Details for: ZNF136

Gene ID: 7695

Symbol: ZNF136

Ensembl ID: ENSG00000196646

Description: zinc finger protein 136

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 93.5419
    Cell Significance Index: -14.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.7726
    Cell Significance Index: -14.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.3379
    Cell Significance Index: -13.9500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.3343
    Cell Significance Index: -16.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.6217
    Cell Significance Index: -13.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.8310
    Cell Significance Index: -15.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2784
    Cell Significance Index: -14.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0674
    Cell Significance Index: -16.0500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.3632
    Cell Significance Index: -10.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.7689
    Cell Significance Index: -6.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9396
    Cell Significance Index: 20.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7562
    Cell Significance Index: 682.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6487
    Cell Significance Index: 8.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5865
    Cell Significance Index: 35.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5607
    Cell Significance Index: 60.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4736
    Cell Significance Index: 77.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3511
    Cell Significance Index: 22.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3126
    Cell Significance Index: 62.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2920
    Cell Significance Index: 20.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2903
    Cell Significance Index: 58.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2882
    Cell Significance Index: 14.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2620
    Cell Significance Index: 30.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2388
    Cell Significance Index: 6.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2224
    Cell Significance Index: 22.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2118
    Cell Significance Index: 13.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2020
    Cell Significance Index: 38.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1864
    Cell Significance Index: 66.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1802
    Cell Significance Index: 24.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1674
    Cell Significance Index: 30.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1660
    Cell Significance Index: 4.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1613
    Cell Significance Index: 19.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1528
    Cell Significance Index: 8.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1387
    Cell Significance Index: 61.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1302
    Cell Significance Index: 3.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1240
    Cell Significance Index: 4.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1209
    Cell Significance Index: 2.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1167
    Cell Significance Index: 6.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1035
    Cell Significance Index: 56.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0863
    Cell Significance Index: 3.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0829
    Cell Significance Index: 10.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0517
    Cell Significance Index: 3.9700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0466
    Cell Significance Index: 32.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0445
    Cell Significance Index: 1.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0409
    Cell Significance Index: 1.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0367
    Cell Significance Index: 1.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0350
    Cell Significance Index: 0.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0199
    Cell Significance Index: 1.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0183
    Cell Significance Index: 34.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0044
    Cell Significance Index: 0.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0037
    Cell Significance Index: 0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0008
    Cell Significance Index: 0.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0026
    Cell Significance Index: -0.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0037
    Cell Significance Index: -5.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0043
    Cell Significance Index: -1.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0054
    Cell Significance Index: -0.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0090
    Cell Significance Index: -6.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0157
    Cell Significance Index: -11.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0177
    Cell Significance Index: -13.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0190
    Cell Significance Index: -2.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0245
    Cell Significance Index: -13.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0277
    Cell Significance Index: -17.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0358
    Cell Significance Index: -6.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0413
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0434
    Cell Significance Index: -4.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0465
    Cell Significance Index: -1.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0472
    Cell Significance Index: -13.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0524
    Cell Significance Index: -3.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0585
    Cell Significance Index: -8.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0693
    Cell Significance Index: -1.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0762
    Cell Significance Index: -3.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0806
    Cell Significance Index: -16.9800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0885
    Cell Significance Index: -1.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1022
    Cell Significance Index: -2.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1098
    Cell Significance Index: -7.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1126
    Cell Significance Index: -1.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1334
    Cell Significance Index: -2.9200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1361
    Cell Significance Index: -1.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1376
    Cell Significance Index: -14.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1405
    Cell Significance Index: -7.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1447
    Cell Significance Index: -2.8300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1450
    Cell Significance Index: -2.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1607
    Cell Significance Index: -12.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1685
    Cell Significance Index: -4.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1758
    Cell Significance Index: -5.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1802
    Cell Significance Index: -11.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1811
    Cell Significance Index: -3.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2086
    Cell Significance Index: -5.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2125
    Cell Significance Index: -9.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2330
    Cell Significance Index: -11.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2498
    Cell Significance Index: -9.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2675
    Cell Significance Index: -7.8800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2873
    Cell Significance Index: -4.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3251
    Cell Significance Index: -7.5100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3424
    Cell Significance Index: -2.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3465
    Cell Significance Index: -12.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3491
    Cell Significance Index: -11.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3503
    Cell Significance Index: -11.4700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3767
    Cell Significance Index: -5.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DNA-binding domain**: ZN136 possesses a zinc finger domain, a conserved structural motif that allows for specific DNA recognition and binding. 2. **RNA polymerase II specificity**: ZN136 exhibits specificity for RNA polymerase II, a key enzyme responsible for transcribing protein-coding genes. 3. **Negative regulation of transcription**: ZN136 can act as a negative regulator of transcription, thereby modulating the expression of target genes. 4. **Cell-type specificity**: ZN136 is highly expressed in specific cell types, such as neural progenitor cells, pulmonary interstitial fibroblasts, and immune cells, suggesting its involvement in tissue development and immune homeostasis. **Pathways and Functions:** 1. **Gene expression (transcription)**: ZN136 regulates gene expression by interacting with specific DNA sequences and modulating RNA polymerase II activity. 2. **Generic transcription pathway**: ZN136 is involved in the generic transcription pathway, which is responsible for transcribing most protein-coding genes. 3. **Metal ion binding**: ZN136's zinc finger domain allows for metal ion binding, which is essential for its DNA-binding function. 4. **Regulation of transcription by RNA polymerase II**: ZN136 modulates transcriptional activity by interacting with RNA polymerase II, thereby influencing the expression of target genes. **Clinical Significance:** ZN136 has been implicated in various diseases and disorders, including: 1. **Immune disorders**: Alterations in ZN136 expression have been linked to immune disorders, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: ZN136 has been implicated in cancer development and progression, particularly in tumors of the lung and colon. 3. **Neurological disorders**: ZN136 has been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ZNF136 is a critical regulator of gene expression and immune response, with implications for various diseases and disorders. Further research is necessary to fully elucidate the mechanisms by which ZN136 modulates transcriptional activity and to explore its therapeutic potential.

Genular Protein ID: 4049415921

Symbol: ZN136_HUMAN

Name: Zinc finger protein 136

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7649249

Title: Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins.

PubMed ID: 7649249

DOI: 10.1016/0014-5793(95)00728-r

PubMed ID: 7557990

Title: Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.

PubMed ID: 7557990

DOI: 10.1006/geno.1995.1040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 540
  • Mass: 62784
  • Checksum: 313297AB22F62952
  • Sequence:
  • MDSVAFEDVD VNFTQEEWAL LDPSQKNLYR DVMWETMRNL ASIGKKWKDQ NIKDHYKHRG 
    RNLRSHMLER LYQTKDGSQR GGIFSQFANQ NLSKKIPGVK LCESIVYGEV SMGQSSLNRH 
    IKDHSGHEPK EYQEYGEKPD TRNQCWKPFS SHHSFRTHEI IHTGEKLYDC KECGKTFFSL 
    KRIRRHIITH SGYTPYKCKV CGKAFDYPSR FRTHERSHTG EKPYECQECG KAFTCITSVR 
    RHMIKHTGDG PYKCKVCGKP FHSLSSFQVH ERIHTGEKPF KCKQCGKAFS CSPTLRIHER 
    THTGEKPYEC KQCGKAFSYL PSLRLHERIH TGEKPFVCKQ CGKAFRSAST FQIHERTHTG 
    EKPYECKECG EAFSCIPSMR RHMIKHTGEG PYKCKVCGKP FHSLSPFRIH ERTHTGEKPY 
    VCKHCGKAFV SSTSIRIHER THTGEKPYEC KQCGKAFSYL NSFRTHEMIH TGEKPFECKR 
    CGKAFRSSSS FRLHERTHTG QKPYHCKECG KAYSCRASFQ RHMLTHAEDG PPYKCMWESL

Genular Protein ID: 3188385948

Symbol: A0A494C0J2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 508
  • Mass: 59026
  • Checksum: D83C043293E5006F
  • Sequence:
  • MWETMRNLAS IGKKWKDQNI KDHYKHRGRN LRSHMLERLY QTKDGSQRGG IFSQFANQNL 
    SKKIPGVKLC ESIVYGEVSM GQSSLNRHIK DHSGHEPKEY QEYGEKPDTR NQCWKPFSSH 
    HSFRTHEIIH TGEKLYDCKE CGKTFFSLKR IRRHIITHSG YTPYKCKVCG KAFDYPSRFR 
    THERSHTGEK PYECQECGKA FTCITSVRRH MIKHTGDGPY KCKVCGKPFH SLSSFQVHER 
    IHTGEKPFKC KQCGKAFSCS PTLRIHERTH TGEKPYECKQ CGKAFSYLPS LRLHERIHTG 
    EKPFVCKQCG KAFRSASTFQ IHERTHTGEK PYECKECGEA FSCIPSMRRH MIKHTGEGPY 
    KCKVCGKPFH SLSPFRIHER THTGEKPYVC KHCGKAFVSS TSIRIHERTH TGEKPYECKQ 
    CGKAFSYLNS FRTHEMIHTG EKPFECKRCG KAFRSSSSFR LHERTHTGQK PYHCKECGKA 
    YSCRASFQRH MLTHAEDGPP YKCMWESL

Genular Protein ID: 1593880738

Symbol: B4DS70_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 474
  • Mass: 54862
  • Checksum: 6A9C12F148B9E423
  • Sequence:
  • MLERLYQTKD GSQRGGIFSQ FANQNLSKKI PGVKLCESIV YGEVSMGQSS LNRHIKDHSG 
    HEPKEYQEYG EKPDTRNQCW KPFSSHHSFR THEIIHTGEK LYDCKECGKT FFSLKRIRRH 
    IITHSGYTPY KCKVCGKAFD YPSRFRTHER SHTGEKPYEC QECGKAFTCI TSVRRHMIKH 
    TGDGPYKCKV CGKPFHSLSS FQVHERIHTG EKPFKCKQCG KAFSCSPTLR IHERTHTGEK 
    PYECKQCGKA FSYLPSLRLH ERIHTGEKPF VCKQCGKAFR SASTFQIHER THTGEKPYEC 
    KECGEAFSRI PSMRRHMIKH TGEGPYKCKV CGKPFHSLSP FRIHERTHTG EKPYVCKHCG 
    KAFVSSTSIR IHERTHTGEK PYECKQCGKA FSYLNSFRTH EMIHTGEKPF ECKRCGKAFR 
    SSSSFRLHER THTGQKPYHC KECGKAYSCR ASFQRHMLTH AEDGPPYKCM WESL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.