: cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets.

PubMed ID: 8182057

DOI: 10.1016/s0021-9258(17)36652-8

PubMed ID: 7925440

Title: Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Ser157 in intact human platelets correlates with fibrinogen receptor inhibition.

PubMed ID: 7925440

DOI: 10.1111/j.1432-1033.1994.00021.x

PubMed ID: 7737110

Title: The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.

PubMed ID: 7737110

DOI: 10.1002/j.1460-2075.1995.tb07146.x

PubMed ID: 10438535

Title: The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding, and actin bundle formation.

PubMed ID: 10438535

DOI: 10.1074/jbc.274.33.23549

PubMed ID: 10801818

Title: Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins.

PubMed ID: 10801818

DOI: 10.1074/jbc.m001698200

PubMed ID: 10637295

Title: LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity.

PubMed ID: 10637295

DOI: 10.1091/mbc.11.1.117

PubMed ID: 15469845

Title: Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.

PubMed ID: 15469845

DOI: 10.1016/j.devcel.2004.07.024

PubMed ID: 14706852

Title: Vasodilator-stimulated phosphoprotein is a substrate for protein kinase C.

PubMed ID: 14706852

DOI: 10.1016/s0014-5793(03)01435-2

PubMed ID: 15939738

Title: Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins.

PubMed ID: 15939738

DOI: 10.1074/jbc.m503957200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16197368

Title: Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser 157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets.

PubMed ID: 16197368

DOI: 10.1042/bj20050796

PubMed ID: 16631741

Title: Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP.

PubMed ID: 16631741

DOI: 10.1016/j.yexcr.2006.03.015

PubMed ID: 17082196

Title: AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein.

PubMed ID: 17082196

DOI: 10.1074/jbc.m608866200

PubMed ID: 18559661

Title: Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes.

PubMed ID: 18559661

DOI: 10.2337/db08-0381

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19109554

Title: Pyrin and ASC co-localize to cellular sites that are rich in polymerizing actin.

PubMed ID: 19109554

DOI: 10.3181/0806-rm-184

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10990454

Title: Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity.

PubMed ID: 10990454

DOI: 10.1093/emboj/19.18.4903

PubMed ID: 15569942

Title: The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat.

PubMed ID: 15569942

DOI: 10.1073/pnas.0403069101

PubMed ID: 17914456

Title: Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP.

PubMed ID: 17914456

DOI: 10.1038/sj.emboj.7601874

PubMed ID: 18689676

Title: Modulation of actin structure and function by phosphorylation of Tyr-53 and profilin binding.

PubMed ID: 18689676

DOI: 10.1073/pnas.0805852105

Sequence Information:

  • Length: 380
  • Mass: 39830
  • Checksum: 17634B8134DEBF59
  • Sequence:
    • MSETVICSSR ATVMLYDDGN KRWLPAGTGP QAFSRVQIYH NPTANSFRVV GRKMQPDQQV 
VINCAIVRGV KYNQATPNFH QWRDARQVWG LNFGSKEDAA QFAAGMASAL EALEGGGPPP 
PPALPTWSVP NGPSPEEVEQ QKRQQPGPSE HIERRVSNAG GPPAPPAGGP PPPPGPPPPP 
GPPPPPGLPP SGVPAAAHGA GGGPPPAPPL PAAQGPGGGG AGAPGLAAAI AGAKLRKVSK 
QEEASGGPTA PKAESGRSGG GGLMEEMNAM LARRRKATQV GEKTPKDESA NQEEPEARVP 
AQSESVRRPW EKNSTTLPRM KSSSSVTTSE TQPCTPSSSD YSDLQRVKQE LLEEVKKELQ 
KVKEEIIEAF VQELRKRGSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.