Details for: ZNF148

Gene ID: 7707

Symbol: ZNF148

Ensembl ID: ENSG00000163848

Description: zinc finger protein 148

Associated with

  • Cellular defense response
    (GO:0006968)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Gamete generation
    (GO:0007276)
  • Golgi apparatus
    (GO:0005794)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Substantia nigra development
    (GO:0021762)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.8
    Marker Score: 49764
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.61
    Marker Score: 58335
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.53
    Marker Score: 5559.5
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.46
    Marker Score: 3308
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.44
    Marker Score: 10222.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.43
    Marker Score: 48344
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.42
    Marker Score: 4654
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.38
    Marker Score: 12507
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.36
    Marker Score: 1173
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.35
    Marker Score: 35203
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.35
    Marker Score: 79508
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.32
    Marker Score: 2813
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.32
    Marker Score: 2666
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.3
    Marker Score: 87466
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.27
    Marker Score: 48534
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.27
    Marker Score: 17428
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.25
    Marker Score: 2428
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.24
    Marker Score: 2138
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.22
    Marker Score: 10278
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.21
    Marker Score: 1285
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.2
    Marker Score: 81096
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.2
    Marker Score: 11793
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.19
    Marker Score: 9069
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.15
    Marker Score: 2680
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.11
    Marker Score: 1233
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.1
    Marker Score: 8755
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.08
    Marker Score: 607
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.06
    Marker Score: 7966
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.06
    Marker Score: 1780
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2
    Marker Score: 18854
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2
    Marker Score: 4784
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2
    Marker Score: 1192
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2
    Marker Score: 1538
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.99
    Marker Score: 2202
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.99
    Marker Score: 721.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.97
    Marker Score: 121236
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.96
    Marker Score: 968
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.96
    Marker Score: 3420
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.88
    Marker Score: 990
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.88
    Marker Score: 2266
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.85
    Marker Score: 1644
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.83
    Marker Score: 17398
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.82
    Marker Score: 1266
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.82
    Marker Score: 2062
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.8
    Marker Score: 666
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.79
    Marker Score: 13528
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.79
    Marker Score: 646
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.79
    Marker Score: 15347
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.79
    Marker Score: 564
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.78
    Marker Score: 746
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.75
    Marker Score: 916
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.75
    Marker Score: 7126
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.75
    Marker Score: 5862
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.72
    Marker Score: 4911.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.7
    Marker Score: 1722
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.7
    Marker Score: 17503
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.69
    Marker Score: 2092
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.69
    Marker Score: 943
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.67
    Marker Score: 624
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.65
    Marker Score: 5419
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.65
    Marker Score: 5849.5
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.64
    Marker Score: 888.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.64
    Marker Score: 417
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.62
    Marker Score: 788
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.61
    Marker Score: 1394
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.6
    Marker Score: 460
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.57
    Marker Score: 2222
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.56
    Marker Score: 3552
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.54
    Marker Score: 858
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.53
    Marker Score: 1979
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.53
    Marker Score: 3522
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.53
    Marker Score: 1151
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.52
    Marker Score: 2343
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.51
    Marker Score: 2128.5
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.48
    Marker Score: 470
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.47
    Marker Score: 596
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.46
    Marker Score: 497
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.44
    Marker Score: 1524.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.42
    Marker Score: 389
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.42
    Marker Score: 1517
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.41
    Marker Score: 3528
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.41
    Marker Score: 1293.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4
    Marker Score: 1477
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.4
    Marker Score: 335
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4
    Marker Score: 22497
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.4
    Marker Score: 4961
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.39
    Marker Score: 8962
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.39
    Marker Score: 1143
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.39
    Marker Score: 3720
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.38
    Marker Score: 2441
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.38
    Marker Score: 906
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.37
    Marker Score: 2303
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.36
    Marker Score: 587
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.35
    Marker Score: 699
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.35
    Marker Score: 1402
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.32
    Marker Score: 483
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.31
    Marker Score: 736
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.31
    Marker Score: 494
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.31
    Marker Score: 893
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.3
    Marker Score: 811

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Other Information

**Key Characteristics:** ZN148 exhibits distinct characteristics that distinguish it from other transcription factors: 1. **Zinc Finger Domain:** The presence of a zinc finger domain enables ZN148 to bind to DNA sequences with high specificity, thereby influencing transcriptional regulation. 2. **Transcriptional Repressor Activity:** ZN148 acts as a transcriptional repressor, negatively regulating DNA-templated transcription and gene expression. 3. **RNA Polymerase II-Specific:** ZN148 interacts with RNA polymerase II, a key enzyme in transcriptional regulation, to modulate gene expression. 4. **Metal Ion Binding:** ZN148's ability to bind metal ions, such as zinc, underscores its potential role in maintaining cellular homeostasis. 5. **Tissue-Specific Expression:** ZN148 is significantly expressed in various cell types, including cortical cells, cardiac myocytes, and neurons, highlighting its involvement in specific cellular processes. **Pathways and Functions:** ZN148 is implicated in several cellular pathways and processes: 1. **Cellular Defense Response:** ZN148's involvement in the cellular defense response suggests its role in protecting cells against pathogens and oxidative stress. 2. **Gamete Generation:** ZN148's expression in gamete cells implies its involvement in the regulation of gamete development and fertility. 3. **Transcriptional Regulation:** ZN148's interaction with RNA polymerase II and DNA-binding transcriptional repressor activity underscores its critical role in regulating gene expression. 4. **Cellular Homeostasis:** ZN148's metal ion-binding capabilities and tissue-specific expression suggest its involvement in maintaining cellular homeostasis and regulating various cellular processes. **Clinical Significance:** ZN148's involvement in cellular defense response, gamete generation, and transcriptional regulation highlights its potential significance in various diseases and disorders: 1. **Neurological Disorders:** ZN148's expression in neurons and involvement in transcriptional regulation suggest its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Reproductive Disorders:** ZN148's expression in gamete cells implies its involvement in reproductive disorders, such as infertility and birth defects. 3. **Cancer:** ZN148's role in regulating gene expression and cellular homeostasis suggests its potential involvement in cancer development and progression. 4. **Infectious Diseases:** ZN148's involvement in the cellular defense response implies its potential role in protecting against infectious diseases. In conclusion, ZNF148 is a multifaceted gene that plays a critical role in regulating various cellular processes, including transcriptional regulation, cellular defense response, and gamete generation. Its clinical significance underscores the potential importance of ZNF148 in various diseases and disorders, highlighting the need for further research to elucidate its precise mechanisms and functions.

Genular Protein ID: 893928357

Symbol: ZN148_HUMAN

Name: Zinc finger protein 148

UniProtKB Accession Codes:

Q9UQR1 D3DN27 O00389 O43591 Q58EY5 Q6PJ98

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 11 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9457682

Title: The human ZBP-89 homolog, located at chromosome 3q21, represses gastrin gene expression.

PubMed ID: 9457682

DOI: 10.1007/s003359900711

PubMed ID: 10359087

Title: Human stromelysin gene promoter activity is modulated by transcription factor ZBP-89.

PubMed ID: 10359087

DOI: 10.1016/s0014-5793(99)00509-8

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15190078

Title: Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and heterogeneous nuclear ribonucleoprotein D-like protein (JKTBP1) reciprocally regulate transcription activity by physical interaction with the BERF-1/ZBP-89 factor.

PubMed ID: 15190078

DOI: 10.1074/jbc.m403160200

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 27964749

Title: Truncating de novo mutations in the Krueppel-type zinc-finger gene ZNF148 in patients with corpus callosum defects, developmental delay, short stature, and dysmorphisms.

PubMed ID: 27964749

DOI: 10.1186/s13073-016-0386-9

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 794
  • Mass: 88976
  • Checksum: 50413723459EBD1F
  • Sequence:
    • MNIDDKLEGL FLKCGGIDEM QSSRTMVVMG GVSGQSTVSG ELQDSVLQDR SMPHQEILAA 
DEVLQESEMR QQDMISHDEL MVHEETVKND EEQMETHERL PQGLQYALNV PISVKQEITF 
TDVSEQLMRD KKQIREPVDL QKKKKRKQRS PAKILTINED GSLGLKTPKS HVCEHCNAAF 
RTNYHLQRHV FIHTGEKPFQ CSQCDMRFIQ KYLLQRHEKI HTGEKPFRCD ECGMRFIQKY 
HMERHKRTHS GEKPYQCEYC LQYFSRTDRV LKHKRMCHEN HDKKLNRCAI KGGLLTSEED 
SGFSTSPKDN SLPKKKRQKT EKKSSGMDKE SALDKSDLKK DKNDYLPLYS SSTKVKDEYM 
VAEYAVEMPH SSVGGSHLED ASGEIHPPKL VLKKINSKRS LKQPLEQNQT ISPLSTYEES 
KVSKYAFELV DKQALLDSEG NADIDQVDNL QEGPSKPVHS STNYDDAMQF LKKKRYLQAA 
SNNSREYALN VGTIASQPSV TQAAVASVID ESTTASILES QALNVEIKSN HDKNVIPDEV 
LQTLLDHYSH KANGQHEISF SVADTEVTSS ISINSSEVPE VTPSENVGSS SQASSSDKAN 
MLQEYSKFLQ QALDRTSQND AYLNSPSLNF VTDNQTLPNQ PAFSSIDKQV YATMPINSFR 
SGMNSPLRTT PDKSHFGLIV GDSQHSFPFS GDETNHASAT STQDFLDQVT SQKKAEAQPV 
HQAYQMSSFE QPFRAPYHGS RAGIATQFST ANGQVNLRGP GTSAEFSEFP LVNVNDNRAG 
MTSSPDATTG QTFG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.