Details for: ZBTB14

Gene ID: 7541

Symbol: ZBTB14

Ensembl ID: ENSG00000198081

Description: zinc finger and BTB domain containing 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 56.2537
    Cell Significance Index: -8.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 34.1030
    Cell Significance Index: -8.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 21.0539
    Cell Significance Index: -9.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.6519
    Cell Significance Index: -8.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.9134
    Cell Significance Index: -8.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.6077
    Cell Significance Index: -9.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.2999
    Cell Significance Index: -8.8400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.5554
    Cell Significance Index: 42.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4201
    Cell Significance Index: -9.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.0609
    Cell Significance Index: -6.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8039
    Cell Significance Index: 48.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7757
    Cell Significance Index: 700.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7047
    Cell Significance Index: 76.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6875
    Cell Significance Index: 68.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5633
    Cell Significance Index: 91.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3658
    Cell Significance Index: 25.3000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.3605
    Cell Significance Index: 5.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3445
    Cell Significance Index: 65.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3174
    Cell Significance Index: 4.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3103
    Cell Significance Index: 19.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2828
    Cell Significance Index: 32.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2446
    Cell Significance Index: 12.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1732
    Cell Significance Index: 7.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1657
    Cell Significance Index: 3.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1656
    Cell Significance Index: 4.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1439
    Cell Significance Index: 6.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1349
    Cell Significance Index: 7.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1347
    Cell Significance Index: 27.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1292
    Cell Significance Index: 57.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1115
    Cell Significance Index: 13.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1095
    Cell Significance Index: 19.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1020
    Cell Significance Index: 2.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0929
    Cell Significance Index: 6.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0842
    Cell Significance Index: 11.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0761
    Cell Significance Index: 41.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0684
    Cell Significance Index: 24.5400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0597
    Cell Significance Index: 0.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0586
    Cell Significance Index: 11.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0554
    Cell Significance Index: 7.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0447
    Cell Significance Index: 5.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0435
    Cell Significance Index: 2.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0322
    Cell Significance Index: 1.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0299
    Cell Significance Index: 0.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0216
    Cell Significance Index: 0.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0186
    Cell Significance Index: 12.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0137
    Cell Significance Index: 0.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0111
    Cell Significance Index: 0.2300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0055
    Cell Significance Index: 0.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -3.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0042
    Cell Significance Index: -0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0049
    Cell Significance Index: -8.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0052
    Cell Significance Index: -7.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0053
    Cell Significance Index: -8.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0089
    Cell Significance Index: -5.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0100
    Cell Significance Index: -7.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0124
    Cell Significance Index: -9.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0149
    Cell Significance Index: -8.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0173
    Cell Significance Index: -2.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0191
    Cell Significance Index: -8.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0192
    Cell Significance Index: -1.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0194
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0208
    Cell Significance Index: -13.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0225
    Cell Significance Index: -6.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0227
    Cell Significance Index: -2.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0270
    Cell Significance Index: -0.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0329
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0334
    Cell Significance Index: -3.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0354
    Cell Significance Index: -5.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0358
    Cell Significance Index: -0.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0508
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0545
    Cell Significance Index: -11.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0560
    Cell Significance Index: -7.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0592
    Cell Significance Index: -2.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0595
    Cell Significance Index: -1.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0861
    Cell Significance Index: -6.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0873
    Cell Significance Index: -6.5100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0881
    Cell Significance Index: -1.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0883
    Cell Significance Index: -5.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0894
    Cell Significance Index: -9.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0984
    Cell Significance Index: -7.7900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1007
    Cell Significance Index: -1.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1019
    Cell Significance Index: -2.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1040
    Cell Significance Index: -4.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1073
    Cell Significance Index: -2.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1088
    Cell Significance Index: -2.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1152
    Cell Significance Index: -1.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1283
    Cell Significance Index: -4.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1331
    Cell Significance Index: -8.1600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1447
    Cell Significance Index: -1.2300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1521
    Cell Significance Index: -1.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1537
    Cell Significance Index: -3.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1547
    Cell Significance Index: -3.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1701
    Cell Significance Index: -5.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1721
    Cell Significance Index: -2.9500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1988
    Cell Significance Index: -1.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2019
    Cell Significance Index: -5.1900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2023
    Cell Significance Index: -1.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2117
    Cell Significance Index: -6.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZBTB14 is a transcriptional regulator that belongs to the BTB family of proteins, characterized by the presence of a BTB domain and zinc fingers. This domain structure enables ZBTB14 to interact with specific DNA sequences, thereby modulating gene expression. The protein's ability to bind to and regulate transcription factors, such as RNA polymerase II, underscores its role in transcriptional control. ZBTB14's expression is widespread, with significant levels detected in various cell types, including immune cells, neurons, and epithelial cells. **Pathways and Functions:** ZBTB14 is implicated in multiple signaling pathways, including: 1. **Cardiac septum development:** ZBTB14 regulates the expression of cardiac-specific genes, contributing to the development of the cardiac septum. 2. **Coronary vasculature development:** The protein's role in vascular development is mediated through the regulation of transcription factors involved in angiogenesis. 3. **Kidney development:** ZBTB14 is necessary for the proper formation and function of the kidney, influencing the expression of genes involved in nephrogenesis. 4. **Immune cell development:** ZBTB14 plays a crucial role in the development and function of immune cells, including immature innate lymphoid cells and GABAergic interneurons. 5. **Transcriptional regulation:** ZBTB14 acts as a transcriptional repressor, modulating the expression of target genes involved in cellular differentiation, proliferation, and survival. **Clinical Significance:** Dysregulation of ZBTB14 has been implicated in various diseases, including: 1. **Immune disorders:** Abnormal expression of ZBTB14 has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** ZBTB14's role in transcriptional regulation makes it a potential target for cancer therapy. 3. **Neurological disorders:** ZBTB14's involvement in neuronal function and development suggests its potential role in neurological disorders, such as autism spectrum disorder and schizophrenia. In conclusion, ZBTB14 is a transcriptional regulator that plays a critical role in various cellular processes, including immune cell development, tissue development, and transcriptional regulation. Further research is necessary to fully elucidate the molecular mechanisms underlying ZBTB14's functions and to explore its therapeutic potential in diseases related to transcriptional dysregulation. **Recommendations for Future Research:** 1. Investigate the molecular mechanisms underlying ZBTB14's role in immune cell development and function. 2. Explore the therapeutic potential of ZBTB14 as a target for immune disorders and cancer. 3. Investigate the relationship between ZBTB14 and other transcriptional regulators in the development of neurological disorders. By further elucidating the functions of ZBTB14, we can gain a deeper understanding of the intricate mechanisms governing cellular development and immune function, ultimately leading to the development of novel therapeutic strategies for diseases related to transcriptional dysregulation.

Genular Protein ID: 190446371

Symbol: ZBT14_HUMAN

Name: Zinc finger and BTB domain-containing protein 14

UniProtKB Accession Codes:

O43829 O00403 Q2TB80

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 5 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9244432

Title: The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (Chr 17) and Zfp161-rs1 (X Chr).

PubMed ID: 9244432

DOI: 10.1006/geno.1997.4784

PubMed ID: 9177479

Title: Expression cloning and intracellular localization of a human ZF5 homologue.

PubMed ID: 9177479

DOI: 10.1016/s0167-4781(97)00045-6

PubMed ID: 17714511

Title: Novel repressor of the human FMR1 gene - identification of p56 human (GCC)(n)-binding protein as a Kruppel-like transcription factor ZF5.

PubMed ID: 17714511

DOI: 10.1111/j.1742-4658.2007.06006.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14706637

Title: Human zinc finger protein 161, a novel transcriptional activator of the dopamine transporter.

PubMed ID: 14706637

DOI: 10.1016/j.bbrc.2003.11.183

PubMed ID: 15629158

Title: Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161.

PubMed ID: 15629158

DOI: 10.1016/j.bbrc.2004.12.048

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 449
  • Mass: 50956
  • Checksum: B99F22E3B1D4E6CE
  • Sequence:
    • MEFFISMSET IKYNDDDHKT LFLKTLNEQR LEGEFCDIAI VVEDVKFRAH RCVLAACSTY 
FKKLFKKLEV DSSSVIEIDF LRSDIFEEVL NYMYTAKISV KKEDVNLMMS SGQILGIRFL 
DKLCSQKRDV SSPDENNGQS KSKYCLKINR PIGDAADTQD DDVEEIGDQD DSPSDDTVEG 
TPPSQEDGKS PTTTLRVQEA ILKELGSEEV RKVNCYGQEV ESMETPESKD LGSQTPQALT 
FNDGMSEVKD EQTPGWTTAA SDMKFEYLLY GHHREQIACQ ACGKTFSDEG RLRKHEKLHT 
ADRPFVCEMC TKGFTTQAHL KEHLKIHTGY KPYSCEVCGK SFIRAPDLKK HERVHSNERP 
FACHMCDKAF KHKSHLKDHE RRHRGEKPFV CGSCTKAFAK ASDLKRHENN MHSERKQVTP 
SAIQSETEQL QAAAMAAEAE QQLETIACS

Genular Protein ID: 1168232812

Symbol: B2R850_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R850

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 449
  • Mass: 50926
  • Checksum: B99652F6B1D4E6DB
  • Sequence:
    • MEFFISMSET IKYNDDDHKT LFLKTLNEQR LEGEFCDIAI VVEDVKFRAH RCVLAACSTY 
FKKLFKKLEV DSSSVIEIDF LRSDIFEEVL NYMYTAKISV KKEDVNLMMS SGQILGIRFL 
DKLCSQKRDV SSPDENNGQS KSKYCLKINR PIGDAADTQD DDVEEIGDQD DSPSDDTVEG 
TPPSQEDGKS PTTTLRVQEA ILKELGSEEV RKVNCYGQEV ESMETPESKD LGSQTPQALT 
FNDGMSEVKD EQTPGWTTAA SDMKFEYLLY GHHREQIACQ ACGKTFSDEG RLRKHEKLHT 
ADRPFVCEMC TKGFTTQAHL KEHLKIHAGY KPYSCEVCGK SFIRAPDLKK HERVHSNERP 
FACHMCDKAF KHKSHLKDHE RRHRGEKPFV CGSCTKAFAK ASDLKRHENN MHSERKQVTP 
SAIQSETEQL QAAAMAAEAE QQLETIACS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.