Details for: WRN

Gene ID: 7486

Symbol: WRN

Ensembl ID: ENSG00000165392

Description: WRN RecQ like helicase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 229.5152
    Cell Significance Index: -35.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 157.7806
    Cell Significance Index: -40.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 83.9616
    Cell Significance Index: -34.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.9626
    Cell Significance Index: -34.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.9614
    Cell Significance Index: -40.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.8907
    Cell Significance Index: -39.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.3394
    Cell Significance Index: -37.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.9477
    Cell Significance Index: -23.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.5802
    Cell Significance Index: -41.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.0028
    Cell Significance Index: 168.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3426
    Cell Significance Index: 464.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8868
    Cell Significance Index: 378.5000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.6145
    Cell Significance Index: 31.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5601
    Cell Significance Index: 1408.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3105
    Cell Significance Index: 80.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2234
    Cell Significance Index: 34.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1032
    Cell Significance Index: 120.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0258
    Cell Significance Index: 38.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0029
    Cell Significance Index: 359.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.9953
    Cell Significance Index: 23.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9515
    Cell Significance Index: 42.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9072
    Cell Significance Index: 69.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8787
    Cell Significance Index: 52.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8644
    Cell Significance Index: 24.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8555
    Cell Significance Index: 591.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8331
    Cell Significance Index: 43.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8005
    Cell Significance Index: 20.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7535
    Cell Significance Index: 10.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7242
    Cell Significance Index: 18.6200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.7120
    Cell Significance Index: 6.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6152
    Cell Significance Index: 41.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5743
    Cell Significance Index: 26.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5735
    Cell Significance Index: 66.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4953
    Cell Significance Index: 89.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4825
    Cell Significance Index: 33.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3933
    Cell Significance Index: 48.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3816
    Cell Significance Index: 13.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3558
    Cell Significance Index: 35.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3487
    Cell Significance Index: 7.5600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3312
    Cell Significance Index: 7.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2998
    Cell Significance Index: 14.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2731
    Cell Significance Index: 37.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2389
    Cell Significance Index: 105.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2353
    Cell Significance Index: 442.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2342
    Cell Significance Index: 360.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2264
    Cell Significance Index: 417.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2112
    Cell Significance Index: 287.1200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1880
    Cell Significance Index: 2.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1761
    Cell Significance Index: 4.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1717
    Cell Significance Index: 77.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1478
    Cell Significance Index: 80.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1466
    Cell Significance Index: 93.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0652
    Cell Significance Index: 3.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0610
    Cell Significance Index: 1.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0373
    Cell Significance Index: 0.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0060
    Cell Significance Index: 0.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0124
    Cell Significance Index: -2.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0311
    Cell Significance Index: -0.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0424
    Cell Significance Index: -31.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0498
    Cell Significance Index: -36.8900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0501
    Cell Significance Index: -0.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0515
    Cell Significance Index: -38.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0650
    Cell Significance Index: -36.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0750
    Cell Significance Index: -46.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0753
    Cell Significance Index: -3.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0774
    Cell Significance Index: -9.9200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0844
    Cell Significance Index: -1.7500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0891
    Cell Significance Index: -1.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1258
    Cell Significance Index: -18.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1286
    Cell Significance Index: -36.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1460
    Cell Significance Index: -4.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1649
    Cell Significance Index: -10.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1759
    Cell Significance Index: -18.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1811
    Cell Significance Index: -21.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1889
    Cell Significance Index: -13.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2142
    Cell Significance Index: -45.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2187
    Cell Significance Index: -28.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2614
    Cell Significance Index: -26.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2714
    Cell Significance Index: -31.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2863
    Cell Significance Index: -1.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2939
    Cell Significance Index: -6.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3066
    Cell Significance Index: -19.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4206
    Cell Significance Index: -31.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4335
    Cell Significance Index: -11.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4396
    Cell Significance Index: -26.9500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4581
    Cell Significance Index: -10.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4701
    Cell Significance Index: -37.2300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4896
    Cell Significance Index: -6.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5344
    Cell Significance Index: -7.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5881
    Cell Significance Index: -18.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6109
    Cell Significance Index: -20.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6395
    Cell Significance Index: -33.5800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6402
    Cell Significance Index: -8.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6643
    Cell Significance Index: -17.7700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6816
    Cell Significance Index: -16.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7017
    Cell Significance Index: -22.4800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7217
    Cell Significance Index: -4.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7437
    Cell Significance Index: -25.8500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7500
    Cell Significance Index: -14.8300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.7602
    Cell Significance Index: -11.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RecQ-like helicase**: WRN exhibits 3'-5' DNA helicase and exonuclease activities, allowing it to unwind and process DNA double-strand breaks, telomeres, and other DNA structures. 2. **Telomere maintenance**: WRN is essential for maintaining telomere length and preventing telomere shortening, which can lead to cellular senescence and apoptosis. 3. **DNA repair**: WRN participates in the repair of DNA double-strand breaks through homologous recombination repair (HRR) and single-strand annealing (SSA). 4. **Cellular senescence**: WRN regulates cellular senescence by controlling the expression of genes involved in DNA damage response and repair. 5. **Expression in various cell types**: WRN is expressed in multiple cell types, including lens epithelial cells, germ cells, and neurons. **Pathways and Functions:** 1. **3'-5' DNA helicase activity**: WRN unwinds DNA double-strand breaks, telomeres, and other DNA structures. 2. **Exonuclease activity**: WRN processes DNA double-strand breaks and telomeres. 3. **Homologous recombination repair (HRR)**: WRN participates in HRR, a process that repairs DNA double-strand breaks by using a template with a similar sequence. 4. **Single-strand annealing (SSA)**: WRN participates in SSA, a process that repairs DNA double-strand breaks by annealing single-stranded DNA ends. 5. **Telomere maintenance**: WRN regulates telomere length and prevents telomere shortening. 6. **Cellular senescence**: WRN regulates cellular senescence by controlling the expression of genes involved in DNA damage response and repair. **Clinical Significance:** 1. **Cancer**: WRN mutations have been implicated in several types of cancer, including breast, ovarian, and colon cancer. 2. **Premature aging**: WRN mutations can lead to premature aging, characterized by telomere shortening and cellular senescence. 3. **Neurodegenerative disorders**: WRN mutations have been linked to neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 4. **Genetic instability**: WRN mutations can lead to genetic instability, increasing the risk of cancer and other diseases. In conclusion, the WRN gene plays a critical role in maintaining genomic stability, telomere length, and cellular senescence. Its dysregulation has been implicated in several diseases, including cancer, premature aging, and neurodegenerative disorders. Further research is needed to fully understand the mechanisms by which WRN regulates DNA repair, telomere maintenance, and cellular senescence, and to develop effective therapeutic strategies for WRN-related diseases.

Genular Protein ID: 1185807910

Symbol: WRN_HUMAN

Name: DNA helicase, RecQ-like type 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8602509

Title: Positional cloning of the Werner's syndrome gene.

PubMed ID: 8602509

DOI: 10.1126/science.272.5259.258

PubMed ID: 16723399

Title: Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.

PubMed ID: 16723399

DOI: 10.1073/pnas.0600645103

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 9288107

Title: The Werner syndrome protein is a DNA helicase.

PubMed ID: 9288107

DOI: 10.1038/ng0997-100

PubMed ID: 9224595

Title: DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system.

PubMed ID: 9224595

DOI: 10.1093/nar/25.15.2973

PubMed ID: 9611231

Title: Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A.

PubMed ID: 9611231

DOI: 10.1093/nar/26.12.2879

PubMed ID: 9618508

Title: Nucleolar localization of the Werner syndrome protein in human cells.

PubMed ID: 9618508

DOI: 10.1073/pnas.95.12.6887

PubMed ID: 10049920

Title: Evolution of the RECQ family of helicases: a Drosophila homolog, Dmblm, is similar to the human Bloom syndrome gene.

PubMed ID: 10049920

DOI: 10.1093/genetics/151.3.1027

PubMed ID: 10212265

Title: Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n.

PubMed ID: 10212265

DOI: 10.1074/jbc.274.18.12797

PubMed ID: 9989816

Title: Two novel regions of interstitial deletion on chromosome 8p in colorectal cancer.

PubMed ID: 9989816

DOI: 10.1038/sj.onc.1202340

PubMed ID: 11863428

Title: A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities.

PubMed ID: 11863428

DOI: 10.1021/bi0157161

PubMed ID: 11889123

Title: Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation.

PubMed ID: 11889123

DOI: 10.1074/jbc.m111523200

PubMed ID: 12704184

Title: The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein.

PubMed ID: 12704184

DOI: 10.1074/jbc.m212798200

PubMed ID: 17961633

Title: Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.

PubMed ID: 17961633

DOI: 10.1016/j.mad.2007.09.001

PubMed ID: 17563354

Title: Werner syndrome protein interacts functionally with translesion DNA polymerases.

PubMed ID: 17563354

DOI: 10.1073/pnas.0702513104

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18596042

Title: The Werner syndrome protein binds replication fork and Holliday junction DNAs as an oligomer.

PubMed ID: 18596042

DOI: 10.1074/jbc.m803370200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19652551

Title: WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts.

PubMed ID: 19652551

DOI: 10.4161/cc.8.17.9410

PubMed ID: 19283071

Title: The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation.

PubMed ID: 19283071

DOI: 10.1371/journal.pone.0004825

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21639834

Title: Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in gamma-irradiation-induced DNA damage responses.

PubMed ID: 21639834

DOI: 10.1134/s000629791105004x

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24308539

Title: Systematic genomic identification of colorectal cancer genes delineating advanced from early clinical stage and metastasis.

PubMed ID: 24308539

DOI: 10.1186/1755-8794-6-54

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27063109

Title: The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins.

PubMed ID: 27063109

DOI: 10.1038/ncomms11242

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16339893

Title: Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein.

PubMed ID: 16339893

DOI: 10.1073/pnas.0509380102

PubMed ID: 16622405

Title: WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing.

PubMed ID: 16622405

DOI: 10.1038/nsmb1088

PubMed ID: 10220139

Title: WRN mutations in Werner syndrome.

PubMed ID: 10220139

DOI: 10.1002/(sici)1098-1004(1999)13:4<271::aid-humu2>3.0.co;2-q

PubMed ID: 17148451

Title: Crystal structure of the HRDC domain of human Werner syndrome protein, WRN.

PubMed ID: 17148451

DOI: 10.1074/jbc.m610142200

PubMed ID: 20159463

Title: Structural basis for DNA strand separation by the unconventional winged-helix domain of RecQ helicase WRN.

PubMed ID: 20159463

DOI: 10.1016/j.str.2009.12.011

PubMed ID: 31733588

Title: Ligand binding characteristics of the Ku80 von Willebrand domain.

PubMed ID: 31733588

DOI: 10.1016/j.dnarep.2019.102739

PubMed ID: 33199508

Title: Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.

PubMed ID: 33199508

DOI: 10.26508/lsa.202000795

PubMed ID: 9021029

Title: Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population.

PubMed ID: 9021029

DOI: 10.1002/(sici)1096-8628(19970211)68:4<494::aid-ajmg30>3.0.co;2-l

PubMed ID: 9450180

Title: Werner syndrome: characterization of mutations in the WRN gene in an affected family.

PubMed ID: 9450180

PubMed ID: 23180761

Title: RECQL5 plays co-operative and complementary roles with WRN syndrome helicase.

PubMed ID: 23180761

DOI: 10.1093/nar/gks1134

PubMed ID: 10206685

Title: The 1396del A mutation and a missense mutation or a rare polymorphism of the WRN gene detected in a French Werner family with a severe phenotype and a case of an unusual vulvar cancer.

PubMed ID: 10206685

DOI: 10.1002/(sici)1098-1004(1998)11:5<413::aid-humu16>3.0.co;2-i

PubMed ID: 10069711

Title: Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians.

PubMed ID: 10069711

DOI: 10.1002/(sici)1096-8628(19990219)82:5<399::aid-ajmg8>3.3.co;2-i

PubMed ID: 11161804

Title: The Werner syndrome gene and global sequence variation.

PubMed ID: 11161804

DOI: 10.1006/geno.2000.6405

PubMed ID: 16673358

Title: The spectrum of WRN mutations in Werner syndrome patients.

PubMed ID: 16673358

DOI: 10.1002/humu.20337

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

Sequence Information:

  • Length: 1432
  • Mass: 162461
  • Checksum: 63F10D19E90AA461
  • Sequence:
  • MSEKKLETTA QQRKCPEWMN VQNKRCAVEE RKACVRKSVF EDDLPFLEFT GSIVYSYDAS 
    DCSFLSEDIS MSLSDGDVVG FDMEWPPLYN RGKLGKVALI QLCVSESKCY LFHVSSMSVF 
    PQGLKMLLEN KAVKKAGVGI EGDQWKLLRD FDIKLKNFVE LTDVANKKLK CTETWSLNSL 
    VKHLLGKQLL KDKSIRCSNW SKFPLTEDQK LYAATDAYAG FIIYRNLEIL DDTVQRFAIN 
    KEEEILLSDM NKQLTSISEE VMDLAKHLPH AFSKLENPRR VSILLKDISE NLYSLRRMII 
    GSTNIETELR PSNNLNLLSF EDSTTGGVQQ KQIREHEVLI HVEDETWDPT LDHLAKHDGE 
    DVLGNKVERK EDGFEDGVED NKLKENMERA CLMSLDITEH ELQILEQQSQ EEYLSDIAYK 
    STEHLSPNDN ENDTSYVIES DEDLEMEMLK HLSPNDNEND TSYVIESDED LEMEMLKSLE 
    NLNSGTVEPT HSKCLKMERN LGLPTKEEEE DDENEANEGE EDDDKDFLWP APNEEQVTCL 
    KMYFGHSSFK PVQWKVIHSV LEERRDNVAV MATGYGKSLC FQYPPVYVGK IGLVISPLIS 
    LMEDQVLQLK MSNIPACFLG SAQSENVLTD IKLGKYRIVY VTPEYCSGNM GLLQQLEADI 
    GITLIAVDEA HCISEWGHDF RDSFRKLGSL KTALPMVPIV ALTATASSSI REDIVRCLNL 
    RNPQITCTGF DRPNLYLEVR RKTGNILQDL QPFLVKTSSH WEFEGPTIIY CPSRKMTQQV 
    TGELRKLNLS CGTYHAGMSF STRKDIHHRF VRDEIQCVIA TIAFGMGINK ADIRQVIHYG 
    APKDMESYYQ EIGRAGRDGL QSSCHVLWAP ADINLNRHLL TEIRNEKFRL YKLKMMAKME 
    KYLHSSRCRR QIILSHFEDK QVQKASLGIM GTEKCCDNCR SRLDHCYSMD DSEDTSWDFG 
    PQAFKLLSAV DILGEKFGIG LPILFLRGSN SQRLADQYRR HSLFGTGKDQ TESWWKAFSR 
    QLITEGFLVE VSRYNKFMKI CALTKKGRNW LHKANTESQS LILQANEELC PKKLLLPSSK 
    TVSSGTKEHC YNQVPVELST EKKSNLEKLY SYKPCDKISS GSNISKKSIM VQSPEKAYSS 
    SQPVISAQEQ ETQIVLYGKL VEARQKHANK MDVPPAILAT NKILVDMAKM RPTTVENVKR 
    IDGVSEGKAA MLAPLLEVIK HFCQTNSVQT DLFSSTKPQE EQKTSLVAKN KICTLSQSMA 
    ITYSLFQEKK MPLKSIAESR ILPLMTIGMH LSQAVKAGCP LDLERAGLTP EVQKIIADVI 
    RNPPVNSDMS KISLIRMLVP ENIDTYLIHM AIEILKHGPD SGLQPSCDVN KRRCFPGSEE 
    ICSSSKRSKE EVGINTETSS AERKRRLPVW FAKGSDTSKK LMDKTKRGGL FS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.