Details for: ZNF33B

Gene ID: 7582

Symbol: ZNF33B

Ensembl ID: ENSG00000196693

Description: zinc finger protein 33B

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 143.9453
    Cell Significance Index: -22.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 78.1412
    Cell Significance Index: -19.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.1561
    Cell Significance Index: -19.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 34.8200
    Cell Significance Index: -23.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.9480
    Cell Significance Index: -20.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.7436
    Cell Significance Index: -23.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.0109
    Cell Significance Index: -21.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9274
    Cell Significance Index: -23.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.7693
    Cell Significance Index: -17.7200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.2317
    Cell Significance Index: -11.4500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.8018
    Cell Significance Index: 61.3500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.9591
    Cell Significance Index: 17.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3759
    Cell Significance Index: 160.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2284
    Cell Significance Index: 16.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1651
    Cell Significance Index: 32.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0801
    Cell Significance Index: 387.4200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.0641
    Cell Significance Index: 6.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0568
    Cell Significance Index: 209.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0508
    Cell Significance Index: 189.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0437
    Cell Significance Index: 209.3600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.8977
    Cell Significance Index: 21.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8335
    Cell Significance Index: 51.2300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.8115
    Cell Significance Index: 10.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.8061
    Cell Significance Index: 13.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7662
    Cell Significance Index: 124.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7007
    Cell Significance Index: 86.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6977
    Cell Significance Index: 6.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6954
    Cell Significance Index: 68.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6836
    Cell Significance Index: 35.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6732
    Cell Significance Index: 37.7800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5817
    Cell Significance Index: 13.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4652
    Cell Significance Index: 35.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4625
    Cell Significance Index: 10.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4545
    Cell Significance Index: 21.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4333
    Cell Significance Index: 73.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3858
    Cell Significance Index: 210.7100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.3804
    Cell Significance Index: 12.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3798
    Cell Significance Index: 24.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3612
    Cell Significance Index: 16.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.3466
    Cell Significance Index: 216.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3149
    Cell Significance Index: 14.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3103
    Cell Significance Index: 280.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2634
    Cell Significance Index: 16.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2206
    Cell Significance Index: 28.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1993
    Cell Significance Index: 88.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1921
    Cell Significance Index: 5.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1749
    Cell Significance Index: 12.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1581
    Cell Significance Index: 30.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1109
    Cell Significance Index: 14.2200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.1061
    Cell Significance Index: 1.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0881
    Cell Significance Index: 5.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0760
    Cell Significance Index: 48.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0719
    Cell Significance Index: 110.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0715
    Cell Significance Index: 9.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0663
    Cell Significance Index: 1.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0640
    Cell Significance Index: 2.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0619
    Cell Significance Index: 114.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0506
    Cell Significance Index: 2.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0423
    Cell Significance Index: 79.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0416
    Cell Significance Index: 1.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0375
    Cell Significance Index: 51.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0374
    Cell Significance Index: 1.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0156
    Cell Significance Index: 11.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0054
    Cell Significance Index: 2.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0060
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0073
    Cell Significance Index: -5.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0088
    Cell Significance Index: -6.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0190
    Cell Significance Index: -0.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0219
    Cell Significance Index: -3.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0247
    Cell Significance Index: -13.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0469
    Cell Significance Index: -4.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0482
    Cell Significance Index: -5.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0559
    Cell Significance Index: -11.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0676
    Cell Significance Index: -1.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0774
    Cell Significance Index: -8.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0804
    Cell Significance Index: -23.1300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0827
    Cell Significance Index: -1.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0900
    Cell Significance Index: -6.7100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0923
    Cell Significance Index: -1.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1072
    Cell Significance Index: -5.6300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1084
    Cell Significance Index: -1.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1215
    Cell Significance Index: -1.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1503
    Cell Significance Index: -7.8300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1565
    Cell Significance Index: -1.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1631
    Cell Significance Index: -4.2900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1644
    Cell Significance Index: -18.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1678
    Cell Significance Index: -5.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1739
    Cell Significance Index: -18.1100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1800
    Cell Significance Index: -3.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1834
    Cell Significance Index: -3.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1894
    Cell Significance Index: -4.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2048
    Cell Significance Index: -16.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2303
    Cell Significance Index: -3.8600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2397
    Cell Significance Index: -6.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2462
    Cell Significance Index: -8.0600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2500
    Cell Significance Index: -5.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2629
    Cell Significance Index: -16.1200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2819
    Cell Significance Index: -3.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3024
    Cell Significance Index: -9.6300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3625
    Cell Significance Index: -4.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DNA-binding transcription activator activity**: ZN33B's primary function is to activate transcription by binding to specific DNA sequences, thereby recruiting RNA polymerase II to initiate gene expression. 2. **RNA polymerase II-specific**: ZN33B is specifically associated with RNA polymerase II, a key enzyme responsible for transcribing protein-coding genes in eukaryotes. 3. **Metal ion binding**: ZN33B contains a zinc finger domain, which binds to metal ions, contributing to its DNA-binding activity. 4. **Highly expressed in multiple tissues**: ZN33B is expressed in various tissues, including kidney proximal convoluted tubule epithelial cells, cardiac muscle cells, and pancreatic acinar cells, highlighting its role in multiple cellular processes. **Pathways and Functions:** 1. **Generic transcription pathway**: ZN33B is involved in the generic transcription pathway, which is responsible for regulating the expression of genes involved in various cellular processes, including cell growth, differentiation, and survival. 2. **Positive regulation of transcription by RNA polymerase II**: ZN33B acts as a transcriptional activator, promoting the recruitment of RNA polymerase II to specific DNA sequences, thereby enhancing gene expression. 3. **Regulation of transcription by RNA polymerase II**: ZN33B's interaction with RNA polymerase II regulates the transcription of target genes, influencing cellular processes such as cell growth, differentiation, and survival. 4. **Metal ion binding**: The zinc finger domain in ZN33B allows it to bind to metal ions, which is essential for its DNA-binding activity and transcriptional regulation. **Clinical Significance:** The ZN33B gene has been associated with various diseases and disorders, including: 1. **Kidney diseases**: Mutations in the ZN33B gene have been linked to kidney diseases, such as polycystic kidney disease (PKD) and nephronophthisis. 2. **Cardiovascular diseases**: ZN33B has been implicated in the regulation of cardiac muscle cell growth and differentiation, making it a potential target for the treatment of cardiovascular diseases. 3. **Neurological disorders**: The ZN33B gene has been associated with neurological disorders, such as epilepsy and schizophrenia, highlighting its role in brain development and function. In conclusion, the Zinc Finger Protein 33B is a transcriptional activator that plays a crucial role in regulating gene expression in various tissues. Its involvement in multiple cellular processes and association with various diseases and disorders make it an important target for further research and therapeutic interventions.

Genular Protein ID: 3666448465

Symbol: ZN33B_HUMAN

Name: Zinc finger protein 33B

UniProtKB Accession Codes:

Q06732 Q06731 Q32MA2 Q86XY8 Q8NDW3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 8 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12566394

Title: Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p.

PubMed ID: 12566394

DOI: 10.1101/gr.644503

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8464732

Title: Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution.

PubMed ID: 8464732

DOI: 10.1093/nar/21.6.1409

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 778
  • Mass: 90683
  • Checksum: D53D23909751DCEF
  • Sequence:
    • MNKVDQKFQG SVSFKDVTVG FTQEEWQHLD PSQRALYRDV MLENYSNLVS VGYCAHKPEV 
IFRLEQGEEP WRLEEEFPSQ SFPEVWTADH LKERSQENQS KHLWEVVFIN NEMLTKEQGN 
VIGIPFNMDV SSFPSRKMFC QYDSRGMSFN TVSELVISKI NYLGKKSDEF NACGKLLLNI 
KHDETHTREK NEVLKNRNTL SHRENTLQHE KIQTLDHNFE YSICQETLLE KAVFNTRKRE 
NAEENNCDYN EFGRTFCDSS SLLFHQIPPS KDSHYEFSDC EKFLCVKSTL SKHDGVPVKH 
YDCGESGNNF RRKLCLSQLQ KGDKGEKHFE CNECGKAFWE KSHLTRHQRV HTGEKHFQCN 
QCGKTFWEKS NLTKHQRSHT GEKPFECNEC GKAFSHKSAL TLHQRTHTGE KPYQCNACGK 
TFYQKSDLTK HQRTHTGQKP YECYECGKSF CMNSHLTVHQ RTHTGEKPFE CLECGKSFCQ 
KSHLTQHQRT HIGDKPYECN ACGKTFYHKS VLTRHQIIHT GLKPYECYEC GKTFCLKSDL 
TIHQRTHTGE KPFACPECGK FFSHKSTLSQ HYRTHTGEKP YECHECGKIF YNKSYLTKHN 
RTHTGEKPYE CNECGKTFCQ KSQLTQHQRI HIGEKPYECN ECGKAFCHKS ALIVHQRTHT 
QEKPYKCNEC GKSFCVKSGL ILHERKHTGE KPYECNECGK SFSHKSSLTV HHRAHTGEKS 
CQCNECGKIF YRKSDLAKHQ RSHTGEKPYE CNTCRKTFSQ KSNLIVHQRT HIGEKPYE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.