Details for: ZNF45

Gene ID: 7596

Symbol: ZNF45

Ensembl ID: ENSG00000124459

Description: zinc finger protein 45

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 63.0363
    Cell Significance Index: -9.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.8341
    Cell Significance Index: -9.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 21.6893
    Cell Significance Index: -10.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 19.6427
    Cell Significance Index: -7.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.3635
    Cell Significance Index: -7.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.2120
    Cell Significance Index: -10.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.5899
    Cell Significance Index: -10.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.7191
    Cell Significance Index: -5.2800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.6677
    Cell Significance Index: -3.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0648
    Cell Significance Index: 105.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6527
    Cell Significance Index: 13.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5611
    Cell Significance Index: 91.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4831
    Cell Significance Index: 436.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3966
    Cell Significance Index: 43.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3648
    Cell Significance Index: 69.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3027
    Cell Significance Index: 8.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2389
    Cell Significance Index: 47.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2265
    Cell Significance Index: 3.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2052
    Cell Significance Index: 14.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1691
    Cell Significance Index: 116.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1657
    Cell Significance Index: 33.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1478
    Cell Significance Index: 9.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1317
    Cell Significance Index: 10.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1230
    Cell Significance Index: 14.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1107
    Cell Significance Index: 19.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1068
    Cell Significance Index: 15.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1050
    Cell Significance Index: 5.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0963
    Cell Significance Index: 34.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0796
    Cell Significance Index: 4.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0760
    Cell Significance Index: 1.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0748
    Cell Significance Index: 1.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0587
    Cell Significance Index: 1.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0530
    Cell Significance Index: 6.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0500
    Cell Significance Index: 1.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0421
    Cell Significance Index: 1.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0367
    Cell Significance Index: 20.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0333
    Cell Significance Index: 1.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0284
    Cell Significance Index: 12.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0142
    Cell Significance Index: 0.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0107
    Cell Significance Index: 0.5000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0087
    Cell Significance Index: 0.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0077
    Cell Significance Index: 0.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0076
    Cell Significance Index: 14.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0043
    Cell Significance Index: 2.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0019
    Cell Significance Index: 3.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0018
    Cell Significance Index: 2.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0012
    Cell Significance Index: -0.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0017
    Cell Significance Index: -2.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0052
    Cell Significance Index: -0.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0091
    Cell Significance Index: -6.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0092
    Cell Significance Index: -1.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0115
    Cell Significance Index: -1.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0119
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0127
    Cell Significance Index: -9.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0135
    Cell Significance Index: -10.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0184
    Cell Significance Index: -0.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0187
    Cell Significance Index: -10.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0226
    Cell Significance Index: -6.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0243
    Cell Significance Index: -15.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0263
    Cell Significance Index: -1.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0349
    Cell Significance Index: -1.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0367
    Cell Significance Index: -6.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0384
    Cell Significance Index: -3.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0419
    Cell Significance Index: -2.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0449
    Cell Significance Index: -5.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0506
    Cell Significance Index: -3.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0561
    Cell Significance Index: -11.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0577
    Cell Significance Index: -7.4500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0588
    Cell Significance Index: -0.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0672
    Cell Significance Index: -4.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0792
    Cell Significance Index: -1.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0818
    Cell Significance Index: -2.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0837
    Cell Significance Index: -6.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0903
    Cell Significance Index: -9.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1062
    Cell Significance Index: -4.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1064
    Cell Significance Index: -2.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1069
    Cell Significance Index: -2.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1085
    Cell Significance Index: -2.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1092
    Cell Significance Index: -8.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1143
    Cell Significance Index: -7.0100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1429
    Cell Significance Index: -2.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1468
    Cell Significance Index: -3.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1571
    Cell Significance Index: -2.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1586
    Cell Significance Index: -3.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1672
    Cell Significance Index: -5.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1945
    Cell Significance Index: -10.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1988
    Cell Significance Index: -6.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2006
    Cell Significance Index: -6.3900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2007
    Cell Significance Index: -3.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2046
    Cell Significance Index: -5.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2105
    Cell Significance Index: -7.3700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2105
    Cell Significance Index: -3.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2213
    Cell Significance Index: -6.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2277
    Cell Significance Index: -6.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2543
    Cell Significance Index: -12.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2559
    Cell Significance Index: -6.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2586
    Cell Significance Index: -7.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2685
    Cell Significance Index: -5.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2690
    Cell Significance Index: -7.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2827
    Cell Significance Index: -3.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Motif:** ZNF45 possesses a zinc finger motif, a protein domain that allows for specific DNA recognition and binding. This motif enables ZNF45 to interact with DNA sequences, influencing transcriptional regulation. 2. **Transcriptional Regulator:** As a transcriptional regulator, ZNF45 modulates gene expression by interacting with RNA polymerase II and other transcriptional machinery components, thereby influencing the transcription of target genes. 3. **Metal Ion Binding:** ZNF45 exhibits metal ion binding capabilities, which may contribute to its role in transcriptional regulation and DNA binding. 4. **Expression in Various Cell Types:** ZNF45 is expressed in multiple cell types, including GABAergic interneurons, forebrain radial glial cells, and intestinal epithelial cells, highlighting its involvement in different developmental and tissue-specific processes. **Pathways and Functions:** 1. **DNA-Binding Transcription Factor Activity:** ZNF45 participates in DNA-binding transcription factor activity, enabling it to regulate gene expression by interacting with specific DNA sequences. 2. **Generic Transcription Pathway:** ZNF45 is involved in the generic transcription pathway, influencing the transcription of a wide range of genes involved in cellular processes. 3. **Metal Ion Binding and Regulation of DNA-templated Transcription:** ZNF45's metal ion binding capabilities may modulate DNA-templated transcription, allowing it to fine-tune gene expression in response to environmental cues. 4. **Regulation of Gene Expression (Transcription):** As a transcriptional regulator, ZNF45 modulates gene expression by interacting with RNA polymerase II and other transcriptional machinery components. **Clinical Significance:** 1. **Developmental Disorders:** Alterations in ZNF45 expression have been linked to developmental disorders, such as intellectual disability and autism spectrum disorder, highlighting its potential role in brain development and function. 2. **Cancer:** ZNF45's involvement in transcriptional regulation and DNA binding may contribute to its role in cancer development and progression. 3. **Intestinal Disorders:** ZNF45's expression in intestinal epithelial cells and goblet cells suggests its potential involvement in intestinal homeostasis and disorders, such as inflammatory bowel disease. 4. **Neurological Disorders:** ZNF45's expression in GABAergic interneurons and forebrain radial glial cells implies its potential role in neurological disorders, such as epilepsy and neurodegenerative diseases. In conclusion, ZNF45 is a multifunctional protein that plays a crucial role in transcriptional regulation, DNA binding, and metal ion binding. Its expression in various cell types and its involvement in different developmental and tissue-specific processes highlight its importance in maintaining cellular homeostasis and preventing disease. Further research is necessary to elucidate the specific mechanisms underlying ZNF45's functions and to explore its potential therapeutic applications.

Genular Protein ID: 679161752

Symbol: ZNF45_HUMAN

Name: Zinc finger protein 45

UniProtKB Accession Codes:

Q02386 P17016 P78472 Q9P1U9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 16 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9067431

Title: Complete coding sequence, exon/intron arrangement and chromosome location of ZNF45, a KRAB-domain-containing gene.

PubMed ID: 9067431

DOI: 10.1159/000134490

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1559709

Title: The identification and characterization of KRAB-domain-containing zinc finger proteins.

PubMed ID: 1559709

DOI: 10.1016/0888-7543(92)90451-w

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 682
  • Mass: 78242
  • Checksum: 9C8E536EB00FCE8B
  • Sequence:
    • MTKSKEAVTF KDVAVVFSEE ELQLLDLAQR KLYRDVMLEN FRNVVSVGHQ STPDGLPQLE 
REEKLWMMKM ATQRDNSSGA KNLKEMETLQ EVGLRYLPHE ELFCSQIWQQ ITRELIKYQD 
SVVNIQRTGC QLEKRDDLHY KDEGFSNQSS HLQVHRVHTG EKPYKGEHCV KSFSWSSHLQ 
INQRAHAGEK PYKCEKCDNA FRRFSSLQAH QRVHSRAKSY TNDASYRSFS QRSHLPHHQR 
VPTGENPYKY EECGRNVGKS SHCQAPLIVH TGEKPYKCEE CGVGFSQRSY LQVHLKVHTG 
KKPYKCEECG KSFSWRSRLQ AHERIHTGEK PYKCNACGKS FSYSSHLNIH CRIHTGEKPY 
KCEECGKGFS VGSHLQAHQI SHTGEKPYKC EECGKGFCRA SNLLDHQRGH TGEKPYQCDA 
CGKGFSRSSD FNIHFRVHTG EKPYKCEECG KGFSQASNLL AHQRGHTGEK PYKCGTCGKG 
FSRSSDLNVH CRIHTGEKPY KCERCGKAFS QFSSLQVHQR VHTGEKPYQC AECGKGFSVG 
SQLQAHQRCH TGEKPYQCEE CGKGFCRASN FLAHRGVHTG EKPYRCDVCG KRFRQRSYLQ 
AHQRVHTGER PYKCEECGKV FSWSSYLQAH QRVHTGEKPY KCEECGKGFS WSSSLIIHQR 
VHADDEGDKD FPSSEDSHRK TR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.