Details for: ZNF155

Gene ID: 7711

Symbol: ZNF155

Ensembl ID: ENSG00000204920

Description: zinc finger protein 155

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.3414
    Cell Significance Index: -13.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.8301
    Cell Significance Index: -13.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.0547
    Cell Significance Index: -13.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.3414
    Cell Significance Index: -11.6300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.9949
    Cell Significance Index: -12.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1048
    Cell Significance Index: 210.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8987
    Cell Significance Index: 258.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8644
    Cell Significance Index: 173.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6261
    Cell Significance Index: 13.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6219
    Cell Significance Index: 61.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6179
    Cell Significance Index: 122.6200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6056
    Cell Significance Index: 9.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5564
    Cell Significance Index: 502.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4969
    Cell Significance Index: 178.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4391
    Cell Significance Index: 24.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4085
    Cell Significance Index: 10.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4085
    Cell Significance Index: 18.0700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4065
    Cell Significance Index: 11.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3755
    Cell Significance Index: 14.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3753
    Cell Significance Index: 40.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3479
    Cell Significance Index: 56.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2881
    Cell Significance Index: 19.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2769
    Cell Significance Index: 21.2500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2556
    Cell Significance Index: 6.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2437
    Cell Significance Index: 14.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2029
    Cell Significance Index: 29.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1965
    Cell Significance Index: 13.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1894
    Cell Significance Index: 11.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1325
    Cell Significance Index: 23.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1320
    Cell Significance Index: 3.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1246
    Cell Significance Index: 2.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0982
    Cell Significance Index: 1.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0956
    Cell Significance Index: 2.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0807
    Cell Significance Index: 9.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0451
    Cell Significance Index: 0.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0271
    Cell Significance Index: 1.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0228
    Cell Significance Index: 12.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0210
    Cell Significance Index: 0.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0183
    Cell Significance Index: 2.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0163
    Cell Significance Index: 10.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0122
    Cell Significance Index: 22.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0077
    Cell Significance Index: 11.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0069
    Cell Significance Index: 0.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0043
    Cell Significance Index: 7.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0007
    Cell Significance Index: 1.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0033
    Cell Significance Index: -1.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0033
    Cell Significance Index: -1.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0121
    Cell Significance Index: -8.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0139
    Cell Significance Index: -10.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0168
    Cell Significance Index: -12.7000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0184
    Cell Significance Index: -0.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0210
    Cell Significance Index: -11.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0217
    Cell Significance Index: -13.5700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0300
    Cell Significance Index: -0.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0338
    Cell Significance Index: -4.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0473
    Cell Significance Index: -5.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0478
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0558
    Cell Significance Index: -9.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0563
    Cell Significance Index: -1.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0569
    Cell Significance Index: -7.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0623
    Cell Significance Index: -3.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0654
    Cell Significance Index: -6.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0683
    Cell Significance Index: -14.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0688
    Cell Significance Index: -8.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0786
    Cell Significance Index: -9.2700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0983
    Cell Significance Index: -1.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1009
    Cell Significance Index: -7.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1109
    Cell Significance Index: -2.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1207
    Cell Significance Index: -12.5700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1281
    Cell Significance Index: -1.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1324
    Cell Significance Index: -4.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1364
    Cell Significance Index: -9.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1375
    Cell Significance Index: -10.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1381
    Cell Significance Index: -6.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1449
    Cell Significance Index: -3.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1558
    Cell Significance Index: -10.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1635
    Cell Significance Index: -4.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1699
    Cell Significance Index: -5.4100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1729
    Cell Significance Index: -2.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1855
    Cell Significance Index: -9.7400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1893
    Cell Significance Index: -3.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1979
    Cell Significance Index: -6.4800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2086
    Cell Significance Index: -2.9300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2184
    Cell Significance Index: -3.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2219
    Cell Significance Index: -7.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2278
    Cell Significance Index: -2.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2461
    Cell Significance Index: -8.6200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2529
    Cell Significance Index: -3.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2554
    Cell Significance Index: -5.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2560
    Cell Significance Index: -5.5300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2677
    Cell Significance Index: -3.8500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2783
    Cell Significance Index: -3.4700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2786
    Cell Significance Index: -6.9500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2849
    Cell Significance Index: -4.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3020
    Cell Significance Index: -6.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3065
    Cell Significance Index: -5.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3097
    Cell Significance Index: -8.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3134
    Cell Significance Index: -8.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3146
    Cell Significance Index: -7.8500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.3274
    Cell Significance Index: -3.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF155 is a member of the zinc finger protein family, characterized by its ability to bind to DNA and regulate gene expression. The protein contains 12 zinc fingers, which are essential for its DNA-binding activity. This gene is specifically expressed in cells that require precise regulation of gene expression, such as neurons and endothelial cells. The expression of ZNF155 is also observed in cells involved in the immune response, suggesting its potential role in modulating immune cell function. **Pathways and Functions:** ZNF155 is involved in several key pathways, including: 1. **DNA-binding transcription factor activity**: ZNF155 binds to specific DNA sequences, thereby regulating the transcription of target genes. 2. **Gene expression (transcription)**: ZNF155 plays a crucial role in regulating gene expression in various cell types, including neurons and endothelial cells. 3. **Metal ion binding**: ZNF155's zinc fingers are essential for its DNA-binding activity, and the metal ions play a critical role in stabilizing the protein structure. 4. **Protein binding**: ZNF155 interacts with other proteins, including transcription factors and chromatin-modifying enzymes, to regulate gene expression. **Clinical Significance:** The clinical significance of ZNF155 is multifaceted: 1. **Neurological disorders**: Alterations in ZNF155 expression have been linked to various neurological disorders, including schizophrenia, autism, and Alzheimer's disease. ZNF155 may play a role in regulating gene expression involved in neural development and function. 2. **Immune system dysregulation**: ZNF155's expression in immune cells suggests its potential role in modulating immune cell function. Dysregulation of ZNF155 may contribute to immune-related disorders, such as autoimmune diseases. 3. **Cancer**: ZNF155's involvement in regulating gene expression may also contribute to cancer development and progression. Further studies are needed to determine its role in cancer. In conclusion, ZNF155 is a complex transcription factor that plays a crucial role in regulating gene expression in various cell types. Its involvement in neurological disorders, immune system dysregulation, and cancer highlights the importance of further research into its mechanisms and clinical significance.

Genular Protein ID: 3989227085

Symbol: ZN155_HUMAN

Name: Zinc finger protein 155

UniProtKB Accession Codes:

Q12901 A2BDE6 B2RB63 B4DM95 J3KQ08 Q6AZZ8 Q9UIE1 Q9UK14

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 4 ExpressionAtlas 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 9 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12743021

Title: Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

PubMed ID: 12743021

DOI: 10.1101/gr.963903

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7557990

Title: Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.

PubMed ID: 7557990

DOI: 10.1006/geno.1995.1040

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 538
  • Mass: 62081
  • Checksum: 3F552DC6A0D84352
  • Sequence:
    • MTTFKEAVTF KDVAVVFTEE ELGLLDPAQR KLYRDVMLEN FRNLLSVGHQ PFHQDTCHFL 
REEKFWMMGT ATQREGNSGG KIQTELESVP EAGAHEEWSC QQIWEQIAKD LTRSQDSIIN 
NSQFFENGDV PSQVEAGLPT IHTGQKPSQG GKCKQSISDV PIFDLPQQLY SEEKSYTCDE 
CGKSICYISA LHVHQRVHVG EKLFMCDVCG KEFSQSSHLQ THQRVHTGEK PFKCEQCGKG 
FSRRSALNVH RKLHTGEKPY ICEACGKAFI HDSQLKEHKR IHTGEKPFKC DICGKTFYFR 
SRLKSHSMVH TGEKPFRCDT CDKSFHQRSA LNRHCMVHTG EKPYRCEQCG KGFIGRLDFY 
KHQVVHTGEK PYNCKECGKS FRWSSCLLNH QRVHSGEKSF KCEECGKGFY TNSQLSSHQR 
SHSGEKPYKC EECGKGYVTK FNLDLHQRVH TGERPYNCKE CGKNFSRASS ILNHKRLHCQ 
KKPFKCEDCG KRLVHRTYRK DQPRDYSGEN PSKCEDCGRR YKRRLNLDIL LSLFLNDT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.