Details for: ZIC1

Gene ID: 7545

Symbol: ZIC1

Ensembl ID: ENSG00000152977

Description: Zic family member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 6.05
    Marker Score: 31749
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 5.93
    Marker Score: 19874
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.99
    Marker Score: 30109
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.83
    Marker Score: 20563
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.72
    Marker Score: 8549.5
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.59
    Marker Score: 30362
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.3
    Marker Score: 3797
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.85
    Marker Score: 1597
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.54
    Marker Score: 9834
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.37
    Marker Score: 1137
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.01
    Marker Score: 995
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.86
    Marker Score: 545
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.73
    Marker Score: 1193.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.64
    Marker Score: 6847
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.4
    Marker Score: 1537
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.23
    Marker Score: 2547.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.22
    Marker Score: 804
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 487
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.12
    Marker Score: 649
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.09
    Marker Score: 1163
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.03
    Marker Score: 6827
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.02
    Marker Score: 566
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.02
    Marker Score: 1778
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.98
    Marker Score: 369
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.94
    Marker Score: 1782
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.93
    Marker Score: 293
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.88
    Marker Score: 676
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.86
    Marker Score: 271
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.85
    Marker Score: 449
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.85
    Marker Score: 3567
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.84
    Marker Score: 338.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.79
    Marker Score: 3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.75
    Marker Score: 210
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.71
    Marker Score: 7207
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.67
    Marker Score: 1370
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 435
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.65
    Marker Score: 564
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.65
    Marker Score: 930
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.64
    Marker Score: 371.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 378
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.62
    Marker Score: 21024
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 476
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 239
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.57
    Marker Score: 232
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.57
    Marker Score: 1358
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.55
    Marker Score: 330
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.54
    Marker Score: 2310
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.53
    Marker Score: 3391
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.51
    Marker Score: 7997
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.51
    Marker Score: 196
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.48
    Marker Score: 1190
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.44
    Marker Score: 234
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 249
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.41
    Marker Score: 2183
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.4
    Marker Score: 307
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.4
    Marker Score: 444
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.39
    Marker Score: 356
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.35
    Marker Score: 1429
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.32
    Marker Score: 246
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.31
    Marker Score: 161
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.31
    Marker Score: 147
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.31
    Marker Score: 423
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3
    Marker Score: 97
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.3
    Marker Score: 109
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.3
    Marker Score: 700
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.29
    Marker Score: 276
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.29
    Marker Score: 132
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.29
    Marker Score: 74
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.28
    Marker Score: 349
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.27
    Marker Score: 107.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.26
    Marker Score: 91
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.25
    Marker Score: 116
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.25
    Marker Score: 93
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.24
    Marker Score: 301
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.23
    Marker Score: 159
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65

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Other Information

**Key Characteristics:** 1. **Transcription Factor Function:** ZIC1 is a member of the Zic family of transcription factors, which are known to regulate gene expression by binding to specific DNA sequences and modulating the transcriptional activity of target genes. 2. **Cell-Specific Expression:** ZIC1 is highly expressed in neurons, glial cells, and neural progenitor cells, suggesting its role in the development and maintenance of these cell types. 3. **Regulation of Neural Development:** ZIC1 plays a critical role in the regulation of neural development, including the specification of the neural plate border, CNS development, and inner ear morphogenesis. 4. **Metabolic and Transport Functions:** ZIC1 exhibits metal ion binding and sequence-specific double-stranded DNA binding capabilities, which may be involved in its regulatory functions. **Pathways and Functions:** 1. **Regulation of Gene Expression:** ZIC1 regulates the expression of target genes through its transcriptional activity, influencing neural and glial cell development. 2. **Cell Differentiation:** ZIC1 promotes the differentiation of neural progenitor cells into various neuronal and glial cell types. 3. **Neural Development:** ZIC1 plays a crucial role in the regulation of neural development, including the specification of the neural plate border and CNS development. 4. **Inner Ear Morphogenesis:** ZIC1 is involved in the regulation of inner ear morphogenesis, which is essential for auditory and vestibular function. 5. **Smoothened Signaling Pathway:** ZIC1 regulates the Smoothened signaling pathway, which is involved in the development of the CNS and the regulation of cell proliferation. **Clinical Significance:** 1. **Neural Developmental Disorders:** Mutations in the ZIC1 gene have been associated with neural developmental disorders, such as holoprosencephaly and brain malformations. 2. **Immunological Responses:** ZIC1 may play a role in modulating immunological responses, particularly in the context of autoimmune diseases and cancer. 3. **Inner Ear Disorders:** ZIC1 mutations have been linked to inner ear disorders, such as hearing loss and balance disorders. 4. **CNS Tumors:** ZIC1 may be involved in the regulation of CNS tumor development and progression. In conclusion, the ZIC1 gene plays a critical role in regulating developmental processes, including neural and glial cell development, and may be involved in immunological responses and inner ear disorders. Further research is necessary to fully understand the functions and clinical significance of this gene.

Genular Protein ID: 3137358208

Symbol: ZIC1_HUMAN

Name: Zinc finger protein ZIC 1

UniProtKB Accession Codes:

Q15915 Q2M3N1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8542595

Title: Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma.

PubMed ID: 8542595

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26340333

Title: Gain-of-function mutations in ZIC1 are associated with coronal craniosynostosis and learning disability.

PubMed ID: 26340333

DOI: 10.1016/j.ajhg.2015.07.007

PubMed ID: 30391508

Title: Mutated zinc finger protein of the cerebellum 1 leads to microcephaly, cortical malformation, callosal agenesis, cerebellar dysplasia, tethered cord and scoliosis.

PubMed ID: 30391508

DOI: 10.1016/j.ejmg.2018.10.018

Sequence Information:

  • Length: 447
  • Mass: 48309
  • Checksum: 4DA3E32C99BF1AAE
  • Sequence:
    • MLLDAGPQYP AIGVTTFGAS RHHSAGDVAE RDVGLGINPF ADGMGAFKLN PSSHELASAG 
QTAFTSQAPG YAAAAALGHH HHPGHVGSYS SAAFNSTRDF LFRNRGFGDA AAAASAQHSL 
FAASAGGFGG PHGHTDAAGH LLFPGLHEQA AGHASPNVVN GQMRLGFSGD MYPRPEQYGQ 
VTSPRSEHYA APQLHGYGPM NVNMAAHHGA GAFFRYMRQP IKQELICKWI EPEQLANPKK 
SCNKTFSTMH ELVTHVTVEH VGGPEQSNHI CFWEECPREG KPFKAKYKLV NHIRVHTGEK 
PFPCPFPGCG KVFARSENLK IHKRTHTGEK PFKCEFEGCD RRFANSSDRK KHMHVHTSDK 
PYLCKMCDKS YTHPSSLRKH MKVHESSSQG SQPSPAASSG YESSTPPTIV SPSTDNPTTS 
SLSPSSSAVH HTAGHSALSS NFNEWYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.