Details for: ZNF174

Gene ID: 7727

Symbol: ZNF174

Ensembl ID: ENSG00000103343

Description: zinc finger protein 174

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 39.9241
    Cell Significance Index: -6.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.7485
    Cell Significance Index: -5.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.4490
    Cell Significance Index: -5.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.1587
    Cell Significance Index: -5.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.2557
    Cell Significance Index: -6.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.9113
    Cell Significance Index: -5.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.6675
    Cell Significance Index: -6.5800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.4564
    Cell Significance Index: 24.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7551
    Cell Significance Index: 122.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7118
    Cell Significance Index: 42.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6029
    Cell Significance Index: 544.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5798
    Cell Significance Index: 63.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4727
    Cell Significance Index: 29.7900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.3547
    Cell Significance Index: 5.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3091
    Cell Significance Index: 3.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3040
    Cell Significance Index: 21.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2336
    Cell Significance Index: 10.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2236
    Cell Significance Index: 26.0600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.2087
    Cell Significance Index: 2.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1740
    Cell Significance Index: 3.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1655
    Cell Significance Index: 4.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1390
    Cell Significance Index: 7.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1227
    Cell Significance Index: 3.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1202
    Cell Significance Index: 6.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1158
    Cell Significance Index: 15.9000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1078
    Cell Significance Index: 1.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1063
    Cell Significance Index: 2.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0874
    Cell Significance Index: 8.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0795
    Cell Significance Index: 15.1200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0750
    Cell Significance Index: 1.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0726
    Cell Significance Index: 32.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0708
    Cell Significance Index: 38.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0661
    Cell Significance Index: 1.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0615
    Cell Significance Index: 12.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0562
    Cell Significance Index: 2.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0516
    Cell Significance Index: 3.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0506
    Cell Significance Index: 3.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0488
    Cell Significance Index: 2.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0485
    Cell Significance Index: 2.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0458
    Cell Significance Index: 8.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0435
    Cell Significance Index: 1.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0390
    Cell Significance Index: 14.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0310
    Cell Significance Index: 1.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0264
    Cell Significance Index: 3.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0209
    Cell Significance Index: 2.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0171
    Cell Significance Index: 1.1100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0109
    Cell Significance Index: 0.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0067
    Cell Significance Index: 0.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0042
    Cell Significance Index: 0.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0017
    Cell Significance Index: 0.2100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0013
    Cell Significance Index: 0.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0022
    Cell Significance Index: -1.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0033
    Cell Significance Index: -6.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0051
    Cell Significance Index: -3.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0055
    Cell Significance Index: -8.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0061
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0063
    Cell Significance Index: -8.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0087
    Cell Significance Index: -4.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0093
    Cell Significance Index: -1.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0100
    Cell Significance Index: -6.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0117
    Cell Significance Index: -1.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0119
    Cell Significance Index: -1.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0134
    Cell Significance Index: -3.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0138
    Cell Significance Index: -8.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0150
    Cell Significance Index: -6.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0194
    Cell Significance Index: -0.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0211
    Cell Significance Index: -0.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0292
    Cell Significance Index: -1.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0312
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0337
    Cell Significance Index: -7.0900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0351
    Cell Significance Index: -0.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0371
    Cell Significance Index: -0.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0376
    Cell Significance Index: -1.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0403
    Cell Significance Index: -3.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0442
    Cell Significance Index: -6.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0448
    Cell Significance Index: -0.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0519
    Cell Significance Index: -0.5900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0526
    Cell Significance Index: -2.1500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0588
    Cell Significance Index: -0.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0626
    Cell Significance Index: -6.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0670
    Cell Significance Index: -4.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0692
    Cell Significance Index: -1.7300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0816
    Cell Significance Index: -1.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0822
    Cell Significance Index: -1.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0884
    Cell Significance Index: -1.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0905
    Cell Significance Index: -0.7600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1048
    Cell Significance Index: -1.5800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1050
    Cell Significance Index: -1.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1076
    Cell Significance Index: -2.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1126
    Cell Significance Index: -3.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1160
    Cell Significance Index: -4.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1162
    Cell Significance Index: -2.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1208
    Cell Significance Index: -1.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1217
    Cell Significance Index: -1.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1240
    Cell Significance Index: -3.9500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1251
    Cell Significance Index: -3.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1368
    Cell Significance Index: -4.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF174 is a member of the zinc finger protein family, characterized by its unique DNA-binding domain, which allows it to interact with specific DNA sequences and regulate gene expression. This protein exhibits a high degree of sequence specificity, binding to cis-regulatory regions of target genes and influencing their transcriptional activity. ZNF174 is also known to interact with other proteins, including RNA polymerase II, to modulate transcriptional processes. **Pathways and Functions:** ZNF174 is involved in multiple cellular pathways, including: 1. **Chromatin organization:** ZNF174 plays a crucial role in maintaining chromatin structure and function, particularly in the context of gene regulation. It interacts with histone proteins and other chromatin-associated factors to regulate chromatin remodeling and transcriptional access. 2. **Transcriptional regulation:** ZNF174 acts as a transcriptional repressor, binding to specific DNA sequences and inhibiting the transcription of target genes. This function is mediated through its interaction with RNA polymerase II and other transcriptional regulators. 3. **Immune function:** ZNF174 has been implicated in the regulation of immune cell development and function, particularly in the context of GABAergic interneurons and intestinal epithelial cells. Its expression is also elevated in various immune-related diseases, including rheumatoid arthritis and multiple sclerosis. **Clinical Significance:** The clinical significance of ZNF174 lies in its potential role as a biomarker for immune-related diseases. Elevated expression of ZNF174 has been observed in patients with autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. Furthermore, ZNF174 may serve as a therapeutic target for the treatment of these diseases, given its involvement in immune cell regulation and transcriptional control. In addition, ZNF174 has been implicated in the development of certain types of cancer, including colorectal cancer. Its expression is often elevated in tumor cells, suggesting a potential role in cancer progression and metastasis. In conclusion, ZNF174 is a complex gene that plays a multifaceted role in gene regulation, chromatin organization, and immune function. Further research is needed to fully elucidate the mechanisms by which ZNF174 regulates transcriptional processes and to explore its potential as a therapeutic target for immune-related diseases. **References:** * [Insert relevant references cited in the article] Note: As this is a hypothetical article, no references are provided. However, in a real article, you would include relevant references to support the claims made about ZNF174.

Genular Protein ID: 4282292695

Symbol: ZN174_HUMAN

Name: Zinc finger protein 174

UniProtKB Accession Codes:

Q15697 Q53Y68 Q9BQ34

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 4 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7673192

Title: Isolation and characterization of a novel zinc-finger protein with transcription repressor activity.

PubMed ID: 7673192

DOI: 10.1074/jbc.270.38.22143

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 15629724

Title: Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain.

PubMed ID: 15629724

DOI: 10.1016/j.molcel.2004.12.015

Sequence Information:

  • Length: 407
  • Mass: 46455
  • Checksum: 1FAB4A631EA2ABCC
  • Sequence:
    • MAAKMEITLS SNTEASSKQE RHIIAKLEEK RGPPLQKNCP DPELCRQSFR RFCYQEVSGP 
QEALSQLRQL CRQWLQPELH TKEQILELLV MEQFLTILPP EIQARVRHRC PMSSKEIVTL 
VEDFHRASKK PKQWVAVCMQ GQKVLLEKTG SQLGEQELPD FQPQTPRRDL RESSPAEPSQ 
AGAYDRLSPH HWEKSPLLQE PTPKLAGTEA PRMRSDNKEN PQQEGAKGAK PCAVSAGRSK 
GNGLQNPEPR GANMSEPRLS RRQVSSPNAQ KPFAHYQRHC RVEYISSPLK SHPLRELKKS 
KGGKRSLSNR LQHLGHQPTR SAKKPYKCDD CGKSFTWNSE LKRHKRVHTG ERPYTCGECG 
NCFGRQSTLK LHQRIHTGEK PYQCGQCGKS FRQSSNLHQH HRLHHGD

Genular Protein ID: 1269178499

Symbol: I3L2H2_HUMAN

Name: N/A

UniProtKB Accession Codes:

I3L2H2

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 249
  • Mass: 28602
  • Checksum: A54C9015823E5C3D
  • Sequence:
    • MAAKMEITLS SNTEASSKQE RHIIAKLEEK RGPPLQKNCP DPELCRQSFR RFCYQEVSGP 
QEALSQLRQL CRQWLQPELH TKEQILELLV MEQFLTILPP EIQARVRHRC PMSSKEIVTL 
VEDFHRASKK PKQWVAVCMQ GQKVLLEKTG SQLGEQELPD FQPQTPRRDL RESSPAEPSQ 
AGAYDRLSPH HWEKSPLLQE PTPKLAGTGK HSAFSLPLIS PLSPSMYLMV LQRHRPHVCV 
FLNVIYNSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.