Details for: LAT2

Gene ID: 7462

Symbol: LAT2

Ensembl ID: ENSG00000086730

Description: linker for activation of T cells family member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 13.85
    Marker Score: 14499.5
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.13
    Marker Score: 3304
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.5
    Marker Score: 29618
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 3.32
    Marker Score: 2017
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.77
    Marker Score: 28039
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.71
    Marker Score: 11077
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.26
    Marker Score: 6713
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.23
    Marker Score: 1575
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.08
    Marker Score: 116238
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.06
    Marker Score: 517
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.04
    Marker Score: 1244
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.96
    Marker Score: 709
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.88
    Marker Score: 4673
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.85
    Marker Score: 912
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.84
    Marker Score: 796
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.83
    Marker Score: 5050
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.78
    Marker Score: 867
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.77
    Marker Score: 7358
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.75
    Marker Score: 713
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.74
    Marker Score: 3027
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.72
    Marker Score: 410
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.69
    Marker Score: 1874
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.68
    Marker Score: 4568
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.63
    Marker Score: 1927.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1147
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.55
    Marker Score: 761
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.55
    Marker Score: 3026
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.55
    Marker Score: 1385
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.55
    Marker Score: 1122
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.55
    Marker Score: 1575
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.51
    Marker Score: 4394
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.49
    Marker Score: 342
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.47
    Marker Score: 1002
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168357
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.43
    Marker Score: 16661
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.42
    Marker Score: 1074
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.4
    Marker Score: 1312
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.31
    Marker Score: 691
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.31
    Marker Score: 649
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.29
    Marker Score: 644
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.28
    Marker Score: 3322.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.25
    Marker Score: 1427
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 837
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.2
    Marker Score: 725
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.2
    Marker Score: 30689
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.17
    Marker Score: 1154
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4780
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.13
    Marker Score: 624
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.12
    Marker Score: 485
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.11
    Marker Score: 665
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.08
    Marker Score: 718
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.06
    Marker Score: 623
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.05
    Marker Score: 697
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.05
    Marker Score: 791
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251759
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.01
    Marker Score: 348
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71779
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48003
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.99
    Marker Score: 6041
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.99
    Marker Score: 2076
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.98
    Marker Score: 274
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.98
    Marker Score: 406
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.98
    Marker Score: 621
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.98
    Marker Score: 6488
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.98
    Marker Score: 313
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.96
    Marker Score: 341
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.96
    Marker Score: 337
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.93
    Marker Score: 298
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 365
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2728
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.91
    Marker Score: 406
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.9
    Marker Score: 227
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5051
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.87
    Marker Score: 603
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.87
    Marker Score: 302
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5271
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.82
    Marker Score: 2051
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.77
    Marker Score: 254
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.77
    Marker Score: 836
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 585.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 685
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.74
    Marker Score: 450
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1182
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.7
    Marker Score: 544
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.7
    Marker Score: 346
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.69
    Marker Score: 165
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.69
    Marker Score: 916
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.67
    Marker Score: 641
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.67
    Marker Score: 489
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.63
    Marker Score: 195
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.62
    Marker Score: 8211

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Other Information

**Key Characteristics:** LAT2 is a cytoplasmic protein that contains a SH2 domain, which is essential for its interaction with phospholipase C-γ (PLC-γ) and protein tyrosine kinases (PTKs). This interaction triggers a cascade of signaling events that lead to the activation of T cells. LAT2 is also known to bind to calcium, which mobilizes intracellular calcium stores and enhances T cell activation. The protein's expression is widespread, with significant presence in thymocytes, myeloid dendritic cells, and B cells, suggesting its importance in various immune cell types. **Pathways and Functions:** LAT2 is involved in several key signaling pathways that regulate T cell activation, proliferation, and survival. These pathways include: 1. **Calcium-mediated signaling:** LAT2's interaction with calcium mobilizes intracellular calcium stores, which in turn activates PLC-γ and PTKs, leading to the production of second messengers and the activation of downstream signaling pathways. 2. **Adaptive immune response:** LAT2 plays a critical role in the activation and proliferation of T cells, which is essential for the adaptive immune response. 3. **B cell activation:** LAT2 is also expressed in B cells and is involved in the activation and differentiation of these cells. 4. **Innate immune response:** LAT2's expression in myeloid dendritic cells and classical monocytes suggests its involvement in the innate immune response. **Clinical Significance:** LAT2's dysregulation has been implicated in various immunological disorders, including: 1. **Immunodeficiency diseases:** LAT2 mutations have been associated with immunodeficiency diseases, such as X-linked agammaglobulinemia (XLA). 2. **Cancer:** LAT2's overexpression has been observed in various types of cancer, including T-cell lymphoma and leukemia. 3. **Autoimmune diseases:** LAT2's dysregulation has been implicated in autoimmune diseases, such as type 1 diabetes and rheumatoid arthritis. In conclusion, LAT2 is a critical gene that plays a pivotal role in the regulation of T cell activation, proliferation, and survival. Its dysregulation has been implicated in various immunological disorders, highlighting the importance of LAT2 in maintaining immune homeostasis. Further research is needed to fully elucidate the mechanisms underlying LAT2's functions and its role in human disease.

Genular Protein ID: 2166712403

Symbol: NTAL_HUMAN

Name: Linker for activation of T-cells family member 2

UniProtKB Accession Codes:

Q9GZY6 A6NFK6 A8K209 A8K4F1 D3DXF9 Q9BXX8 Q9NZY9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 20 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11124535

Title: Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome.

PubMed ID: 11124535

DOI: 10.1159/000056790

PubMed ID: 11003705

Title: Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23.

PubMed ID: 11003705

DOI: 10.1007/s003350010166

PubMed ID: 12486104

Title: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.

PubMed ID: 12486104

DOI: 10.1084/jem.20021405

PubMed ID: 12514734

Title: LAB: a new membrane-associated adaptor molecule in B cell activation.

PubMed ID: 12514734

DOI: 10.1038/ni882

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15010370

Title: NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation.

PubMed ID: 15010370

DOI: 10.1182/blood-2003-08-2769

PubMed ID: 14722116

Title: The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB.

PubMed ID: 14722116

DOI: 10.1074/jbc.m311394200

PubMed ID: 16160011

Title: Transmembrane adaptor molecules: a new category of lymphoid-cell markers.

PubMed ID: 16160011

DOI: 10.1182/blood-2005-06-2273

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 243
  • Mass: 26550
  • Checksum: 222D2CCF3C71C503
  • Sequence:
    • MSSGTELLWP GAALLVLLGV AASLCVRCSR PGAKRSEKIY QQRSLREDQQ SFTGSRTYSL 
VGQAWPGPLA DMAPTRKDKL LQFYPSLEDP ASSRYQNFSK GSRHGSEEAY IDPIAMEYYN 
WGRFSKPPED DDANSYENVL ICKQKTTETG AQQEGIGGLC RGDLSLSLAL KTGPTSGLCP 
SASPEEDEES EDYQNSASIH QWRESRKVMG QLQREASPGP VGSPDEEDGE PDYVNGEVAA 
TEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.