Details for: MAPKAPK3

Gene ID: 7867

Symbol: MAPKAPK3

Ensembl ID: ENSG00000114738

Description: MAPK activated protein kinase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 102.4139
    Cell Significance Index: -15.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.3347
    Cell Significance Index: -15.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 34.6433
    Cell Significance Index: -17.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.4393
    Cell Significance Index: -16.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.1554
    Cell Significance Index: -16.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.6629
    Cell Significance Index: -1.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2422
    Cell Significance Index: -16.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.1361
    Cell Significance Index: -11.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.3537
    Cell Significance Index: 69.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.0763
    Cell Significance Index: 55.5400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.5336
    Cell Significance Index: 28.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.4516
    Cell Significance Index: 38.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2233
    Cell Significance Index: 73.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1096
    Cell Significance Index: 109.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9219
    Cell Significance Index: 107.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8923
    Cell Significance Index: 97.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8515
    Cell Significance Index: 768.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6142
    Cell Significance Index: 99.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5977
    Cell Significance Index: 45.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5358
    Cell Significance Index: 7.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4678
    Cell Significance Index: 32.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3823
    Cell Significance Index: 19.8600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3250
    Cell Significance Index: 7.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2759
    Cell Significance Index: 7.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2698
    Cell Significance Index: 12.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2576
    Cell Significance Index: 16.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2562
    Cell Significance Index: 12.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2317
    Cell Significance Index: 126.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2257
    Cell Significance Index: 4.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2201
    Cell Significance Index: 27.0600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1948
    Cell Significance Index: 1.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1901
    Cell Significance Index: 13.4500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1869
    Cell Significance Index: 1.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1693
    Cell Significance Index: 30.5300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1632
    Cell Significance Index: 2.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1607
    Cell Significance Index: 71.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1568
    Cell Significance Index: 20.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1492
    Cell Significance Index: 4.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1424
    Cell Significance Index: 3.9800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.1401
    Cell Significance Index: 2.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1381
    Cell Significance Index: 6.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1293
    Cell Significance Index: 25.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0940
    Cell Significance Index: 2.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0681
    Cell Significance Index: 12.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0676
    Cell Significance Index: 0.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0597
    Cell Significance Index: 4.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0508
    Cell Significance Index: 8.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0397
    Cell Significance Index: 74.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0300
    Cell Significance Index: 22.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0263
    Cell Significance Index: 18.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0254
    Cell Significance Index: 0.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0248
    Cell Significance Index: 15.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0210
    Cell Significance Index: 2.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0090
    Cell Significance Index: 6.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0086
    Cell Significance Index: 0.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0026
    Cell Significance Index: 0.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0004
    Cell Significance Index: 0.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0081
    Cell Significance Index: -14.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0086
    Cell Significance Index: -1.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0097
    Cell Significance Index: -14.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0138
    Cell Significance Index: -18.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0154
    Cell Significance Index: -1.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0161
    Cell Significance Index: -7.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0180
    Cell Significance Index: -13.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0215
    Cell Significance Index: -0.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0264
    Cell Significance Index: -14.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0275
    Cell Significance Index: -9.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0306
    Cell Significance Index: -19.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0526
    Cell Significance Index: -15.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0542
    Cell Significance Index: -1.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0564
    Cell Significance Index: -11.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0623
    Cell Significance Index: -3.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0637
    Cell Significance Index: -2.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0642
    Cell Significance Index: -7.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0654
    Cell Significance Index: -7.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0695
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0911
    Cell Significance Index: -19.1900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1010
    Cell Significance Index: -0.9300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1097
    Cell Significance Index: -0.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1420
    Cell Significance Index: -14.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1487
    Cell Significance Index: -11.7800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1726
    Cell Significance Index: -1.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1782
    Cell Significance Index: -9.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1862
    Cell Significance Index: -10.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1918
    Cell Significance Index: -7.8600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1994
    Cell Significance Index: -1.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2018
    Cell Significance Index: -2.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2186
    Cell Significance Index: -13.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2374
    Cell Significance Index: -14.9600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2389
    Cell Significance Index: -3.6000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2526
    Cell Significance Index: -7.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2579
    Cell Significance Index: -15.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2678
    Cell Significance Index: -18.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2876
    Cell Significance Index: -4.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3019
    Cell Significance Index: -15.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3108
    Cell Significance Index: -7.9900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3455
    Cell Significance Index: -4.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3623
    Cell Significance Index: -9.6800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3727
    Cell Significance Index: -8.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine/Threonine Kinase Activity:** MAPKAPK3 possesses protein serine/threonine kinase activity, which enables it to phosphorylate and regulate various substrates involved in immune response and cellular stress. 2. **MAPK Pathway Activation:** MAPKAPK3 is activated by the MAPK pathway, which is a critical signaling cascade involved in the regulation of various cellular processes, including inflammation, apoptosis, and cellular differentiation. 3. **Calmodulin Binding:** MAPKAPK3 interacts with calmodulin, a calcium-binding protein, which modulates its activity and regulates its interaction with other proteins. 4. **Cellular Stress Response:** MAPKAPK3 is involved in the regulation of cellular stress responses, including oxidative stress-induced senescence and apoptosis. **Pathways and Functions:** 1. **Immune Response:** MAPKAPK3 is involved in the regulation of immune response, particularly in the signaling cascades initiated by Toll-like receptors, cytokines, and lipopolysaccharides. 2. **MAPK Cascade:** MAPKAPK3 is a key effector of the MAPK cascade, which regulates various cellular processes, including inflammation, apoptosis, and cellular differentiation. 3. **Calmodulin Signaling:** MAPKAPK3 interacts with calmodulin, which modulates its activity and regulates its interaction with other proteins. 4. **Protein Phosphorylation:** MAPKAPK3 phosphorylates and regulates various substrates involved in immune response and cellular stress. **Clinical Significance:** 1. **Inflammatory Diseases:** MAPKAPK3 has been implicated in the pathogenesis of various inflammatory diseases, including rheumatoid arthritis, atherosclerosis, and inflammatory bowel disease. 2. **Cancer:** MAPKAPK3 has been shown to play a role in cancer progression, particularly in the regulation of apoptosis and cellular differentiation. 3. **Neurological Disorders:** MAPKAPK3 has been implicated in the pathogenesis of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Transplantation:** MAPKAPK3 has been shown to play a role in the regulation of immune response and graft rejection in transplantation. In conclusion, MAPKAPK3 is a key regulator of immune response, cellular stress, and inflammation. Its dysregulation has been implicated in various diseases, including inflammatory disorders, cancer, and neurological disorders. Further research is needed to fully understand the role of MAPKAPK3 in human disease and to develop therapeutic strategies targeting this gene.

Genular Protein ID: 778126635

Symbol: MAPK3_HUMAN

Name: MAP kinase-activated protein kinase 3

UniProtKB Accession Codes:

Q16644 B5BU67

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 3 ELM 1 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 3 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8626550

Title: Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase.

PubMed ID: 8626550

DOI: 10.1074/jbc.271.14.8488

PubMed ID: 8622688

Title: 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region.

PubMed ID: 8622688

DOI: 10.1128/mcb.16.3.868

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8774846

Title: A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.

PubMed ID: 8774846

DOI: 10.1016/0014-5793(96)00816-2

PubMed ID: 10383393

Title: Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation.

PubMed ID: 10383393

DOI: 10.1074/jbc.274.27.18947

PubMed ID: 10781029

Title: Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity.

PubMed ID: 10781029

DOI: 10.1074/jbc.c901040199

PubMed ID: 15302577

Title: Mitogen-activated 3p kinase is active in the nucleus.

PubMed ID: 15302577

DOI: 10.1016/j.yexcr.2004.05.027

PubMed ID: 15563468

Title: MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1.

PubMed ID: 15563468

DOI: 10.1074/jbc.m407155200

PubMed ID: 18021073

Title: Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex.

PubMed ID: 18021073

DOI: 10.1042/bj20071149

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20599781

Title: MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin.

PubMed ID: 20599781

DOI: 10.1016/j.bcp.2010.06.021

PubMed ID: 18508601

Title: MK2 and MK3--a pair of isoenzymes?

PubMed ID: 18508601

DOI: 10.2741/3095

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 26744326

Title: A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium.

PubMed ID: 26744326

DOI: 10.1093/hmg/ddv624

PubMed ID: 19937655

Title: High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand.

PubMed ID: 19937655

DOI: 10.1002/pro.294

PubMed ID: 21565500

Title: Structure-based lead identification of ATP-competitive MK2 inhibitors.

PubMed ID: 21565500

DOI: 10.1016/j.bmcl.2011.04.018

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 382
  • Mass: 42987
  • Checksum: 405F958B7F54E6F3
  • Sequence:
    • MDGETAEEQG GPVPPPVAPG GPGLGGAPGG RREPKKYAVT DDYQLSKQVL GLGVNGKVLE 
CFHRRTGQKC ALKLLYDSPK ARQEVDHHWQ ASGGPHIVCI LDVYENMHHG KRCLLIIMEC 
MEGGELFSRI QERGDQAFTE REAAEIMRDI GTAIQFLHSH NIAHRDVKPE NLLYTSKEKD 
AVLKLTDFGF AKETTQNALQ TPCYTPYYVA PEVLGPEKYD KSCDMWSLGV IMYILLCGFP 
PFYSNTGQAI SPGMKRRIRL GQYGFPNPEW SEVSEDAKQL IRLLLKTDPT ERLTITQFMN 
HPWINQSMVV PQTPLHTARV LQEDKDHWDE VKEEMTSALA TMRVDYDQVK IKDLKTSNNR 
LLNKRRKKQA GSSSASQGCN NQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.