Details for: MOGS

Gene ID: 7841

Symbol: MOGS

Ensembl ID: ENSG00000115275

Description: mannosyl-oligosaccharide glucosidase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 128.1621
    Cell Significance Index: -19.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 78.2595
    Cell Significance Index: -19.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.8053
    Cell Significance Index: -19.0200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.9780
    Cell Significance Index: -22.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.9321
    Cell Significance Index: -19.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.2310
    Cell Significance Index: -21.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.8840
    Cell Significance Index: -21.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4688
    Cell Significance Index: -21.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.6330
    Cell Significance Index: -14.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.2075
    Cell Significance Index: -7.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.1738
    Cell Significance Index: 253.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4091
    Cell Significance Index: 153.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3775
    Cell Significance Index: 82.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3721
    Cell Significance Index: 18.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8415
    Cell Significance Index: 22.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7760
    Cell Significance Index: 154.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7517
    Cell Significance Index: 20.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7358
    Cell Significance Index: 119.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7297
    Cell Significance Index: 21.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7063
    Cell Significance Index: 19.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5825
    Cell Significance Index: 27.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5280
    Cell Significance Index: 11.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4487
    Cell Significance Index: 23.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4102
    Cell Significance Index: 224.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3984
    Cell Significance Index: 71.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3614
    Cell Significance Index: 9.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3299
    Cell Significance Index: 66.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3234
    Cell Significance Index: 14.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3016
    Cell Significance Index: 37.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2865
    Cell Significance Index: 54.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2099
    Cell Significance Index: 189.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1996
    Cell Significance Index: 27.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1853
    Cell Significance Index: 81.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1821
    Cell Significance Index: 8.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1596
    Cell Significance Index: 11.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1475
    Cell Significance Index: 52.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1454
    Cell Significance Index: 14.3800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1231
    Cell Significance Index: 1.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1187
    Cell Significance Index: 7.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1179
    Cell Significance Index: 9.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1146
    Cell Significance Index: 2.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1128
    Cell Significance Index: 78.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1085
    Cell Significance Index: 6.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1012
    Cell Significance Index: 13.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1006
    Cell Significance Index: 7.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0958
    Cell Significance Index: 16.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0655
    Cell Significance Index: 4.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0575
    Cell Significance Index: 2.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0188
    Cell Significance Index: 11.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0177
    Cell Significance Index: 33.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0130
    Cell Significance Index: 24.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0053
    Cell Significance Index: 8.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0043
    Cell Significance Index: 0.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0012
    Cell Significance Index: -0.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0048
    Cell Significance Index: -0.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0091
    Cell Significance Index: -12.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0097
    Cell Significance Index: -4.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0103
    Cell Significance Index: -7.7700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0123
    Cell Significance Index: -0.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0135
    Cell Significance Index: -9.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0232
    Cell Significance Index: -3.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0233
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0248
    Cell Significance Index: -18.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0364
    Cell Significance Index: -20.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0376
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0395
    Cell Significance Index: -24.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0430
    Cell Significance Index: -4.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0554
    Cell Significance Index: -15.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0705
    Cell Significance Index: -2.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0727
    Cell Significance Index: -4.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1176
    Cell Significance Index: -24.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1247
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1266
    Cell Significance Index: -14.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1441
    Cell Significance Index: -3.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1477
    Cell Significance Index: -4.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1719
    Cell Significance Index: -11.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1761
    Cell Significance Index: -4.7100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1771
    Cell Significance Index: -1.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1771
    Cell Significance Index: -9.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1831
    Cell Significance Index: -19.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1873
    Cell Significance Index: -5.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2246
    Cell Significance Index: -13.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2247
    Cell Significance Index: -6.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2378
    Cell Significance Index: -10.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2562
    Cell Significance Index: -20.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2789
    Cell Significance Index: -7.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2892
    Cell Significance Index: -10.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2912
    Cell Significance Index: -4.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2995
    Cell Significance Index: -6.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3096
    Cell Significance Index: -7.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3203
    Cell Significance Index: -16.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3276
    Cell Significance Index: -8.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3310
    Cell Significance Index: -6.4600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4159
    Cell Significance Index: -6.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4342
    Cell Significance Index: -13.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4388
    Cell Significance Index: -22.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4479
    Cell Significance Index: -15.6900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4531
    Cell Significance Index: -3.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4539
    Cell Significance Index: -14.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4561
    Cell Significance Index: -8.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** MOGS is a glucosidase enzyme that catalyzes the hydrolysis of mannose-oligosaccharides, specifically the Glc3Man9GlcNAc2 oligosaccharide. 2. **Cellular Localization:** MOGS is primarily expressed in the endoplasmic reticulum (ER) and ER membrane, where it regulates N-glycosylation processes. 3. **Tissue Distribution:** MOGS is significantly expressed in various tissues, including the cerebral cortex, forebrain radial glial cells, absorptive cells, placental villous trophoblasts, intestinal crypt stem cells, and nasal mucosa goblet cells. 4. **Protein Interaction:** MOGS interacts with other enzymes and proteins involved in the N-glycosylation pathway, including calnexin and calreticulin. **Pathways and Functions:** 1. **N-Glycosylation Pathway:** MOGS is involved in the trimming of N-glycans, specifically the Glc3Man9GlcNAc2 oligosaccharide, which is essential for protein maturation and proper folding. 2. **Endoplasmic Reticulum (ER) Quality Control:** MOGS regulates the ER quality control process by controlling the levels of immature N-glycans, thereby preventing protein misfolding and aggregation. 3. **Viral Infection Pathways:** MOGS has been implicated in the regulation of viral protein processing and maturation, particularly in the context of SARS-CoV-1 and SARS-CoV-2 infections. 4. **Protein Homeostasis:** MOGS contributes to maintaining protein homeostasis by regulating the levels of N-glycans and preventing protein misfolding. **Clinical Significance:** 1. **Congenital Dysglycans (CDG) Type 2B:** MOGS mutations have been associated with CDG type 2B, a disorder characterized by defective glycosylation and neurological abnormalities. 2. **Late SARS-CoV-2 Infection Events:** MOGS has been implicated in the regulation of viral protein processing and maturation, which may contribute to the severity of late SARS-CoV-2 infection events. 3. **Glycosylation-Related Disorders:** MOGS dysregulation has been linked to various glycosylation-related disorders, including metabolic disorders and infectious diseases. 4. **Therapeutic Targeting:** MOGS has emerged as a potential therapeutic target for treating glycosylation-related disorders, particularly those associated with defective N-glycosylation pathways. In conclusion, MOGS plays a critical role in regulating N-glycosylation pathways, maintaining protein homeostasis, and preventing protein misfolding. Its dysregulation has been implicated in various diseases, including CDG type 2B and late SARS-CoV-2 infection events. Further research is necessary to fully elucidate the mechanisms by which MOGS regulates N-glycosylation pathways and to explore its potential as a therapeutic target for treating glycosylation-related disorders.

Genular Protein ID: 1078942740

Symbol: MOGS_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7635146

Title: Cloning and expression of glucosidase I from human hippocampus.

PubMed ID: 7635146

DOI: 10.1111/j.1432-1033.1995.tb20706.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10788335

Title: A novel disorder caused by defective biosynthesis of N-linked oligosaccharides due to glucosidase I deficiency.

PubMed ID: 10788335

DOI: 10.1086/302948

PubMed ID: 12145188

Title: Processing of N-linked carbohydrate chains in a patient with glucosidase I deficiency (CDG type IIb).

PubMed ID: 12145188

DOI: 10.1093/glycob/cwf050

Sequence Information:

  • Length: 837
  • Mass: 91918
  • Checksum: 11C5B09301B50DEE
  • Sequence:
  • MARGERRRRA VPAEGVRTAE RAARGGPGRR DGRGGGPRST AGGVALAVVV LSLALGMSGR 
    WVLAWYRARR AVTLHSAPPV LPADSSSPAV APDLFWGTYR PHVYFGMKTR SPKPLLTGLM 
    WAQQGTTPGT PKLRHTCEQG DGVGPYGWEF HDGLSFGRQH IQDGALRLTT EFVKRPGGQH 
    GGDWSWRVTV EPQDSGTSAL PLVSLFFYVV TDGKEVLLPE VGAKGQLKFI SGHTSELGDF 
    RFTLLPPTSP GDTAPKYGSY NVFWTSNPGL PLLTEMVKSR LNSWFQHRPP GAPPERYLGL 
    PGSLKWEDRG PSGQGQGQFL IQQVTLKIPI SIEFVFESGS AQAGGNQALP RLAGSLLTQA 
    LESHAEGFRE RFEKTFQLKE KGLSSGEQVL GQAALSGLLG GIGYFYGQGL VLPDIGVEGS 
    EQKVDPALFP PVPLFTAVPS RSFFPRGFLW DEGFHQLVVQ RWDPSLTREA LGHWLGLLNA 
    DGWIGREQIL GDEARARVPP EFLVQRAVHA NPPTLLLPVA HMLEVGDPDD LAFLRKALPR 
    LHAWFSWLHQ SQAGPLPLSY RWRGRDPALP TLLNPKTLPS GLDDYPRASH PSVTERHLDL 
    RCWVALGARV LTRLAEHLGE AEVAAELGPL AASLEAAESL DELHWAPELG VFADFGNHTK 
    AVQLKPRPPQ GLVRVVGRPQ PQLQYVDALG YVSLFPLLLR LLDPTSSRLG PLLDILADSR 
    HLWSPFGLRS LAASSSFYGQ RNSEHDPPYW RGAVWLNVNY LALGALHHYG HLEGPHQARA 
    AKLHGELRAN VVGNVWRQYQ ATGFLWEQYS DRDGRGMGCR PFHGWTSLVL LAMAEDY

Genular Protein ID: 830820384

Symbol: Q58F09_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 837
  • Mass: 91907
  • Checksum: 696FA72FA65E65B2
  • Sequence:
  • MARGERRRRA VPAEGVRTAE RAARGGPGRR DGRGGGPRST AGGVALAVVV LSLALGMSGR 
    WVLAWYRARR AVTLHSAPPV LPADSSSPAV APDLFWGTYR PHVYFGMKTR SPKPLLTGLM 
    WAQQGTTPGT PKLRHTCEQG DGVGPYGWEF HDGLSFGRQH IQDGALRLTT EFVKRPGGQH 
    GGDWSWRVTV EPQDSGTSAL PLVSLFFYVV TDGKEVLLPE VGAKGQLKFI SGHTSELGNF 
    RFTLLPPTSP GDTAPKYGSY NVFWTSNPGL PLLTEMVKSR LNSWFQHRPP GASPERYLGL 
    PGSLKWEDRG PSGQGQGQFL IQQVTLKIPI SIEFVFESGS AQAGGNQALP RLAGSLLTQA 
    LESHAEGFRE RFEKTFQLKE KGLSSGEQVL GQAALSGLLG GIGYFYGQGL VLPDIGVEGS 
    EQKVDPALFP PVPLFTAVPS RSFFPRGFLW DEGFHQLVVQ RWDPSLTREA LGHWLGLLNA 
    DGWIGREQIL GDEARARVPP EFLVQRAVHA NPPTLLLPVA HMLEVGDPDD LAFLRKALPR 
    LHAWFSWLHQ SQAGPLPLSY RWRGRDPALP TLLNPKTLPS GLDDYPRASH PSVTERHLDL 
    RCWVALGARV LTRLAEHLGE AEVAAELGPL AASLEAAESL DELHWAPELG VFADFGNHTK 
    AVQLKPRPPQ GLVRVVGRPQ PQLQYVDALG YVSLFPLLLR LLDPTSSRLG PLLDILADSR 
    HLWSPFGLRS LAASSSFYGQ RNSEHDPPYW RGAVWLNVNY LALGALHHYG HLEGPHQARA 
    AKLHGELRAN VVGNVWRQYQ ATGFLWEQYS DRDGRGMGCR PFHGWTSLVL LAMAEDY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.