Details for: ZIC1

Gene ID: 7545

Symbol: ZIC1

Ensembl ID: ENSG00000152977

Description: Zic family member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 11.8631
    Cell Significance Index: 203.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.0609
    Cell Significance Index: 66.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.4875
    Cell Significance Index: 91.2000
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.4273
    Cell Significance Index: 15.8500
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.0040
    Cell Significance Index: 11.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5213
    Cell Significance Index: 99.2200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.4713
    Cell Significance Index: 4.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3258
    Cell Significance Index: 18.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3024
    Cell Significance Index: 19.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2467
    Cell Significance Index: 156.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2434
    Cell Significance Index: 458.2500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2176
    Cell Significance Index: 5.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2062
    Cell Significance Index: 4.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1784
    Cell Significance Index: 161.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0744
    Cell Significance Index: 7.3600
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.0621
    Cell Significance Index: 0.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0532
    Cell Significance Index: 8.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0327
    Cell Significance Index: 1.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0316
    Cell Significance Index: 0.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0049
    Cell Significance Index: 0.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0022
    Cell Significance Index: 1.5600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0072
    Cell Significance Index: -0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0148
    Cell Significance Index: -27.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0186
    Cell Significance Index: -28.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0213
    Cell Significance Index: -29.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0272
    Cell Significance Index: -12.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0349
    Cell Significance Index: -25.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0444
    Cell Significance Index: -20.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0464
    Cell Significance Index: -26.1600
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0577
    Cell Significance Index: -0.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0622
    Cell Significance Index: -1.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0686
    Cell Significance Index: -24.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0728
    Cell Significance Index: -20.9600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0931
    Cell Significance Index: -1.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0944
    Cell Significance Index: -5.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0945
    Cell Significance Index: -6.5400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1075
    Cell Significance Index: -4.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1130
    Cell Significance Index: -5.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1188
    Cell Significance Index: -23.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1236
    Cell Significance Index: -22.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1243
    Cell Significance Index: -26.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1281
    Cell Significance Index: -25.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1302
    Cell Significance Index: -18.9200
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.1359
    Cell Significance Index: -1.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1462
    Cell Significance Index: -24.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1481
    Cell Significance Index: -15.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1551
    Cell Significance Index: -3.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1638
    Cell Significance Index: -8.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1678
    Cell Significance Index: -21.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1683
    Cell Significance Index: -11.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1831
    Cell Significance Index: -25.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1845
    Cell Significance Index: -22.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2013
    Cell Significance Index: -23.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2216
    Cell Significance Index: -22.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2335
    Cell Significance Index: -26.7500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2565
    Cell Significance Index: -5.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2673
    Cell Significance Index: -7.4700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2848
    Cell Significance Index: -1.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2929
    Cell Significance Index: -21.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3252
    Cell Significance Index: -8.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3487
    Cell Significance Index: -21.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3814
    Cell Significance Index: -29.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3868
    Cell Significance Index: -26.0100
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: -0.3950
    Cell Significance Index: -3.6600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4175
    Cell Significance Index: -10.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4385
    Cell Significance Index: -20.6100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4525
    Cell Significance Index: -10.9600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4655
    Cell Significance Index: -6.8700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.5011
    Cell Significance Index: -3.2600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.5407
    Cell Significance Index: -5.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5499
    Cell Significance Index: -28.8700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5883
    Cell Significance Index: -8.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5910
    Cell Significance Index: -12.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6238
    Cell Significance Index: -27.5900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6304
    Cell Significance Index: -9.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6744
    Cell Significance Index: -11.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7157
    Cell Significance Index: -33.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7267
    Cell Significance Index: -27.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7342
    Cell Significance Index: -25.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7449
    Cell Significance Index: -15.8700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.7561
    Cell Significance Index: -12.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7688
    Cell Significance Index: -25.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7750
    Cell Significance Index: -22.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7836
    Cell Significance Index: -28.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7928
    Cell Significance Index: -25.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8445
    Cell Significance Index: -22.5500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8552
    Cell Significance Index: -10.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8630
    Cell Significance Index: -23.4900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.8680
    Cell Significance Index: -22.1200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.9144
    Cell Significance Index: -12.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9150
    Cell Significance Index: -26.1100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.9220
    Cell Significance Index: -29.1600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9236
    Cell Significance Index: -15.9700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.9382
    Cell Significance Index: -10.2000
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.9447
    Cell Significance Index: -10.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9509
    Cell Significance Index: -25.4800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.9593
    Cell Significance Index: -19.5200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.0007
    Cell Significance Index: -6.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0120
    Cell Significance Index: -26.6100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.0253
    Cell Significance Index: -24.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor Function:** ZIC1 is a member of the Zic family of transcription factors, which are known to regulate gene expression by binding to specific DNA sequences and modulating the transcriptional activity of target genes. 2. **Cell-Specific Expression:** ZIC1 is highly expressed in neurons, glial cells, and neural progenitor cells, suggesting its role in the development and maintenance of these cell types. 3. **Regulation of Neural Development:** ZIC1 plays a critical role in the regulation of neural development, including the specification of the neural plate border, CNS development, and inner ear morphogenesis. 4. **Metabolic and Transport Functions:** ZIC1 exhibits metal ion binding and sequence-specific double-stranded DNA binding capabilities, which may be involved in its regulatory functions. **Pathways and Functions:** 1. **Regulation of Gene Expression:** ZIC1 regulates the expression of target genes through its transcriptional activity, influencing neural and glial cell development. 2. **Cell Differentiation:** ZIC1 promotes the differentiation of neural progenitor cells into various neuronal and glial cell types. 3. **Neural Development:** ZIC1 plays a crucial role in the regulation of neural development, including the specification of the neural plate border and CNS development. 4. **Inner Ear Morphogenesis:** ZIC1 is involved in the regulation of inner ear morphogenesis, which is essential for auditory and vestibular function. 5. **Smoothened Signaling Pathway:** ZIC1 regulates the Smoothened signaling pathway, which is involved in the development of the CNS and the regulation of cell proliferation. **Clinical Significance:** 1. **Neural Developmental Disorders:** Mutations in the ZIC1 gene have been associated with neural developmental disorders, such as holoprosencephaly and brain malformations. 2. **Immunological Responses:** ZIC1 may play a role in modulating immunological responses, particularly in the context of autoimmune diseases and cancer. 3. **Inner Ear Disorders:** ZIC1 mutations have been linked to inner ear disorders, such as hearing loss and balance disorders. 4. **CNS Tumors:** ZIC1 may be involved in the regulation of CNS tumor development and progression. In conclusion, the ZIC1 gene plays a critical role in regulating developmental processes, including neural and glial cell development, and may be involved in immunological responses and inner ear disorders. Further research is necessary to fully understand the functions and clinical significance of this gene.

Genular Protein ID: 3137358208

Symbol: ZIC1_HUMAN

Name: Zinc finger protein ZIC 1

UniProtKB Accession Codes:

Q15915 Q2M3N1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8542595

Title: Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma.

PubMed ID: 8542595

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26340333

Title: Gain-of-function mutations in ZIC1 are associated with coronal craniosynostosis and learning disability.

PubMed ID: 26340333

DOI: 10.1016/j.ajhg.2015.07.007

PubMed ID: 30391508

Title: Mutated zinc finger protein of the cerebellum 1 leads to microcephaly, cortical malformation, callosal agenesis, cerebellar dysplasia, tethered cord and scoliosis.

PubMed ID: 30391508

DOI: 10.1016/j.ejmg.2018.10.018

Sequence Information:

  • Length: 447
  • Mass: 48309
  • Checksum: 4DA3E32C99BF1AAE
  • Sequence:
    • MLLDAGPQYP AIGVTTFGAS RHHSAGDVAE RDVGLGINPF ADGMGAFKLN PSSHELASAG 
QTAFTSQAPG YAAAAALGHH HHPGHVGSYS SAAFNSTRDF LFRNRGFGDA AAAASAQHSL 
FAASAGGFGG PHGHTDAAGH LLFPGLHEQA AGHASPNVVN GQMRLGFSGD MYPRPEQYGQ 
VTSPRSEHYA APQLHGYGPM NVNMAAHHGA GAFFRYMRQP IKQELICKWI EPEQLANPKK 
SCNKTFSTMH ELVTHVTVEH VGGPEQSNHI CFWEECPREG KPFKAKYKLV NHIRVHTGEK 
PFPCPFPGCG KVFARSENLK IHKRTHTGEK PFKCEFEGCD RRFANSSDRK KHMHVHTSDK 
PYLCKMCDKS YTHPSSLRKH MKVHESSSQG SQPSPAASSG YESSTPPTIV SPSTDNPTTS 
SLSPSSSAVH HTAGHSALSS NFNEWYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.