Details for: ZNF99

Gene ID: 7652

Symbol: ZNF99

Ensembl ID: ENSG00000213973

Description: zinc finger protein 99

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 18.4834
    Cell Significance Index: -2.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 11.1574
    Cell Significance Index: -2.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.3359
    Cell Significance Index: -2.8800
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.0072
    Cell Significance Index: 7.6100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4306
    Cell Significance Index: 10.4300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.3346
    Cell Significance Index: 4.3200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2250
    Cell Significance Index: 5.6100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2038
    Cell Significance Index: 2.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1557
    Cell Significance Index: 44.8100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1025
    Cell Significance Index: 0.7900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0996
    Cell Significance Index: 2.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0930
    Cell Significance Index: 5.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0763
    Cell Significance Index: 1.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0580
    Cell Significance Index: 1.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0381
    Cell Significance Index: 7.6500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0132
    Cell Significance Index: 0.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0126
    Cell Significance Index: 0.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0125
    Cell Significance Index: 4.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0070
    Cell Significance Index: 12.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0065
    Cell Significance Index: 12.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0043
    Cell Significance Index: 6.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0042
    Cell Significance Index: 2.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0039
    Cell Significance Index: 0.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0033
    Cell Significance Index: 4.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0018
    Cell Significance Index: 1.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0008
    Cell Significance Index: 0.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0002
    Cell Significance Index: 0.0800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0019
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0038
    Cell Significance Index: -2.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0039
    Cell Significance Index: -2.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0043
    Cell Significance Index: -0.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0051
    Cell Significance Index: -2.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0051
    Cell Significance Index: -2.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0054
    Cell Significance Index: -0.2400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0057
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0073
    Cell Significance Index: -1.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0094
    Cell Significance Index: -0.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0113
    Cell Significance Index: -1.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0122
    Cell Significance Index: -0.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0125
    Cell Significance Index: -2.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0144
    Cell Significance Index: -3.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0194
    Cell Significance Index: -2.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0211
    Cell Significance Index: -2.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0215
    Cell Significance Index: -2.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0215
    Cell Significance Index: -2.5400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0229
    Cell Significance Index: -0.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0230
    Cell Significance Index: -2.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0231
    Cell Significance Index: -0.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0234
    Cell Significance Index: -2.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0247
    Cell Significance Index: -1.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0276
    Cell Significance Index: -0.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0282
    Cell Significance Index: -1.7800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0287
    Cell Significance Index: -0.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0306
    Cell Significance Index: -1.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0333
    Cell Significance Index: -2.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0335
    Cell Significance Index: -1.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0337
    Cell Significance Index: -2.6700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0361
    Cell Significance Index: -0.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0361
    Cell Significance Index: -1.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0408
    Cell Significance Index: -1.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0440
    Cell Significance Index: -1.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0448
    Cell Significance Index: -1.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0456
    Cell Significance Index: -1.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0459
    Cell Significance Index: -1.2300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0509
    Cell Significance Index: -0.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0514
    Cell Significance Index: -1.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0520
    Cell Significance Index: -2.4500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0526
    Cell Significance Index: -0.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0540
    Cell Significance Index: -1.1300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0623
    Cell Significance Index: -0.9200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0642
    Cell Significance Index: -0.8400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0642
    Cell Significance Index: -2.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0662
    Cell Significance Index: -2.8800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0714
    Cell Significance Index: -1.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0726
    Cell Significance Index: -2.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0736
    Cell Significance Index: -1.7000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0755
    Cell Significance Index: -1.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0760
    Cell Significance Index: -2.7900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0773
    Cell Significance Index: -1.1000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0780
    Cell Significance Index: -1.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0783
    Cell Significance Index: -2.7200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0792
    Cell Significance Index: -0.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0803
    Cell Significance Index: -4.0600
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0810
    Cell Significance Index: -0.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0814
    Cell Significance Index: -1.6100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0823
    Cell Significance Index: -1.1100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0824
    Cell Significance Index: -1.6600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0834
    Cell Significance Index: -1.7700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0858
    Cell Significance Index: -2.4600
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.0860
    Cell Significance Index: -0.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0861
    Cell Significance Index: -2.2000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0876
    Cell Significance Index: -0.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0882
    Cell Significance Index: -2.5400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0885
    Cell Significance Index: -0.5300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0894
    Cell Significance Index: -1.1300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0898
    Cell Significance Index: -2.1900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0929
    Cell Significance Index: -1.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0934
    Cell Significance Index: -2.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DNA-binding transcription activator**: ZNF99 possesses a zinc finger domain, which enables it to bind to specific DNA sequences and activate transcription of target genes. 2. **RNA polymerase II-specific**: ZNF99 interacts with RNA polymerase II, a key enzyme responsible for transcribing protein-coding genes, and regulates its activity. 3. **Metal ion binding**: ZNF99 contains a metal ion-binding domain, which allows it to interact with metal ions and modulate its DNA-binding activity. 4. **Cell-type specificity**: ZNF99 is expressed in various cell types, including retinal cone cells, germ cells, and GABAergic interneurons, suggesting its role in specific cellular processes. **Pathways and Functions:** 1. **Generic transcription pathway**: ZNF99 regulates the expression of genes involved in cellular homeostasis, differentiation, and development. 2. **Regulation of transcription by RNA polymerase II**: ZNF99 interacts with RNA polymerase II and modulates its activity, influencing the transcription of target genes. 3. **Metal ion binding**: ZNF99's metal ion-binding domain enables it to interact with metal ions, which in turn modulates its DNA-binding activity. 4. **Positive regulation of transcription**: ZNF99 acts as a transcriptional activator, promoting the expression of target genes. **Clinical Significance:** 1. **Developmental disorders**: Abnormal expression of ZNF99 has been linked to developmental disorders, such as retinal degeneration and neural tube defects. 2. **Cancer**: Dysregulation of ZNF99 has been observed in various cancers, including colorectal and breast cancer, suggesting its potential role in tumorigenesis. 3. **Neurological disorders**: ZNF99's expression in GABAergic interneurons and its role in regulating transcriptional activity make it a potential target for therapeutic interventions in neurological disorders, such as epilepsy and Alzheimer's disease. 4. **Intestinal diseases**: ZNF99's expression in goblet cells and absorptive cells suggests its potential role in maintaining intestinal homeostasis and preventing diseases, such as inflammatory bowel disease. In conclusion, the Zinc Finger Protein 99 (ZNF99) is a transcriptional regulator that plays a critical role in regulating gene expression in various cell types. Its dysregulation has been linked to developmental disorders, cancer, and neurological diseases, highlighting the need for further research into its clinical significance and potential therapeutic applications.

Genular Protein ID: 82228665

Symbol: ZNF99_HUMAN

Name: Zinc finger protein 99

UniProtKB Accession Codes:

A8MXY4 M0R335

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 8467795

Title: Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.

PubMed ID: 8467795

DOI: 10.1002/j.1460-2075.1993.tb05781.x

Sequence Information:

  • Length: 864
  • Mass: 100791
  • Checksum: DF66A625F51E5149
  • Sequence:
    • MGSLTFWDVT IEFALEEWQC LDMAQQNLYR NVMLENYRNL VFLGIAVSKL DLITCLKQGK 
EPWNMKRHEM VTKPPVISSH FTQDFWPDQS IKDSFQEIIL RTYARCGHKN LRLRKDCESV 
NEGKMHEEAY NKLNQCWTTT QGKIFQCNKY VKVFHKYSNS NRYKIRHTKK KTFKCMKCSK 
SFFMLSHLIQ HKRIHTRENI YKCEERGKAF KWFSTLIKHK IIHTEDKPYK YKKCGKAFNI 
SSMFTKCKII HTGKKPCKCE ECGKVFNNSS TLMKHKIIHT GKKPYKCEEC GKAFKQSSHL 
TRHKAIHTGE KPYKCEECGK AFNHFSALRK HQIIHTGKKP YKCEECGKAF SQSSTLRKHE 
IIHTEEKPYK YEECGKAFSN LSALRKHEII HTGQKPYKCE ECGKAFKWSS KLTVHKVIHT 
AEKPCKCEEC GKAFKRFSAL RKHKIIHTGK QPYKCEECSK AFSNFSALRK HEIIHTGEKP 
YKCEECGKAF KWSSKLTVHK VIHMEEKPCK CEECGKAFKH FSALRKHKII HTGKKPYKCE 
ECGKAFNNSS TLMKHKIIHT GKKPYKCEEC GKAFKQSSHL TRHKAIHTGE KPYKCEECGK 
AFNHFSALRK HQIIHTGKKP YKCEECGKAF SQSSTLRKHE IIHTGEKPYK CEECGKAFKW 
SSHLTRHKVI HTEEKPYKCE ECGKAFNHFS ALRKHKIIHT GKKPYKCEEC GKAFSQSSTL 
RKHEIIHTGE KPYKCEECGK AFKWSSKLTV HKVIHTAEKP CKCEECGKAF KHFSALRKHK 
IIHTGKKPYK CEECGKAFNN SSTLRKHEII HTGEKSYKCE ECGKAFQWSS KLTLHKVIHM 
ERNPANVKNV AKLLNISQPL ENMR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.