Details for: LAT2

Gene ID: 7462

Symbol: LAT2

Ensembl ID: ENSG00000086730

Description: linker for activation of T cells family member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 107.5571
    Cell Significance Index: -16.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.5531
    Cell Significance Index: -18.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 39.0952
    Cell Significance Index: -20.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.5366
    Cell Significance Index: -16.6900
  • Cell Name: centroblast (CL0009112)
    Fold Change: 7.9295
    Cell Significance Index: 18.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.2654
    Cell Significance Index: 339.7000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.6847
    Cell Significance Index: 72.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3715
    Cell Significance Index: -17.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.1556
    Cell Significance Index: -9.1000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 4.0959
    Cell Significance Index: 10.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.9478
    Cell Significance Index: 242.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.8908
    Cell Significance Index: 53.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.6610
    Cell Significance Index: 313.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.8777
    Cell Significance Index: -5.0300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.6400
    Cell Significance Index: 10.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.3576
    Cell Significance Index: 36.3200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.1529
    Cell Significance Index: 7.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6646
    Cell Significance Index: 65.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6219
    Cell Significance Index: 561.4900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.5832
    Cell Significance Index: 10.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4126
    Cell Significance Index: 8.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3441
    Cell Significance Index: 55.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3093
    Cell Significance Index: 7.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2981
    Cell Significance Index: 59.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2370
    Cell Significance Index: 25.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2171
    Cell Significance Index: 150.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2154
    Cell Significance Index: 41.0000
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.2076
    Cell Significance Index: 0.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1204
    Cell Significance Index: 24.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1012
    Cell Significance Index: 7.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0882
    Cell Significance Index: 3.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0584
    Cell Significance Index: 20.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0189
    Cell Significance Index: 3.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0158
    Cell Significance Index: 2.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0033
    Cell Significance Index: -5.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0047
    Cell Significance Index: -8.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0086
    Cell Significance Index: -11.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0090
    Cell Significance Index: -0.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0091
    Cell Significance Index: -5.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0149
    Cell Significance Index: -0.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0161
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0210
    Cell Significance Index: -15.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0222
    Cell Significance Index: -16.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0253
    Cell Significance Index: -13.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0262
    Cell Significance Index: -19.2200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0270
    Cell Significance Index: -1.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0329
    Cell Significance Index: -20.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0342
    Cell Significance Index: -2.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0353
    Cell Significance Index: -19.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0386
    Cell Significance Index: -17.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0399
    Cell Significance Index: -1.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0406
    Cell Significance Index: -0.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0519
    Cell Significance Index: -5.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0580
    Cell Significance Index: -1.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0587
    Cell Significance Index: -16.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0912
    Cell Significance Index: -11.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0912
    Cell Significance Index: -11.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0985
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0996
    Cell Significance Index: -20.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1060
    Cell Significance Index: -2.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1066
    Cell Significance Index: -18.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1085
    Cell Significance Index: -6.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1185
    Cell Significance Index: -16.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1211
    Cell Significance Index: -3.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1241
    Cell Significance Index: -14.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1521
    Cell Significance Index: -19.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1545
    Cell Significance Index: -16.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1617
    Cell Significance Index: -9.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1735
    Cell Significance Index: -19.8800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1871
    Cell Significance Index: -2.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2008
    Cell Significance Index: -13.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2047
    Cell Significance Index: -9.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2370
    Cell Significance Index: -6.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2540
    Cell Significance Index: -18.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2689
    Cell Significance Index: -11.9000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.2901
    Cell Significance Index: -2.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2970
    Cell Significance Index: -18.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3043
    Cell Significance Index: -5.2200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3141
    Cell Significance Index: -13.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3221
    Cell Significance Index: -15.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3227
    Cell Significance Index: -12.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3280
    Cell Significance Index: -17.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3334
    Cell Significance Index: -17.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3390
    Cell Significance Index: -17.6600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3409
    Cell Significance Index: -4.9500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3750
    Cell Significance Index: -9.1500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3786
    Cell Significance Index: -5.3800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3938
    Cell Significance Index: -5.7600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3995
    Cell Significance Index: -7.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4517
    Cell Significance Index: -12.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4544
    Cell Significance Index: -15.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4964
    Cell Significance Index: -10.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4988
    Cell Significance Index: -15.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5000
    Cell Significance Index: -16.3700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.5153
    Cell Significance Index: -6.5300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.5163
    Cell Significance Index: -16.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5168
    Cell Significance Index: -18.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5435
    Cell Significance Index: -15.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5557
    Cell Significance Index: -19.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LAT2 is a cytoplasmic protein that contains a SH2 domain, which is essential for its interaction with phospholipase C-γ (PLC-γ) and protein tyrosine kinases (PTKs). This interaction triggers a cascade of signaling events that lead to the activation of T cells. LAT2 is also known to bind to calcium, which mobilizes intracellular calcium stores and enhances T cell activation. The protein's expression is widespread, with significant presence in thymocytes, myeloid dendritic cells, and B cells, suggesting its importance in various immune cell types. **Pathways and Functions:** LAT2 is involved in several key signaling pathways that regulate T cell activation, proliferation, and survival. These pathways include: 1. **Calcium-mediated signaling:** LAT2's interaction with calcium mobilizes intracellular calcium stores, which in turn activates PLC-γ and PTKs, leading to the production of second messengers and the activation of downstream signaling pathways. 2. **Adaptive immune response:** LAT2 plays a critical role in the activation and proliferation of T cells, which is essential for the adaptive immune response. 3. **B cell activation:** LAT2 is also expressed in B cells and is involved in the activation and differentiation of these cells. 4. **Innate immune response:** LAT2's expression in myeloid dendritic cells and classical monocytes suggests its involvement in the innate immune response. **Clinical Significance:** LAT2's dysregulation has been implicated in various immunological disorders, including: 1. **Immunodeficiency diseases:** LAT2 mutations have been associated with immunodeficiency diseases, such as X-linked agammaglobulinemia (XLA). 2. **Cancer:** LAT2's overexpression has been observed in various types of cancer, including T-cell lymphoma and leukemia. 3. **Autoimmune diseases:** LAT2's dysregulation has been implicated in autoimmune diseases, such as type 1 diabetes and rheumatoid arthritis. In conclusion, LAT2 is a critical gene that plays a pivotal role in the regulation of T cell activation, proliferation, and survival. Its dysregulation has been implicated in various immunological disorders, highlighting the importance of LAT2 in maintaining immune homeostasis. Further research is needed to fully elucidate the mechanisms underlying LAT2's functions and its role in human disease.

Genular Protein ID: 2166712403

Symbol: NTAL_HUMAN

Name: Linker for activation of T-cells family member 2

UniProtKB Accession Codes:

Q9GZY6 A6NFK6 A8K209 A8K4F1 D3DXF9 Q9BXX8 Q9NZY9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 20 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11124535

Title: Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome.

PubMed ID: 11124535

DOI: 10.1159/000056790

PubMed ID: 11003705

Title: Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23.

PubMed ID: 11003705

DOI: 10.1007/s003350010166

PubMed ID: 12486104

Title: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.

PubMed ID: 12486104

DOI: 10.1084/jem.20021405

PubMed ID: 12514734

Title: LAB: a new membrane-associated adaptor molecule in B cell activation.

PubMed ID: 12514734

DOI: 10.1038/ni882

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15010370

Title: NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation.

PubMed ID: 15010370

DOI: 10.1182/blood-2003-08-2769

PubMed ID: 14722116

Title: The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB.

PubMed ID: 14722116

DOI: 10.1074/jbc.m311394200

PubMed ID: 16160011

Title: Transmembrane adaptor molecules: a new category of lymphoid-cell markers.

PubMed ID: 16160011

DOI: 10.1182/blood-2005-06-2273

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 243
  • Mass: 26550
  • Checksum: 222D2CCF3C71C503
  • Sequence:
    • MSSGTELLWP GAALLVLLGV AASLCVRCSR PGAKRSEKIY QQRSLREDQQ SFTGSRTYSL 
VGQAWPGPLA DMAPTRKDKL LQFYPSLEDP ASSRYQNFSK GSRHGSEEAY IDPIAMEYYN 
WGRFSKPPED DDANSYENVL ICKQKTTETG AQQEGIGGLC RGDLSLSLAL KTGPTSGLCP 
SASPEEDEES EDYQNSASIH QWRESRKVMG QLQREASPGP VGSPDEEDGE PDYVNGEVAA 
TEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.