Details for: ZNF185

Gene ID: 7739

Symbol: ZNF185

Ensembl ID: ENSG00000147394

Description: zinc finger protein 185 with LIM domain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 38.8311
    Cell Significance Index: -6.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.0532
    Cell Significance Index: -5.3400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 12.7336
    Cell Significance Index: -6.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.9911
    Cell Significance Index: -5.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.8907
    Cell Significance Index: -6.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.0836
    Cell Significance Index: 127.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.5459
    Cell Significance Index: -6.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1485
    Cell Significance Index: 59.6600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.1254
    Cell Significance Index: 16.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9855
    Cell Significance Index: 27.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8997
    Cell Significance Index: 8.2900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.8367
    Cell Significance Index: 7.1900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.7285
    Cell Significance Index: 7.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7283
    Cell Significance Index: 138.6000
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 0.6341
    Cell Significance Index: 0.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4412
    Cell Significance Index: 43.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3785
    Cell Significance Index: 206.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3678
    Cell Significance Index: 22.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3210
    Cell Significance Index: 289.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3206
    Cell Significance Index: 34.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3059
    Cell Significance Index: 55.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3034
    Cell Significance Index: 134.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2899
    Cell Significance Index: 35.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2540
    Cell Significance Index: 41.3200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2078
    Cell Significance Index: 4.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1668
    Cell Significance Index: 4.5400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1504
    Cell Significance Index: 2.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1415
    Cell Significance Index: 9.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1015
    Cell Significance Index: 7.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0840
    Cell Significance Index: 9.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0806
    Cell Significance Index: 3.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0686
    Cell Significance Index: 47.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0680
    Cell Significance Index: 3.0800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.0678
    Cell Significance Index: 0.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0587
    Cell Significance Index: 1.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0585
    Cell Significance Index: 11.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0459
    Cell Significance Index: 16.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0417
    Cell Significance Index: 78.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0342
    Cell Significance Index: 4.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0314
    Cell Significance Index: 0.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0310
    Cell Significance Index: 47.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0293
    Cell Significance Index: 54.0200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0292
    Cell Significance Index: 0.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0274
    Cell Significance Index: 2.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0153
    Cell Significance Index: 1.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0150
    Cell Significance Index: 2.9700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0136
    Cell Significance Index: 0.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0060
    Cell Significance Index: 3.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0020
    Cell Significance Index: 0.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0027
    Cell Significance Index: -3.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0032
    Cell Significance Index: -2.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0052
    Cell Significance Index: -3.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0071
    Cell Significance Index: -5.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0106
    Cell Significance Index: -1.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0109
    Cell Significance Index: -6.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0112
    Cell Significance Index: -0.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0143
    Cell Significance Index: -1.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0159
    Cell Significance Index: -0.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0185
    Cell Significance Index: -0.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0225
    Cell Significance Index: -6.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0227
    Cell Significance Index: -0.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0232
    Cell Significance Index: -2.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0255
    Cell Significance Index: -4.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0306
    Cell Significance Index: -1.1600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0310
    Cell Significance Index: -0.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0311
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0328
    Cell Significance Index: -6.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0347
    Cell Significance Index: -0.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0424
    Cell Significance Index: -0.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0454
    Cell Significance Index: -0.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0455
    Cell Significance Index: -1.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0465
    Cell Significance Index: -1.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0554
    Cell Significance Index: -5.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0573
    Cell Significance Index: -2.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0636
    Cell Significance Index: -4.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0686
    Cell Significance Index: -1.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0709
    Cell Significance Index: -5.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0729
    Cell Significance Index: -5.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0734
    Cell Significance Index: -4.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0758
    Cell Significance Index: -4.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0761
    Cell Significance Index: -2.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0891
    Cell Significance Index: -4.6400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0914
    Cell Significance Index: -0.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0945
    Cell Significance Index: -1.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1006
    Cell Significance Index: -5.2800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1088
    Cell Significance Index: -1.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1141
    Cell Significance Index: -3.3600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1161
    Cell Significance Index: -1.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1193
    Cell Significance Index: -4.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1237
    Cell Significance Index: -2.5900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1241
    Cell Significance Index: -5.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1300
    Cell Significance Index: -4.1400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1404
    Cell Significance Index: -4.4400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1412
    Cell Significance Index: -1.2000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1435
    Cell Significance Index: -3.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF185 is a member of the zinc finger protein family, characterized by its unique LIM domain, which is involved in protein-protein interactions and DNA binding. This gene exhibits tissue-specific expression, with notable presence in squamous epithelial cells, stratified epithelial cells, and endothelial cells. The expression of ZNF185 is also observed in stem cells, suggesting its potential role in maintaining cellular homeostasis and regulating cellular differentiation. **Pathways and Functions:** ZNF185 is involved in various cellular pathways, including: 1. **Cytoplasmic organization:** ZNF185 is implicated in the regulation of cytoskeletal dynamics, which is essential for maintaining cell shape and integrity. 2. **Focal adhesion:** ZNF185 interacts with focal adhesion proteins, influencing cell adhesion and migration. 3. **Protein binding:** ZNF185 interacts with various proteins, including transcription factors and signaling molecules, to regulate cellular processes. 4. **Zinc ion binding:** The LIM domain of ZNF185 is responsible for binding zinc ions, which is crucial for its protein-protein interactions and DNA binding. **Functions:** The functions of ZNF185 are multifaceted and involve: 1. **Cellular differentiation:** ZNF185 regulates cellular differentiation by interacting with transcription factors and signaling molecules. 2. **Cellular adhesion:** ZNF185 influences cell adhesion by interacting with focal adhesion proteins. 3. **Cytoplasmic organization:** ZNF185 regulates cytoskeletal dynamics, maintaining cell shape and integrity. 4. **DNA binding:** ZNF185 binds to DNA, influencing gene expression and cellular homeostasis. **Clinical Significance:** The clinical significance of ZNF185 is an area of active research. Given its expression in various tissues and its involvement in cellular processes, ZNF185 may play a role in the development and progression of various diseases, including: 1. **Cancer:** ZNF185 may contribute to tumorigenesis by regulating cellular differentiation and adhesion. 2. **Cardiovascular diseases:** ZNF185 may influence endothelial cell function, contributing to the development of cardiovascular diseases. 3. **Neurological disorders:** ZNF185 may play a role in maintaining neuronal homeostasis, and its dysregulation may contribute to neurological disorders. In conclusion, ZNF185 is a novel gene with significant implications for our understanding of cellular biology. Further research is necessary to uncover the full extent of its functions and clinical significance, but it is clear that ZNF185 will be an important area of investigation in the coming years.

Genular Protein ID: 1726315283

Symbol: ZN185_HUMAN

Name: Zinc finger protein 185

UniProtKB Accession Codes:

O15231 A4FTV3 A6NME5 B4DLE9 B7Z771 B8K2L9 B8K2M0 B8K2M1 B8K2M2 E9PFR6 F5GXF7 F5GZL4 F8W8V7 H0Y4M8 O00345 Q8N1R8 Q9NSD2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 7 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 14 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 RefSeq 14 SMART 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9268636

Title: Genomic structure of a novel LIM domain gene (ZNF185) in Xq28 and comparisons with the orthologous murine transcript.

PubMed ID: 9268636

DOI: 10.1006/geno.1997.4810

PubMed ID: 16799630

Title: ZNF185, an actin-cytoskeleton-associated growth inhibitory LIM protein in prostate cancer.

PubMed ID: 16799630

DOI: 10.1038/sj.onc.1209769

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10854409

Title: Comparative genome sequence analysis of the Bpa/Str region in mouse and man.

PubMed ID: 10854409

DOI: 10.1101/gr.10.6.758

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 689
  • Mass: 73525
  • Checksum: 0CCA739701FE1423
  • Sequence:
    • MSISALGGRT KGKPLPPGEE ERNNVLKQMK VRTTLKGDKS WITKQDESEG RTIELPSGRS 
RATSFSSAGE VPKPRPPSTR APTGYIIRGV FTKPIDSSSQ PQQQFPKANG TPKSAASLVR 
TANAGPPRPS SSGYKMTTED YKKLAPYNIR RSSTSGDTEE EEEEEVVPFS SDEQKRRSEA 
ASGVLRRTAP REHSYVLSAA KKSTGPTQET QAPFIAKRVE VVEEDGPSEK SQDPPALARS 
TPGSNSADGG RTKASRAIWI ECLPSMPSPA GSQELSSRGE EIVRLQILTP RAGLRLVAPD 
VEGMRSSPGN KDKEAPCSRE LQRDLAGEEA FRAPNTDAAR SSAQLSDGNV GSGATGSRPE 
GLAAVDIGSE RGSSSATSVS AVPADRKSNS TAAQEDAKAD PKGALADYEG KDVATRVGEA 
WQERPGAPRG GQGDPAVPAQ QPADPSTPER QSSPSGSEQL VRRESCGSSV LTDFEGKDVA 
TKVGEAWQDR PGAPRGGQGD PAVPTQQPAD PSTPEQQNSP SGSEQFVRRE SCTSRVRSPS 
SCMVTVTVTA TSEQPHIYIP APASELDSSS TTKGILFVKE YVNASEVSSG KPVSARYSNV 
SSIEDSFAME KKPPCGSTPY SERTTGGICT YCNREIRDCP KITLEHLGIC CHEYCFKCGI 
CSKPMGDLLD QIFIHRDTIH CGKCYEKLF

Genular Protein ID: 3987663354

Symbol: B3KPM4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KPM4

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 1 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 RefSeq 8 SMART 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 147
  • Mass: 16246
  • Checksum: D929458BCBD78E66
  • Sequence:
    • MVTVTVTATS EQPHIYIPAP ASELDSSSTT KGILFVKEYV NASEVSSGKP VSARYSNVSS 
IEDSFAMEKK PPCGSTPYSE RTTGGICTYC NREIRDCPKI TLEHLGICCH EYCFKCGICS 
KPMGDLLDQI FIHRDTIHCG KCYEKLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.