Details for: PCGF2

Gene ID: 7703

Symbol: PCGF2

Ensembl ID: ENSG00000277258

Description: polycomb group ring finger 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 53.8208
    Cell Significance Index: -25.4100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 37.9421
    Cell Significance Index: -25.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5953
    Cell Significance Index: -5.6800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.8267
    Cell Significance Index: 18.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7378
    Cell Significance Index: 202.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0334
    Cell Significance Index: 21.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8726
    Cell Significance Index: 45.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8356
    Cell Significance Index: 754.4900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7227
    Cell Significance Index: 5.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6129
    Cell Significance Index: 66.6700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6003
    Cell Significance Index: 6.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5923
    Cell Significance Index: 81.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5888
    Cell Significance Index: 35.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5674
    Cell Significance Index: 92.2800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4185
    Cell Significance Index: 5.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4162
    Cell Significance Index: 227.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4084
    Cell Significance Index: 21.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3646
    Cell Significance Index: 72.3600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3626
    Cell Significance Index: 2.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3439
    Cell Significance Index: 62.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3265
    Cell Significance Index: 20.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.3189
    Cell Significance Index: 32.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3070
    Cell Significance Index: 61.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3006
    Cell Significance Index: 20.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2955
    Cell Significance Index: 10.2700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2548
    Cell Significance Index: 2.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2475
    Cell Significance Index: 30.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2243
    Cell Significance Index: 10.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1998
    Cell Significance Index: 25.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1865
    Cell Significance Index: 4.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1837
    Cell Significance Index: 34.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1652
    Cell Significance Index: 73.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1486
    Cell Significance Index: 6.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1310
    Cell Significance Index: 3.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1170
    Cell Significance Index: 3.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1029
    Cell Significance Index: 36.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1023
    Cell Significance Index: 70.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0711
    Cell Significance Index: 7.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0635
    Cell Significance Index: 10.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0601
    Cell Significance Index: 0.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0396
    Cell Significance Index: 1.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0227
    Cell Significance Index: 1.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0180
    Cell Significance Index: 33.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0139
    Cell Significance Index: 0.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0080
    Cell Significance Index: 0.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0021
    Cell Significance Index: 3.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0018
    Cell Significance Index: 2.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0033
    Cell Significance Index: -2.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0042
    Cell Significance Index: -0.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0058
    Cell Significance Index: -3.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0082
    Cell Significance Index: -6.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0165
    Cell Significance Index: -12.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0198
    Cell Significance Index: -26.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0370
    Cell Significance Index: -20.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0407
    Cell Significance Index: -25.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0430
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0450
    Cell Significance Index: -5.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0454
    Cell Significance Index: -20.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0669
    Cell Significance Index: -4.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0825
    Cell Significance Index: -2.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0828
    Cell Significance Index: -12.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0860
    Cell Significance Index: -24.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0892
    Cell Significance Index: -11.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1072
    Cell Significance Index: -22.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1099
    Cell Significance Index: -3.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1193
    Cell Significance Index: -2.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1258
    Cell Significance Index: -3.3600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1280
    Cell Significance Index: -5.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1314
    Cell Significance Index: -3.2900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1622
    Cell Significance Index: -0.9800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1733
    Cell Significance Index: -2.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1895
    Cell Significance Index: -8.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1911
    Cell Significance Index: -1.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2083
    Cell Significance Index: -11.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2090
    Cell Significance Index: -21.7700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2095
    Cell Significance Index: -1.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2335
    Cell Significance Index: -17.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2496
    Cell Significance Index: -19.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2634
    Cell Significance Index: -31.0600
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.2766
    Cell Significance Index: -2.1500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2928
    Cell Significance Index: -5.1800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3094
    Cell Significance Index: -4.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3215
    Cell Significance Index: -5.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3377
    Cell Significance Index: -20.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4117
    Cell Significance Index: -26.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4194
    Cell Significance Index: -18.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4220
    Cell Significance Index: -9.2400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4546
    Cell Significance Index: -3.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4841
    Cell Significance Index: -14.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4906
    Cell Significance Index: -12.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4993
    Cell Significance Index: -17.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5082
    Cell Significance Index: -19.2500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5313
    Cell Significance Index: -6.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5385
    Cell Significance Index: -17.1500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5405
    Cell Significance Index: -7.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5458
    Cell Significance Index: -17.8700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5842
    Cell Significance Index: -12.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6091
    Cell Significance Index: -22.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6208
    Cell Significance Index: -16.6100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6281
    Cell Significance Index: -13.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PCGF2 is a member of the RING finger protein family, which is characterized by the presence of a RING (ring finger) domain. This domain is responsible for the protein's ability to interact with other proteins and regulate their activity. PCGF2 is also a member of the Polycomb group family, which is known for its role in regulating gene expression and cellular development. The protein contains a unique combination of protein-protein interaction domains, including a RING finger domain, a PHD finger domain, and a cyclin-dependent kinase (CDK) interaction domain. **Pathways and Functions:** PCGF2 plays a crucial role in regulating gene expression and cellular development through several key pathways. These include: 1. **Anterior Hox Gene Activation in Hindbrain Development:** PCGF2 has been shown to play a critical role in the activation of anterior Hox genes in hindbrain development during early embryogenesis. 2. **Chromatin Remodeling:** PCGF2 has been implicated in chromatin remodeling, which is essential for the regulation of gene expression and cellular development. 3. **Apoptotic Signaling Pathway:** PCGF2 has been shown to regulate the apoptotic signaling pathway, which is critical for the elimination of damaged or unwanted cells. 4. **Transcriptional Regulation:** PCGF2 has been implicated in transcriptional regulation, including the regulation of gene expression by RNA polymerase II. **Clinical Significance:** The dysregulation of PCGF2 has been implicated in various diseases, including: 1. **Cancer:** PCGF2 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders:** PCGF2 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Developmental Disorders:** PCGF2 has been implicated in developmental disorders, including Down syndrome and autism spectrum disorder. 4. **Immune System Disorders:** PCGF2 has been implicated in immune system disorders, including rheumatoid arthritis and lupus. In conclusion, PCGF2 is a critical regulator of gene expression and cellular development. Its dysregulation has been implicated in a wide range of diseases, including cancer, neurological disorders, developmental disorders, and immune system disorders. Further research is needed to fully understand the role of PCGF2 in human disease and to develop effective therapeutic strategies. **Significantly Expressed Cells:** The following cells have been shown to express PCGF2: 1. Kidney proximal convoluted tubule epithelial cell 2. Pulmonary interstitial fibroblast 3. Extravillous trophoblast 4. Skeletal muscle satellite cell 5. Respiratory epithelial cell 6. Enteric neuron 7. Type EC enteroendocrine cell 8. Neural crest cell 9. Tracheal goblet cell 10. Epithelial cell of nephron **Proteins:** The following protein has been identified as PCGF2: 1. PCGF2_HUMAN (Polycomb group RING finger protein 2)

Genular Protein ID: 3927000568

Symbol: PCGF2_HUMAN

Name: Polycomb group RING finger protein 2

UniProtKB Accession Codes:

P35227 A6NGD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 34 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 6 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8325509

Title: Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif.

PubMed ID: 8325509

DOI: 10.1016/0378-1119(93)90275-8

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19636380

Title: Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.

PubMed ID: 19636380

DOI: 10.1371/journal.pone.0006380

PubMed ID: 21282530

Title: Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells.

PubMed ID: 21282530

DOI: 10.1074/mcp.m110.002642

PubMed ID: 26151332

Title: BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase.

PubMed ID: 26151332

DOI: 10.1038/ncomms8621

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30343942

Title: Missense mutations of the Pro65 residue of PCGF2 cause a recognizable syndrome associated with craniofacial, neurological, cardiovascular, and skeletal features.

PubMed ID: 30343942

DOI: 10.1016/j.ajhg.2018.09.012

Sequence Information:

  • Length: 344
  • Mass: 37788
  • Checksum: A910BCD4C0CE9927
  • Sequence:
    • MHRTTRIKIT ELNPHLMCAL CGGYFIDATT IVECLHSFCK TCIVRYLETN KYCPMCDVQV 
HKTRPLLSIR SDKTLQDIVY KLVPGLFKDE MKRRRDFYAA YPLTEVPNGS NEDRGEVLEQ 
EKGALSDDEI VSLSIEFYEG ARDRDEKKGP LENGDGDKEK TGVRFLRCPA AMTVMHLAKF 
LRNKMDVPSK YKVEVLYEDE PLKEYYTLMD IAYIYPWRRN GPLPLKYRVQ PACKRLTLAT 
VPTPSEGTNT SGASECESVS DKAPSPATLP ATSSSLPSPA TPSHGSPSSH GPPATHPTSP 
TPPSTASGAT TAANGGSLNC LQTPSSTSRG RKMTVNGAPV PPLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.