Details for: XPA
Gene ID: 7507
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: XPA
Ensembl ID: ENSG00000136936
Description: XPA, DNA damage recognition and repair factor
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 7.42rCSI 5.75%PRS 42.06
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CSI 7.41rCSI 5.83%PRS 47.96
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CSI 6.97rCSI 7.22%PRS 47.52
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CSI 6.12rCSI 9.78%PRS 45.33
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CSI 5.78rCSI 7.9%PRS 44.35
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CSI 5.09rCSI 6.33%PRS 25.94
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CSI 4.95rCSI 12.52%PRS 49.82
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CSI 4.29rCSI 6.47%PRS 43.56
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CSI 4.08rCSI 4.2%PRS 59.07
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CSI 4.01rCSI 5.94%PRS 46.43
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CSI 3.89rCSI 5.2%PRS 64.2
-
CSI 3.63rCSI 7.73%PRS 46.66
-
CSI 3.54rCSI 2.69%PRS 52.75
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CSI 3.34rCSI 15.98%PRS 40.28
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CSI 3.2rCSI 8.13%PRS 38.28
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CSI 3.19rCSI 1.89%PRS 56.1
-
CSI 3.06rCSI 2.45%PRS 63.13
-
CSI 2.95rCSI 2.84%PRS 42.3
-
CSI 2.94rCSI 3.08%PRS 44.24
-
CSI 2.93rCSI 2.89%PRS 43.91
-
CSI 2.93rCSI 7.04%PRS 59.21
-
CSI 2.91rCSI 8.19%PRS 42.73
-
CSI 2.9rCSI 4.25%PRS 41.72
-
CSI 2.86rCSI 3.93%PRS 62.45
-
CSI 2.8rCSI 3.96%PRS 39.01
-
CSI 2.78rCSI 3.58%PRS 28.26
-
CSI 2.67rCSI 1.86%PRS 49.92
-
CSI 2.67rCSI 2.08%PRS 58.09
-
CSI 2.67rCSI 3.13%PRS 56.82
-
CSI 2.62rCSI 2.2%PRS 58.86
-
CSI 2.58rCSI 1.92%PRS 54.56
-
CSI 2.57rCSI 1.73%PRS 51.46
-
CSI 2.52rCSI 2.7%PRS 39.67
-
CSI 2.47rCSI 2.97%PRS 40
-
CSI 2.43rCSI 2.34%PRS 65.68
-
CSI 2.42rCSI 1.68%PRS 54.25
-
CSI 2.3rCSI 2.4%PRS 42.44
-
CSI 2.26rCSI 14.09%PRS 34.9
-
CSI 2.23rCSI 5.82%PRS 40.89
-
CSI 2.2rCSI 1.9%PRS 50.78
-
CSI 2.19rCSI 2.79%PRS 46.82
-
CSI 2.19rCSI 1.65%PRS 44.92
-
CSI 2.17rCSI 10.89%PRS 52.4
-
CSI 2.16rCSI 2.36%PRS 45.59
-
CSI 2.13rCSI 3.87%PRS 35.87
-
CSI 2.12rCSI 1.67%PRS 30.42
-
CSI 2.11rCSI 1.51%PRS 54.17
-
CSI 2.1rCSI 1.74%PRS 40.27
-
CSI 2.08rCSI 1.81%PRS 50.49
-
CSI 2.08rCSI 2.08%PRS 36.37
-
CSI 2.07rCSI 3.04%PRS 52.56
-
CSI 2.04rCSI 7.39%PRS 60.78
-
CSI 2.03rCSI 48.49%PRS 26.75
-
CSI 2.02rCSI 1.64%PRS 42.69
-
CSI 2.01rCSI 1.6%PRS 63.51
-
CSI 1.98rCSI 1.95%PRS 56.89
-
CSI 1.98rCSI 2.36%PRS 27.28
-
CSI 1.97rCSI 47.49%PRS 27.63
-
CSI 1.96rCSI 3.44%PRS 34.77
-
CSI 1.92rCSI 4.4%PRS 41.13
-
CSI 1.89rCSI 2.91%PRS 48.45
-
CSI 1.86rCSI 1.24%PRS 45.73
-
CSI 1.83rCSI 1.37%PRS 60.01
-
CSI 1.83rCSI 1.51%PRS 42.69
-
CSI 1.83rCSI 2.5%PRS 46.39
-
CSI 1.82rCSI 2.43%PRS 50
-
CSI 1.76rCSI 2.62%PRS 44.67
-
CSI 1.76rCSI 5.04%PRS 58.83
-
CSI 1.76rCSI 2.44%PRS 41.36
-
CSI 1.69rCSI 4.98%PRS 45.76
-
CSI 1.68rCSI 3.83%PRS 35.89
-
CSI 1.67rCSI 6.27%PRS 35.54
-
CSI 1.67rCSI 2.6%PRS 68.87
-
CSI 1.67rCSI 3.35%PRS 32.42
-
CSI 1.66rCSI 1.46%PRS 31.77
-
CSI 1.66rCSI 1.24%PRS 56.24
-
CSI 1.65rCSI 1.45%PRS 46.53
-
CSI 1.65rCSI 1.25%PRS 53.57
-
CSI 1.63rCSI 1.51%PRS 62.07
-
CSI 1.63rCSI 2.13%PRS 54.57
-
CSI 1.6rCSI 2.36%PRS 38.26
-
CSI 1.6rCSI 1.49%PRS 41.7
-
CSI 1.59rCSI 3.09%PRS 43.64
-
CSI 1.58rCSI 1.38%PRS 51.23
-
CSI 1.58rCSI 1.17%PRS 35.98
-
CSI 1.58rCSI 1.85%PRS 45.43
-
CSI 1.58rCSI 3.91%PRS 39.94
-
CSI 1.55rCSI 2.46%PRS 35.54
-
CSI 1.53rCSI 2.74%PRS 40.27
-
CSI 1.52rCSI 1.17%PRS 40.36
-
CSI 1.5rCSI 2.06%PRS 51.89
-
CSI 1.5rCSI 1.68%PRS 57.71
-
CSI 1.48rCSI 1.8%PRS 49.18
-
CSI 1.46rCSI 2.08%PRS 44.42
-
CSI 1.43rCSI 1.24%PRS 45.39
-
CSI 1.42rCSI 3.28%PRS 34.38
-
CSI 1.42rCSI 1.15%PRS 42.26
-
CSI 1.39rCSI 1.29%PRS 42.72
-
CSI 1.39rCSI 1.9%PRS 69.51
-
CSI 1.39rCSI 1.74%PRS 51.07
-
CSI 0.1rCSI 0.8%PRS 54.0%
-
CSI 0.2rCSI 3.8%PRS 35.2%
-
CSI 0.2rCSI 1.7%PRS 30.2%
-
CSI 0.3rCSI 1.6%PRS 52.7%
-
CSI 0.3rCSI 2.0%PRS 28.6%
-
CSI 0.4rCSI 1.7%PRS 28.2%
-
CSI 0.5rCSI 3.9%PRS 80.7%
-
CSI 0.5rCSI 3.3%PRS 30.6%
-
CSI 0.5rCSI 1.3%PRS 44.3%
-
CSI 0.5rCSI 7.0%PRS 67.5%
-
CSI 0.5rCSI 0.7%PRS 46.3%
-
CSI 0.5rCSI 1.7%PRS 49.7%
-
CSI 0.6rCSI 1.6%PRS 57.2%
-
CSI 0.6rCSI 1.1%PRS 50.1%
-
CSI 0.6rCSI 2.1%PRS 31.2%
-
CSI 0.7rCSI 1.9%PRS 59.0%
-
CSI 0.7rCSI 1.7%PRS 41.7%
-
CSI 0.7rCSI 1.9%PRS 33.9%
-
CSI 0.7rCSI 1.7%PRS 72.4%
-
CSI 0.7rCSI 2.2%PRS 28.4%
-
CSI 0.7rCSI 1.7%PRS 26.6%
-
CSI 0.7rCSI 3.1%PRS 58.4%
-
CSI 0.7rCSI 2.0%PRS 56.3%
-
CSI 0.7rCSI 2.5%PRS 34.4%
-
CSI 0.7rCSI 1.4%PRS 32.4%
-
CSI 0.7rCSI 1.1%PRS 33.9%
-
CSI 0.8rCSI 1.9%PRS 33.1%
-
CSI 0.8rCSI 2.4%PRS 30.6%
-
CSI 0.8rCSI 1.3%PRS 33.2%
-
CSI 0.8rCSI 3.7%PRS 40.4%
-
CSI 0.9rCSI 1.6%PRS 40.5%
-
CSI 1.0rCSI 1.5%PRS 42.3%
-
CSI 1.0rCSI 1.5%PRS 39.8%
-
CSI 1.0rCSI 2.2%PRS 39.1%
-
CSI 1.0rCSI 1.9%PRS 51.4%
-
CSI 1.0rCSI 1.7%PRS 27.4%
-
CSI 1.0rCSI 1.7%PRS 29.4%
-
CSI 1.1rCSI 1.2%PRS 32.6%
-
CSI 1.1rCSI 1.6%PRS 38.6%
-
CSI 1.1rCSI 1.5%PRS 35.7%
-
CSI 1.1rCSI 1.9%PRS 35.6%
-
CSI 1.1rCSI 1.7%PRS 42.7%
-
CSI 1.1rCSI 3.5%PRS 39.0%
-
CSI 1.1rCSI 3.9%PRS 26.3%
-
CSI 1.1rCSI 3.6%PRS 45.0%
-
CSI 1.2rCSI 1.8%PRS 36.2%
-
CSI 1.2rCSI 2.6%PRS 31.1%
-
CSI 1.2rCSI 2.6%PRS 47.9%
-
CSI 1.2rCSI 2.1%PRS 33.2%
-
CSI 1.2rCSI 2.8%PRS 28.0%
-
CSI 1.2rCSI 1.4%PRS 36.6%
-
CSI 1.3rCSI 2.2%PRS 26.4%
-
CSI 1.3rCSI 1.3%PRS 54.5%
-
CSI 1.3rCSI 2.5%PRS 41.5%
-
CSI 1.3rCSI 3.7%PRS 41.9%
-
CSI 1.3rCSI 1.4%PRS 41.4%
-
CSI 1.3rCSI 1.1%PRS 46.7%
-
CSI 1.3rCSI 0.9%PRS 43.4%
-
CSI 1.3rCSI 1.3%PRS 33.0%
-
CSI 1.3rCSI 1.7%PRS 38.0%
-
CSI 1.4rCSI 2.2%PRS 33.2%
-
CSI 1.4rCSI 1.2%PRS 38.5%
-
CSI 1.4rCSI 1.8%PRS 39.8%
-
CSI 1.4rCSI 1.7%PRS 51.1%
-
CSI 1.4rCSI 1.9%PRS 69.5%
-
CSI 1.4rCSI 1.3%PRS 42.7%
-
CSI 1.4rCSI 1.2%PRS 42.3%
-
CSI 1.4rCSI 3.3%PRS 34.4%
-
CSI 1.4rCSI 1.2%PRS 45.4%
-
CSI 1.5rCSI 2.1%PRS 44.4%
-
CSI 1.5rCSI 1.8%PRS 49.2%
-
CSI 1.5rCSI 1.7%PRS 57.7%
-
CSI 1.5rCSI 2.1%PRS 51.9%
-
CSI 1.5rCSI 1.2%PRS 40.4%
-
CSI 1.5rCSI 2.7%PRS 40.3%
-
CSI 1.6rCSI 2.5%PRS 35.5%
-
CSI 1.6rCSI 3.9%PRS 39.9%
-
CSI 1.6rCSI 1.9%PRS 45.4%
-
CSI 1.6rCSI 1.2%PRS 36.0%
-
CSI 1.6rCSI 1.4%PRS 51.2%
-
CSI 1.6rCSI 3.1%PRS 43.6%
-
CSI 1.6rCSI 1.5%PRS 41.7%
-
CSI 1.6rCSI 2.4%PRS 38.3%
-
CSI 1.6rCSI 2.1%PRS 54.6%
-
CSI 1.6rCSI 1.5%PRS 62.1%
-
CSI 1.7rCSI 1.3%PRS 53.6%
-
CSI 1.7rCSI 1.5%PRS 46.5%
-
CSI 1.7rCSI 1.2%PRS 56.2%
-
CSI 1.7rCSI 1.5%PRS 31.8%
-
CSI 1.7rCSI 3.4%PRS 32.4%
-
CSI 1.7rCSI 2.6%PRS 68.9%
-
CSI 1.7rCSI 6.3%PRS 35.5%
-
CSI 1.7rCSI 3.8%PRS 35.9%
-
CSI 1.7rCSI 5.0%PRS 45.8%
-
CSI 1.8rCSI 2.4%PRS 41.4%
-
CSI 1.8rCSI 5.0%PRS 58.8%
-
CSI 1.8rCSI 2.6%PRS 44.7%
-
CSI 1.8rCSI 2.4%PRS 50.0%
-
CSI 1.8rCSI 2.5%PRS 46.4%
-
CSI 1.8rCSI 1.5%PRS 42.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2791788058
Symbol: XPA_HUMAN
Name: DNA repair protein complementing XP-A cells
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2234061
Title: Analysis of a human DNA excision repair gene involved in group A Xeroderma pigmentosum and containing a zinc-finger domain.
PubMed ID: 2234061
DOI: 10.1038/348073a0
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8294029
Title: Genomic characterization of the human DNA excision repair-controlling gene XPAC.
PubMed ID: 8294029
PubMed ID: 7700386
Title: RPA involvement in the damage-recognition and incision steps of nucleotide excision repair.
PubMed ID: 7700386
DOI: 10.1038/374566a0
PubMed ID: 8543191
Title: Characterization of the human XPA promoter.
PubMed ID: 8543191
PubMed ID: 1918083
Title: Identification and characterization of xpac protein, the gene product of the human XPAC (Xeroderma pigmentosum group A complementing) gene.
PubMed ID: 1918083
PubMed ID: 1601884
Title: Mutational analysis of the structure and function of the Xeroderma pigmentosum group A complementing protein. Identification of essential domains for nuclear localization and DNA excision repair.
PubMed ID: 1601884
PubMed ID: 8504220
Title: Molecular analysis of Xeroderma pigmentosum group A gene.
PubMed ID: 8504220
DOI: 10.1007/bf01891230
PubMed ID: 10447254
Title: A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy.
PubMed ID: 10447254
DOI: 10.1002/(sici)1098-1004(1999)14:1<9::aid-humu2>3.0.co;2-6
PubMed ID: 16540648
Title: Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation.
PubMed ID: 16540648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19197159
Title: UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity.
PubMed ID: 19197159
DOI: 10.4161/cc.8.4.7844
PubMed ID: 20304803
Title: Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase.
PubMed ID: 20304803
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 9699634
Title: Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA.
PubMed ID: 9699634
DOI: 10.1038/1400
PubMed ID: 10563794
Title: Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies.
PubMed ID: 10563794
DOI: 10.1021/bi991755p
PubMed ID: 31253769
Title: Structural basis of TFIIH activation for nucleotide excision repair.
PubMed ID: 31253769
PubMed ID: 1339397
Title: Molecular basis of group A Xeroderma pigmentosum: a missense mutation and two deletions located in a zinc finger consensus sequence of the XPAC gene.
PubMed ID: 1339397
DOI: 10.1007/bf02265282
PubMed ID: 1372103
Title: Identification of splicing mutations of the last nucleotides of exons, a nonsense mutation, and a missense mutation of the XPAC gene as causes of group A Xeroderma pigmentosum.
PubMed ID: 1372103
PubMed ID: 9671271
Title: Distribution of mutations in the human Xeroderma pigmentosum group A gene and their relationships to the functional regions of the DNA damage recognition protein.
PubMed ID: 9671271
DOI: 10.1002/(sici)1098-1004(1998)12:2<103::aid-humu5>3.0.co;2-6
Sequence Information:
- Length: 273
- Mass: 31368
- Checksum: F89F735219A8494B
- Sequence:
MAAADGALPE AAALEQPAEL PASVRASIER KRQRALMLRQ ARLAARPYSA TAAAATGGMA NVKAAPKIID TGGGFILEEE EEEEQKIGKV VHQPGPVMEF DYVICEECGK EFMDSYLMNH FDLPTCDNCR DADDKHKLIT KTEAKQEYLL KDCDLEKREP PLKFIVKKNP HHSQWGDMKL YLKLQIVKRS LEVWGSQEAL EEAKEVRQEN REKMKQKKFD KKVKELRRAV RSSVWKRETI VHQHEYGPEE NLEDDMYRKT CTMCGHELTY EKM