Details for: ZNF226

Gene ID: 7769

Symbol: ZNF226

Ensembl ID: ENSG00000167380

Description: zinc finger protein 226

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 136.1662
    Cell Significance Index: -21.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 79.4422
    Cell Significance Index: -20.1500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 51.7784
    Cell Significance Index: -21.3300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 49.9658
    Cell Significance Index: -23.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.0761
    Cell Significance Index: -19.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 43.7415
    Cell Significance Index: -22.5000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 35.0957
    Cell Significance Index: -23.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.1625
    Cell Significance Index: -19.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.4597
    Cell Significance Index: -22.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.3800
    Cell Significance Index: -19.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8932
    Cell Significance Index: -23.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.5055
    Cell Significance Index: -16.9100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.5792
    Cell Significance Index: 41.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9110
    Cell Significance Index: 148.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8174
    Cell Significance Index: 42.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8139
    Cell Significance Index: 7.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6589
    Cell Significance Index: 8.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6505
    Cell Significance Index: 17.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6245
    Cell Significance Index: 39.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5864
    Cell Significance Index: 40.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5828
    Cell Significance Index: 318.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5769
    Cell Significance Index: 104.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5760
    Cell Significance Index: 30.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5493
    Cell Significance Index: 110.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5193
    Cell Significance Index: 63.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4408
    Cell Significance Index: 9.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3891
    Cell Significance Index: 38.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3773
    Cell Significance Index: 135.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3501
    Cell Significance Index: 9.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2967
    Cell Significance Index: 40.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2917
    Cell Significance Index: 263.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2900
    Cell Significance Index: 6.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2508
    Cell Significance Index: 49.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2484
    Cell Significance Index: 11.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2331
    Cell Significance Index: 14.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1783
    Cell Significance Index: 13.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1751
    Cell Significance Index: 5.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1639
    Cell Significance Index: 31.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1575
    Cell Significance Index: 20.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1559
    Cell Significance Index: 11.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1329
    Cell Significance Index: 91.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1301
    Cell Significance Index: 57.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1009
    Cell Significance Index: 5.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0967
    Cell Significance Index: 6.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0917
    Cell Significance Index: 5.9200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0814
    Cell Significance Index: 0.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0247
    Cell Significance Index: 46.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0201
    Cell Significance Index: 0.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0144
    Cell Significance Index: 0.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0119
    Cell Significance Index: 7.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0074
    Cell Significance Index: 1.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0066
    Cell Significance Index: 12.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0058
    Cell Significance Index: 8.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0011
    Cell Significance Index: -0.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0047
    Cell Significance Index: -2.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0083
    Cell Significance Index: -3.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0101
    Cell Significance Index: -1.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0154
    Cell Significance Index: -0.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0175
    Cell Significance Index: -2.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0179
    Cell Significance Index: -13.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0184
    Cell Significance Index: -10.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0223
    Cell Significance Index: -3.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0438
    Cell Significance Index: -1.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0439
    Cell Significance Index: -4.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0468
    Cell Significance Index: -2.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0470
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0496
    Cell Significance Index: -10.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0558
    Cell Significance Index: -1.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0588
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0660
    Cell Significance Index: -7.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0679
    Cell Significance Index: -19.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0736
    Cell Significance Index: -2.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0785
    Cell Significance Index: -9.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0831
    Cell Significance Index: -2.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1014
    Cell Significance Index: -6.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1024
    Cell Significance Index: -1.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1043
    Cell Significance Index: -1.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1067
    Cell Significance Index: -5.5600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1103
    Cell Significance Index: -0.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1673
    Cell Significance Index: -4.4000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1868
    Cell Significance Index: -21.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1989
    Cell Significance Index: -4.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2035
    Cell Significance Index: -21.1900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2137
    Cell Significance Index: -2.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2285
    Cell Significance Index: -18.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2306
    Cell Significance Index: -5.8900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2443
    Cell Significance Index: -3.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2465
    Cell Significance Index: -5.1600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2824
    Cell Significance Index: -4.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3139
    Cell Significance Index: -9.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3289
    Cell Significance Index: -4.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3300
    Cell Significance Index: -20.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3367
    Cell Significance Index: -11.7000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3458
    Cell Significance Index: -2.8200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3555
    Cell Significance Index: -3.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3634
    Cell Significance Index: -9.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3649
    Cell Significance Index: -9.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3657
    Cell Significance Index: -10.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc finger domain**: ZNF226 possesses a zinc finger domain, which is a conserved protein motif that allows for specific DNA binding. 2. **Transcriptional activator**: ZNF226 acts as a transcriptional activator, promoting the expression of target genes. 3. **RNA polymerase II specificity**: The gene is specifically associated with RNA polymerase II, a crucial enzyme responsible for transcribing protein-coding genes. 4. **Metal ion binding**: ZNF226 exhibits metal ion binding capabilities, which may contribute to its transcriptional regulatory functions. 5. **Tissue-specific expression**: The gene is expressed in various cell types, including germ cells, choroid plexus epithelial cells, and dopaminergic neurons. **Pathways and Functions:** 1. **Transcriptional regulation**: ZNF226 plays a crucial role in regulating gene expression through specific DNA binding and interaction with RNA polymerase II. 2. **Metal ion-dependent transcription**: The gene's metal ion binding capabilities may influence its transcriptional regulatory functions. 3. **Gene expression (transcription)**: ZNF226 is involved in the transcriptional activation of target genes, promoting their expression. 4. **Generic transcription pathway**: The gene participates in the generic transcription pathway, which is responsible for the expression of most genes. 5. **Regulation of transcription by RNA polymerase II**: ZNF226 regulates transcription by interacting with RNA polymerase II, a critical enzyme for gene expression. **Clinical Significance:** 1. **Neurological disorders**: ZNF226 has been implicated in neurological disorders, including Parkinson's disease, where it may play a role in transcriptional regulation and dopamine signaling. 2. **Cancer**: The gene's involvement in transcriptional regulation and metal ion binding may contribute to its potential role in cancer development and progression. 3. **Neurodevelopmental disorders**: ZNF226's expression in dopaminergic neurons and other neural cell types suggests its potential involvement in neurodevelopmental disorders, such as autism spectrum disorder. 4. **Germ cell development**: The gene's expression in germ cells highlights its importance in reproductive biology and fertility. In conclusion, the Zinc Finger Protein 226 is a critical regulator of transcriptional activity, playing a significant role in various cellular processes, including gene expression, metal ion binding, and RNA polymerase II interaction. Its implications in disease, including neurological disorders, cancer, and neurodevelopmental disorders, underscore the importance of further research into its functions and potential therapeutic applications.

Genular Protein ID: 3479553368

Symbol: ZN226_HUMAN

Name: Zinc finger protein 226

UniProtKB Accession Codes:

Q9NYT6 Q8WWE6 Q96TE6 Q9NS44

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 6 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 15 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12743021

Title: Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

PubMed ID: 12743021

DOI: 10.1101/gr.963903

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 803
  • Mass: 91921
  • Checksum: 256DE75551A932A8
  • Sequence:
    • MNMFKEAVTF KDVAVAFTEE ELGLLGPAQR KLYRDVMVEN FRNLLSVGHP PFKQDVSPIE 
RNEQLWIMTT ATRRQGNLGE KNQSKLITVQ DRESEEELSC WQIWQQIAND LTRCQDSMIN 
NSQCHKQGDF PYQVGTELSI QISEDENYIV NKADGPNNTG NPEFPILRTQ DSWRKTFLTE 
SQRLNRDQQI SIKNKLCQCK KGVDPIGWIS HHDGHRVHKS EKSYRPNDYE KDNMKILTFD 
HNSMIHTGQK SYQCNECKKP FSDLSSFDLH QQLQSGEKSL TCVERGKGFC YSPVLPVHQK 
VHVGEKLKCD ECGKEFSQGA HLQTHQKVHV IEKPYKCKQC GKGFSRRSAL NVHCKVHTAE 
KPYNCEECGR AFSQASHLQD HQRLHTGEKP FKCDACGKSF SRNSHLQSHQ RVHTGEKPYK 
CEECGKGFIC SSNLYIHQRV HTGEKPYKCE ECGKGFSRPS SLQAHQGVHT GEKSYICTVC 
GKGFTLSSNL QAHQRVHTGE KPYKCNECGK SFRRNSHYQV HLVVHTGEKP YKCEICGKGF 
SQSSYLQIHQ KAHSIEKPFK CEECGQGFNQ SSRLQIHQLI HTGEKPYKCE ECGKGFSRRA 
DLKIHCRIHT GEKPYNCEEC GKVFRQASNL LAHQRVHSGE KPFKCEECGK SFGRSAHLQA 
HQKVHTGDKP YKCDECGKGF KWSLNLDMHQ RVHTGEKPYK CGECGKYFSQ ASSLQLHQSV 
HTGEKPYKCD VCGKVFSRSS QLQSHQRVHT GEKPYKCEIC GKSFSWRSNL TVHHRIHVGD 
KSYKSNRGGK NIRESTQEKK SIK

Genular Protein ID: 3354749236

Symbol: B2RBM0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RBM0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 94
  • Mass: 10827
  • Checksum: 8CEB53751E389870
  • Sequence:
    • MNMFKEAVTF KDVAVAFTEE ELGLLGPAQR KLYRDVMVEN FRNLLSVGHP PFKQDVSPIE 
RNEQLWIMTT ATRRQGNLDT LLEKALLLYD LAQT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.