Details for: ZNF112

Gene ID: 7771

Symbol: ZNF112

Ensembl ID: ENSG00000062370

Description: zinc finger protein 112

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 75.9908
    Cell Significance Index: -11.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.9306
    Cell Significance Index: -11.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.1873
    Cell Significance Index: -9.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.8980
    Cell Significance Index: -9.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.5867
    Cell Significance Index: -11.8200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.1991
    Cell Significance Index: 19.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1238
    Cell Significance Index: 213.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6848
    Cell Significance Index: 67.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5662
    Cell Significance Index: 511.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5356
    Cell Significance Index: 33.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4379
    Cell Significance Index: 26.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4350
    Cell Significance Index: 47.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3995
    Cell Significance Index: 80.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3850
    Cell Significance Index: 62.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2426
    Cell Significance Index: 87.0200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.2329
    Cell Significance Index: 3.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2217
    Cell Significance Index: 15.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1777
    Cell Significance Index: 5.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1630
    Cell Significance Index: 7.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1577
    Cell Significance Index: 5.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1411
    Cell Significance Index: 7.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1164
    Cell Significance Index: 33.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1123
    Cell Significance Index: 5.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1100
    Cell Significance Index: 2.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1069
    Cell Significance Index: 6.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1056
    Cell Significance Index: 19.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1051
    Cell Significance Index: 12.2500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0905
    Cell Significance Index: 1.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0849
    Cell Significance Index: 5.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0845
    Cell Significance Index: 6.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0785
    Cell Significance Index: 1.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0562
    Cell Significance Index: 24.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0276
    Cell Significance Index: 0.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0248
    Cell Significance Index: 13.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0107
    Cell Significance Index: 0.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0104
    Cell Significance Index: 2.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0095
    Cell Significance Index: 1.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0004
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0021
    Cell Significance Index: -0.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0032
    Cell Significance Index: -5.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0052
    Cell Significance Index: -3.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0063
    Cell Significance Index: -8.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0089
    Cell Significance Index: -6.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0095
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0126
    Cell Significance Index: -9.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0147
    Cell Significance Index: -11.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0179
    Cell Significance Index: -8.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0185
    Cell Significance Index: -10.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0302
    Cell Significance Index: -4.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0381
    Cell Significance Index: -4.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0432
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0553
    Cell Significance Index: -9.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0556
    Cell Significance Index: -3.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0569
    Cell Significance Index: -5.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0590
    Cell Significance Index: -4.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0592
    Cell Significance Index: -12.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0647
    Cell Significance Index: -8.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0709
    Cell Significance Index: -8.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0934
    Cell Significance Index: -11.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0955
    Cell Significance Index: -4.8300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0972
    Cell Significance Index: -2.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1021
    Cell Significance Index: -6.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1138
    Cell Significance Index: -11.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1146
    Cell Significance Index: -8.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1236
    Cell Significance Index: -3.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1263
    Cell Significance Index: -10.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1372
    Cell Significance Index: -6.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1451
    Cell Significance Index: -3.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1571
    Cell Significance Index: -8.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1745
    Cell Significance Index: -11.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1749
    Cell Significance Index: -3.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1854
    Cell Significance Index: -2.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1917
    Cell Significance Index: -6.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2016
    Cell Significance Index: -6.6000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2023
    Cell Significance Index: -5.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2031
    Cell Significance Index: -6.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2037
    Cell Significance Index: -3.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2093
    Cell Significance Index: -5.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2107
    Cell Significance Index: -3.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2251
    Cell Significance Index: -6.0100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2269
    Cell Significance Index: -7.9500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2396
    Cell Significance Index: -2.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2507
    Cell Significance Index: -4.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2514
    Cell Significance Index: -6.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2571
    Cell Significance Index: -6.7600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2612
    Cell Significance Index: -10.7000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2628
    Cell Significance Index: -3.2600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2752
    Cell Significance Index: -5.8400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2869
    Cell Significance Index: -4.9600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2907
    Cell Significance Index: -6.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2994
    Cell Significance Index: -6.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3108
    Cell Significance Index: -7.9900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3135
    Cell Significance Index: -4.4000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3139
    Cell Significance Index: -7.8300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3166
    Cell Significance Index: -6.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3252
    Cell Significance Index: -9.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3292
    Cell Significance Index: -6.8900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3311
    Cell Significance Index: -6.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** ZNF112 acts as a transcriptional activator, regulating the expression of target genes involved in various biological processes, including immune responses and development. 2. **RNA Polymerase II Specificity:** ZNF112 is specifically bound to RNA polymerase II, a key enzyme responsible for transcribing protein-coding genes. 3. **DNA Binding:** ZNF112 binds to specific DNA sequences, allowing it to recruit RNA polymerase II and other transcriptional machinery to regulate gene expression. 4. **Cell Type Specificity:** ZNF112 is expressed in a range of cell types, including those of the immune system, such as GABAergic interneurons and intestinal epithelial cells. **Pathways and Functions:** 1. **Generic Transcription Pathway:** ZNF112 is involved in the regulation of transcription by RNA polymerase II, which is a crucial step in the generic transcription pathway. 2. **Metal Ion Binding:** ZNF112 contains zinc finger motifs that bind to metal ions, which are essential for its DNA binding activity. 3. **Regulation of Transcription by RNA Polymerase II:** ZNF112 regulates transcription by RNA polymerase II, which is involved in the expression of protein-coding genes. 4. **Positive Regulation of Transcription:** ZNF112 acts as a transcriptional activator, promoting the expression of target genes. **Clinical Significance:** 1. **Immune System Disorders:** Dysregulation of ZNF112 has been implicated in several immune system disorders, including autoimmune diseases and immunodeficiency disorders. 2. **Neurological Disorders:** ZNF112 is expressed in the brain and plays a role in regulating gene expression in neurons, making it a potential target for the treatment of neurological disorders. 3. **Cancer:** ZNF112 has been shown to be involved in the regulation of gene expression in cancer cells, making it a potential target for cancer therapy. 4. **Gene Therapy:** ZNF112 has been identified as a potential target for gene therapy, particularly in the treatment of immune system disorders. In conclusion, ZNF112 is a transcription factor that plays a crucial role in regulating gene expression in various cell types, including those of the immune system. Its dysregulation has been implicated in several diseases, highlighting the importance of this protein in maintaining immune homeostasis. Further research is needed to fully understand the functions and significance of ZNF112, but its potential as a therapeutic target makes it an exciting area of study.

Genular Protein ID: 2254814850

Symbol: ZN112_HUMAN

Name: Zinc finger protein 112

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12743021

Title: Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

PubMed ID: 12743021

DOI: 10.1101/gr.963903

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 913
  • Mass: 105842
  • Checksum: 45F1E5A0EFBDFFC0
  • Sequence:
  • MTKFQEMVTF KDVAVVFTEE ELGLLDSVQR KLYRDVMLEN FRNLLLVAHQ PFKPDLISQL 
    EREEKLLMVE TETPRDGCSG RKNQQKMESI QEVTVSYFSP KELSSRQTWQ QSAGGLIRCQ 
    DFLKVFQGKN SQLQEQGNSL GQVWAGIPVQ ISEDKNYIFT HIGNGSNYIK SQGYPSWRAH 
    HSWRKMYLKE SHNYQCRCQQ ISMKNHFCKC DSVSWLSHHN DKLEVHRKEN YSCHDCGEDI 
    MKVSLLNQES IQTEEKPYPC TGYRKAFSND SSSEVHQQFH LEGKPYTYSS CGKGCNYSSL 
    LHIHQNIERE DDIENSHLKS YQRVHTEEKP CKCGEYGENF NHCSPLNTYE LIHTGEMSYR 
    HNIYEKAFSH SLDLNSIFRV HTRDEPHEYE ENENVFNQSS CLQVHQKIHT EEKLYTDIEY 
    GKSFICSSNL DIQHRVHMEE NSYNSEECGN GFSLASHFQD LQIVHTKEQP YKRYVCSNSF 
    SHNLYLQGHP KIHIGEKPRK EHGNGFNWSS KLKDHQRVHT GQKPYKCNIC GKGFNHRSVL 
    NVHQRVHTGE KPYKCEECDK GFSRSSYLQA HQRVHTGEKP YKCEECGKGF SRNSYLQGHQ 
    RVHTGEKPYK CEECGKGFSR SSHLQGHQRV HTGEKPFKCE ECGKGFSWSF NLQIHQRVHT 
    GEKPYKCEEC GKGFSKASTL LAHQRVHTGE KPYQCDECGK SFSQRSYLQS HQSVHSGERP 
    YICEVCGKGF SQRAYLQGHQ RVHTRVKPYK CEMCGKGFSQ SSRLEAHRRV HTGGKPYKCE 
    VCTKGFSESS RLQAHQRVHV EGRPYKCEQC GKGFSGYSSL QAHHRVHTGE KPYKCEVCGK 
    GFSQRSNLQA HQRVHTGEKP YKCDACGKGF RWSSGLLIHQ RVHSSDKFYK SEDYGKDYPS 
    SENLHRNEDS VLF

Genular Protein ID: 890626817

Symbol: Q0VG01_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 907
  • Mass: 104958
  • Checksum: 517EB8EFA5E4A224
  • Sequence:
  • MVTFKDVAVV FTEEELGLLD SVQRKLYRDV MLENFRNLLL VAHQPFKPDL ISQLEREEKL 
    LMVETETPRD GCSGRKNQQK MESIQEVTVS YFSPKELSSR QTWQQSAGGL IRCQDFLKVF 
    QGKNSQLQEQ GNSLGQVWAG IPVQISEDKN YILTHIGNGS NYIKSQGYPS WRAHHSWRKM 
    YLKESHNYQC RCQQISMKNH FCKCDSVSWL SHHNDKLEVH RKENYSCHDC GEDIMKVSLL 
    NQESIQTEEK PYPCTGYRKA FSNDSSSEVH QQFHLEGKPY TYSSCGKGCN YSSLLHIHQN 
    IEREDDIENS HLKSYQRVHT EEKPCKCGEY GENFNHCSPL NTYELIHTGE MSYRHNIYEK 
    AFSHSLDLNS IFRVHTRDEP HEYEENENVF NQSSCLQVHQ KIHTEEKLYT DIEYGKSFIC 
    SSNLDIQHRV HMEENSYNSQ ECGNGFSLAS HFQDLQIVHT KEQPYKRYVC SNSFSHNLHL 
    QGHPKIHIGE KPRKEHGNGF NWSSKLKDHQ RVHTGQKPYK CNICGKGFNH RSVLNVHQRV 
    HTGEKPYKCE ECDKGFSRSS YLQAHQRVHT GEKPYKCEEC GKGFSRNSYL QGHQRVHTGE 
    KPYKCEECGK GFSRSSHLQG HQRVHTGEKP FKCEECGKGF SWSFNLQIHQ RVHTGEKPYK 
    CEECGKGFSK ASTLLAHQRV HTGEKPYQCD ECGKSFSQRS YLQSHQSVHS GERPYICEVC 
    GKGFSQRAYL QGHQRVHTRV KPYKCEMCGK GFSQSSRLEA HRRVHTGGKP YKCAVCTKGF 
    SESSRLQAHQ RVHVEGRPYK CEQCGKGFSG YSSLQAHHRV HTGEKPYKCE VCGKGFSQRS 
    NLQAHQRVHT GEKPYKCDAC GKGFRWSSGL LIHQRVHSSD KFYKSEDYGK DYPSSENLHR 
    NEDSVLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.