Details for: WRN
Gene ID: 7486
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: WRN
Ensembl ID: ENSG00000165392
Description: WRN RecQ like helicase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 24.39rCSI 50.36%PRS 56.8
-
CSI 12.81rCSI 21.51%PRS 36.03
-
CSI 12.2rCSI 19.27%PRS 54.6
-
CSI 10.55rCSI 25.63%PRS 34.81
-
CSI 10.13rCSI 31.66%PRS 37.42
-
CSI 8.7rCSI 23.98%PRS 49.07
-
CSI 8.68rCSI 19.17%PRS 40.29
-
CSI 7.8rCSI 19.32%PRS 51.14
-
CSI 7.21rCSI 11.5%PRS 46.44
-
CSI 7rCSI 18.58%PRS 66.11
-
CSI 6.67rCSI 8.3%PRS 55.3
-
CSI 6.44rCSI 23.17%PRS 34.69
-
CSI 6.4rCSI 9.65%PRS 56.25
-
CSI 5.9rCSI 26.2%PRS 52.31
-
CSI 5.81rCSI 34.24%PRS 37.47
-
CSI 5.64rCSI 10.56%PRS 42.07
-
CSI 5.48rCSI 20.54%PRS 45.47
-
CSI 5.27rCSI 18.04%PRS 43.07
-
CSI 4.88rCSI 18.45%PRS 36.83
-
CSI 4.8rCSI 9.75%PRS 33.94
-
CSI 4.74rCSI 3.74%PRS 40.34
-
CSI 4.67rCSI 11.85%PRS 42.91
-
CSI 4.6rCSI 10.07%PRS 62.03
-
CSI 4.47rCSI 6.81%PRS 49.62
-
CSI 4.4rCSI 4.72%PRS 51.65
-
CSI 4.32rCSI 9.81%PRS 58.28
-
CSI 4.31rCSI 3.36%PRS 71.13
-
CSI 4.31rCSI 5.15%PRS 35.85
-
CSI 4.31rCSI 8.95%PRS 50.45
-
CSI 4.28rCSI 31.48%PRS 40.41
-
CSI 4.28rCSI 4.94%PRS 47.06
-
CSI 4.1rCSI 9.35%PRS 45.58
-
CSI 3.98rCSI 5.11%PRS 50.93
-
CSI 3.95rCSI 5.59%PRS 49.58
-
CSI 3.92rCSI 2.75%PRS 73.03
-
CSI 3.76rCSI 5.22%PRS 52.44
-
CSI 3.62rCSI 2.72%PRS 57.76
-
CSI 3.59rCSI 8.18%PRS 50.56
-
CSI 3.57rCSI 4.27%PRS 71.72
-
CSI 3.53rCSI 6.35%PRS 46.36
-
CSI 3.49rCSI 8.4%PRS 61.89
-
CSI 3.43rCSI 2.39%PRS 63.36
-
CSI 3.41rCSI 5.59%PRS 42.97
-
CSI 3.41rCSI 4.67%PRS 58.65
-
CSI 3.4rCSI 7.84%PRS 43.3
-
CSI 3.39rCSI 5.97%PRS 50.66
-
CSI 3.35rCSI 2.34%PRS 55.72
-
CSI 3.34rCSI 5.49%PRS 58.62
-
CSI 3.33rCSI 7.61%PRS 52.6
-
CSI 3.31rCSI 4.87%PRS 47.45
-
CSI 3.31rCSI 2.94%PRS 51.61
-
CSI 3.31rCSI 5.84%PRS 35.03
-
CSI 3.29rCSI 4.22%PRS 47.04
-
CSI 3.27rCSI 2.64%PRS 63
-
CSI 3.22rCSI 9.57%PRS 63.61
-
CSI 3.17rCSI 18.27%PRS 53.46
-
CSI 3.15rCSI 2.85%PRS 50.04
-
CSI 3.05rCSI 6.13%PRS 42.5
-
CSI 3.03rCSI 2.82%PRS 52.9
-
CSI 3rCSI 9.25%PRS 63.43
-
CSI 2.98rCSI 7.76%PRS 52.4
-
CSI 2.91rCSI 16.46%PRS 38.72
-
CSI 2.78rCSI 2.44%PRS 41.62
-
CSI 2.75rCSI 3.3%PRS 51.28
-
CSI 2.73rCSI 9.13%PRS 39.61
-
CSI 2.68rCSI 2.93%PRS 56.83
-
CSI 2.65rCSI 2.51%PRS 53.36
-
CSI 2.58rCSI 3.71%PRS 43.45
-
CSI 2.56rCSI 6.47%PRS 61.66
-
CSI 2.55rCSI 2.35%PRS 54.28
-
CSI 2.55rCSI 7.45%PRS 79.01
-
CSI 2.52rCSI 9.87%PRS 29.71
-
CSI 2.49rCSI 4.37%PRS 45.24
-
CSI 2.47rCSI 3.19%PRS 37.08
-
CSI 2.46rCSI 12.24%PRS 51.75
-
CSI 2.45rCSI 3.28%PRS 54.3
-
CSI 2.45rCSI 2.03%PRS 54.81
-
CSI 2.42rCSI 58.05%PRS 35.4
-
CSI 2.42rCSI 4.19%PRS 43.39
-
CSI 2.41rCSI 2.46%PRS 69.91
-
CSI 2.38rCSI 57.33%PRS 36.38
-
CSI 2.31rCSI 2.03%PRS 58.61
-
CSI 2.27rCSI 6.44%PRS 51.71
-
CSI 2.25rCSI 3.33%PRS 58.57
-
CSI 2.24rCSI 2.78%PRS 34.28
-
CSI 2.21rCSI 3.55%PRS 38.17
-
CSI 2.18rCSI 1.77%PRS 54.41
-
CSI 2.18rCSI 44.42%PRS 44.59
-
CSI 2.18rCSI 6.32%PRS 43.53
-
CSI 2.11rCSI 1.71%PRS 53.63
-
CSI 2.07rCSI 9.9%PRS 52.75
-
CSI 2.06rCSI 2.38%PRS 43.11
-
CSI 2.02rCSI 8.17%PRS 51.53
-
CSI 2rCSI 3.2%PRS 56.97
-
CSI 2rCSI 4.47%PRS 36.8
-
CSI 1.99rCSI 40.57%PRS 45.93
-
CSI 1.99rCSI 5.32%PRS 44.87
-
CSI 1.97rCSI 1.52%PRS 54.17
-
CSI 1.94rCSI 5.16%PRS 43.7
-
CSI 1.92rCSI 8.45%PRS 45.01
-
CSI 0.3rCSI 2.0%PRS 45.2%
-
CSI 0.4rCSI 2.1%PRS 63.6%
-
CSI 0.5rCSI 3.2%PRS 49.7%
-
CSI 0.5rCSI 2.6%PRS 76.3%
-
CSI 0.6rCSI 4.9%PRS 46.6%
-
CSI 0.6rCSI 4.5%PRS 50.0%
-
CSI 0.6rCSI 1.7%PRS 51.2%
-
CSI 0.6rCSI 8.9%PRS 44.8%
-
CSI 0.7rCSI 5.1%PRS 47.5%
-
CSI 0.8rCSI 0.6%PRS 52.7%
-
CSI 0.8rCSI 4.1%PRS 64.7%
-
CSI 0.9rCSI 4.6%PRS 67.2%
-
CSI 0.9rCSI 2.1%PRS 41.3%
-
CSI 0.9rCSI 3.7%PRS 64.7%
-
CSI 0.9rCSI 3.0%PRS 41.0%
-
CSI 1.0rCSI 2.2%PRS 66.8%
-
CSI 1.0rCSI 2.1%PRS 45.1%
-
CSI 1.0rCSI 1.8%PRS 61.5%
-
CSI 1.0rCSI 6.8%PRS 50.8%
-
CSI 1.0rCSI 2.8%PRS 61.3%
-
CSI 1.0rCSI 3.4%PRS 52.0%
-
CSI 1.0rCSI 1.3%PRS 49.1%
-
CSI 1.1rCSI 6.3%PRS 49.2%
-
CSI 1.1rCSI 6.8%PRS 36.7%
-
CSI 1.1rCSI 5.1%PRS 49.1%
-
CSI 1.2rCSI 9.4%PRS 46.7%
-
CSI 1.2rCSI 10.0%PRS 40.2%
-
CSI 1.2rCSI 3.2%PRS 61.5%
-
CSI 1.2rCSI 2.2%PRS 69.3%
-
CSI 1.3rCSI 4.3%PRS 54.4%
-
CSI 1.4rCSI 2.5%PRS 45.9%
-
CSI 1.4rCSI 1.3%PRS 43.8%
-
CSI 1.4rCSI 1.7%PRS 61.6%
-
CSI 1.4rCSI 2.4%PRS 31.2%
-
CSI 1.4rCSI 3.1%PRS 50.9%
-
CSI 1.4rCSI 6.4%PRS 73.5%
-
CSI 1.5rCSI 6.5%PRS 37.9%
-
CSI 1.5rCSI 3.9%PRS 57.4%
-
CSI 1.5rCSI 2.2%PRS 56.8%
-
CSI 1.5rCSI 5.9%PRS 69.3%
-
CSI 1.6rCSI 4.6%PRS 51.4%
-
CSI 1.6rCSI 7.5%PRS 52.4%
-
CSI 1.6rCSI 2.4%PRS 53.8%
-
CSI 1.6rCSI 4.1%PRS 48.5%
-
CSI 1.6rCSI 3.2%PRS 51.3%
-
CSI 1.6rCSI 2.6%PRS 45.7%
-
CSI 1.7rCSI 1.4%PRS 57.9%
-
CSI 1.7rCSI 4.5%PRS 51.5%
-
CSI 1.7rCSI 1.8%PRS 58.9%
-
CSI 1.7rCSI 4.1%PRS 63.7%
-
CSI 1.7rCSI 4.2%PRS 47.6%
-
CSI 1.7rCSI 4.2%PRS 54.5%
-
CSI 1.8rCSI 5.6%PRS 50.2%
-
CSI 1.8rCSI 3.9%PRS 42.2%
-
CSI 1.8rCSI 5.6%PRS 39.9%
-
CSI 1.8rCSI 6.9%PRS 45.0%
-
CSI 1.9rCSI 1.9%PRS 52.0%
-
CSI 1.9rCSI 4.4%PRS 62.5%
-
CSI 1.9rCSI 2.9%PRS 61.6%
-
CSI 1.9rCSI 2.6%PRS 47.8%
-
CSI 1.9rCSI 3.1%PRS 43.3%
-
CSI 1.9rCSI 8.5%PRS 45.0%
-
CSI 1.9rCSI 5.2%PRS 43.7%
-
CSI 2.0rCSI 1.5%PRS 54.2%
-
CSI 2.0rCSI 5.3%PRS 44.9%
-
CSI 2.0rCSI 40.6%PRS 45.9%
-
CSI 2.0rCSI 4.5%PRS 36.8%
-
CSI 2.0rCSI 3.2%PRS 57.0%
-
CSI 2.0rCSI 8.2%PRS 51.5%
-
CSI 2.1rCSI 2.4%PRS 43.1%
-
CSI 2.1rCSI 9.9%PRS 52.8%
-
CSI 2.1rCSI 1.7%PRS 53.6%
-
CSI 2.2rCSI 6.3%PRS 43.5%
-
CSI 2.2rCSI 44.4%PRS 44.6%
-
CSI 2.2rCSI 1.8%PRS 54.4%
-
CSI 2.2rCSI 3.6%PRS 38.2%
-
CSI 2.2rCSI 2.8%PRS 34.3%
-
CSI 2.3rCSI 3.3%PRS 58.6%
-
CSI 2.3rCSI 6.4%PRS 51.7%
-
CSI 2.3rCSI 2.0%PRS 58.6%
-
CSI 2.4rCSI 57.3%PRS 36.4%
-
CSI 2.4rCSI 2.5%PRS 69.9%
-
CSI 2.4rCSI 4.2%PRS 43.4%
-
CSI 2.4rCSI 58.1%PRS 35.4%
-
CSI 2.5rCSI 2.0%PRS 54.8%
-
CSI 2.5rCSI 3.3%PRS 54.3%
-
CSI 2.5rCSI 12.2%PRS 51.8%
-
CSI 2.5rCSI 3.2%PRS 37.1%
-
CSI 2.5rCSI 4.4%PRS 45.2%
-
CSI 2.5rCSI 9.9%PRS 29.7%
-
CSI 2.6rCSI 7.5%PRS 79.0%
-
CSI 2.6rCSI 2.4%PRS 54.3%
-
CSI 2.6rCSI 6.5%PRS 61.7%
-
CSI 2.6rCSI 3.7%PRS 43.5%
-
CSI 2.7rCSI 2.5%PRS 53.4%
-
CSI 2.7rCSI 2.9%PRS 56.8%
-
CSI 2.7rCSI 9.1%PRS 39.6%
-
CSI 2.8rCSI 3.3%PRS 51.3%
-
CSI 2.8rCSI 2.4%PRS 41.6%
-
CSI 2.9rCSI 16.5%PRS 38.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1185807910
Symbol: WRN_HUMAN
Name: DNA helicase, RecQ-like type 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8602509
Title: Positional cloning of the Werner's syndrome gene.
PubMed ID: 8602509
PubMed ID: 16723399
Title: Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.
PubMed ID: 16723399
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 9288107
PubMed ID: 9224595
Title: DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system.
PubMed ID: 9224595
PubMed ID: 9611231
Title: Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A.
PubMed ID: 9611231
PubMed ID: 9618508
Title: Nucleolar localization of the Werner syndrome protein in human cells.
PubMed ID: 9618508
PubMed ID: 10049920
Title: Evolution of the RECQ family of helicases: a Drosophila homolog, Dmblm, is similar to the human Bloom syndrome gene.
PubMed ID: 10049920
PubMed ID: 10212265
Title: Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n.
PubMed ID: 10212265
PubMed ID: 9989816
Title: Two novel regions of interstitial deletion on chromosome 8p in colorectal cancer.
PubMed ID: 9989816
PubMed ID: 11863428
Title: A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities.
PubMed ID: 11863428
DOI: 10.1021/bi0157161
PubMed ID: 11889123
Title: Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation.
PubMed ID: 11889123
PubMed ID: 12704184
Title: The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein.
PubMed ID: 12704184
PubMed ID: 17961633
Title: Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.
PubMed ID: 17961633
PubMed ID: 17563354
Title: Werner syndrome protein interacts functionally with translesion DNA polymerases.
PubMed ID: 17563354
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18596042
Title: The Werner syndrome protein binds replication fork and Holliday junction DNAs as an oligomer.
PubMed ID: 18596042
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19652551
Title: WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts.
PubMed ID: 19652551
DOI: 10.4161/cc.8.17.9410
PubMed ID: 19283071
Title: The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation.
PubMed ID: 19283071
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21639834
Title: Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in gamma-irradiation-induced DNA damage responses.
PubMed ID: 21639834
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24308539
Title: Systematic genomic identification of colorectal cancer genes delineating advanced from early clinical stage and metastasis.
PubMed ID: 24308539
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 27063109
Title: The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins.
PubMed ID: 27063109
DOI: 10.1038/ncomms11242
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 16339893
Title: Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein.
PubMed ID: 16339893
PubMed ID: 16622405
Title: WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing.
PubMed ID: 16622405
DOI: 10.1038/nsmb1088
PubMed ID: 10220139
Title: WRN mutations in Werner syndrome.
PubMed ID: 10220139
DOI: 10.1002/(sici)1098-1004(1999)13:4<271::aid-humu2>3.0.co;2-q
PubMed ID: 17148451
Title: Crystal structure of the HRDC domain of human Werner syndrome protein, WRN.
PubMed ID: 17148451
PubMed ID: 20159463
Title: Structural basis for DNA strand separation by the unconventional winged-helix domain of RecQ helicase WRN.
PubMed ID: 20159463
PubMed ID: 31733588
Title: Ligand binding characteristics of the Ku80 von Willebrand domain.
PubMed ID: 31733588
PubMed ID: 33199508
Title: Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
PubMed ID: 33199508
PubMed ID: 9021029
Title: Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population.
PubMed ID: 9021029
DOI: 10.1002/(sici)1096-8628(19970211)68:4<494::aid-ajmg30>3.0.co;2-l
PubMed ID: 9450180
Title: Werner syndrome: characterization of mutations in the WRN gene in an affected family.
PubMed ID: 9450180
PubMed ID: 23180761
Title: RECQL5 plays co-operative and complementary roles with WRN syndrome helicase.
PubMed ID: 23180761
DOI: 10.1093/nar/gks1134
PubMed ID: 10206685
Title: The 1396del A mutation and a missense mutation or a rare polymorphism of the WRN gene detected in a French Werner family with a severe phenotype and a case of an unusual vulvar cancer.
PubMed ID: 10206685
DOI: 10.1002/(sici)1098-1004(1998)11:5<413::aid-humu16>3.0.co;2-i
PubMed ID: 10069711
Title: Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians.
PubMed ID: 10069711
DOI: 10.1002/(sici)1096-8628(19990219)82:5<399::aid-ajmg8>3.3.co;2-i
PubMed ID: 11161804
Title: The Werner syndrome gene and global sequence variation.
PubMed ID: 11161804
PubMed ID: 16673358
Title: The spectrum of WRN mutations in Werner syndrome patients.
PubMed ID: 16673358
DOI: 10.1002/humu.20337
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 18987736
Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.
PubMed ID: 18987736
DOI: 10.1038/nature07485
Sequence Information:
- Length: 1432
- Mass: 162461
- Checksum: 63F10D19E90AA461
- Sequence:
MSEKKLETTA QQRKCPEWMN VQNKRCAVEE RKACVRKSVF EDDLPFLEFT GSIVYSYDAS DCSFLSEDIS MSLSDGDVVG FDMEWPPLYN RGKLGKVALI QLCVSESKCY LFHVSSMSVF PQGLKMLLEN KAVKKAGVGI EGDQWKLLRD FDIKLKNFVE LTDVANKKLK CTETWSLNSL VKHLLGKQLL KDKSIRCSNW SKFPLTEDQK LYAATDAYAG FIIYRNLEIL DDTVQRFAIN KEEEILLSDM NKQLTSISEE VMDLAKHLPH AFSKLENPRR VSILLKDISE NLYSLRRMII GSTNIETELR PSNNLNLLSF EDSTTGGVQQ KQIREHEVLI HVEDETWDPT LDHLAKHDGE DVLGNKVERK EDGFEDGVED NKLKENMERA CLMSLDITEH ELQILEQQSQ EEYLSDIAYK STEHLSPNDN ENDTSYVIES DEDLEMEMLK HLSPNDNEND TSYVIESDED LEMEMLKSLE NLNSGTVEPT HSKCLKMERN LGLPTKEEEE DDENEANEGE EDDDKDFLWP APNEEQVTCL KMYFGHSSFK PVQWKVIHSV LEERRDNVAV MATGYGKSLC FQYPPVYVGK IGLVISPLIS LMEDQVLQLK MSNIPACFLG SAQSENVLTD IKLGKYRIVY VTPEYCSGNM GLLQQLEADI GITLIAVDEA HCISEWGHDF RDSFRKLGSL KTALPMVPIV ALTATASSSI REDIVRCLNL RNPQITCTGF DRPNLYLEVR RKTGNILQDL QPFLVKTSSH WEFEGPTIIY CPSRKMTQQV TGELRKLNLS CGTYHAGMSF STRKDIHHRF VRDEIQCVIA TIAFGMGINK ADIRQVIHYG APKDMESYYQ EIGRAGRDGL QSSCHVLWAP ADINLNRHLL TEIRNEKFRL YKLKMMAKME KYLHSSRCRR QIILSHFEDK QVQKASLGIM GTEKCCDNCR SRLDHCYSMD DSEDTSWDFG PQAFKLLSAV DILGEKFGIG LPILFLRGSN SQRLADQYRR HSLFGTGKDQ TESWWKAFSR QLITEGFLVE VSRYNKFMKI CALTKKGRNW LHKANTESQS LILQANEELC PKKLLLPSSK TVSSGTKEHC YNQVPVELST EKKSNLEKLY SYKPCDKISS GSNISKKSIM VQSPEKAYSS SQPVISAQEQ ETQIVLYGKL VEARQKHANK MDVPPAILAT NKILVDMAKM RPTTVENVKR IDGVSEGKAA MLAPLLEVIK HFCQTNSVQT DLFSSTKPQE EQKTSLVAKN KICTLSQSMA ITYSLFQEKK MPLKSIAESR ILPLMTIGMH LSQAVKAGCP LDLERAGLTP EVQKIIADVI RNPPVNSDMS KISLIRMLVP ENIDTYLIHM AIEILKHGPD SGLQPSCDVN KRRCFPGSEE ICSSSKRSKE EVGINTETSS AERKRRLPVW FAKGSDTSKK LMDKTKRGGL FS