Details for: ZNF215

Gene ID: 7762

Symbol: ZNF215

Ensembl ID: ENSG00000149054

Description: zinc finger protein 215

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 32.9165
    Cell Significance Index: -5.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.7916
    Cell Significance Index: -5.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.1770
    Cell Significance Index: -5.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.3153
    Cell Significance Index: -4.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2061
    Cell Significance Index: 26.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1759
    Cell Significance Index: 223.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8419
    Cell Significance Index: 83.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5890
    Cell Significance Index: 531.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5419
    Cell Significance Index: 32.5300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5338
    Cell Significance Index: 58.0700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.4885
    Cell Significance Index: 8.0500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.4709
    Cell Significance Index: 4.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4593
    Cell Significance Index: 74.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4141
    Cell Significance Index: 11.9300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3902
    Cell Significance Index: 6.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3753
    Cell Significance Index: 8.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3304
    Cell Significance Index: 8.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3257
    Cell Significance Index: 14.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2837
    Cell Significance Index: 81.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2622
    Cell Significance Index: 18.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2171
    Cell Significance Index: 43.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1989
    Cell Significance Index: 6.9900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1823
    Cell Significance Index: 4.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1714
    Cell Significance Index: 34.0200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1637
    Cell Significance Index: 2.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1549
    Cell Significance Index: 4.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1338
    Cell Significance Index: 2.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1324
    Cell Significance Index: 2.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1318
    Cell Significance Index: 15.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1226
    Cell Significance Index: 43.9800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.1064
    Cell Significance Index: 1.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0866
    Cell Significance Index: 5.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0724
    Cell Significance Index: 2.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0723
    Cell Significance Index: 49.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0683
    Cell Significance Index: 3.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0609
    Cell Significance Index: 2.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0517
    Cell Significance Index: 2.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0414
    Cell Significance Index: 5.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0363
    Cell Significance Index: 5.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0257
    Cell Significance Index: 4.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0092
    Cell Significance Index: 5.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0083
    Cell Significance Index: 1.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0050
    Cell Significance Index: 0.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0040
    Cell Significance Index: 1.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0035
    Cell Significance Index: 6.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0025
    Cell Significance Index: 4.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0020
    Cell Significance Index: 3.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0012
    Cell Significance Index: 0.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0016
    Cell Significance Index: -0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0018
    Cell Significance Index: -2.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0019
    Cell Significance Index: -0.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0044
    Cell Significance Index: -0.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0051
    Cell Significance Index: -0.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0056
    Cell Significance Index: -0.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0064
    Cell Significance Index: -4.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0073
    Cell Significance Index: -5.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0089
    Cell Significance Index: -5.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0098
    Cell Significance Index: -5.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0112
    Cell Significance Index: -0.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0174
    Cell Significance Index: -2.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0207
    Cell Significance Index: -2.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0225
    Cell Significance Index: -0.6300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0265
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0271
    Cell Significance Index: -5.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0273
    Cell Significance Index: -1.9300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0342
    Cell Significance Index: -0.3200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0343
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0379
    Cell Significance Index: -4.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0408
    Cell Significance Index: -5.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0431
    Cell Significance Index: -4.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0482
    Cell Significance Index: -1.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0483
    Cell Significance Index: -1.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0486
    Cell Significance Index: -5.0600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0519
    Cell Significance Index: -0.6700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0525
    Cell Significance Index: -2.2900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0537
    Cell Significance Index: -0.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0540
    Cell Significance Index: -3.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0584
    Cell Significance Index: -4.4800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0591
    Cell Significance Index: -0.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0592
    Cell Significance Index: -1.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0600
    Cell Significance Index: -2.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0616
    Cell Significance Index: -1.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0666
    Cell Significance Index: -2.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0702
    Cell Significance Index: -5.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0716
    Cell Significance Index: -2.2800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0766
    Cell Significance Index: -1.1000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0777
    Cell Significance Index: -1.0900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0794
    Cell Significance Index: -1.5700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0813
    Cell Significance Index: -1.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0815
    Cell Significance Index: -4.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0828
    Cell Significance Index: -5.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0885
    Cell Significance Index: -5.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0971
    Cell Significance Index: -3.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1059
    Cell Significance Index: -5.3500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1060
    Cell Significance Index: -1.4300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1073
    Cell Significance Index: -0.8100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1107
    Cell Significance Index: -2.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1108
    Cell Significance Index: -1.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulator:** ZNF215 acts as a transcriptional regulator by binding to specific DNA sequences and influencing the expression of target genes. 2. **RNA Polymerase II Specific:** ZNF215 is specifically associated with RNA polymerase II (RNAPII), which is a key enzyme responsible for transcribing protein-coding genes. 3. **Metal Ion Binding:** ZNF215 contains a metal ion-binding domain, which is essential for its DNA-binding activity. 4. **Cell-Specific Expression:** ZNF215 is expressed in various cell types, including neuroendocrine cells, mural cells, and immune cells, suggesting a potential role in different cellular processes. **Pathways and Functions:** 1. **DNA-Binding Transcription Factor Activity:** ZNF215 binds to specific DNA sequences and regulates transcription by interacting with RNAPII and other transcriptional co-regulators. 2. **Gene Expression (Transcription):** ZNF215 plays a crucial role in regulating gene expression by modulating the transcription of target genes. 3. **Generic Transcription Pathway:** ZNF215 is involved in the generic transcription pathway, which is a fundamental process that regulates the expression of most genes in the cell. 4. **Regulation of Transcription by RNAPII:** ZNF215 regulates transcription by interacting with RNAPII and influencing its activity. **Significance in Development and Immune Processes:** 1. **Neurodevelopment:** ZNF215 is expressed in the developing brain and plays a role in regulating the expression of genes involved in neuronal development. 2. **Immune Cell Development:** ZNF215 is expressed in immune cells, including double-negative thymocytes and transit-amplifying cells, suggesting a potential role in immune cell development and function. 3. **Intestinal Epithelium:** ZNF215 is expressed in the intestinal epithelium and plays a role in regulating the expression of genes involved in intestinal homeostasis. **Clinical Significance:** 1. **Neurological Disorders:** Aberrant expression of ZNF215 has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. 2. **Cancer:** ZNF215 has been implicated in the development and progression of certain types of cancer, including colon cancer. 3. **Immune System Dysregulation:** ZNF215 plays a role in regulating immune cell development and function, and its dysregulation may contribute to immune system dysregulation in various diseases. In conclusion, ZNF215 is a transcriptional regulator that plays a crucial role in regulating gene expression in various cellular contexts. Its expression is observed in numerous cell types, including neuroendocrine cells, immune cells, and the developing brain and intestinal epithelium. Further studies are needed to fully elucidate the functions and significance of ZNF215 in developmental and immune processes, as well as its potential role in various diseases.

Genular Protein ID: 2042621075

Symbol: ZN215_HUMAN

Name: Zinc finger protein 215

UniProtKB Accession Codes:

Q9UL58 Q96C84

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 4 ExpressionAtlas 1 GO 6 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10762538

Title: Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome.

PubMed ID: 10762538

DOI: 10.1086/302892

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 517
  • Mass: 60034
  • Checksum: B14A6791E763C41E
  • Sequence:
    • MQPLSKLMAI SKPRNLSLRE QREVLRADMS WQQETNPVVE THDSEASRQK FRHFQYLKVS 
GPHEALSQLW ELCLQWLRPE IHTKKQIIEL LVLEQFLAIL PEEVRTWVNL QHPNNSKDMV 
TLIEDVIEML EDEDMPCKDS ALQMGSIKEK MKAGSRTGKP QEPVTFKDVV VEFSKEEWGQ 
LDSAVKNLYR NVMLENFRNL NSLRKAHLLS KPFESLKLES KKKRWIMEKE IPRKTIFDMK 
SISGEESSHG VIMTRLTESG HPSSDAWKGE NWLYRNQKKW DINLPQEAFI PETIYTEEED 
FECSENKKSF DINSVSSICA IQVGIPSRKG SPKCDKFKTY FKFNLDSVGK QHSEYEYGND 
LSLSTDIRHQ KSHTTMNSYE CYQCGKAFCR SSSLIRHQII HTGEKPYKCS ECGRFFNRRT 
NLTKHQKLHA EAKACTSNKC GKAFSKSEDS NNPTLHFGNN FYQCVNCGKS FNRSSSLIRH 
QMIHTGEKPF KCKECSKAFN RSSNLVKHQK LHTRDKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.