Details for: ZNF90

Gene ID: 7643

Symbol: ZNF90

Ensembl ID: ENSG00000213988

Description: zinc finger protein 90

Associated with

  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Zinc ion binding
    (GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 57.6038
    Cell Significance Index: -8.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 29.2721
    Cell Significance Index: -13.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.1050
    Cell Significance Index: -6.8800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 20.6253
    Cell Significance Index: -13.8400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 13.3379
    Cell Significance Index: 30.0700
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 10.4102
    Cell Significance Index: 30.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.3734
    Cell Significance Index: -12.7900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 7.2529
    Cell Significance Index: 46.3000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 5.9948
    Cell Significance Index: 39.7700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.7382
    Cell Significance Index: 45.8200
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 4.0828
    Cell Significance Index: 23.4100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.8479
    Cell Significance Index: 23.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4262
    Cell Significance Index: -13.5200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.7378
    Cell Significance Index: 18.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.6478
    Cell Significance Index: -5.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.2595
    Cell Significance Index: -6.9400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.1286
    Cell Significance Index: 18.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0723
    Cell Significance Index: 411.2500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.7685
    Cell Significance Index: 10.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.6105
    Cell Significance Index: 34.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.6014
    Cell Significance Index: -4.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3318
    Cell Significance Index: 37.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1074
    Cell Significance Index: 29.5700
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.1031
    Cell Significance Index: 2.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.0686
    Cell Significance Index: 27.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0151
    Cell Significance Index: 60.9400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.9068
    Cell Significance Index: 5.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7685
    Cell Significance Index: 83.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6512
    Cell Significance Index: 588.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6091
    Cell Significance Index: 31.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5510
    Cell Significance Index: 89.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4179
    Cell Significance Index: 23.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4101
    Cell Significance Index: 78.0500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.4035
    Cell Significance Index: 3.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3749
    Cell Significance Index: 37.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3739
    Cell Significance Index: 25.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3663
    Cell Significance Index: 12.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2963
    Cell Significance Index: 7.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2885
    Cell Significance Index: 5.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2781
    Cell Significance Index: 17.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1876
    Cell Significance Index: 21.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1745
    Cell Significance Index: 77.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1712
    Cell Significance Index: 12.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1491
    Cell Significance Index: 3.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1423
    Cell Significance Index: 19.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0979
    Cell Significance Index: 12.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0957
    Cell Significance Index: 4.3400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0948
    Cell Significance Index: 1.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0906
    Cell Significance Index: 2.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0884
    Cell Significance Index: 48.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0879
    Cell Significance Index: 5.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0743
    Cell Significance Index: 56.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0617
    Cell Significance Index: 11.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0499
    Cell Significance Index: 8.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0484
    Cell Significance Index: 5.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0423
    Cell Significance Index: 0.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0376
    Cell Significance Index: 51.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0218
    Cell Significance Index: 0.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0153
    Cell Significance Index: 5.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0136
    Cell Significance Index: 1.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0108
    Cell Significance Index: 1.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0106
    Cell Significance Index: 19.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0086
    Cell Significance Index: 0.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0043
    Cell Significance Index: 6.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0024
    Cell Significance Index: 0.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0051
    Cell Significance Index: -2.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0128
    Cell Significance Index: -9.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0145
    Cell Significance Index: -10.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0152
    Cell Significance Index: -9.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0170
    Cell Significance Index: -9.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0196
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0222
    Cell Significance Index: -13.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0276
    Cell Significance Index: -2.8200
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0278
    Cell Significance Index: -0.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0281
    Cell Significance Index: -5.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0497
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0642
    Cell Significance Index: -7.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0661
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0661
    Cell Significance Index: -13.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0693
    Cell Significance Index: -1.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0940
    Cell Significance Index: -2.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0966
    Cell Significance Index: -7.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0966
    Cell Significance Index: -6.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1001
    Cell Significance Index: -7.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1066
    Cell Significance Index: -11.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1068
    Cell Significance Index: -6.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1217
    Cell Significance Index: -7.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1232
    Cell Significance Index: -6.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1591
    Cell Significance Index: -12.6000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1627
    Cell Significance Index: -1.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1638
    Cell Significance Index: -7.7000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1724
    Cell Significance Index: -1.7900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1770
    Cell Significance Index: -1.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1894
    Cell Significance Index: -9.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1911
    Cell Significance Index: -3.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2153
    Cell Significance Index: -10.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2247
    Cell Significance Index: -9.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2556
    Cell Significance Index: -6.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain:** ZNF90 contains a zinc finger domain, which is a crucial structural motif that enables the protein to bind to specific DNA sequences. This domain is essential for ZNF90's ability to regulate gene expression. 2. **Transcription Factor Activity:** ZNF90 exhibits transcription factor activity, which allows it to bind to specific DNA sequences and regulate gene expression. This activity is mediated by its zinc finger domain and RNA polymerase II-specific regulation. 3. **Cellular Expression:** ZNF90 is significantly expressed in various cell types, including neural progenitor cells, ionocytes, kidney cells, and stem cells of the epidermis. This widespread expression suggests that ZNF90 plays a critical role in maintaining cellular homeostasis and regulating cellular differentiation. 4. **Regulation of Gene Expression:** ZNF90 regulates gene expression by binding to specific DNA sequences and recruiting RNA polymerase II. This recruitment enables the protein to influence transcriptional initiation and elongation. **Pathways and Functions:** 1. **DNA-Binding Transcription Factor Activity:** ZNF90's ability to bind to specific DNA sequences enables it to regulate gene expression. This activity is mediated by its zinc finger domain and RNA polymerase II-specific regulation. 2. **RNA Polymerase II-Specific Regulation:** ZNF90's involvement in RNA polymerase II-specific regulation underscores its role in regulating transcriptional initiation and elongation. 3. **Zinc Ion Binding:** ZNF90's ability to bind zinc ions is essential for its structural integrity and transcriptional activity. 4. **Cellular Differentiation:** ZNF90's involvement in regulating cellular differentiation suggests that it plays a critical role in maintaining cellular homeostasis and promoting cellular development. **Clinical Significance:** 1. **Cancer Association:** ZNF90 has been implicated in various cancers, including breast, lung, and colon cancer. Its overexpression has been linked to tumorigenesis and poor prognosis. 2. **Neurological Disorders:** ZNF90 has been associated with neurological disorders, including Alzheimer's disease and Parkinson's disease. Its involvement in regulating gene expression suggests that it may play a role in maintaining neuronal homeostasis. 3. **Immune System Regulation:** ZNF90's involvement in regulating immune responses suggests that it may play a critical role in maintaining immune homeostasis and preventing autoimmune diseases. In conclusion, ZNF90 is a multifaceted transcription factor that plays a critical role in regulating gene expression and cellular differentiation. Its involvement in various cellular processes, including DNA-binding transcription factor activity, RNA polymerase II-specific regulation, and zinc ion binding, underscores its complexity. Further research is needed to fully elucidate ZNF90's role in various diseases and disorders, and to explore its potential as a therapeutic target.

Genular Protein ID: 702656634

Symbol: ZNF90_HUMAN

Name: Zinc finger protein 90

UniProtKB Accession Codes:

Q03938 B9EH87

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15146197

Title: Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

PubMed ID: 15146197

DOI: 10.1038/nbt971

PubMed ID: 2023909

Title: The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.

PubMed ID: 2023909

DOI: 10.1073/pnas.88.9.3608

Sequence Information:

  • Length: 601
  • Mass: 69058
  • Checksum: DEF44E0762A0C74D
  • Sequence:
    • MGPLEFRDVA IEFSLEEWHC LDTAQQNLYR DVMLENYRHL VFLGIVVTKP DLITCLEQGK 
KPFTVKRHEM IAKSPVMCFH FAQDLCPEQS LKDSFQKVIV TRYEKREYGN LELKKGCESV 
DEGKVHKRGY NGLNQCLTAT QSKVFQCDTY VKVSHIFSNS NRHKIRDTGK KPFKCIECGK 
AFNQSSTLAT HKKIHTGEIT CKCEECGKAF NRSSHLTSHK RIHTGEKRYK CEDCGKELKY 
SSTLTAHKRI HTGEKRYKCE DCGKELKYSS TLTAHKRIHT GEKPYKCDKC GRAFISSSIL 
YVHKISHTEE KPYKCEECGK AFKLSSILST HKRIHTGEKP YKCEECGKAF RRSLVLRTHK 
RIHTGEKPYK CDKCGKAFIS SSLLYKHKIS HSEKKPYKCE ECGKAFKRSS TLTIHKISHT 
EEKPYKCQEC DKVFKRSSAL STHKIIHSGE KPYKCEECGK AFKRSSNLTT HKISHTEEKL 
YKCQECDKAF KYSSALSTHK IIHSGENPYK CEECGKAFKR SSVLSKHKII HTGAKPYKCE 
ECGKAFKRSS QLTSHKISHT GEKPYKCEEC GKAFNLSSDL NTHKRIHIGQ KAYIVKNMAN 
L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.