Details for: ZNF43

Gene ID: 7594

Symbol: ZNF43

Ensembl ID: ENSG00000198521

Description: zinc finger protein 43

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 140.7951
    Cell Significance Index: -21.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 80.0731
    Cell Significance Index: -20.3100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 48.1866
    Cell Significance Index: -22.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.2023
    Cell Significance Index: -18.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.6912
    Cell Significance Index: -18.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.7760
    Cell Significance Index: -23.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.0389
    Cell Significance Index: -21.5400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.1827
    Cell Significance Index: -18.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9173
    Cell Significance Index: -23.3500
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 2.7902
    Cell Significance Index: 3.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.2367
    Cell Significance Index: 125.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.6267
    Cell Significance Index: 34.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3590
    Cell Significance Index: 1227.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.2927
    Cell Significance Index: 187.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0337
    Cell Significance Index: 112.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9214
    Cell Significance Index: 149.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7829
    Cell Significance Index: 141.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7321
    Cell Significance Index: 20.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6617
    Cell Significance Index: 131.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6541
    Cell Significance Index: 50.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5349
    Cell Significance Index: 10.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5318
    Cell Significance Index: 106.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5039
    Cell Significance Index: 34.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4664
    Cell Significance Index: 167.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2968
    Cell Significance Index: 36.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2856
    Cell Significance Index: 18.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2404
    Cell Significance Index: 12.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2372
    Cell Significance Index: 32.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2314
    Cell Significance Index: 435.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2304
    Cell Significance Index: 5.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2271
    Cell Significance Index: 6.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2223
    Cell Significance Index: 42.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2199
    Cell Significance Index: 4.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2131
    Cell Significance Index: 11.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2125
    Cell Significance Index: 21.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1803
    Cell Significance Index: 79.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1599
    Cell Significance Index: 87.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1225
    Cell Significance Index: 3.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1143
    Cell Significance Index: 5.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1069
    Cell Significance Index: 2.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0957
    Cell Significance Index: 6.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0769
    Cell Significance Index: 48.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0764
    Cell Significance Index: 9.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0698
    Cell Significance Index: 8.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0642
    Cell Significance Index: 1.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0534
    Cell Significance Index: 6.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0420
    Cell Significance Index: 64.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0404
    Cell Significance Index: 18.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0382
    Cell Significance Index: 1.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0369
    Cell Significance Index: 68.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0312
    Cell Significance Index: 0.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0281
    Cell Significance Index: 0.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0280
    Cell Significance Index: 0.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0102
    Cell Significance Index: 13.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0119
    Cell Significance Index: -8.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0139
    Cell Significance Index: -10.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0235
    Cell Significance Index: -17.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0341
    Cell Significance Index: -5.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0342
    Cell Significance Index: -1.2000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0359
    Cell Significance Index: -0.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0361
    Cell Significance Index: -20.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0438
    Cell Significance Index: -2.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0466
    Cell Significance Index: -1.6200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0610
    Cell Significance Index: -0.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0706
    Cell Significance Index: -3.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0805
    Cell Significance Index: -23.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0826
    Cell Significance Index: -8.4400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0968
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1041
    Cell Significance Index: -11.9300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1064
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1071
    Cell Significance Index: -22.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1118
    Cell Significance Index: -14.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1178
    Cell Significance Index: -3.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1222
    Cell Significance Index: -3.9200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1225
    Cell Significance Index: -0.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1255
    Cell Significance Index: -3.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1271
    Cell Significance Index: -9.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1311
    Cell Significance Index: -13.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1359
    Cell Significance Index: -2.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1417
    Cell Significance Index: -7.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1425
    Cell Significance Index: -2.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1832
    Cell Significance Index: -8.5400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2181
    Cell Significance Index: -2.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2299
    Cell Significance Index: -18.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2359
    Cell Significance Index: -10.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2813
    Cell Significance Index: -7.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2894
    Cell Significance Index: -10.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2981
    Cell Significance Index: -2.7500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.3278
    Cell Significance Index: -3.8100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3343
    Cell Significance Index: -2.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3520
    Cell Significance Index: -10.0900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.3542
    Cell Significance Index: -3.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3628
    Cell Significance Index: -22.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3673
    Cell Significance Index: -12.0300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.3870
    Cell Significance Index: -3.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3928
    Cell Significance Index: -12.5100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3977
    Cell Significance Index: -8.4400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3983
    Cell Significance Index: -4.9400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.4112
    Cell Significance Index: -2.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4125
    Cell Significance Index: -11.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc finger domain**: ZNF43 contains a characteristic zinc finger domain, which is a type of DNA-binding motif that allows the protein to interact with specific DNA sequences. 2. **RNA polymerase II interaction**: ZNF43 interacts with RNA polymerase II, a key enzyme responsible for transcription of protein-coding genes. 3. **Transcriptional activation**: ZNF43 acts as a transcriptional activator, promoting the expression of target genes. 4. **Widespread expression**: ZNF43 is highly expressed in various cell types, including taste receptor cells, mesangial cells, and epithelial cells of the lower respiratory tract. **Pathways and Functions:** ZNF43 is involved in several transcriptional pathways, including: 1. **Generic transcription pathway**: ZNF43 regulates the expression of genes involved in various cellular processes, including cell growth, differentiation, and survival. 2. **Metal ion binding**: ZNF43 binds to metal ions, which can influence its DNA-binding activity and transcriptional regulation. 3. **DNA binding**: ZNF43 binds to specific DNA sequences, allowing it to regulate transcription of target genes. 4. **Regulation of transcription by RNA polymerase II**: ZNF43 interacts with RNA polymerase II, promoting the expression of target genes. **Clinical Significance:** ZNF43 has been implicated in various diseases, including: 1. **Neurological disorders**: ZNF43 has been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may play a role in the regulation of gene expression. 2. **Cancer**: ZNF43 has been found to be overexpressed in certain types of cancer, suggesting its potential role as a tumor suppressor. 3. **Respiratory diseases**: ZNF43 may play a role in the regulation of gene expression in respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). 4. **Gastrointestinal disorders**: ZNF43 has been implicated in gastrointestinal disorders, such as inflammatory bowel disease (IBD), where it may regulate the expression of genes involved in inflammation and immune response. In conclusion, ZNF43 is a transcriptional regulator that plays a crucial role in the regulation of gene expression through its interaction with RNA polymerase II. Its widespread expression in various cell types and its involvement in multiple physiological processes make it an important target for further research, particularly in the context of disease.

Genular Protein ID: 2806229579

Symbol: ZNF43_HUMAN

Name: Zinc finger protein 43

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1711675

Title: A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines.

PubMed ID: 1711675

DOI: 10.1093/nar/19.11.2921

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2023909

Title: The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.

PubMed ID: 2023909

DOI: 10.1073/pnas.88.9.3608

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 809
  • Mass: 94124
  • Checksum: 03386F299D6794C4
  • Sequence:
  • MGPLTFMDVA IEFCLEEWQC LDIAQQNLYR NVMLENYRNL VFLGIAVSKP DLITCLEQEK 
    EPWEPMRRHE MVAKPPVMCS HFTQDFWPEQ HIKDPFQKAT LRRYKNCEHK NVHLKKDHKS 
    VDECKVHRGG YNGFNQCLPA TQSKIFLFDK CVKAFHKFSN SNRHKISHTE KKLFKCKECG 
    KSFCMLPHLA QHKIIHTRVN FCKCEKCGKA FNCPSIITKH KRINTGEKPY TCEECGKVFN 
    WSSRLTTHKK NYTRYKLYKC EECGKAFNKS SILTTHKIIR TGEKFYKCKE CAKAFNQSSN 
    LTEHKKIHPG EKPYKCEECG KAFNWPSTLT KHKRIHTGEK PYTCEECGKA FNQFSNLTTH 
    KRIHTAEKFY KCTECGEAFS RSSNLTKHKK IHTEKKPYKC EECGKAFKWS SKLTEHKLTH 
    TGEKPYKCEE CGKAFNWPST LTKHNRIHTG EKPYKCEVCG KAFNQFSNLT THKRIHTAEK 
    PYKCEECGKA FSRSSNLTKH KKIHIEKKPY KCEECGKAFK WSSKLTEHKI THTGEKPYKC 
    EECGKAFNHF SILTKHKRIH TGEKPYKCEE CGKAFTQSSN LTTHKKIHTG EKFYKCEECG 
    KAFTQSSNLT THKKIHTGGK PYKCEECGKA FNQFSTLTKH KIIHTEEKPY KCEECGKAFK 
    WSSTLTKHKI IHTGEKPYKC EECGKAFKLS STLSTHKIIH TGEKPYKCEK CGKAFNRSSN 
    LIEHKKIHTG EQPYKCEECG KAFNYSSHLN THKRIHTKEQ PYKCKECGKA FNQYSNLTTH 
    NKIHTGEKLY KPEDVTVILT TPQTFSNIK

Genular Protein ID: 3776905239

Symbol: A0A087WSW2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 818
  • Mass: 95104
  • Checksum: E90C0E24AFB7B7FE
  • Sequence:
  • MPGHPGSWEM GPLTFMDVAI EFCLEEWQCL DIAQQNLYRN VMLENYRNLV FLGIAVSKPD 
    LITCLEQEKE PWEPMRRHEM VAKPPVMCSH FTQDFWPEQH IKDPFQKATL RRYKNCEHKN 
    VHLKKDHKSV DECKVHRGGY NGFNQCLPAT QSKIFLFDKC VKAFHKFSNS NRHKISHTEK 
    KLFKCKECGK SFCMLPHLAQ HKIIHTRVNF CKCEKCGKAF NCPSIITKHK RINTGEKPYT 
    CEECGKVFNW SSRLTTHKKN YTRYKLYKCE ECGKAFNKSS ILTTHKIIRT GEKFYKCKEC 
    AKAFNQSSNL TEHKKIHPGE KPYKCEECGK AFNWPSTLTK HKRIHTGEKP YTCEECGKAF 
    NQFSNLTTHK RIHTAEKFYK CTECGEAFSR SSNLTKHKKI HTEKKPYKCE ECGKAFKWSS 
    KLTEHKLTHT GEKPYKCEEC GKAFNWPSTL TKHNRIHTGE KPYKCEVCGK AFNQFSNLTT 
    HKRIHTAEKP YKCEECGKAF SRSSNLTKHK KIHIEKKPYK CEECGKAFKW SSKLTEHKIT 
    HTGEKPYKCE ECGKAFNHFS ILTKHKRIHT GEKPYKCEEC GKAFTQSSNL TTHKKIHTGE 
    KFYKCEECGK AFTQSSNLTT HKKIHTGGKP YKCEECGKAF NQFSTLTKHK IIHTEEKPYK 
    CEECGKAFKW SSTLTKHKII HTGEKPYKCE ECGKAFKLSS TLSTHKIIHT GEKPYKCEKC 
    GKAFNRSSNL IEHKKIHTGE QPYKCEECGK AFNYSSHLNT HKRIHTKEQP YKCKECGKAF 
    NQYSNLTTHN KIHTGEKLYK PEDVTVILTT PQTFSNIK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.