Details for: ZNF224

Gene ID: 7767

Symbol: ZNF224

Ensembl ID: ENSG00000267680

Description: zinc finger protein 224

Associated with

  • Epigenetic regulation of gene expression
    (R-HSA-212165)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Regulation of endogenous retroelements
    (R-HSA-9842860)
  • Regulation of endogenous retroelements by krab-zfp proteins
    (R-HSA-9843940)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear membrane
    (GO:0031965)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Transcription repressor complex
    (GO:0017053)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 127.7442
    Cell Significance Index: -19.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.3797
    Cell Significance Index: -18.1100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 47.4575
    Cell Significance Index: -19.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 43.0820
    Cell Significance Index: -20.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.8792
    Cell Significance Index: -17.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.2667
    Cell Significance Index: -17.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.7159
    Cell Significance Index: -20.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.1463
    Cell Significance Index: -16.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.3535
    Cell Significance Index: -21.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2841
    Cell Significance Index: -16.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4412
    Cell Significance Index: -9.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0915
    Cell Significance Index: 985.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7840
    Cell Significance Index: 85.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7694
    Cell Significance Index: 154.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5195
    Cell Significance Index: 33.5200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4575
    Cell Significance Index: 7.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4407
    Cell Significance Index: 87.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4337
    Cell Significance Index: 29.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4248
    Cell Significance Index: 152.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3621
    Cell Significance Index: 65.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3172
    Cell Significance Index: 9.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3145
    Cell Significance Index: 16.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3084
    Cell Significance Index: 13.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3046
    Cell Significance Index: 6.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3026
    Cell Significance Index: 41.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2669
    Cell Significance Index: 16.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2659
    Cell Significance Index: 50.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2558
    Cell Significance Index: 3.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2293
    Cell Significance Index: 125.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2156
    Cell Significance Index: 5.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2103
    Cell Significance Index: 20.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2066
    Cell Significance Index: 15.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2043
    Cell Significance Index: 10.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1860
    Cell Significance Index: 10.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1735
    Cell Significance Index: 21.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1619
    Cell Significance Index: 9.9500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1511
    Cell Significance Index: 2.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1500
    Cell Significance Index: 7.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1260
    Cell Significance Index: 55.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1202
    Cell Significance Index: 3.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1040
    Cell Significance Index: 6.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0655
    Cell Significance Index: 2.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0624
    Cell Significance Index: 2.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0552
    Cell Significance Index: 2.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0548
    Cell Significance Index: 7.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0457
    Cell Significance Index: 29.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0390
    Cell Significance Index: 73.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0340
    Cell Significance Index: 1.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0164
    Cell Significance Index: 0.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0148
    Cell Significance Index: 6.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0143
    Cell Significance Index: 0.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0111
    Cell Significance Index: 20.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0074
    Cell Significance Index: 11.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0079
    Cell Significance Index: -5.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0091
    Cell Significance Index: -12.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0117
    Cell Significance Index: -0.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0144
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0195
    Cell Significance Index: -14.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0225
    Cell Significance Index: -17.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0270
    Cell Significance Index: -0.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0291
    Cell Significance Index: -0.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0321
    Cell Significance Index: -18.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0344
    Cell Significance Index: -21.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0372
    Cell Significance Index: -3.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0586
    Cell Significance Index: -16.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0615
    Cell Significance Index: -7.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0624
    Cell Significance Index: -4.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0652
    Cell Significance Index: -9.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0690
    Cell Significance Index: -8.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0710
    Cell Significance Index: -12.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0991
    Cell Significance Index: -2.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1005
    Cell Significance Index: -21.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1063
    Cell Significance Index: -12.1800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1068
    Cell Significance Index: -1.3300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1156
    Cell Significance Index: -1.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1202
    Cell Significance Index: -3.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1434
    Cell Significance Index: -1.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1512
    Cell Significance Index: -2.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1578
    Cell Significance Index: -4.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1601
    Cell Significance Index: -4.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1706
    Cell Significance Index: -5.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1759
    Cell Significance Index: -18.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2172
    Cell Significance Index: -5.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2224
    Cell Significance Index: -5.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2251
    Cell Significance Index: -7.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2278
    Cell Significance Index: -6.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2302
    Cell Significance Index: -18.2300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2536
    Cell Significance Index: -5.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2716
    Cell Significance Index: -16.6500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2818
    Cell Significance Index: -5.9800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2824
    Cell Significance Index: -2.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3000
    Cell Significance Index: -6.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3218
    Cell Significance Index: -10.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3497
    Cell Significance Index: -3.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3513
    Cell Significance Index: -11.5000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3568
    Cell Significance Index: -18.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3780
    Cell Significance Index: -5.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3795
    Cell Significance Index: -10.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4105
    Cell Significance Index: -14.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DNA-binding activity:** ZN224 exhibits specific DNA-binding capabilities, allowing it to regulate gene expression by interacting with RNA polymerase II and other transcriptional regulators. 2. **Transcriptional activation and repression:** ZN224 can act as a transcriptional activator or repressor, depending on the context and the genes it interacts with. 3. **Neural specificity:** ZN224 is predominantly expressed in neural cells, including neurons and glial cells, suggesting a specialized role in neuronal development and function. 4. **Metal ion binding:** ZN224 contains a metal ion-binding motif, which is essential for its DNA-binding activity. **Pathways and Functions:** 1. **Generic transcription pathway:** ZN224 is involved in the regulation of gene expression through interactions with RNA polymerase II, a key enzyme in the transcriptional machinery. 2. **Regulation of transcription by RNA polymerase II:** ZN224 modulates transcriptional activity by interacting with RNA polymerase II, influencing the expression of genes involved in neuronal development and function. 3. **Negative regulation of DNA-templated transcription:** ZN224 can act as a transcriptional repressor, inhibiting the expression of genes involved in neuronal development and function. 4. **Positive regulation of transcription by RNA polymerase II:** ZN224 can also act as a transcriptional activator, enhancing the expression of genes involved in neuronal development and function. **Clinical Significance:** 1. **Neurological disorders:** Alterations in ZN224 expression have been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Neuronal development and function:** ZN224 plays a crucial role in neuronal development and function, and dysregulation of this protein may contribute to neurological disorders. 3. **Cancer:** ZN224 has been implicated in the regulation of gene expression in cancer cells, suggesting a potential role in cancer development and progression. 4. **Neurodegenerative diseases:** ZN224 may play a role in the regulation of gene expression in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Huntington's disease. In conclusion, ZNF224 is a transcriptional regulator that plays a crucial role in regulating gene expression in neural cells. Its dysregulation has been implicated in various neurological disorders, and further research is needed to fully understand its role in human disease.

Genular Protein ID: 3426483368

Symbol: ZN224_HUMAN

Name: Zinc finger protein 224

UniProtKB Accession Codes:

Q9NZL3 A6NFW9 P17033 Q86V10 Q8IZC8 Q9UID9 Q9Y2P6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12743021

Title: Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

PubMed ID: 12743021

DOI: 10.1101/gr.963903

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10585455

Title: Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB.

PubMed ID: 10585455

DOI: 10.1074/jbc.274.50.35741

PubMed ID: 12239212

Title: Inhibition of Wilms tumor 1 transactivation by bone marrow zinc finger 2, a novel transcriptional repressor.

PubMed ID: 12239212

DOI: 10.1074/jbc.m205667200

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

PubMed ID: 20587513

Title: Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells.

PubMed ID: 20587513

DOI: 10.1158/0008-5472.can-10-0255

PubMed ID: 23665872

Title: Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.

PubMed ID: 23665872

DOI: 10.1007/s00018-013-1359-4

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 707
  • Mass: 82280
  • Checksum: E9C1346D52BBF38F
  • Sequence:
    • MTTFKEAMTF KDVAVVFTEE ELGLLDLAQR KLYRDVMLEN FRNLLSVGHQ AFHRDTFHFL 
REEKIWMMKT AIQREGNSGD KIQTEMETVS EAGTHQEWSF QQIWEKIASD LTRSQDLMIN 
SSQFSKEGDF PCQTEAGLSV IHTRQKSSQG NGYKPSFSDV SHFDFHQQLH SGEKSHTCDE 
CGKNFCYISA LRIHQRVHMG EKCYKCDVCG KEFSQSSHLQ THQRVHTGEK PFKCVECGKG 
FSRRSALNVH HKLHTGEKPY NCEECGKAFI HDSQLQEHQR IHTGEKPFKC DICGKSFCGR 
SRLNRHSMVH TAEKPFRCDT CDKSFRQRSA LNSHRMIHTG EKPYKCEECG KGFICRRDLY 
THHMVHTGEK PYNCKECGKS FRWASCLLKH QRVHSGEKPF KCEECGKGFY TNSQCYSHQR 
SHSGEKPYKC VECGKGYKRR LDLDFHQRVH TGEKLYNCKE CGKSFSRAPC LLKHERLHSG 
EKPFQCEECG KRFTQNSHLH SHQRVHTGEK PYKCEKCGKG YNSKFNLDMH QKVHTGERPY 
NCKECGKSFG WASCLLKHQR LHSGEKPFKC EECGKRFTQN SQLHSHQRVH TGEKPYKCDE 
CGKGFSWSST RLTHQRRHSR ETPLKCEQHG KNIVQNSFSK VQEKVHSVEK PYKCEDCGKG 
YNRRLNLDMH QRVHMGEKTW KCRECDMCFS QASSLRLHQN VHVGEKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.