Details for: ZNF133

Gene ID: 7692

Symbol: ZNF133

Ensembl ID: ENSG00000125846

Description: zinc finger protein 133

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 131.5373
    Cell Significance Index: -20.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 79.4028
    Cell Significance Index: -20.1400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 48.7441
    Cell Significance Index: -20.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 41.5808
    Cell Significance Index: -16.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.8376
    Cell Significance Index: -20.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5984
    Cell Significance Index: -20.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.3040
    Cell Significance Index: -20.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.2487
    Cell Significance Index: -7.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5628
    Cell Significance Index: 313.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2875
    Cell Significance Index: 255.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0654
    Cell Significance Index: 202.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9507
    Cell Significance Index: 341.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.8342
    Cell Significance Index: 18.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8054
    Cell Significance Index: 21.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7951
    Cell Significance Index: 35.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7759
    Cell Significance Index: 29.3800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7189
    Cell Significance Index: 17.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7155
    Cell Significance Index: 43.9800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7066
    Cell Significance Index: 13.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6650
    Cell Significance Index: 65.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5254
    Cell Significance Index: 474.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5247
    Cell Significance Index: 35.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4715
    Cell Significance Index: 26.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4310
    Cell Significance Index: 12.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3182
    Cell Significance Index: 34.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3182
    Cell Significance Index: 24.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3089
    Cell Significance Index: 50.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2881
    Cell Significance Index: 33.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2489
    Cell Significance Index: 14.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2392
    Cell Significance Index: 10.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2322
    Cell Significance Index: 6.6900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2249
    Cell Significance Index: 2.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1982
    Cell Significance Index: 5.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1676
    Cell Significance Index: 3.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1645
    Cell Significance Index: 113.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1543
    Cell Significance Index: 27.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1185
    Cell Significance Index: 7.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1064
    Cell Significance Index: 3.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0797
    Cell Significance Index: 5.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0535
    Cell Significance Index: 23.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0412
    Cell Significance Index: 22.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0400
    Cell Significance Index: 75.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0396
    Cell Significance Index: 1.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0376
    Cell Significance Index: 57.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0341
    Cell Significance Index: 62.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0219
    Cell Significance Index: 2.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0216
    Cell Significance Index: 13.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0216
    Cell Significance Index: 2.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0166
    Cell Significance Index: 7.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0123
    Cell Significance Index: 0.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0097
    Cell Significance Index: 13.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0203
    Cell Significance Index: -14.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0221
    Cell Significance Index: -3.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0231
    Cell Significance Index: -17.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0258
    Cell Significance Index: -19.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0282
    Cell Significance Index: -1.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0333
    Cell Significance Index: -18.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0370
    Cell Significance Index: -23.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0425
    Cell Significance Index: -2.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0566
    Cell Significance Index: -16.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0608
    Cell Significance Index: -7.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0666
    Cell Significance Index: -9.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0678
    Cell Significance Index: -1.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0842
    Cell Significance Index: -10.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0978
    Cell Significance Index: -10.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0987
    Cell Significance Index: -4.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1007
    Cell Significance Index: -11.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1048
    Cell Significance Index: -5.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1053
    Cell Significance Index: -22.1700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1070
    Cell Significance Index: -2.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1093
    Cell Significance Index: -7.7300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1262
    Cell Significance Index: -2.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1272
    Cell Significance Index: -3.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1273
    Cell Significance Index: -3.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1426
    Cell Significance Index: -2.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1540
    Cell Significance Index: -18.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1674
    Cell Significance Index: -17.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1782
    Cell Significance Index: -3.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1813
    Cell Significance Index: -13.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1989
    Cell Significance Index: -6.3700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2009
    Cell Significance Index: -2.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2104
    Cell Significance Index: -6.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2161
    Cell Significance Index: -13.2500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2205
    Cell Significance Index: -2.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2227
    Cell Significance Index: -7.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2342
    Cell Significance Index: -18.5500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2417
    Cell Significance Index: -4.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2498
    Cell Significance Index: -4.1800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2624
    Cell Significance Index: -4.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2654
    Cell Significance Index: -17.1300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2724
    Cell Significance Index: -4.0200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2868
    Cell Significance Index: -3.6200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2902
    Cell Significance Index: -6.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3240
    Cell Significance Index: -4.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3315
    Cell Significance Index: -11.5200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3499
    Cell Significance Index: -5.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3593
    Cell Significance Index: -9.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3728
    Cell Significance Index: -13.0600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3809
    Cell Significance Index: -5.7400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3862
    Cell Significance Index: -5.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF133 is a member of the zinc finger protein family, characterized by its ability to bind to specific DNA sequences. It belongs to the class II zinc finger protein family, which is involved in the regulation of transcription. ZNF133 is specifically expressed in the brain, particularly in neuronal populations involved in the regulation of neural circuits and synaptic plasticity. The protein exhibits a high degree of tissue specificity, with significant expression in GABAergic interneurons, which are essential for the proper functioning of neural circuits. **Pathways and Functions:** ZNF133 is involved in the regulation of transcription by interacting with RNA polymerase II, a key enzyme responsible for the transcription of genes. It is also involved in the negative regulation of transcription by RNA polymerase II, suggesting a role in the fine-tuning of gene expression. Additionally, ZNF133 is involved in the metal ion binding, which is essential for its DNA-binding activity. The protein's ability to bind to specific DNA sequences allows it to regulate the expression of genes involved in neural development and function. **Clinical Significance:** Dysregulation of ZNF133 has been implicated in various neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorder. The protein's role in regulating neural circuits and synaptic plasticity makes it a potential target for therapeutic interventions. Furthermore, the protein's expression in specific neuronal populations suggests that ZNF133 may play a role in the pathogenesis of these disorders. Future studies are needed to elucidate the mechanisms underlying ZNF133's role in these disorders and to explore its potential as a therapeutic target. **Conclusion:** In conclusion, ZNF133 is a transcription factor that plays a crucial role in the development and function of the nervous system. Its specific expression in GABAergic interneurons and other neuronal populations highlights its importance in regulating neural circuits and synaptic plasticity. Further research is needed to elucidate the mechanisms underlying ZNF133's role in neurological disorders and to explore its potential as a therapeutic target.

Genular Protein ID: 3979201205

Symbol: ZN133_HUMAN

Name: Zinc finger protein 133

UniProtKB Accession Codes:

P52736 A8K5S4 B4DHU7 B4DIB8 B7ZAS1 F5H289 J3KQ11 J3KQJ0 Q53XU1 Q5JXV8 Q9BUV2 Q9H443

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 13 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 31 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7649249

Title: Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins.

PubMed ID: 7649249

DOI: 10.1016/0014-5793(95)00728-r

PubMed ID: 7557990

Title: Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.

PubMed ID: 7557990

DOI: 10.1006/geno.1995.1040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 654
  • Mass: 73388
  • Checksum: CF1D47B223A6DD84
  • Sequence:
    • MAFRDVAVDF TQDEWRLLSP AQRTLYREVM LENYSNLVSL GISFSKPELI TQLEQGKETW 
REEKKCSPAT CPADPEPELY LDPFCPPGFS SQKFPMQHVL CNHPPWIFTC LCAEGNIQPG 
DPGPGDQEKQ QQASEGRPWS DQAEGPEGEG AMPLFGRTKK RTLGAFSRPP QRQPVSSRNG 
LRGVELEASP AQSGNPEETD KLLKRIEVLG FGTVNCGECG LSFSKMTNLL SHQRIHSGEK 
PYVCGVCEKG FSLKKSLARH QKAHSGEKPI VCRECGRGFN RKSTLIIHER THSGEKPYMC 
SECGRGFSQK SNLIIHQRTH SGEKPYVCRE CGKGFSQKSA VVRHQRTHLE EKTIVCSDCG 
LGFSDRSNLI SHQRTHSGEK PYACKECGRC FRQRTTLVNH QRTHSKEKPY VCGVCGHSFS 
QNSTLISHRR THTGEKPYVC GVCGRGFSLK SHLNRHQNIH SGEKPIVCKD CGRGFSQQSN 
LIRHQRTHSG EKPMVCGECG RGFSQKSNLV AHQRTHSGER PYVCRECGRG FSHQAGLIRH 
KRKHSREKPY MCRQCGLGFG NKSALITHKR AHSEEKPCVC RECGQGFLQK SHLTLHQMTH 
TGEKPYVCKT CGRGFSLKSH LSRHRKTTSV HHRLPVQPDP EPCAGQPSDS LYSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.