Details for: ZNF121

Gene ID: 7675

Symbol: ZNF121

Ensembl ID: ENSG00000197961

Description: zinc finger protein 121

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 107.7500
    Cell Significance Index: -16.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 60.1632
    Cell Significance Index: -15.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.0153
    Cell Significance Index: -18.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 38.5962
    Cell Significance Index: -15.6800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 27.4209
    Cell Significance Index: -18.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.5123
    Cell Significance Index: -15.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.6639
    Cell Significance Index: -18.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.7062
    Cell Significance Index: -17.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6857
    Cell Significance Index: -18.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.8701
    Cell Significance Index: -8.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5123
    Cell Significance Index: 78.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4560
    Cell Significance Index: 39.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3919
    Cell Significance Index: 18.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0460
    Cell Significance Index: 113.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0378
    Cell Significance Index: 197.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9936
    Cell Significance Index: 59.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9610
    Cell Significance Index: 25.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9522
    Cell Significance Index: 154.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8483
    Cell Significance Index: 168.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7490
    Cell Significance Index: 21.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5573
    Cell Significance Index: 100.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5534
    Cell Significance Index: 68.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5316
    Cell Significance Index: 36.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5171
    Cell Significance Index: 29.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4281
    Cell Significance Index: 19.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4006
    Cell Significance Index: 80.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3943
    Cell Significance Index: 11.0200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3217
    Cell Significance Index: 4.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3077
    Cell Significance Index: 8.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2784
    Cell Significance Index: 6.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2720
    Cell Significance Index: 20.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2663
    Cell Significance Index: 117.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2458
    Cell Significance Index: 134.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2434
    Cell Significance Index: 87.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2406
    Cell Significance Index: 11.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2316
    Cell Significance Index: 16.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2008
    Cell Significance Index: 181.2800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1960
    Cell Significance Index: 1.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1908
    Cell Significance Index: 26.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1794
    Cell Significance Index: 17.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1744
    Cell Significance Index: 13.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1640
    Cell Significance Index: 10.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1333
    Cell Significance Index: 17.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1298
    Cell Significance Index: 7.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1163
    Cell Significance Index: 2.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1106
    Cell Significance Index: 6.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0895
    Cell Significance Index: 3.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0845
    Cell Significance Index: 1.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0766
    Cell Significance Index: 1.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0513
    Cell Significance Index: 2.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0372
    Cell Significance Index: 2.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0183
    Cell Significance Index: 0.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0156
    Cell Significance Index: 21.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0126
    Cell Significance Index: 23.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0122
    Cell Significance Index: 1.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0086
    Cell Significance Index: 0.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0061
    Cell Significance Index: 9.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0022
    Cell Significance Index: 4.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0005
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0070
    Cell Significance Index: -1.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0119
    Cell Significance Index: -0.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0123
    Cell Significance Index: -9.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0126
    Cell Significance Index: -1.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0131
    Cell Significance Index: -9.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0138
    Cell Significance Index: -10.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0144
    Cell Significance Index: -6.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0280
    Cell Significance Index: -4.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0289
    Cell Significance Index: -16.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0300
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0318
    Cell Significance Index: -19.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0409
    Cell Significance Index: -4.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0450
    Cell Significance Index: -5.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0479
    Cell Significance Index: -13.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0502
    Cell Significance Index: -0.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0584
    Cell Significance Index: -1.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0623
    Cell Significance Index: -7.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0653
    Cell Significance Index: -2.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0747
    Cell Significance Index: -2.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0764
    Cell Significance Index: -2.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0836
    Cell Significance Index: -1.8300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0919
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0922
    Cell Significance Index: -19.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1077
    Cell Significance Index: -5.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1237
    Cell Significance Index: -3.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1266
    Cell Significance Index: -4.4000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1323
    Cell Significance Index: -1.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1495
    Cell Significance Index: -3.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1567
    Cell Significance Index: -16.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1711
    Cell Significance Index: -10.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1783
    Cell Significance Index: -5.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1838
    Cell Significance Index: -4.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2022
    Cell Significance Index: -4.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2033
    Cell Significance Index: -16.1000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2416
    Cell Significance Index: -3.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2541
    Cell Significance Index: -13.3400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2567
    Cell Significance Index: -3.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2659
    Cell Significance Index: -5.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2956
    Cell Significance Index: -4.4300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2968
    Cell Significance Index: -4.3800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3309
    Cell Significance Index: -3.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Zinc Finger Domain**: ZNF121 contains a conserved zinc finger domain, which is essential for its DNA-binding activity. This domain allows the protein to recognize and bind to specific sequences within the genome. 2. **Transcriptional Regulation**: ZNF121 regulates transcription by interacting with RNA polymerase II, a key enzyme involved in the transcriptional process. This interaction modulates gene expression by either activating or repressing the transcription of specific genes. 3. **Cell Type-Specific Expression**: ZNF121 is expressed in a wide range of cell types, including bladder urothelial cells, skeletal muscle satellite stem cells, and corneal epithelial cells. Its expression is often cell-type specific, suggesting a specialized role in each cell type. 4. **Conserved Sequence**: The ZNF121 gene has a highly conserved sequence, indicating its importance in maintaining cellular homeostasis and development. **Pathways and Functions** 1. **DNA-Binding Transcription Factor Activity**: ZNF121 binds to specific DNA sequences, regulating transcription by interacting with RNA polymerase II. 2. **RNA Polymerase II-Specific Regulation**: ZNF121 regulates the transcription of specific genes by interacting with RNA polymerase II, a key enzyme involved in the transcriptional process. 3. **Metal Ion Binding**: The zinc finger domain of ZNF121 allows it to bind to metal ions, which are essential for its DNA-binding activity. 4. **Nucleus and Protein Binding**: ZNF121 is localized to the nucleus and interacts with other proteins, regulating transcription and cellular processes. **Clinical Significance** 1. **Cancer Research**: ZNF121 has been implicated in various cancers, including bladder cancer and pancreatic cancer. Its expression and function are often dysregulated in cancer cells, suggesting a potential role in tumorigenesis. 2. **Neurological Disorders**: ZNF121 has been associated with neurological disorders, including schizophrenia and autism. Its expression and function in the brain are critical for regulating gene expression and neuronal development. 3. **Developmental Biology**: ZNF121 plays a crucial role in development, regulating gene expression in embryonic stem cells and tissue development. Its dysregulation can lead to developmental abnormalities. 4. **Regenerative Medicine**: ZNF121 has been identified as a potential therapeutic target for regenerative medicine, particularly in the context of tissue repair and regeneration. In conclusion, ZNF121 is a critical transcription factor protein that regulates gene expression in various cell types. Its unique zinc finger domain and interaction with RNA polymerase II make it an essential regulator of transcription. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and developmental abnormalities. Further research is needed to fully understand the role of ZNF121 in human health and disease.

Genular Protein ID: 3577322893

Symbol: ZN121_HUMAN

Name: Zinc finger protein 121

UniProtKB Accession Codes:

P58317

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 8468057

Title: A novel zinc finger cDNA with a polymorphic pentanucleotide repeat (ATTTT)n maps on human chromosome 19p.

PubMed ID: 8468057

DOI: 10.1006/geno.1993.1116

Sequence Information:

  • Length: 390
  • Mass: 44694
  • Checksum: 5E824D279B5235EE
  • Sequence:
    • MAEIHNGGEL CDFMENGEIF SEHSCLNAHM GTENTGDTYD CDEYGENFPM LHNSAPAGET 
LSVLNQCRKA FSLPPNVHQR TWIGDKSFEY SDCEEAFVDQ SHLQANRITH NGETLYEQKQ 
CGRAFTYSTS HAVSVKMHTV EKPYECKECG KFFRYSSYLN SHMRTHTGEK PYECKECGKC 
FTVSSHLVEH VRIHTGEKPY QCKECGRAFA GRSGLTKHVR IHTGEKPYEC NECGKAYNRF 
YLLTEHFKTH TEEKPFECKV CGKSFRSSSC LKNHFRIHTG IKPYKCKECG KAFTVSSSLH 
NHVKIHTGEK PYECKDCGKA FATSSQLIEH IRTHTGEKPY ICKECGKTFR ASSHLQKHVR 
IHTGEKPYIC NECGKAYNRF YLLTKHLKTH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.